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Cancer Clinical Pharmacology
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Book Synopsis Cancer Clinical Pharmacology by : Jan H. M. Schellens
Download or read book Cancer Clinical Pharmacology written by Jan H. M. Schellens and published by Oxford University Press. This book was released on 2005-05-05 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book considers both the theory and practice of clinical pharmacology where it is relevant to cancer treatment. It covers the basics of clinical pharmacology in oncology and cancer therapeutics, discussing the specific classes of anti-cancer agents in detail. Edited and written by a mix of generalist cancer clinical pharmacologists and sub-specialists within this area, the book allows the reader to develop both general clinical pharmacology skills and specialist knowledge for particular cancer chemotherapy agents.
Book Synopsis Cancer Pharmacology by : Ashkan Emadi, MD, PhD
Download or read book Cancer Pharmacology written by Ashkan Emadi, MD, PhD and published by Springer Publishing Company. This book was released on 2023-10-06 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs, Second Edition is a visually engaging reference detailing the essential basic and clinical science of all approved, effective, and life-prolonging drug therapies in oncology. Now with a greater emphasis on clinical context, application, and management in each chapter, this significantly revised edition provides both early-career and seasoned clinicians with a practical, bench-to-bedside approach and patient-oriented guide. The book provides detailed coverage of the major advances in cancer pharmacology at the forefront of our standards of care for solid tumors and hematologic malignancies, in addition to the basic science that is directly necessary and applicable when at the patient’s bedside. Everything from traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents is explored, in addition to a new chapter covering pharmacogenomics. Accompanied by elegant illustrations, each chapter details the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic and molecular properties of the various agents, and their mechanisms of action. The book covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more. Thoroughly updated to include new FDA-approved treatments and applications, and written by leading experts in cancer pharmacology, this second edition continues to be a “must have” for anyone involved in the basic, translational, or clinical aspects of oncology and hematology, including clinicians, pharmacists, nurses, and trainees. Key Features: Over 150 beautiful illustrations depict structures, pharmacokinetics, pharmacodynamics, and pharmacogenomics associated with each class of agents Contains more than 160 high-yield hematology and oncology board-style chapter review questions (more than double the previous edition) with descriptive rationales Describes how chemotherapy, targeted therapy, immunotherapy, and hormonal therapy work, and why they are expected to work adjuvantly, neoadjuvantly, and in combination with other treatment modalities Thoroughly updated and revised chapters cover new FDA drug approvals, disease-site indications, clinical applications and management of drug-to-drug interactions, and toxicities Discusses challenges related to drug development, drug approval, and regulatory issues in relation to anticancer treatments Provides important pharmacotherapy context with clinical pearls in each chapter that help support a patient-oriented, bedside approach
Book Synopsis Pharmacokinetics in Drug Development by : Peter L. Bonate
Download or read book Pharmacokinetics in Drug Development written by Peter L. Bonate and published by Springer. This book was released on 2016-10-06 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume, the specific challenges and problems facing the evaluation of new oncology agents are explored with regards to pharmacokinetic, pharmacodynamic modeling and clinical pharmacology development strategies. This book delivers, with an emphasis on the oncology therapeutic area, the goals set in the first three volumes: namely – to provide clinical pharmacologists practical insights for the application of pharmacology, pharmacokinetics and pharmacodynamics for new drug development strategies. Pharmacokinetic-pharmacodynamic concepts for tyrosine kinases, the evaluation of cardiac repolarization prolongation through QTc interval effects, efficacy- and safety-response analyses to support new drug approvals, clinical and preclinical tumor growth modeling, and flat- vs weight-based dose selection are showcased from an oncology clinical pharmacologist’s point-of-view. Oncology development strategies are surveyed for new FDA-approvals to identify patterns in expectations at time of first approval. The special considerations necessary to address combination drug development, metronomics, biosimilars and breakthrough therapies are also presented.
