Calcium Regulation By Calcium Binding Proteins In Neurodegenerative Disorders

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Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders

Author : Claus W. Heizmann
Publisher : Springer Science & Business Media
ISBN 13 : 3662216892
Total Pages : 148 pages
Book Rating : 4.6/5 (622 download)

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Book Synopsis Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders by : Claus W. Heizmann

Download or read book Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders written by Claus W. Heizmann and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the recent advances in the knowledge of the structure and physiological functions of the calcium-binding proteins in the central nervous system, describes their cellular distribution and developmental appearance, and discusses their possible association with neurodegenerative disorders and their use as diagnostic tools. This is the first book describing the structure, localization, and functions of calcium-binding proteins in the central nervous system and their involvement in neurodegenerative disorders. It is of great value to neurobiologists, clinicians, pharmacologists, biochemists and molecular biologists.

Calcium: The molecular basis of calcium action in biology and medicine

Author : R. Pochet
Publisher : Springer Science & Business Media
ISBN 13 : 9401006881
Total Pages : 746 pages
Book Rating : 4.4/5 (1 download)

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Book Synopsis Calcium: The molecular basis of calcium action in biology and medicine by : R. Pochet

Download or read book Calcium: The molecular basis of calcium action in biology and medicine written by R. Pochet and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world. The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era. The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets. In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches. Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists. The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.

Brain Aging

Author : David R. Riddle
Publisher : CRC Press
ISBN 13 : 9781420005523
Total Pages : 408 pages
Book Rating : 4.0/5 (55 download)

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Book Synopsis Brain Aging by : David R. Riddle

Download or read book Brain Aging written by David R. Riddle and published by CRC Press. This book was released on 2007-04-19 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

Calcium Signalling in Alzheimer’s Disease

Author : Mounia Chami
Publisher : MDPI
ISBN 13 : 3036504982
Total Pages : 162 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis Calcium Signalling in Alzheimer’s Disease by : Mounia Chami

Download or read book Calcium Signalling in Alzheimer’s Disease written by Mounia Chami and published by MDPI. This book was released on 2021-04-22 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer’s disease (AD) is the most well-known neurodegenerative disorder, causing dementia. In recent decades, several studies have reported calcium dysregulation in AD occurring through the intervention of several calcium receptors and channels, and affecting different cellular compartments, such as mitochondria, the endoplasmic reticulum, lysosomes, and microdomains within the plasma membrane. Calcium signalling dysregulation is now considered a common proximal cause of dysfunctional neurons and glial supporting cells. This book gathers the newest results and advances in calcium signaling deregulation mechanisms in AD, how they are linked to other players involved in AD, and the potential therapies targeting calcium alterations to treat AD.

Calcium Signaling: From Physiology to Diseases

Author : Senthilkumar Rajagopal
Publisher : Springer
ISBN 13 : 9811051607
Total Pages : 91 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Calcium Signaling: From Physiology to Diseases by : Senthilkumar Rajagopal

Download or read book Calcium Signaling: From Physiology to Diseases written by Senthilkumar Rajagopal and published by Springer. This book was released on 2017-09-28 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on disorders of calcium channels and the use of drugs to treat calcium-related disorders and their associated toxicities. In particular, it discusses the role of various natural products and their attributes in preventing problems associated with calcium imbalances. In addition, the book analyzes trends in the processing of natural products using nanotechnology and their implications in calcium-related disorders. Lastly, it explores some of the most promising aspects of research into calcium signalling disorders – which is especially important, given the wide variety of cellular processes that are controlled by calcium ions – and provides a trustworthy source of up-to-date information in this area of research.

Molecular Mechanisms of Neurodegenerative Diseases

Author : Marie-Francoise Chesselet
Publisher : Springer Science & Business Media
ISBN 13 : 1592590063
Total Pages : 416 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Molecular Mechanisms of Neurodegenerative Diseases by : Marie-Francoise Chesselet

Download or read book Molecular Mechanisms of Neurodegenerative Diseases written by Marie-Francoise Chesselet and published by Springer Science & Business Media. This book was released on 2000-10-19 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

Interrelations between Essential Metal Ions and Human Diseases

Author : Astrid Sigel
Publisher : Springer Science & Business Media
ISBN 13 : 9400775008
Total Pages : 573 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Interrelations between Essential Metal Ions and Human Diseases by : Astrid Sigel

Download or read book Interrelations between Essential Metal Ions and Human Diseases written by Astrid Sigel and published by Springer Science & Business Media. This book was released on 2014-01-27 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.

