Ccn Intercellular Signaling Proteins Advances In Research And Application 2013 Edition

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CCN Intercellular Signaling Proteins—Advances in Research and Application: 2012 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481612107
Total Pages : 66 pages
Book Rating : 4.4/5 (816 download)

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Download or read book CCN Intercellular Signaling Proteins—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: CCN Intercellular Signaling Proteins—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about CCN Intercellular Signaling Proteins in a concise format. The editors have built CCN Intercellular Signaling Proteins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about CCN Intercellular Signaling Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of CCN Intercellular Signaling Proteins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

CCN Intercellular Signaling Proteins—Advances in Research and Application: 2013 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481698192
Total Pages : 54 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis CCN Intercellular Signaling Proteins—Advances in Research and Application: 2013 Edition by :

Download or read book CCN Intercellular Signaling Proteins—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: CCN Intercellular Signaling Proteins—Advances in Research and Application: 2013 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about ZZZAdditional Research in a compact format. The editors have built CCN Intercellular Signaling Proteins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of CCN Intercellular Signaling Proteins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

CCN Intercellular Signaling Proteins: Advances in Research and Application: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464939470
Total Pages : 53 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis CCN Intercellular Signaling Proteins: Advances in Research and Application: 2011 Edition by :

Download or read book CCN Intercellular Signaling Proteins: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt: CCN Intercellular Signaling Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about CCN Intercellular Signaling Proteins in a concise format. The editors have built CCN Intercellular Signaling Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about CCN Intercellular Signaling Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of CCN Intercellular Signaling Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Intercellular Signaling Peptides and Proteins—Advances in Research and Application: 2013 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481688995
Total Pages : 626 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis Intercellular Signaling Peptides and Proteins—Advances in Research and Application: 2013 Edition by :

Download or read book Intercellular Signaling Peptides and Proteins—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intercellular Signaling Peptides and Proteins—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Agouti-Related Protein. The editors have built Intercellular Signaling Peptides and Proteins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Agouti-Related Protein in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Intercellular Signaling Peptides and Proteins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Intercellular Signaling Peptides and Proteins: Advances in Research and Application: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464921415
Total Pages : 545 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Intercellular Signaling Peptides and Proteins: Advances in Research and Application: 2011 Edition by :

Download or read book Intercellular Signaling Peptides and Proteins: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intercellular Signaling Peptides and Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Intercellular Signaling Peptides and Proteins. The editors have built Intercellular Signaling Peptides and Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Intercellular Signaling Peptides and Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Intercellular Signaling Peptides and Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Research of Pathogenesis and Novel Therapeutics in Arthritis

Author : Chih-Hsin Tang
Publisher : MDPI
ISBN 13 : 3038970654
Total Pages : 366 pages
Book Rating : 4.0/5 (389 download)

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Book Synopsis Research of Pathogenesis and Novel Therapeutics in Arthritis by : Chih-Hsin Tang

Download or read book Research of Pathogenesis and Novel Therapeutics in Arthritis written by Chih-Hsin Tang and published by MDPI. This book was released on 2019-06-04 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arthritis has a high prevalence globally and includes over 100 different types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. The exact etiology of arthritis remains unclear and no cure exists. Anti-inflammatory drugs are commonly used in the treatment of arthritis but are associated with significant side effects. Novel modes of therapy and additional prognostic biomarkers are urgently needed for arthritis patients. This book summarizes and discusses the global picture of the current understanding of arthritis.

Medical Imaging Informatics

Author : Alex A.T. Bui
Publisher : Springer Science & Business Media
ISBN 13 : 1441903852
Total Pages : 454 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Medical Imaging Informatics by : Alex A.T. Bui

Download or read book Medical Imaging Informatics written by Alex A.T. Bui and published by Springer Science & Business Media. This book was released on 2009-12-01 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Imaging Informatics provides an overview of this growing discipline, which stems from an intersection of biomedical informatics, medical imaging, computer science and medicine. Supporting two complementary views, this volume explores the fundamental technologies and algorithms that comprise this field, as well as the application of medical imaging informatics to subsequently improve healthcare research. Clearly written in a four part structure, this introduction follows natural healthcare processes, illustrating the roles of data collection and standardization, context extraction and modeling, and medical decision making tools and applications. Medical Imaging Informatics identifies core concepts within the field, explores research challenges that drive development, and includes current state-of-the-art methods and strategies.

