Car T Cell Therapies For Non Hematopoietic Malignancies Taking Off The Training Wheels

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CAR-T Cell Therapies for Non-Hematopoietic Malignancies: Taking Off The Training Wheels

Author : Avery Dexter Posey, Jr.
Publisher : Frontiers Media SA
ISBN 13 : 2889636879
Total Pages : 164 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis CAR-T Cell Therapies for Non-Hematopoietic Malignancies: Taking Off The Training Wheels by : Avery Dexter Posey, Jr.

Download or read book CAR-T Cell Therapies for Non-Hematopoietic Malignancies: Taking Off The Training Wheels written by Avery Dexter Posey, Jr. and published by Frontiers Media SA. This book was released on 2020-04-24 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chimeric antigen receptor (CAR) T cell therapies for leukemia (e.g. tisagenlecleucel) and lymphoma (e.g. axicabtagene ciloleucel) have recently received regulatory approval in the United States. Phase I/II trials have demonstrated complete remission of refractory or relapsed tumors in 50% - 94% patients. However, the clinical successes of engineered T cells for the treatment of solid malignancies have thus far been few and far between. Furthermore, several instances of severe and lethal toxicities have arisen due to on-target, off-tumor recognition of antigen by T cell products. Recent advances in phase I trials for solid tumors, as well as in pre-clinical models, have revealed several variables that will be important to consider for the successful use of CAR-T cells in treating solid tumors. These variables include (i) regional versus systemic delivery; (ii) scFv versus ligand interactions; (iii) antigen loss versus escape; (iv) epitope spreading and (v) checkpoint expression on immune cells or tumor cells. Also, there remains outstanding mechanistic questions related to why differences exist in the persistence and tonic signaling of second-generation CD28 versus 4-1BB co-stimulated CAR-T cells. In addition, we are now learning the roles of lympho-depleting regimens (and associated toxicities) in modifying the persistence of engineered T cell therapies. A more comprehensive view of CAR-T cell strategies and important advances, both of pre-clinical and clinical evaluations, in solid tumors is necessary to drive these therapies forward.

Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy

Author : Mahmoud Aljurf
Publisher : Springer Nature
ISBN 13 : 3030644928
Total Pages : 181 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy by : Mahmoud Aljurf

Download or read book Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy written by Mahmoud Aljurf and published by Springer Nature. This book was released on 2021-02-19 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a concise yet comprehensive overview on how to build a quality management program for hematopoietic stem cell transplantation (HSCT) and cellular therapy. The text reviews all the essential steps and elements necessary for establishing a quality management program and achieving accreditation in HSCT and cellular therapy. Specific areas of focus include document development and implementation, audits and validation, performance measurement, writing a quality management plan, the accreditation process, data management, and maintaining a quality management program. Written by experts in the field, Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy: A Practical Guide is a valuable resource for physicians, healthcare professionals, and laboratory staff involved in the creation and maintenance of a state-of-the-art HSCT and cellular therapy program.

Bulletin of the Atomic Scientists

Author :
Publisher :
ISBN 13 :
Total Pages : 64 pages
Book Rating : 4./5 ( download)

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Book Synopsis Bulletin of the Atomic Scientists by :

Download or read book Bulletin of the Atomic Scientists written by and published by . This book was released on 1972-10 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Bulletin of the Atomic Scientists is the premier public resource on scientific and technological developments that impact global security. Founded by Manhattan Project Scientists, the Bulletin's iconic "Doomsday Clock" stimulates solutions for a safer world.

Human Genome Editing

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309452880
Total Pages : 329 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Human Genome Editing by : National Academies of Sciences, Engineering, and Medicine

Download or read book Human Genome Editing written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-08-13 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

B Cell Receptor Signaling

Author : Tomohiro Kurosaki
Publisher : Springer
ISBN 13 : 3319261339
Total Pages : 233 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis B Cell Receptor Signaling by : Tomohiro Kurosaki

Download or read book B Cell Receptor Signaling written by Tomohiro Kurosaki and published by Springer. This book was released on 2015-12-26 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.

The European Blood and Marrow Transplantation Textbook for Nurses

Author : Michelle Kenyon
Publisher : Springer
ISBN 13 : 3319500260
Total Pages : 318 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis The European Blood and Marrow Transplantation Textbook for Nurses by : Michelle Kenyon

Download or read book The European Blood and Marrow Transplantation Textbook for Nurses written by Michelle Kenyon and published by Springer. This book was released on 2018-03-14 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.

The Practice of Surgical Pathology

Author : Diana Weedman Molavi
Publisher : Springer
ISBN 13 : 3319592114
Total Pages : 399 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis The Practice of Surgical Pathology by : Diana Weedman Molavi

Download or read book The Practice of Surgical Pathology written by Diana Weedman Molavi and published by Springer. This book was released on 2017-08-24 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: In pathology education within North America, there exists a wide gap in the pedagogy between medical school and residency. As a result, the pathology intern often comes into residency unprepared. Completely illustrated in color, this book lays the foundation of practical pathology and provides a scaffold on which to build a knowledge base. It includes basic introductory material and progresses through each organ system. Within each chapter, there is a brief review of salient normal histology, a discussion of typical specimen types, a strategic approach to the specimen, and a discussion of how the multitude of different diagnoses relate to each other.

