Cancer Risk Assessment

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Genetic Toxicology and Cancer Risk Assessment

Author : Wai Nang Choy
Publisher : CRC Press
ISBN 13 : 0824745221
Total Pages : 405 pages
Book Rating : 4.8/5 (247 download)

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Book Synopsis Genetic Toxicology and Cancer Risk Assessment by : Wai Nang Choy

Download or read book Genetic Toxicology and Cancer Risk Assessment written by Wai Nang Choy and published by CRC Press. This book was released on 2001-08-31 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines! Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models discusses the threshold concept of carcinogenesis demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens considers structural activity relationship (SAR) analysis of chemical carcinogenicity describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays illustrates the use of genetic biomarkers for dosimetry analysis and more! Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

Cancer Risk Assessment

Author : Peter G. Shields
Publisher : CRC Press
ISBN 13 : 1000611345
Total Pages : 800 pages
Book Rating : 4.0/5 (6 download)

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Book Synopsis Cancer Risk Assessment by : Peter G. Shields

Download or read book Cancer Risk Assessment written by Peter G. Shields and published by CRC Press. This book was released on 2005-05-24 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: The assessment of cancer risk is a complex process that requires the examination of etiological agents, real-world environments, and individual rates of exposure. This reference offers practical approaches to determine cancer risk in individuals, groups of exposed persons, and the general public in relation to individual genetic and acquired suscep

Handbook of Cancer Risk Assessment and Prevention

Author : Graham A. Colditz
Publisher : Jones & Bartlett Learning
ISBN 13 : 9780763718831
Total Pages : 372 pages
Book Rating : 4.7/5 (188 download)

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Book Synopsis Handbook of Cancer Risk Assessment and Prevention by : Graham A. Colditz

Download or read book Handbook of Cancer Risk Assessment and Prevention written by Graham A. Colditz and published by Jones & Bartlett Learning. This book was released on 2004 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written for health care providers at all levels, this handbook covers in depth fourteen of the most common cancers in the U.S. -- providing for each a scientific summary of risk factors, a risk assessment tool for patients, and helpful hints to promote risk-reducing lifestyle changes. Additional chapters focus specifically on five key lifestyle behaviors that lower not only the risk of cancer but also the risk of other chronic diseases.Throughout its entirety, the handbook emphasizes the importance of communicating risk effectively to patients. A chapter is devoted solely to this topic, and risk information about each cancer is presented in a variety of formats. Finally, the risk assessment tools -- adaptations from the popular website Your Cancer Risk -- offer patients the option to estimate their cancer risk and receive practical, personal tips for lowering that risk.At a time when the public is surrounded by conflicting health messages, especially from the media and the Internet, the Handbook of Cancer Risk-Assessment and Prevention is an essential source for reliable, up-to-date information on cancer prevention. It delivers positive health messages and offers practical advice that health care providers can use to help patients implement strategies to prevent cancer and other chronic diseases.

Science and Decisions

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309120462
Total Pages : 422 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Science and Decisions by : National Research Council

Download or read book Science and Decisions written by National Research Council and published by National Academies Press. This book was released on 2009-03-24 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.

Cancer Risk Assessment

Author : Samuel C. Morris
Publisher : CRC Press
ISBN 13 : 1000104303
Total Pages : 417 pages
Book Rating : 4.0/5 (1 download)

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Book Synopsis Cancer Risk Assessment by : Samuel C. Morris

Download or read book Cancer Risk Assessment written by Samuel C. Morris and published by CRC Press. This book was released on 2020-07-24 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the National Academy of Sciences approach to quantitative risk assessment. Emphasizes how an accurate assessment of cancer risk must draw on a wide range of disciplines, such as biology, chemistry, physics, engineering, and the social sciences. Provides tables of Poisson confidence limit fa

Health Risks from Exposure to Low Levels of Ionizing Radiation

Author : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation
Publisher : National Academies Press
ISBN 13 : 0309133343
Total Pages : 422 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Health Risks from Exposure to Low Levels of Ionizing Radiation by : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation

Download or read book Health Risks from Exposure to Low Levels of Ionizing Radiation written by Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation and published by National Academies Press. This book was released on 2006-03-23 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.