Converging Technologies for Improving Human Performance

Author : Mihail C. Roco
Publisher : Springer Science & Business Media
ISBN 13 : 9401703590
Total Pages : 477 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Converging Technologies for Improving Human Performance by : Mihail C. Roco

Download or read book Converging Technologies for Improving Human Performance written by Mihail C. Roco and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: M. C. Roco and W.S. Bainbridge In the early decades of the 21st century, concentrated efforts can unify science based on the unity of nature, thereby advancing the combination of nanotechnology, biotechnology, information technology, and new technologies based in cognitive science. With proper attention to ethical issues and societal needs, converging in human abilities, societal technologies could achieve a tremendous improvement outcomes, the nation's productivity, and the quality of life. This is a broad, cross cutting, emerging and timely opportunity of interest to individuals, society and humanity in the long term. The phrase "convergent technologies" refers to the synergistic combination of four major "NBIC" (nano-bio-info-cogno) provinces of science and technology, each of which is currently progressing at a rapid rate: (a) nanoscience and nanotechnology; (b) biotechnology and biomedicine, including genetic engineering; (c) information technology, including advanced computing and communications; (d) cognitive science, including cognitive neuroscience. Timely and Broad Opportunity. Convergence of diverse technologies is based on material unity at the nanoscale and on technology integration from that scale.

Paper to Digital

Author : Ziming Liu
Publisher : Libraries Unlimited
ISBN 13 :
Total Pages : 184 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Paper to Digital by : Ziming Liu

Download or read book Paper to Digital written by Ziming Liu and published by Libraries Unlimited. This book was released on 2008-10-30 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Is the paperless society really possible? What is the future of paper in the Digital Age? Based on extensive statistics and six separate surveys, Paper to Digital explores the evolution and changing characteristics of documents in the Information Age. Resultant implications are studied through the examination of emerging issues in the digital environment. This timely book represents a useful and scholarly exploration of a major concern in our society.

Advances in Fingerprint Technology

Author : Ashim K. Datta
Publisher : CRC Press
ISBN 13 : 1420041347
Total Pages : 457 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Advances in Fingerprint Technology by : Ashim K. Datta

Download or read book Advances in Fingerprint Technology written by Ashim K. Datta and published by CRC Press. This book was released on 2001-06-15 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fingerprints constitute one of the most important categories of physical evidence, and it is among the few that can be truly individualized. During the last two decades, many new and exciting developments have taken place in the field of fingerprint science, particularly in the realm of methods for developing latent prints and in the growth of imag

CCN Proteins

Author : Bernard Perbal
Publisher : World Scientific
ISBN 13 : 1783260335
Total Pages : 324 pages
Book Rating : 4.7/5 (832 download)

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Book Synopsis CCN Proteins by : Bernard Perbal