Book Synopsis Symposium on Clinical Pharmacology by : William A. Creasey
Download or read book Symposium on Clinical Pharmacology written by William A. Creasey and published by Elsevier. This book was released on 2013-10-22 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Symposium on Clinical Pharmacology reviews advances in clinical pharmacology, with emphasis on how to materially improve the efficacy of cancer chemotherapy. Topics range from absorption, protein binding, distribution, and excretion of antineoplastic drugs to factors affecting the biotransformation and activity of antitumor drugs. The transport of tumor-inhibitory agents across cell membranes is also examined, together with factors influencing drug selectivity and the mechanisms of clinical drug resistance. This volume is comprised of 23 chapters and begins with a brief summary of the different kinds of pharmacokinetic models and how detailed kinetic investigations of a drug in animals may provide further insight into modes of its clinical use. The next chapter considers the chief factors in determining the effective concentration of a drug at a receptor site as well as the duration and intensity of drug effect, citing antineoplastic agents as examples. The role of enzymatic activation and inactivation in drug selectivity is also discussed, along with the general mechanisms of clinical resistance to cancer chemotherapy; biochemical and pharmacological principles of combination chemotherapy; and the reaction and effects of nitrosoureas. This book will be of interest to clinicians, pharmacologists, and biochemists.
Book Synopsis The Easy Book of Cancer Pharmacology by : Esther Una Cidon
Download or read book The Easy Book of Cancer Pharmacology written by Esther Una Cidon and published by Nova Science Publishers. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents the efforts of young oncologists, haematologists, pharmacists and oncology nurses who are highly motivated and encouraged by the significant development of new effective anticancer drugs. Since the discovery of antimetabolites and alkylating agents in the 1940s and 1950s, many new products have been introduced into our daily arsenal not only through chemotherapy agents, but also by means of biological or immunotherapeutic drugs whose side effects differ significantly. The idea of this book was born from a simple observation and confirmation of fact. New doctors in training experience high levels of stress and lack of confidence when confronting cancer patients and explaining a treatment or managing frequent side effects. Patients questions will only add more nervousness, and this will lead to a failure in the doctor-patient relationship, causing the patients mistrust and doctors frustration. Nurses dealing with these patients will suffer pressure too, as many questions regarding antineoplastic drugs will be asked of them and patients expect them to ease their doubts. This feeling of vulnerability in front of a patient, though a part of the maturation process when becoming a professional caretaker, causes discomfort and incertitude. In this context, it is crucial to gain great knowledge about pharmacokinetic and pharmacological features of each active anticancer drug used, as well as the indications, dosages, interactions and toxicities, to be able to face the daily practice of oncology without concerns and manage daily therapeutic complications easily. This may be considered very difficult, taking into account the huge number of active agents doctors manage routinely, but doctors have accepted the challenge and designed a straightforward, comprehensible book to solve this issue. The Easy Book of Cancer Pharmacology provides the means to overcome the problem. It is conceived as an accessible, concise and yet exhaustive tool which displays a vast amounts of knowledge in a very schematic way. It is easy to consult and offers a very practical expertise to develop the ability of managing effectively each antineoplastic agent quickly. It gives the necessary insights to explain this to the patients with confidence. Each chapter reviews one active drug and shows the information with a pragmatic style, and they are divided into different sections. Each section covers distinct aspects of the agent, from general characteristics to more specific details related to clinical pharmacology. In quickly advancing fields such as oncology, such a book is necessary to help update the ever-developing and expanding knowledge of clinicians and patients in an efficient and effective manner.
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis Physicians' Cancer Chemotherapy Drug Manual 2014 by : Edward Chu
Download or read book Physicians' Cancer Chemotherapy Drug Manual 2014 written by Edward Chu and published by Jones & Bartlett Publishers. This book was released on 2014-03-21 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated for 2014, the Physicians' Cancer Chemotherapy Drug Manual 2014 is an up-to-date guide to the latest information on standard therapy and recent advances in the field. Written by world-class experts in clinical cancer therapeutics, this essential reference provides a complete, easy-to-use catalog of over 100 drugs and commonly used drug regimens--both on- and off-label--for the treatment of all the major cancers. Special features: - Revised to reflect rapid advances in the field - A specific chapter focused on profiling antiemetic drug and antiemetic treatment regimens. - Diagrams of drug structures and pathways for many of the agents. - Offers a comprehensive discussion of clinical pharmacology, special considerations, indications, and dosages. - Covers toxicity and drug-drug interactions. - A section on chemotherapy regimens for all major cancers. - Provides an overview of the basic principles of cancer drug therapy.