Risk Assessment and Management in Cancer Genetics

Author : Fiona Lalloo
Publisher : Oxford University Press
ISBN 13 : 9780198529606
Total Pages : 296 pages
Book Rating : 4.5/5 (296 download)

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Book Synopsis Risk Assessment and Management in Cancer Genetics by : Fiona Lalloo

Download or read book Risk Assessment and Management in Cancer Genetics written by Fiona Lalloo and published by Oxford University Press. This book was released on 2005-09-29 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive text will help the non-specialist undertake cancer risk assessment in the context of a family history, which also provides the foundation for cancer genetics for the specialist.

Breast Cancer

Author : Wendell Armstrong
Publisher : Nova Science Publishers
ISBN 13 : 9781634851848
Total Pages : 0 pages
Book Rating : 4.8/5 (518 download)

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Book Synopsis Breast Cancer by : Wendell Armstrong

Download or read book Breast Cancer written by Wendell Armstrong and published by Nova Science Publishers. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer risk prediction models provide an important approach to assess risk and susceptibility by identifying individuals at high risk, facilitating the design and planning of clinical chemoprevention trials, and allowing the evaluation of interventions. Conventional breast cancer risk model includes the cumulative estrogen exposure data such as age, age at menarche and menopause, age at first live birth, and use of HRT in risk calculation, since estrogens are the main risk factor for mammary carcinogenesis. The most widely known and commonly used model for breast cancer risk assessment is the Gail model, which focuses primarily on non-genetic risk factors, with limited information on family history. The first chapter of this book examines breast cancer risk assessment models. The following chapters discuss the association between obesity and breast cancer development; current and future standards for treatment of breast cancer and long term care of patients; and mastectomies and voluntarism.

Science and Judgment in Risk Assessment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030904894X
Total Pages : 668 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Science and Judgment in Risk Assessment by : National Research Council

Download or read book Science and Judgment in Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 1994-01-01 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: The public depends on competent risk assessment from the federal government and the scientific community to grapple with the threat of pollution. When risk reports turn out to be overblownâ€"or when risks are overlookedâ€"public skepticism abounds. This comprehensive and readable book explores how the U.S. Environmental Protection Agency (EPA) can improve its risk assessment practices, with a focus on implementation of the 1990 Clean Air Act Amendments. With a wealth of detailed information, pertinent examples, and revealing analysis, the volume explores the "default option" and other basic concepts. It offers two views of EPA operations: The first examines how EPA currently assesses exposure to hazardous air pollutants, evaluates the toxicity of a substance, and characterizes the risk to the public. The second, more holistic, view explores how EPA can improve in several critical areas of risk assessment by focusing on cross-cutting themes and incorporating more scientific judgment. This comprehensive volume will be important to the EPA and other agencies, risk managers, environmental advocates, scientists, faculty, students, and concerned individuals.

Saving Women's Lives

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309165946
Total Pages : 384 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Saving Women's Lives by : National Research Council

Download or read book Saving Women's Lives written by National Research Council and published by National Academies Press. This book was released on 2005-03-18 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The outlook for women with breast cancer has improved in recent years. Due to the combination of improved treatments and the benefits of mammography screening, breast cancer mortality has decreased steadily since 1989. Yet breast cancer remains a major problem, second only to lung cancer as a leading cause of death from cancer for women. To date, no means to prevent breast cancer has been discovered and experience has shown that treatments are most effective when a cancer is detected early, before it has spread to other tissues. These two facts suggest that the most effective way to continue reducing the death toll from breast cancer is improved early detection and diagnosis. Building on the 2001 report Mammography and Beyond, this new book not only examines ways to improve implementation and use of new and current breast cancer detection technologies but also evaluates the need to develop tools that identify women who would benefit most from early detection screening. Saving Women's Lives: Strategies for Improving Breast Cancer Detection and Diagnosis encourages more research that integrates the development, validation, and analysis of the types of technologies in clinical practice that promote improved risk identification techniques. In this way, methods and technologies that improve detection and diagnosis can be more effectively developed and implemented.