Download or read book CCN Proteins written by Bernard Perbal and published by World Scientific. This book was released on 2005-06-17 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: The CCN Proteins are thought to play key roles in the biology of normal cell, tissue, organ, and body, and altered expression of CCN proteins is associated with several pathologies, including fibrosis and cancer. Because of its importance, the CCN field is expanding at a fast pace. Research articles in this field have recently increased logarithmically, and a book that is up-to-date, comprehensive, authoritative and affords insights into the biological roles of CCN proteins, is timely. CCN Protein: A New Family of Cell Growth and Differentiation Regulators presents the most recent progress in the field of CCN proteins, a new family of secretory signaling molecules that are involved in several fundamental biological progress. These proteins share a unique multimodular organization and present a partial identity with four families of regulatory proteins controling growth and development. The book covers the roles of CCN proteins in the control of cell proliferation and differentiation during normal development, wound repair, chondrogenesis and bone development, angiogenesis, tissue regeneration, fibrosis, renal diseases and cancer development. Contents: The CCN Family of Proteins: An Overview (B Perbal & M Takigawa)Roles of CCN2/CTGF in the Control of Growth and Regeneration (M Takigawa et al.)Integrin-Mediated CCN Functions (L F Lau & S C-T Lam)Expression and Roles of CCN2 During Odontogenesis (M Kanyama et al.)CCN Genes and the Kidney (B L Riser et al.)CCN Proteins in Liver Injury and Disease (A W Rachfal & D R Brigstock)Genetic Analysis of CCN Gene Function in Mammalian Development (L M Dornbach & K M Lyons)CCN Family in Embryonic Development (Non-Mammalian Models) (B Latinkic)CCN3 Expression and its Role During Development (K-I Katsube)Regulation of CCN Proteins by Alternations of the Cytoskeleton (B Chaqour & M Goppelt-Struebe)Pathogenesis of Systemic Sclerosis and CCN2 (Connective Tissue Growth Factor) (K Takehara)Function and Regulation of CCN5 (M R Gray & J J Castellot Jr)CCN3: A Multifunctional Signaling Regulator (N Planque et al.)CCN Proteins and Connexins: Interactions and Growth Control (C Fu et al.)The Role of CCN1 in Tumorigenesis and Cancer Progression (J O'Kelly & H P Koeffler)CCN4 and CCN6 Variants in Wnt-Inducible Signaling Pathway (S Tanaka) Readership: Biochemists, biologists, molecular biologists, physiologists, pathologists, and medical and dental doctors interested in the study of CCN proteins, growth factors, extracellular matrix proteins, signaling molecules, and mechanisms of gene expression. Key Features:First such book in the CCN fieldChapters are written by the most prominent specialists in the fieldKeywords:Cyr 61;CTGF;NOV;WISP;Elm-1;rCop-1;Growth Factor;Extracellular Matrix;Signaling;Gene Expression;Cancer Fibrogenesis

Mechanotransduction

Author :
Publisher : Academic Press
ISBN 13 : 0123983274
Total Pages : 384 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Mechanotransduction by :

Download or read book Mechanotransduction written by and published by Academic Press. This book was released on 2014-07-29 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction. Provides a unique combination of perspectives from biologists and engineers Engaging to people of many training backgrounds

Tumor Organoids

Author : Shay Soker
Publisher : Humana Press
ISBN 13 : 3319605119
Total Pages : 213 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Tumor Organoids by : Shay Soker

Download or read book Tumor Organoids written by Shay Soker and published by Humana Press. This book was released on 2017-10-20 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Handbook of Composites from Renewable Materials, Nanocomposites

Author : Vijay Kumar Thakur
Publisher : John Wiley & Sons
ISBN 13 : 1119224462
Total Pages : 1172 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Handbook of Composites from Renewable Materials, Nanocomposites by : Vijay Kumar Thakur

Download or read book Handbook of Composites from Renewable Materials, Nanocomposites written by Vijay Kumar Thakur and published by John Wiley & Sons. This book was released on 2017-04-06 with total page 1172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique multidisciplinary 8-volume set focuses on the emerging issues concerning synthesis, characterization, design, manufacturing and various other aspects of composite materials from renewable materials and provides a shared platform for both researcher and industry. The Handbook of Composites from Renewable Materials comprises a set of 8 individual volumes that brings an interdisciplinary perspective to accomplish a more detailed understanding of the interplay between the synthesis, structure, characterization, processing, applications and performance of these advanced materials. The Handbook comprises 169 chapters from world renowned experts covering a multitude of natural polymers/ reinforcement/ fillers and biodegradable materials. Volume 7 is solely focused on the "Nanocomposites: Science and Fundamentals" of renewable materials. Some of the important topics include but not limited to: Preparation, characterization, and applications of nanomaterials from renewable resources; hydrogels and its nanocomposites from renewable resources: preparation of chitin-based nanocomposite materials through gelation with ionic liquid; starch-based bionanocomposites; biorenewable nanofiber and nanocrystal; investigation of wear characteristics of dental composite reinforced with rice husk-derived nanosilica filler particles; performance of regenerated cellulose/vermiculite nanocomposites fabricated via ionic liquid; preparation, structure, properties, and interactions of the PVA/cellulose composites; green composites with cellulose nanoreinforcements; biomass composites from bamboo-based micro/nanofibers; synthesis and medicinal properties of polycarbonates and resins from renewable sources; nanostructured polymer composites with modified carbon nanotubes; organic–inorganic nanocomposites derived from polysaccharides; natural polymer-based nanocomposites; cellulose whisker-based green polymer composites; poly (lactic acid) nanocomposites reinforced with different additives; nanocrystalline cellulose; halloysite-based bionanocomposites; nanostructurated composites based on biodegradable polymers and silver nanoparticles; starch-based biomaterials and nanocomposites; green nanocomposites based on PLA and natural organic fillers; and chitin and chitosan-based nanocomposites.