Book Synopsis Concise Clinical Pharmacology by : Raymond Hohl
Download or read book Concise Clinical Pharmacology written by Raymond Hohl and published by . This book was released on 2008-03 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Useful for cancer therapeutics for real-world patient care, this book serves as a resource on the clinical use of anti-cancer medicines. Oriented towards everyday patient care, it details what drug to use, when to use it, and how the drug metabolizes. It places special emphasis on interactions with other, non-cancer medications.
Author :Anthony J. Perissinotti, PharmD, BCOP Publisher :Springer Publishing Company ISBN 13 :1617052523 Total Pages :205 pages Book Rating :4.6/5 (17 download)
Book Synopsis Cancer Pharmacology and Pharmacotherapy Review by : Anthony J. Perissinotti, PharmD, BCOP
Download or read book Cancer Pharmacology and Pharmacotherapy Review written by Anthony J. Perissinotti, PharmD, BCOP and published by Springer Publishing Company. This book was released on 2016-03-14 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Pharmacology and Pharmacotherapy Review is the first book devoted entirely to providing the ‘must-know’ facts on each cancer agent—including their pharmacokinetics, FDA-approved indications, toxicity, interactions, and other important information that is commonly found on board examinations and essential for any clinician or practitioner to review. The authors, an oncologist and two pharmacists, have developed a handy question-and-answer format to present the material in digestible bursts. As the pharmacology section continues to represent a major portion of the medical oncology exam and a key component on oncology MOC exams, this portable study guide will help prepare anyone looking to fine-tune their knowledge on cancer drugs before the test. Not to mention, with recent advancements in the field of cancer treatment, it has become more cumbersome to recall and maintain essential knowledge of every cancer therapeutic—making this book not only an exam resource but also a handy quick reference for oncologists and pharmacists alike. KEY FEATURES Conveniently organized and arranged by drug class and subtypes for easier recall and classification Includes proper dosage adjustments to account for liver and kidney dysfunction Features tables throughout that provide quick reference regarding FDA-approved medications Simplified diagrams and illustrations facilitate the pharmacokinetic processes
Book Synopsis Handbook of Anticancer Pharmacokinetics and Pharmacodynamics by : Michelle A. Rudek
Download or read book Handbook of Anticancer Pharmacokinetics and Pharmacodynamics written by Michelle A. Rudek and published by Springer Science & Business Media. This book was released on 2014-01-10 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development
Book Synopsis Clinical Pharmacology and Therapeutics by : Gerard A. McKay
Download or read book Clinical Pharmacology and Therapeutics written by Gerard A. McKay and published by John Wiley & Sons. This book was released on 2011-11-28 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lecture Notes: Clinical Pharmacology and Therapeutics provides all the necessary information, within one short volume, to achieve a thorough understanding of how drugs work, their interaction with the body in health and disease, and how to use these drugs appropriately in clinical situations. Presented in an easy-to-use format, this eighth edition builds on the clinical relevance for which the title has become well-known, and features an up-to-date review of drug use across all major clinical disciplines, together with an overview of contemporary medicines regulation and drug development. Key features include: A section devoted to the practical aspects of prescribing Clinical scenarios and accompanying questions to contextualise information End-of-chapter summary boxes Numerous figures and tables which help distil the information for revision purposes Whether you need to develop or refresh your knowledge of pharmacology, Lecture Notes: Clinical Pharmacology and Therpeutics presents 'need to know' information for those involved in prescribing drugs.
Book Synopsis Clinical Pharmacology and Oncology by : Jochen Kuhlmann
Download or read book Clinical Pharmacology and Oncology written by Jochen Kuhlmann and published by . This book was released on 1996 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cancer Chemotherapy and Biotherapy by : Bruce A. Chabner
Download or read book Cancer Chemotherapy and Biotherapy written by Bruce A. Chabner and published by Lippincott Williams & Wilkins. This book was released on 2011-12-07 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.