Managing Breast Cancer Risk

Author : Monica Morrow
Publisher : PMPH-USA
ISBN 13 : 9781550092608
Total Pages : 328 pages
Book Rating : 4.0/5 (926 download)

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Book Synopsis Managing Breast Cancer Risk by : Monica Morrow

Download or read book Managing Breast Cancer Risk written by Monica Morrow and published by PMPH-USA. This book was released on 2003 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Managing Breast Cancer Risk is a single source for information needed by primary care physicians, nurses, gynecologists, as well as oncologic specialists who deal with women who are concerned about breast cancer. Its purpose is to bring together a multidisciplinary group of experts to address breast cancer risk in a clinically meaningful way. Chapters providing detailed information on individual risk factors are accompanied by a discussion of models, which integrate multiple factors for a more complete assessment of risk. Traditional strategies for risk management, including surveillance and prophylactic surgery, are reviewed, and the data on newer techniques such as ductal lavage and screening with magnetic resonance is presented. The rational for chemoprevention with selective estrogen receptor modulators (SERMS) is discussed, and the evidence for tamoxifen as a chemopreventative is updated. The potential for chemoprevention with newer SERMS and the aromatase inhibitors is reviewed. Finally, the critical (and often ignored) areas of quality of life and symptom management are addressed.

Risk Assessment of Radon in Drinking Water

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309173671
Total Pages : 293 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Risk Assessment of Radon in Drinking Water by : National Research Council

Download or read book Risk Assessment of Radon in Drinking Water written by National Research Council and published by National Academies Press. This book was released on 1999-06-24 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Safe Drinking Water Act directs the U.S. Environmental Protection Agency (EPA) to regulate the quality of drinking water, including its concentration of radon, an acknowledged carcinogen. This book presents a valuable synthesis of information about the total inhalation and ingestion risks posed by radon in public drinking water, including comprehensive reviews of data on the transfer of radon from water to indoor air and on outdoor levels of radon in the United States. It also presents a new analysis of a biokinetic model developed to determine the risks posed by ingestion of radon and reviews inhalation risks and the carcinogenesis process. The volume includes scenarios for quantifying the reduction in health risk that might be achieved by a program to reduce public exposure to radon. Risk Assessment of Radon in Drinking Water, reflecting research and analysis mandated by 1996 amendments to the Safe Drinking Water Act, provides comment on a variety of methods to reduce radon entry into homes and to reduce the concentrations of radon in indoor air and in water. The models, analysis, and reviews of literature contained in this book are intended to provide information that EPA will need to set a new maximum contaminant level, as it is required to do in 2000.

Reducing Environmental Cancer Risk

Author : Suzanne H. Reuben
Publisher : DIANE Publishing
ISBN 13 : 1437934218
Total Pages : 240 pages
Book Rating : 4.4/5 (379 download)

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Book Synopsis Reducing Environmental Cancer Risk by : Suzanne H. Reuben

Download or read book Reducing Environmental Cancer Risk written by Suzanne H. Reuben and published by DIANE Publishing. This book was released on 2010-10 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though overall cancer incidence and mortality have continued to decline in recent years, cancer continues to devastate the lives of far too many Americans. In 2009 alone, 1.5 million American men, women, and children were diagnosed with cancer, and 562,000 died from the disease. There is a growing body of evidence linking environmental exposures to cancer. The Pres. Cancer Panel dedicated its 2008¿2009 activities to examining the impact of environmental factors on cancer risk. The Panel considered industrial, occupational, and agricultural exposures as well as exposures related to medical practice, military activities, modern lifestyles, and natural sources. This report presents the Panel¿s recommend. to mitigate or eliminate these barriers. Illus.