Systems Immunology and Infection Microbiology

Author : Bor-Sen Chen
Publisher : Academic Press
ISBN 13 : 0128173351
Total Pages : 673 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Systems Immunology and Infection Microbiology by : Bor-Sen Chen

Download or read book Systems Immunology and Infection Microbiology written by Bor-Sen Chen and published by Academic Press. This book was released on 2021-03-16 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Immunology and Infection Microbiology provides a large amount of biological system models, diagrams and flowcharts to illustrate development procedures and help users understand the results of systems immunology and infection microbiology. Chapters discuss systems immunology, systems infection microbiology, systematic inflammation and immune responses in restoration and regeneration process, systems' innate and adaptive immunity in infection process, systematic genetic and epigenetic pathogenic/defensive mechanism during bacterial infection on human cells is introduced, and the systematic genetic and epigenetic pathogenic/defensive mechanisms during viral infection on human cells. This book provides new big data-driven and systems-driven systems immunology and infection microbiology to researchers applying systems biology and bioinformatics in their work. It is also invaluable to several members of biomedical field who are interested in learning more about those approaches. Encompasses one applicable example in every chapter to illustrate the solution procedure from big data mining, network modeling, host/pathogen cross-talk detection, drug target identification and systems drug design Presents flowcharts to represent the development procedure of systematic immunology and infection in a very clear format Contains 100 color diagrams to help readers understand the related biological networks, their corresponding mechanisms, and significant network biomarkers for therapeutic drug design

Production of Recombinant Proteins

Author : Gerd Gellissen
Publisher : John Wiley & Sons
ISBN 13 : 3527604413
Total Pages : 429 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Production of Recombinant Proteins by : Gerd Gellissen

Download or read book Production of Recombinant Proteins written by Gerd Gellissen and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the choices of microbial and eukaryotic expression systems for production of recombinant proteins are many, most researchers in academic and industrial settings do not have ready access to pertinent biological and technical information since it is normally scattered throughout the scientific literature. This book closes the gap by providing information on the general biology of the host organism, a description of the expression platform, a methodological section -- with strains, genetic elements, vectors and special methods, where applicable -- as well as examples of proteins produced with the respective platform. The systems thus described are well balanced by the inclusion of three prokaryotes (two Gram-negatives and one Gram-positive), four yeasts, two filamentous fungi and two higher eukaryotic cell systems -- mammalian and plant cells. Throughout, the book provides valuable practical and theoretical information on the criteria and schemes for selecting the appropriate expression platform, the possibility and practicality of a universal expression vector, and on comparative industrial-scale fermentation, with the production of a recombinant Hepatitis B vaccine chosen as an industrial example. With a foreword by Herbert P. Schweizer, Colorado State University, USA: "As a whole, this book is a valuable and overdue resource for a varied audience. It is a practical guide for academic and industrial researchers who are confronted with the design of the most suitable expression platform for their favorite protein for technical or pharmaceutical purposes. In addition, the book is also a valuable study resource for professors and students in the fields of applied biology and biotechnology."

Human Genome Editing

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309452880
Total Pages : 329 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Human Genome Editing by : National Academies of Sciences, Engineering, and Medicine

Download or read book Human Genome Editing written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-08-13 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.