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Breaking Of The Excitatory Inhibitory Balance In Neural Networks
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Book Synopsis Breaking of the Excitatory-inhibitory Balance in Neural Networks by : Cristina Pericas Iturriagagoitia
Download or read book Breaking of the Excitatory-inhibitory Balance in Neural Networks written by Cristina Pericas Iturriagagoitia and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental and theoretical study of membrane potentials of neurons in culture provide evidence of some of the mechanisms responsible for excitatory-inhibitory imbalance.
Book Synopsis Impact of Excitation-inhibition Balance/imbalance on Dynamics of Cortical Neural Networks by : Vidit Agrawal
Download or read book Impact of Excitation-inhibition Balance/imbalance on Dynamics of Cortical Neural Networks written by Vidit Agrawal and published by . This book was released on 2019 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this research is to study the implications of excitation/inhibition balance and imbalance on the dynamics of ongoing (spontaneous) neural activity in the cerebral cortex region of the brain. The first research work addresses the question that why among the continuum of Excitation-Inhibition balance configurations, particular configuration should be favored? We calculate the entropy of neural network dynamics by studying an analytically tractable network of binary neurons. Our main result from this work is that the entropy maximizes at regime which is neither excitation-dominant nor inhibition-dominant but at the boundary of both. Along this boundary we see there is a trade-off between high and robust entropy. Weak synapse strengths yield entropy which is high but drops rapidly under parameter change. Strong synapse strengths, on the other hand yield a lower, but more robust, network entropy. The second research work is motivated from experiments suggest that the cerebral cortex can also operate near a critical phase transition. It has been observed in many physical systems that the governing physical laws obey a fractal symmetry near critical phase transition. This symmetry exists irrespective of the observational length-scale. Thus, we hypothesize that the laws governing cortical dynamics may obey scale-change symmetry. We test and confirm this hypothesis using two different computational models. Further, we extend the transformational scheme show that as a mouse awakens from anesthesia, scale-change symmetry emerges. The third research project is motivated by experimental observations from in motor cortex under modulation of inhibitory inputs. We found that low intensity increase (decrease) in overall inhibition in cortex causes decrease (increase) in spiking activity for some neurons. Even though, the population level activity largely unchanged. This behavior is paradoxical when compared to the status quo that says that increase (decrease) inhibition should lead to decrease (increase) in neural spiking activity. We simulated similar dynamical change to inhibitory signal modulation in neural network model. We found that this paradoxical behavior arises due to sparse connectivity and inhomogeneity in inhibitory weights.
Book Synopsis Inhibitory Synaptic Plasticity by : Melanie A. Woodin
Download or read book Inhibitory Synaptic Plasticity written by Melanie A. Woodin and published by Springer Science & Business Media. This book was released on 2010-11-02 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will explore the most recent findings on cellular mechanisms of inhibitory plasticity and its functional role in shaping neuronal circuits, their rewiring in response to experience, drug addiction and in neuropathology. Inhibitory Synaptic Plasticity will be of particular interest to neuroscientists and neurophysiologists.
Book Synopsis Excitatory-inhibitory Balance, Imbalance, and Amplification in Cortical Network Models by : Christopher L. Ebsch
Download or read book Excitatory-inhibitory Balance, Imbalance, and Amplification in Cortical Network Models written by Christopher L. Ebsch and published by . This book was released on 2019 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Statistical Mechanics of Neural Networks by : Haiping Huang
Download or read book Statistical Mechanics of Neural Networks written by Haiping Huang and published by Springer Nature. This book was released on 2022-01-04 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights a comprehensive introduction to the fundamental statistical mechanics underneath the inner workings of neural networks. The book discusses in details important concepts and techniques including the cavity method, the mean-field theory, replica techniques, the Nishimori condition, variational methods, the dynamical mean-field theory, unsupervised learning, associative memory models, perceptron models, the chaos theory of recurrent neural networks, and eigen-spectrums of neural networks, walking new learners through the theories and must-have skillsets to understand and use neural networks. The book focuses on quantitative frameworks of neural network models where the underlying mechanisms can be precisely isolated by physics of mathematical beauty and theoretical predictions. It is a good reference for students, researchers, and practitioners in the area of neural networks.