Book Synopsis Chemistry and Pharmacology of Anticancer Drugs by : David E. Thurston
Download or read book Chemistry and Pharmacology of Anticancer Drugs written by David E. Thurston and published by CRC Press. This book was released on 2021-03-17 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: While drug therapies developed in the last 80 years have markedly improved treatment outcomes and the management of some types of cancers, the lack of effectiveness and side effects associated with the most common treatment types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugs is a comprehensive survey of all families of anticancer agents and therapeutic approaches currently in use or in advanced stages of clinical trials, including biological-based therapies. The book is unique in providing molecular structures for all anticancer agents, discussing them in terms of history of development, chemistry, mechanism of action, structure–function relationships, and pharmacology. It also provides relevant information on side effects, dosing, and formulation. The authors, renowned scientists in cancer research and drug discovery, also provide up-to-date information on the drug discovery process, including discussions of new research tools, tumor-targeting strategies, and fundamental concepts in the relatively new areas of precision medicine and chemoprevention. Chemistry and Pharmacology of Anticancer Drugs is an indispensable resource for cancer researchers, medicinal chemists and other biomedical scientists involved in the development of new anticancer therapies. Its breadth of coverage, clear explanations, and illustrations also make it suitable for undergraduate and postgraduate courses in medicine, pharmacy, nursing, dentistry, nutrition, the biomedical sciences, and related disciplines. Key Features: Summarizes the fundamental causes of cancer, modes of treatment, and strategies for cancer drug discovery Brings together a broad spectrum of information relating to the chemistry and pharmacology of all families of anticancer agents and therapies Includes up-to-date information on cutting-edge aspects of cancer treatments such as biomarkers, pharmacogenetics, and pharmacogenomics Features new chapters on the "Evolution of Anticancer Therapies", "Antibody-Based Therapies", and "Cancer Chemoprevention"
Book Synopsis Cancer Chemo- and Immunopharmacology by : G. Mathe
Download or read book Cancer Chemo- and Immunopharmacology written by G. Mathe and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Local treatment cures about 30 to 40% of cancers, this proportion depending on the follow-up required to establish it. This means that 60 to 70% of the malignant neoplasias are disseminated either perceptibly (leukemias, visible metas tases) or imperceptibly, forming a 'minimal imperceptible disease', which local treatment leaves, whether it consists of surgery, radiotherapy, or surgery plus radiotherapy. When the neoplastic tissue is voluminous enough to be per ceptible, cures can be obtained with chemotherapy or chemo immunotherapy. When the neoplastic disease is imperceptible, made up of micrometastases, it apparently can be cured by systemic postsurgical chemotherapy, immunotherapy, or chemoimmunotherapy. Hence there is the need for intensive development of these medical therapies which are applied by the medical oncol ogist and, at present, consist of chemotherapy, immuno therapy, or chemoimmunotherapy. These medical thera peutics can only grow with scientific development, the main weapon of which is experimental and clinical pharmacology. These volumes report the communications presented at the 1979 EORTC Annual Plenary Session on Cancer Chemo and Immunopharmacology.
Book Synopsis Physicians' Cancer Chemotherapy Drug Manual 2013 by : Edward Chu
Download or read book Physicians' Cancer Chemotherapy Drug Manual 2013 written by Edward Chu and published by Jones & Bartlett Publishers. This book was released on 2012-12-28 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated for 2013, the Physicians’ Cancer Chemotherapy Drug Manual 2013 is an up-to-date guide to the latest information on standard therapy and recent advances in the field. Written by world-class experts in clinical cancer therapeutics, this essential reference provides a complete, easy-to-use catalog of over 100 drugs and commonly used drug regimens—both on- and off-label—for the treatment of all the major cancers. Special features: • Revised to reflect rapid advances in the field, incorporating treatment strategies and new drugs like brentuximab, carfilzomib, crizotinib, pertuzumab, rogorafenib, vemurafenib, and vismodegib. • A specific chapter focused on profiling antiemetic drug and antiemetic treatment regimens. • Diagrams of drug structures and pathways for many of the agents. • Offers a comprehensive discussion of clinical pharmacology, special considerations, indications, and dosages. • Covers toxicity and drug–drug interactions. • A section on chemotherapy regimens for all major cancers. • Provides an overview of the basic principles of cancer drug therapy. • Contains an easy to load and use CD version. Mobile version of Physicians’ Cancer Chemotherapy Drug Manual also available!
Book Synopsis Clinical Pharmacology of Anti-neoplastic Drugs by : H. M. Pinedo
Download or read book Clinical Pharmacology of Anti-neoplastic Drugs written by H. M. Pinedo and published by Elsevier-North-Holland Biomedical Press. This book was released on 1978 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: