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Biomarkers In Autoimmune Diseases Of The Central Nervous System
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Book Synopsis Biomarkers in Autoimmune Diseases of the Central Nervous System by : Mei-Ping Ding
Download or read book Biomarkers in Autoimmune Diseases of the Central Nervous System written by Mei-Ping Ding and published by Frontiers Media SA. This book was released on 2023-09-25 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune diseases of the central nervous system (CNS) are a group of complex and disabling disorders characterized by the immune system mistakenly attacking the CNS. During the last 2 decades, we have witnessed a rapidly evolving spectrum of CNS autoimmune diseases, which has become a research hotspot in neurology. These include CNS inflammatory demyelinating diseases such as multiple sclerosis and neuromyelitis optical spectrum disorders, paraneoplastic, and other autoimmune encephalomyelitis and CNS involvement in systemic autoimmune diseases. Recently, although remarkable discoveries have accumulated more understanding of the autoimmune basis behind the physiopathologic mechanism, the exact pathogenic processes are still unclear. Patients may present with a variety of manifestations, posing a great challenge to diagnosis and management. The determination of biomarkers plays a significant role in CNS autoimmune diseases. Biomarkers can reflect the presence, nature, and intensity of certain immune responses triggered by both genetic and environmental processes, and bear great importance in guiding clinical diagnosis, estimating disease risk or prognosis, evaluating disease severity, and monitoring progression or response to therapy. For instance, the detection of disease-specific antibodies can contribute to the accurate diagnosis and precise treatment. Moreover, identifying the diverse biomarkers could further help to achieve the ultimate goal of personalized medicine.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309463688 Total Pages :89 pages Book Rating :4.3/5 (94 download)
Book Synopsis Biomarkers of Neuroinflammation by : National Academies of Sciences, Engineering, and Medicine
Download or read book Biomarkers of Neuroinflammation written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-02-16 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.
Book Synopsis Brain Neurotrauma by : Firas H. Kobeissy
Download or read book Brain Neurotrauma written by Firas H. Kobeissy and published by CRC Press. This book was released on 2015-02-25 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.
Book Synopsis Mechanisms of Disease Pathogenesis in Multiple Sclerosis by : Francisco Javier Quintana
Download or read book Mechanisms of Disease Pathogenesis in Multiple Sclerosis written by Francisco Javier Quintana and published by Elsevier. This book was released on 2024-06-28 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book. Summarizes our current understanding of Multiple Sclerosis Discusses clinical features and available biomarker monitoring Focuses on mechanisms that drive disease pathogenesis
Book Synopsis Biomarkers for Traumatic Brain Injury by : Svetlana Dambinova
Download or read book Biomarkers for Traumatic Brain Injury written by Svetlana Dambinova and published by Royal Society of Chemistry. This book was released on 2012 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to injuries sustained in sports and in combat, interest in traumatic brain injury (TBI) has never been greater. This book will fulfill a gap in understanding of what is occurring in the brain following injury that can subsequently be detected in biological fluids and imaging.
Download or read book Autoimmune Neurology written by and published by Elsevier. This book was released on 2016-03-11 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities
Book Synopsis Topical Diagnosis in Neurology by : Mathias Bähr
Download or read book Topical Diagnosis in Neurology written by Mathias Bähr and published by Thieme. This book was released on 2019-04-29 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: The perennial neurology classic, updated and expanded The sixth edition of Duus' classic Topical Diagnosis in Neurology builds on the clear, integrated presentation of anatomy, function, and disorders of the central nervous system that made it a success for almost over five decades, serving as a quick reference for practitioners and trainees alike. It elucidates the neuroanatomical pathways that lead to specific clinical syndromes, and demonstrates how comprehensive anatomical knowledge combined with a thorough neurological examination can help localize and categorize a lesion and arrive at a differential diagnosis. The time-tested logical, thematic structure with useful summaries, at the beginning of each chapter, and color-coded section headings enable readers to distinguish neuroanatomical from clinical material at a glance and enable efficient and time saving study. Features of the sixth edition: New tables and clinical case examples Improved descriptions of neuroanatomical/neurophysiological basics in the context of clinical symptoms Twenty-three new illustrations, to a total of more than 400 illustrations A wide range of study aids and clinical correlations that support the emphasis on integrative medicine in the current medical school curricula Topical Diagnosis in Neurology is an ideal reference for neurologists and neuroscientists who correlate neurological diseases with anatomical location to arrive at a diagnosis or understand a clinical syndrome. It is also an essential tool for trainees and advanced students who need a solid grounding in key neurofunctional relationships.
Book Synopsis Reassessing the immune system contribution in multiple sclerosis: Therapeutic target, biomarkers of disease and immune pathogenesis by : Maria Teresa Cencioni
Download or read book Reassessing the immune system contribution in multiple sclerosis: Therapeutic target, biomarkers of disease and immune pathogenesis written by Maria Teresa Cencioni and published by Frontiers Media SA. This book was released on 2023-04-10 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis White Matter Diseases by : Massimo Filippi
Download or read book White Matter Diseases written by Massimo Filippi and published by Springer Nature. This book was released on 2020-02-13 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides cutting-edge information on the epidemiology, etiopathogenesis, clinical manifestations, diagnostic procedures and treatment approaches for the main white matter (WM) disorders of the central nervous system (CNS). WM lesions are associated with many neurological conditions, and with aging. The diagnostic work-up of neurological diseases characterized by the presence of these lesions has changed dramatically over the past few years. This is mainly due on the one hand to the discovery of specific pathogenetic factors in some of these conditions, and on the order to the optimized use of diagnostic tools. All of this has resulted in new diagnostic algorithms, and in the identification of new neurological conditions. The book offers neurologists essential guidance in the diagnosis and treatment of the most frequent WM conditions, promoting their correct and cost-saving diagnosis and management. By integrating neurological, laboratory and imaging concepts with the demands of accurate diagnosis, this reference guide provides a state-of-the-art overview of the current state of knowledge on these conditions, as well as practical guidelines for their diagnosis and treatment.
Book Synopsis Demyelinating Disorders of the Central Nervous System in Childhood by : Dorothée Chabas
Download or read book Demyelinating Disorders of the Central Nervous System in Childhood written by Dorothée Chabas and published by Cambridge University Press. This book was released on 2011-03-17 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although multiple sclerosis and other disorders of myelin formation and repair are most commonly associated with adults, they can also occur in infants, children and adolescents. Up to 5 percent of those with MS experience symptoms before the age of 18, and the number of cases diagnosed is rising. There is a lack of awareness about these diseases in childhood, however, even amongst pediatric neurologists and MS specialists. Demyelinating Disorders of the Central Nervous System in Childhood provides comprehensive coverage of these diseases, highlighting throughout the differences between management in childhood and in adults. With sections dedicated to the diagnosis, course, treatment and biology of pediatric MS, detailed chapters on other childhood demyelinating diseases, including acute disseminated encephomyelitis, optic neuritis, acute complete transverse myelitis and neuromyelitis optica, are also provided. Essential reading for pediatric neurologists and MS specialists, this book will also be valuable reading for adult neurologists and pediatricians.
Book Synopsis Multiple Sclerosis and Related Disorders: Challenges and Approaches to Mechanisms, Biomarkers, and Therapeutic Targets by : Jinzhou Feng
Download or read book Multiple Sclerosis and Related Disorders: Challenges and Approaches to Mechanisms, Biomarkers, and Therapeutic Targets written by Jinzhou Feng and published by Frontiers Media SA. This book was released on 2024-05-28 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis (MS) is an autoimmune condition that causes inflammatory damage to the central nervous system. The pathologic features are diffuse and focal inflammation, demyelination, gliosis, and neuronal damage in the optic nerves, brain, and spinal cord. Multiple sclerosis remains a challenging and disabling disease. There is a greater understanding of the underlying genetic and environmental factors driving the disorder, including low vitamin D levels, smoking, and obesity. Early and accurate diagnosis is essential and needs to be supported by diagnostic criteria, including imaging and spinal fluid abnormalities in patients with clinically isolated syndromes. Other demyelinating diseases are neuromyelitis optica spectrum disorders (NMOSD), anti-myelin oligodendrocyte glycoprotein antibody disease (MOGAD), and acute disseminated encephalomyelitis (ADEM).
Book Synopsis Monitoring Metabolic Status by : Institute of Medicine
Download or read book Monitoring Metabolic Status written by Institute of Medicine and published by National Academies Press. This book was released on 2004-08-29 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: The U.S. military's concerns about the individual combat service member's ability to avoid performance degradation, in conjunction with the need to maintain both mental and physical capabilities in highly stressful situations, have led to and interest in developing methods by which commanders can monitor the status of the combat service members in the field. This report examines appropriate biological markers, monitoring technologies currently available and in need of development, and appropriate algorithms to interpret the data obtained in order to provide information for command decisions relative to the physiological "readiness" of each combat service member. More specifically, this report also provides responses to questions posed by the military relative to monitoring the metabolic regulation during prolonged, exhaustive efforts, where nutrition/hydration and repair mechanisms may be mismatched to intakes and rest, or where specific metabolic derangements are present.
Book Synopsis Induction of Central Nervous System Disease by the Adaptive Immune Response by : Robert Weissert
Download or read book Induction of Central Nervous System Disease by the Adaptive Immune Response written by Robert Weissert and published by Frontiers Media SA. This book was released on 2017-11-23 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last years it has become evident that many neurological diseases of the central nervous system (CNS) are induced by a specific adaptive immune response directed against molecules expressed on CNS-resident cells. Well-recognized examples are anti-N-Methyl-D-Aspartate Receptor (NMDAR) encephalitis which is characterized by the presence of antibodies against neuron-expressed NMDAR, or neuromyelitis optica (NMO), induced by antibodies to astrocyte-expressed aquaporin-4. Many more examples exist, and antibodies, and T or/and B cells have increasingly been associated with CNS disease. Often the symptoms of these diseases have not been typically reported to have an immune aetiology. Beside classical neurological symptoms like ataxia, vision disturbance, and motor or sensory symptoms, these can include cognitive disturbances, behavioral abnormalities, or/and epileptic seizures. Although much has been learned regarding the pathophysiology of prototypic examples of these disorders, there are still major gaps in our understanding of their biology. This may be due to the fact that they are rare diseases, and their therapies are still very limited. This research topic includes contributions addressing the analysis of the adaptive immune response driving disease including target antigens, molecular epitope mapping, and factors involved in the disease pathogenesis such as complement activation cascades, genetic and genomic regulation, as well as environmental triggers. Diagnostic criteria and methods, and treatment are also discussed. The overall aim of the volume is to review progress in our pathophysiological understanding of immune-mediated CNS disorders in order to advance diagnostic and therapeutic approaches, and ultimately improve outcomes for patients.
Book Synopsis Pathophysiologic Insights from Biomarker Studies in Neurological Disorders by : Tobias Ruck
Download or read book Pathophysiologic Insights from Biomarker Studies in Neurological Disorders written by Tobias Ruck and published by Frontiers Media SA. This book was released on 2020-04-01 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Autoimmune Diseases: New Insights for the Healthcare Professional: 2013 Edition by :
Download or read book Autoimmune Diseases: New Insights for the Healthcare Professional: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-07-22 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune Diseases: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Genetics. The editors have built Autoimmune Diseases: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Genetics in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Autoimmune Diseases: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Advances in Autoimmune Diseases of the Nervous System Research and Treatment: 2011 Edition by :
Download or read book Advances in Autoimmune Diseases of the Nervous System Research and Treatment: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Autoimmune Diseases of the Nervous System Research and Treatment: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Autoimmune Diseases of the Nervous System. The editors have built Advances in Autoimmune Diseases of the Nervous System Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Autoimmune Diseases of the Nervous System in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Autoimmune Diseases of the Nervous System Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Primary Progressive Multiple Sclerosis by : M. Filippi
Download or read book Primary Progressive Multiple Sclerosis written by M. Filippi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Why are there no effective treatments for my condition? Why do researchers exclude patients with primary progressive multiple sclerosis from enrolling in clinical trials? Please let me know if you hear of studies that I might be allowed to enter or treatments that I could try for my condition. " Thus, in recent years, the sad lament of the patient with primary progressive MS (PPMS). This variant, often in the guise of a chronic progressive myelopathy or, less commonly, progressive cerebellar or bulbar dysfunction, usually responds poorly to corticosteroids and rarely seems to benefit to a significant degree from intensive immunosuppressive treatments. In recent years, most randomized clin ical trials have excluded PPMS patients on two counts. Clinical worsening devel ops slowly in PPMS and may not be recognized during the course of a 2-or 3-year trial even in untreated control patients. This factor alone adds to the potential for a type 2 error or, at the very least, inflates the sample size and duration of the trial. In addition, there is mounting evidence that progressive axonal degeneration and neuronal loss (rather than active, recurrent inflammation) may be important components of the pathology in this form of the disease. Although contemporary trials are evaluating whether PPMS patients may benefit from treatment with the ~-interferons and glatiramer acetate, preliminary, uncontrolled clinical experi ence suggests that the results may not be dramatic.