Book Synopsis Methods and Models in Neurophysics by : Carson Chow
Download or read book Methods and Models in Neurophysics written by Carson Chow and published by Elsevier. This book was released on 2005 with total page 876 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. E. Marder, Experimenting with theory -- 2. A. Borysuk and J. Rinzel, Understanding neuronal dynamics by geometrical dissection of minimal models -- 3. D. Terman, Geometry singular perturbation analysis of neuronal dynamics -- 4. G. Mato, Theory of neural synchrony -- 5. M. Shelley, Some useful numerical techniques for simulating integrate-and-fire networks -- 6. D. Golomb, Propagation of pulses in cortical networks: the single-spike approximation -- 7. M. Tsodyks, Activity-dependent transmission in neocortical synapses -- 8. H. Sompolinsky and J. White, Theory of large recurrent networks: from spikes to behavior -- 9. C. van Vreeswijk, Irregular activity in large networks of neurons -- 10. N. Brunel, Network models of memory -- 11. P. Bressloff, Pattern formation in visual cortex -- 12. F. Wolf, Symmetry breaking and pattern selection in visual cortical development -- 13. A. Treves and Y. Roudi, On the evolution of the brain -- 14. E. Brown, Theory of point processes for neural syst ...
Download or read book Dynamic-Clamp written by Alain Destexhe and published by Springer Science & Business Media. This book was released on 2009-03-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dynamic-clamp is a fascinating electrophysiology technique that consists of merging living neurons with computational models. The dynamic-clamp (also called “conductance injection”) allows experimentalists and theoreticians to challenge neurons (or any other type of cell) with complex conductance stimuli generated by a computer. The technique can be implemented from neural simulation environments and a variety of custom-made or commercial systems. The real-time interaction between the computer and cell also enables the design of recording paradigms with unprecedented accuracy via a computational model of the electrode. Dynamic-Clamp: From Principles to Applications contains contributions from leading researchers in the field, who investigate these paradigms at the cellular or network level, in vivo and in vitro, and in different brain regions and cardiac cells. Topics discussed include the addition of artificially-generated synaptic activity to neurons; adding, amplifying or neutralizing voltage-dependent conductances; creating hybrid networks with real and artificial cells; attaching simulated dendritic tree structures to the living cell; and connecting different neurons. This book will be of interest to experimental biophysicists, neurophysiologists, and cardiac physiologists, as well as theoreticians, engineers, and computational neuroscientists. Graduate and undergraduate students will also find up-to-date coverage of physiological problems and how they are investigated.
Book Synopsis Spiking Neuron Models by : Wulfram Gerstner
Download or read book Spiking Neuron Models written by Wulfram Gerstner and published by Cambridge University Press. This book was released on 2002-08-15 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurons in the brain communicate by short electrical pulses, the so-called action potentials or spikes. How can we understand the process of spike generation? How can we understand information transmission by neurons? What happens if thousands of neurons are coupled together in a seemingly random network? How does the network connectivity determine the activity patterns? And, vice versa, how does the spike activity influence the connectivity pattern? These questions are addressed in this 2002 introduction to spiking neurons aimed at those taking courses in computational neuroscience, theoretical biology, biophysics, or neural networks. The approach will suit students of physics, mathematics, or computer science; it will also be useful for biologists who are interested in mathematical modelling. The text is enhanced by many worked examples and illustrations. There are no mathematical prerequisites beyond what the audience would meet as undergraduates: more advanced techniques are introduced in an elementary, concrete fashion when needed.
Download or read book Tau Biology written by Akihiko Takashima and published by Springer Nature. This book was released on 2020-02-24 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.
Book Synopsis Cognitive Plasticity in Neurologic Disorders by : Joseph I. Tracy
Download or read book Cognitive Plasticity in Neurologic Disorders written by Joseph I. Tracy and published by Oxford University Press, USA. This book was released on 2014-12-02 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume makes clear that the cognitive and behavioural symptoms of neurologic disorders and syndromes are dynamic and changing. Each chapter describes the neuroplastic processes at work in a particular condition, giving rise to these ongoing cognitive changes.
Book Synopsis Handbook of Brain Connectivity by : Viktor K. Jirsa
Download or read book Handbook of Brain Connectivity written by Viktor K. Jirsa and published by Springer. This book was released on 2007-08-16 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our contemporary understanding of brain function is deeply rooted in the ideas of the nonlinear dynamics of distributed networks. Cognition and motor coordination seem to arise from the interactions of local neuronal networks, which themselves are connected in large scales across the entire brain. The spatial architectures between various scales inevitably influence the dynamics of the brain and thereby its function. But how can we integrate brain connectivity amongst these structural and functional domains? Our Handbook provides an account of the current knowledge on the measurement, analysis and theory of the anatomical and functional connectivity of the brain. All contributors are leading experts in various fields concerning structural and functional brain connectivity. In the first part of the Handbook, the chapters focus on an introduction and discussion of the principles underlying connected neural systems. The second part introduces the currently available non-invasive technologies for measuring structural and functional connectivity in the brain. Part three provides an overview of the analysis techniques currently available and highlights new developments. Part four introduces the application and translation of the concepts of brain connectivity to behavior, cognition and the clinical domain.
Book Synopsis Ageing and Dementia by : Kurt Jellinger
Download or read book Ageing and Dementia written by Kurt Jellinger and published by Springer Science & Business Media. This book was released on 2002-08-20 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidemiological studies, modern clinical, neuroimaging, neuropsychological, molecular biological, and genetic studies have considerably enhanced our knowledge about ageing processes of the human brain, its sequelae, diagnostic, and therapeutic possibilities and limits. In addition to Alzheimer's disease and other degenerative dementias, the impact of cerebrovascular lesions and their risk factors in the pathogenesis of cognitive disorders of the aged are increasingly acknowledged, and the recognition of mild cognitive impairment as a frequent initial stage of developing dementia is becoming an increasingly important diagnostic and therapeutic problem. The included papers were presented at the 7th International Symposium in Graz, Sept. 2001 and give a timely overview of the current and future concepts of pathogenesis, diagnosis, and treatment strategies of pathological brain ageing and dementias, early recognition of mild cognitive impairment and future possiblities of prevention of dementing processes.
Book Synopsis The Frontal Cortex by : Marie T. Banich
Download or read book The Frontal Cortex written by Marie T. Banich and published by MIT Press. This book was released on 2024-09-03 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: An in-depth investigation of the structure, neuronal mechanisms, and computations of the frontal lobe that enable higher-level thought. Experts from neurobiology, neuroanatomy, evolutionary biology, cognitive neuroscience, computational neuroscience, and clinical science examine how the neuronal structure of the frontal lobes enables unique aspects of higher-level thought. Implications for understanding disrupted function in neurological and psychiatric disorders, as well as societal issues, such as volitional control of behavior and educational practice, are also considered.
Book Synopsis Fast Oscillations in Cortical Circuits by : Roger D. Traub
Download or read book Fast Oscillations in Cortical Circuits written by Roger D. Traub and published by MIT Press. This book was released on 1999 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Fast Oscillations in Cortical Circuits, the authors use a combination of electrophysiological and computer modeling techniques to analyze how large networks of neurons can produce both epileptic seizures and functionally relevant synchronized oscillations.
Book Synopsis Neuroscience in the 21st Century by : Donald W. Pfaff
Download or read book Neuroscience in the 21st Century written by Donald W. Pfaff and published by Springer. This book was released on 2016-10-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.
Book Synopsis Excitatory-Inhibitory Balance by : Takao K. Hensch
Download or read book Excitatory-Inhibitory Balance written by Takao K. Hensch and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new perspective on brain function depends upon an understanding of the interaction and integration of excitation and inhibition. A recent surge in research activity focused on inhibitory interneurons now makes a more balanced view possible. Technological advances such as improved imaging methods, visualized patch-clamp recording, multiplex single-cell PCR, and gene-targeted deletion or knock-in mice are some of the novel tools featured in this book. This book will provide an integrated view of neuron function, operating in a balanced regime of excitation and inhibition. It is a timely contribution emphasizing how this balance is established, maintained, and modified from the molecular to system levels. The broad spectrum of topics from molecular to cellular and system/computational neuroscience will appeal to a wide audience of advanced graduate students, post-docs, and faculty. Moreover, this book this book features active young researchers from around the world, who are currently educating the brain scientists of tomorrow.
Book Synopsis From Structure to Function in Neuronal Networks: Effects of Adaptation, Time-Delays, and Noise by : Serhiy Yanchuk
Download or read book From Structure to Function in Neuronal Networks: Effects of Adaptation, Time-Delays, and Noise written by Serhiy Yanchuk and published by Frontiers Media SA. This book was released on 2022-05-06 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