Cancer Risk Assessment

Author : Ching-Hung Hsu
Publisher : John Wiley & Sons
ISBN 13 : 1118035127
Total Pages : 727 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Cancer Risk Assessment by : Ching-Hung Hsu

Download or read book Cancer Risk Assessment written by Ching-Hung Hsu and published by John Wiley & Sons. This book was released on 2010-12-08 with total page 727 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.

Assess Your True Risk of Breast Cancer

Author : Patricia Kelly
Publisher : Holt Paperbacks
ISBN 13 : 9780805064681
Total Pages : 276 pages
Book Rating : 4.0/5 (646 download)

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Book Synopsis Assess Your True Risk of Breast Cancer by : Patricia Kelly

Download or read book Assess Your True Risk of Breast Cancer written by Patricia Kelly and published by Holt Paperbacks. This book was released on 2000-10-13 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to give women the tools they need to realistically assess their risk of getting breast cancer--and choose the best course of action Ask women what their number-one health fear is and most will not hesitate before answering "breast cancer." The recent proliferation of easily misunderstood and often contradictory statistics about breast cancer and its causes, however, is scaring many women who have only a small risk of contracting the disease. Assess Your True Risk of Breast Cancer is designed to help women evaluate what their risk really is and then determine what the next step should be based on that risk. Written by a leading expert in the field, the book discusses everything from studies on how age and family history relate to breast cancer risk, to those on hormone replacement therapy and breast cancer, enabling a woman to understand and focus on her own personal situation. Whether providing advice on how to get more extensive testing, counseling, and preventative measures when necessary, or offering the welcome assurance that the risk is small enough to warrant just annual checkups, mammograms, and regular self-examinations, Assess Your True Risk of Breast Cancer replaces rumors and scare tactics with solid, practical, and vital information.

Guidelines for carcinogen risk assessment

Author :
Publisher : DIANE Publishing
ISBN 13 : 1428904565
Total Pages : 166 pages
Book Rating : 4.4/5 (289 download)

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Book Synopsis Guidelines for carcinogen risk assessment by :

Download or read book Guidelines for carcinogen risk assessment written by and published by DIANE Publishing. This book was released on 2005 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Uncertainty in Risk Assessment, Risk Management, and Decision Making

Author : V.T. Covello
Publisher : Springer Science & Business Media
ISBN 13 : 1468453173
Total Pages : 523 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Uncertainty in Risk Assessment, Risk Management, and Decision Making by : V.T. Covello

Download or read book Uncertainty in Risk Assessment, Risk Management, and Decision Making written by V.T. Covello and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: The subject of this volume--uncertainties in risk assessment and management--reflects an important theme in health, safety, and environ mental decision making. MOst technological hazards are characterized by substantial uncertainty. Recent examples include nuclear waste disposal, acid rain, asbestos in schools, carcinogens in food, and hazardous waste. realing with such uncertainty is arguably the most difficult and challeng ing task facing risk assessors and managers today. Four primary sources of uncertainty in risk assessment and management can be identified: (1) uncertainties about definitions; (2) uncertainties about scientific facts; (3) uncertainties about risk perceptions and atti tudes; and (4) uncertainties about values. Uncertainties about definitions derive primarily from disagreements about the meaning and interpretation of key concepts, such as probability. Uncertainties about scientific facts derive primarily from disagreements about failure modes, the probability and magnitude of adverse health or environmental consequences, cause and effect relationships, dose-response relationships, and exposure patterns. Uncertainties about risk perceptions and attitudes derive primarily from disagreements about what constitutes a significant or acceptable level of risk. Uncertainties about values derive primarily from disagreements about the desirability or worth of alternative risk management actions or conse quences. The papers in this volume address each of these sources of uncertainty from a variety of perspectives. Reflecting the broad scope of risk assess ment and risk management research, the papers include contributions from safety engineers, epidemiologists, toxicologists, chemists, biostatisticians, biologists, decision analysts, economists, psychologists, political scien tists, sociologists, ethicists, and lawyers.