Mohs Micrographic Surgery

Author : Keyvan Nouri
Publisher : Springer Science & Business Media
ISBN 13 : 144712152X
Total Pages : 558 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Mohs Micrographic Surgery by : Keyvan Nouri

Download or read book Mohs Micrographic Surgery written by Keyvan Nouri and published by Springer Science & Business Media. This book was released on 2012-02-15 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is written for dermatologists, otolaryngologists, facial plastic surgeons and any physician who want to provide state of the art treatment for skin cancer patients. Considering the high incidence of non-melanoma skin cancers such as Basal Cell Carcinoma and Squamous Cell Carcinoma (accounting for over one million cases per year in the United States) and since Mohs Micrographic Surgery has become the treatment of choice for these skin cancers, the popularity of this technique has been increasing dramatically, worldwide.

Cancer and Aging

Author : M. Extermann
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318023078
Total Pages : 179 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Cancer and Aging by : M. Extermann

Download or read book Cancer and Aging written by M. Extermann and published by Karger Medical and Scientific Publishers. This book was released on 2013-01-18 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment options, nursing and exercise programs. The book is rounded off by a discussion on the impact of the metabolic syndrome illustrating the interactions between comorbidity and cancer and a chapter on frailty.This book provides the reader with insights that will hopefully foster his or her reflection in their own research and practice to further the development of this most exciting field. Given the aging of the population worldwide and the high prevalence of cancer, it is essential reading not only for oncologists and geriatricians but for all health practitioners.

Contemporary Bone Marrow Transplantation

Author : Mammen Chandy
Publisher : Springer
ISBN 13 : 9783030363574
Total Pages : 0 pages
Book Rating : 4.3/5 (635 download)

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Book Synopsis Contemporary Bone Marrow Transplantation by : Mammen Chandy

Download or read book Contemporary Bone Marrow Transplantation written by Mammen Chandy and published by Springer. This book was released on 2021-03-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Marrow transplantation or Hematopoietic stem cell transplantation is a life saving procedure in a number of diseases,hematological and non hematological, which fail alternative medical management or have no other treatment options. It has transformed the lives of thousands of patients and their families around the world battling with fatal or debilitating diseases.There are many unique aspects of bone marrow transplantation which makes it very different from solid organ transplants. There is an enormous amount of research going on in this field both at clinical and basic science levels.With the rapidly changing world and field of transplantation, there is a need for an authoritative and up to date resource for transplant professionals. This book titled Contemporary Bone Marrow Transplantation aims to be a reference text comprehensively covering various facets of hematopoietic stem cell transplants with latest insights about the technique and basic science behind it . The book is the product of collective effort of transplant professionals round the world, and will reflect their experience as well as the current standard of care practices in Stem cell transplantation.The book will be divided into different sections focusing on the basic science of bone marrow transplant, the technical aspects of the procedure itself and the supportive care of transplant patients.There will also be a section each on epidemiology, upcoming trends and also case studies , which will discuss real case scenarios from the experience of the authors, to illustrate the practical challenges in managing bone marrow transplant recipients.

Pediatric Board Study Guide

Author : Osama Naga
Publisher : Springer
ISBN 13 : 3319101153
Total Pages : 611 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Pediatric Board Study Guide by : Osama Naga

Download or read book Pediatric Board Study Guide written by Osama Naga and published by Springer. This book was released on 2015-03-27 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers the most frequently asked and tested points on the pediatric board exam. Each chapter offers a quick review of specific diseases and conditions clinicians need to know during the patient encounter. Easy-to-use and comprehensive, clinicians will find this guide to be the ideal final resource needed before taking the pediatric board exam.

Central Nervous System Tumours

Author : Thomas James Deeley
Publisher :
ISBN 13 :
Total Pages : 346 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Central Nervous System Tumours by : Thomas James Deeley

Download or read book Central Nervous System Tumours written by Thomas James Deeley and published by . This book was released on 1974 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Human Stem Cell Manual

Author : Suzanne Peterson
Publisher : Academic Press
ISBN 13 : 0123854741
Total Pages : 652 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Human Stem Cell Manual by : Suzanne Peterson

Download or read book Human Stem Cell Manual written by Suzanne Peterson and published by Academic Press. This book was released on 2012-10-22 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: This manual is a comprehensive compilation of "methods that work" for deriving, characterizing, and differentiating hPSCs, written by the researchers who developed and tested the methods and use them every day in their laboratories. The manual is much more than a collection of recipes; it is intended to spark the interest of scientists in areas of stem cell biology that they may not have considered to be important to their work. The second edition of the Human Stem Cell Manual is an extraordinary laboratory guide for both experienced stem cell researchers and those just beginning to use stem cells in their work. - Offers a comprehensive guide for medical and biology researchers who want to use stem cells for basic research, disease modeling, drug development, and cell therapy applications - Provides a cohesive global view of the current state of stem cell research, with chapters written by pioneering stem cell researchers in Asia, Europe, and North America - Includes new chapters devoted to recently developed methods, such as iPSC technology, written by the scientists who made these breakthroughs