Calcium-binding Proteins in Health and Disease

Author : Anthony W. Norman
Publisher :
ISBN 13 :
Total Pages : 629 pages
Book Rating : 4.:/5 (112 download)

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Book Synopsis Calcium-binding Proteins in Health and Disease by : Anthony W. Norman

Download or read book Calcium-binding Proteins in Health and Disease written by Anthony W. Norman and published by . This book was released on 1987 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neuronal Calcium Sensors in Health and Disease

Author : Karl-Wilhelm Koch
Publisher : Frontiers Media SA
ISBN 13 : 288963342X
Total Pages : 313 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Neuronal Calcium Sensors in Health and Disease by : Karl-Wilhelm Koch

Download or read book Neuronal Calcium Sensors in Health and Disease written by Karl-Wilhelm Koch and published by Frontiers Media SA. This book was released on 2020-01-16 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Store-Operated Calcium Channels

Author :
Publisher : Academic Press
ISBN 13 : 0124079385
Total Pages : 298 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Store-Operated Calcium Channels by :

Download or read book Store-Operated Calcium Channels written by and published by Academic Press. This book was released on 2013-07-24 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels. Contributors are authoritative researchers who have produced important advances in the field. The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject.

Calcium Signalling and Disease

Author : Ernesto Carafoli
Publisher : Springer Science & Business Media
ISBN 13 : 1402061919
Total Pages : 592 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Calcium Signalling and Disease by : Ernesto Carafoli

Download or read book Calcium Signalling and Disease written by Ernesto Carafoli and published by Springer Science & Business Media. This book was released on 2007-09-29 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.

Novel Calcium-binding Proteins

Author : Claus W. Heizmann
Publisher : Springer
ISBN 13 :
Total Pages : 648 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Novel Calcium-binding Proteins by : Claus W. Heizmann

Download or read book Novel Calcium-binding Proteins written by Claus W. Heizmann and published by Springer. This book was released on 1991 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Calcium-Binding Proteins and Rage

Author : Claus Heizmann
Publisher : Humana Press
ISBN 13 : 9781493959761
Total Pages : 440 pages
Book Rating : 4.9/5 (597 download)

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Book Synopsis Calcium-Binding Proteins and Rage by : Claus Heizmann

Download or read book Calcium-Binding Proteins and Rage written by Claus Heizmann and published by Humana Press. This book was released on 2016-05-01 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Methods in Molecular Biology book reviews common techniques for studying calcium binding proteins, underlining the diagnostic and clinical importance of this family of proteins. Offers materials lists, protocols, troubleshooting advice and more."

Autophagy and Cancer

Author : Hong-Gang Wang
Publisher : Springer Science & Business Media
ISBN 13 : 1461465613
Total Pages : 267 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Autophagy and Cancer by : Hong-Gang Wang

Download or read book Autophagy and Cancer written by Hong-Gang Wang and published by Springer Science & Business Media. This book was released on 2013-03-30 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it.

Handbook of Neurochemistry and Molecular Neurobiology

Author : Katsuhiko Mikoshiba
Publisher : Springer Science & Business Media
ISBN 13 : 0387303383
Total Pages : 635 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Handbook of Neurochemistry and Molecular Neurobiology by : Katsuhiko Mikoshiba

Download or read book Handbook of Neurochemistry and Molecular Neurobiology written by Katsuhiko Mikoshiba and published by Springer Science & Business Media. This book was released on 2009-05-18 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the Handbook of Neurochemistry and Molecular Biology focuses on molecular events involved in synapse formation, synaptic plasticity and ongoing neural activity. The volume explores axonal growth cones, synapse development, and mechanisms of LTP and LTD, and calcium dynamics. Particular attention is given to function and trafficking of membrane proteins including various ion channels, aquaporines, gap junctions.

Capacitative Calcium Entry

Author : James W. Putney
Publisher : Springer
ISBN 13 :
Total Pages : 238 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Capacitative Calcium Entry by : James W. Putney

Download or read book Capacitative Calcium Entry written by James W. Putney and published by Springer. This book was released on 1997-06-15 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protein Carbonylation

Author : Joaquim Ros
Publisher : John Wiley & Sons
ISBN 13 : 1119074916
Total Pages : 416 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Protein Carbonylation by : Joaquim Ros

Download or read book Protein Carbonylation written by Joaquim Ros and published by John Wiley & Sons. This book was released on 2017-06-26 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein carbonylation has attracted the interest of a great number of laboratories since the pioneering studies at the Earl Stadtman’s lab at NIH started in early 1980s. Since then, detecting protein carbonyls in oxidative stress situations became a highly efficient tool to uncover biomarkers of oxidative damage in normal and altered cell physiology. In this book, research groups from several areas of interest have contributed to update the knowledge regarding detection, analyses and identification of carbonylated proteins and the sites where these modifications occur. The scientific community will benefit from these reviews since they deal with specific, detailed technical approaches to study formation and detection of protein carbonyls. Moreover, the biological impact of such modifications in metabolic, physiologic and structural functions and, how these alterations can help understanding the downstream effects on cell function are discussed. Oxidative stress occurs in all living organisms and affects proteins and other macromolecules: Protein carbonylation is a measure of oxidative stress in biological systems Mass spectrometry, fluorescent labelling, antibody based detection, biotinylated protein selection and other methods for detecting protein carbonyls and modification sites in proteins are described Aging, neurodegenerative diseases, obstructive pulmonary diseases, malaria, cigarette smoke, adipose tissue and its relationship with protein carbonylation Direct oxidation, glycoxidation and modifications by lipid peroxidation products as protein carbonylation pathways Emerging methods for characterizing carbonylated protein networks and affected metabolic pathways