Sickle Cell Pain

Author : Samir K. Ballas
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496331834
Total Pages : 1004 pages
Book Rating : 4.4/5 (963 download)

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Book Synopsis Sickle Cell Pain by : Samir K. Ballas

Download or read book Sickle Cell Pain written by Samir K. Ballas and published by Lippincott Williams & Wilkins. This book was released on 2015-06-01 with total page 1004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sickle Cell Pain is a panoramic, in-depth exploration of every scientific, human, and social dimension of this cruel disease. This comprehensive, definitive work is unique in that it is the only book devoted to sickle cell pain, as opposed to general aspects of the disease. The 752-page book links sickle cell pain to basic, clinical, and translational research, addressing various aspects of sickle pain from molecular biology to the psychosocial aspects of the disease. Supplemented with patient narratives, case studies, and visual art, Sickle Cell Pain’s scientific rigor extends through its discussion of analgesic pharmacology, including abuse-deterrent formulations. The book also addresses in great detail inequities in access to care, stereotyping and stigmatization of patients, the implications of rapidly evolving models of care, and recent legislation and litigation and their consequences.

The Handbook of Sports Medicine and Science

Author : Niels H. Secher
Publisher : John Wiley & Sons
ISBN 13 : 1444312626
Total Pages : 182 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis The Handbook of Sports Medicine and Science by : Niels H. Secher

Download or read book The Handbook of Sports Medicine and Science written by Niels H. Secher and published by John Wiley & Sons. This book was released on 2009-04-08 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume in the Handbook of Sports Medicine and Science series delivers up-to-date scientific knowledge alongside practical applications in rowing, making it an invaluable resource for researchers, coaches and rowers of all abilities. Published under the auspices of the International Olympic Committee, in collaboration with the International Rowing Federation (FISA), Rowing: Provides key knowledge of the historical, nutritional and psychological aspects of rowing Offers ground-breaking physiological insights which can help shape future training methodologies Features a rowing periodization plan to help trainers and athletes create comprehensive and effective training programs, racing plans and tactics. Rowing brings together internationally renowned experts with experience in competitive rowing and sports medicine, making this the complete handbook of medicine, science and practice in rowing.

Bone Tumors

Author : Jim S. Wu
Publisher : Springer Science & Business Media
ISBN 13 : 1441908080
Total Pages : 424 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Bone Tumors by : Jim S. Wu

Download or read book Bone Tumors written by Jim S. Wu and published by Springer Science & Business Media. This book was released on 2012-06-03 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Tumors: A Practical Guide to Imaging is a concise guide to common tumors encountered by physicians in daily practice. The authors make use of high-yield facts, differential diagnoses, and extensive radiological images to introduce a wide range of bone tumors, focusing on their classic appearance and location in order to provide readers with a solid foundation of knowledge for tumor recognition and evaluation. The book includes explanations of methods for properly evaluating bone lesions, common imaging modalities used for diagnosis, and individual chapters covering different classes of benign and malignant tumors, including cartilage, osseous, fibrous, miscellaneous, and bone metastases. The book concludes with a comprehensive selection of 75 unknown cases, including brief clinical history, description of imaging findings, best differential diagnoses, and short discussion revealing the most likely diagnosis. Bone Tumors is an ideal resource for practicing physicians and residents in radiology, orthopedic surgery, pathology, and primary care. About the Authors Jim S. Wu, MD, is Assistant Professor of Radiology at Beth Israel Deaconess Medical Center, Harvard Medical School. Mary G. Hochman, MD, is Chief of the Section of Musculoskeletal Imaging and Assistant Professor of Radiology at Beth Israel Deaconess Medical Center, Harvard Medical School.

Critical Care of the Pediatric Immunocompromised Hematology/Oncology Patient

Author : Christine N. Duncan
Publisher : Springer
ISBN 13 : 3030013227
Total Pages : 417 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Critical Care of the Pediatric Immunocompromised Hematology/Oncology Patient by : Christine N. Duncan

Download or read book Critical Care of the Pediatric Immunocompromised Hematology/Oncology Patient written by Christine N. Duncan and published by Springer. This book was released on 2019-02-01 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive overview of critical care of the pediatric immunocompromised hematology-oncology patient. The text focuses on unique aspects of the pediatric immunocompromised patient that predisposes the child to significant illness, and presents critical care management strategies specific to the patient population. In addition to chapters on oncology, primary immune deficiency, immunocompromised hematology, and hematopoietic cell transplant patients, the book covers the changing landscape of ICU care, pharmacologic considerations, and psychological and social aspects of the critical care of hematology-oncology patients. Written by experts from a range of disciplines, Critical Care of the Pediatric Immunocompromised Hematology/Oncology Patient: An Evidence-Based Guide is a valuable resource for clinicians and practitioners who treat this patient population.