Antiviral Research

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Antiviral Methods and Protocols

Author : Edwin Yunhao Gong
Publisher : Humana
ISBN 13 : 9781493960354
Total Pages : 0 pages
Book Rating : 4.9/5 (63 download)

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Book Synopsis Antiviral Methods and Protocols by : Edwin Yunhao Gong

Download or read book Antiviral Methods and Protocols written by Edwin Yunhao Gong and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although antiviral drugs have been successfully developed for some viral diseases, there remains a clear, unmet medical need to develop novel antiviral agents for the control and management of many viruses that currently have no or limited treatment options as well as a need to overcome the limitations associated with the existing antiviral drugs, such as adverse effects and emergence of drug-resistant mutations. The second edition of Antiviral Methods and Protocols features: All chapters are new and written by experts in the field, reflecting the major recent technical advances in antiviral research and discovery. This edition focuses on many important human viruses, such as human immunodeficiency virus type 1 (HIV-1), hepatitis viruses (hepatitis B and C viruses), herpes viruses, human respiratory syncytial virus (RSV), and influenza virus, while also featuring some important emerging viruses, such as dengue virus, West Nile virus, and chikungunya virus. As a volume in the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Antiviral Methods and Protocols, Second Edition will serve as an excellent laboratory reference for pharmaceutical and academic biologists, medicinal chemists, and pharmacologists as well as for virologists in the field of antiviral research and drug discovery.

Recent Advances in Animal Virology

Author : Yashpal Singh Malik
Publisher : Springer Nature
ISBN 13 : 9811390738
Total Pages : 471 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Recent Advances in Animal Virology by : Yashpal Singh Malik

Download or read book Recent Advances in Animal Virology written by Yashpal Singh Malik and published by Springer Nature. This book was released on 2019-11-14 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the prominence and implication of the viral diseases that are a major threat to animals around the globe. A number of these diseases have also shown links with human populations, which has implications for public health. This book offers detailed and up-to-date information on viral diseases in livestock and poultry that were and/or are still a problem. Including cutting-edge developments, it also highlights several landmark contributions in the field of virology from India. Additionally, the book features tables and figures showing important clinical data and recommendations, with references for further information. It also explores the economic impact of viral diseases for farmers and the livestock industry, providing several examples. Further, it presents the latest information on viral diseases in global context, with a focus on state-of-art, molecular tools for the development of diagnostics, prophylactics and therapeutics. Lastly, the book also describes the challenges posed by the emerging and transboundary viral infections and our preparedness to counter them.

Advances in Antiviral Drug Design

Author : E. De Clercq
Publisher : Elsevier
ISBN 13 : 9780080548241
Total Pages : 264 pages
Book Rating : 4.5/5 (482 download)

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Book Synopsis Advances in Antiviral Drug Design by : E. De Clercq

Download or read book Advances in Antiviral Drug Design written by E. De Clercq and published by Elsevier. This book was released on 2007-07-30 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regularly reviewing the "state-of-the-art" developments in the antiviral drug research field, this latest volume spans the conceptual design and chemical synthesis of new antiviral compounds. It discusses their structure-activity relationship, mechanism and targets of action, pharmacological behavior, antiviral activity spectrum, and therapeutic potential for clinical use.

Human Herpesviruses

Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Human Herpesviruses by : Ann Arvin

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Advances in Antiviral Research

Author : Naveen Kumar
Publisher : Springer Nature
ISBN 13 : 9819991951
Total Pages : 463 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Advances in Antiviral Research by : Naveen Kumar

Download or read book Advances in Antiviral Research written by Naveen Kumar and published by Springer Nature. This book was released on with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Some Antiviral and Antineoplastic Drugs, and Other Pharmaceutical Agents

Author : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher : World Health Organization
ISBN 13 :
Total Pages : 536 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Some Antiviral and Antineoplastic Drugs, and Other Pharmaceutical Agents by : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans

Download or read book Some Antiviral and Antineoplastic Drugs, and Other Pharmaceutical Agents written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 2000 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evaluates the carcinogenic risks to humans posed by the use of four antiretroviral agents four DNA topoisomerase II inhibitors used in the treatment of cancer and an additional three pharmaceutical agents (hydroxyures phenolphthalein and vitamin K substances). The volume marks the first IARC evaluation of nucleoside analogs that act as antiviral agents. The evaluation responds in part to recent findings that zidovudine (AZT) an effective antiretroviral agent now being given to pregnant HIV-infected women to prevent maternal-to-fetal transmission of the virus is a transplacental carcinogen in mice. The opening monograph evaluates the carcinogenicity to humans of the antiretroviral nucleoside analogs zidovudine (AZT) zalcitabine (ddC) and didanosine (ddI) and the antiherpesvirus drug aciclovir. Of these aciclovir and didanosine could not be classified on the basis of available data. For zidovudine transplacental administration to mice resulted in an increased incidence and multiplicity of lung and liver tumours and in an increased incidence of female reproductive tract tumours in one study but not in another involving treatment at a lower dose. Despite observation of toxic effects in some studies of humans human carcinogenicity data were judged to provide inadequate evidence of carcinogenicity in humans. Zidovudine was classified as possibly carcinogenic to humans. Similar weaknesses in human carcinogenicity data for zalcitabine which consistently induces thymic lymphomas in mice resulted in its classification as possibly carcinogenic to humans. The second monograph evaluates four DNA topoisomerase II inhibitors: etoposide teniposide mitoxantrone and amsacrine. Of these etoposide - one of the most widely used and effective cytotoxic drugs in combination therapy - was classified as probably carcinogenic to humans and etoposide in combination with cisplatin and bleomycin was judged to be carcinogenic to humans. Teniposide was classified as probably carcinogenic to humans and mitoxantrone and amsacrine were classified as possibly carcinogenic to humans. Of the three pharmaceutical agents evaluated in the final monograph hydroxyurea which is widely used in cancer treatment and increasingly in combination with didanosine in HIV infection could not be classified. Phenolphthalein a widely used laxative now being withdrawn from the market in many countries because of toxicological concerns was classified as possibly carcinogenic. Vitamin K substances could not be classified on the basis of available evidence.

Antiviral Drug Discovery and Development

Author : Xinyong Liu
Publisher : Springer Nature
ISBN 13 : 9811602670
Total Pages : 357 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Antiviral Drug Discovery and Development by : Xinyong Liu

Download or read book Antiviral Drug Discovery and Development written by Xinyong Liu and published by Springer Nature. This book was released on 2021-07-13 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.

Antiviral Drug Strategies

Author : Erik De Clercq
Publisher : John Wiley & Sons
ISBN 13 : 3527635963
Total Pages : 632 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Antiviral Drug Strategies by : Erik De Clercq

Download or read book Antiviral Drug Strategies written by Erik De Clercq and published by John Wiley & Sons. This book was released on 2011-04-08 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de Clercq, the world authority on small molecule antiviral drugs, who has developed more new antivirals than anyone else.

Antiviral Research

Author : Robert L. LaFemina
Publisher :
ISBN 13 : 9781555814397
Total Pages : 0 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Antiviral Research by : Robert L. LaFemina

Download or read book Antiviral Research written by Robert L. LaFemina and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Antiviral Drugs

Author : Wieslaw M. Kazmierski
Publisher : John Wiley & Sons
ISBN 13 : 0470455632
Total Pages : 484 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Antiviral Drugs by : Wieslaw M. Kazmierski

Download or read book Antiviral Drugs written by Wieslaw M. Kazmierski and published by John Wiley & Sons. This book was released on 2011-08-23 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on new small molecule approaches to combat viral infections. The chapters describe the discovery and development from bench through the clinic of relatively recently-approved antiviral drugs and compounds in advanced clinical development. Organized by a virus (such as HIV, HCV, RSV, influenza, HBV and CMV) and written by top academic and industrial authorities in the field, the book provides a unique opportunity to study, understand and apply discovery and development principles and learning without the need for an individual to research, analyze and synthesize all immense sourcing references. Topics showcase challenges and solutions of issues encountered, offering tremendous experience accumulated over many years of research that will be particularly useful to basic and bench scientists as well as clinicians as they continue discovering and developing new drugs and therapies.

Environment-Friendly Antiviral Agents for Plants

Author : Baoan Song
Publisher : Springer Science & Business Media
ISBN 13 : 3642036929
Total Pages : 305 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Environment-Friendly Antiviral Agents for Plants by : Baoan Song

Download or read book Environment-Friendly Antiviral Agents for Plants written by Baoan Song and published by Springer Science & Business Media. This book was released on 2011-01-26 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant virus disease is a worldwide threat to agriculture. Environment-Friendly Antiviral Agents for Plants systematically describes the basic theory, new ideas, and new methods to discover novel antiviral agents through research on plant immune activation. The cutting-edge research methodology, technology and progress on novel antiviral agent innovation are systematically described. With abundant illustrations and figures, the book is intended for researchers and practitioners in the fields of pesticide science, plant protection, organic chemistry, fine chemicals, applied chemistry, environment chemistry and agriculture science. Dr. Baoan Song and Dr. Song Yang are professors at the Center for R&D of Fine Chemicals, Guizhou University, China; Mr. Linhong Jin and Dr. Pinaki S. Bhadury are associate professors there.

Natural Products As Antiviral Agents

Author : Chung Chu
Publisher :
ISBN 13 : 9781461534150
Total Pages : 292 pages
Book Rating : 4.5/5 (341 download)

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Book Synopsis Natural Products As Antiviral Agents by : Chung Chu

Download or read book Natural Products As Antiviral Agents written by Chung Chu and published by . This book was released on 2014-01-15 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Viral Bioterrorism and Biodefense

Author : E. de Clercq
Publisher : Elsevier
ISBN 13 : 9780444513267
Total Pages : 162 pages
Book Rating : 4.5/5 (132 download)

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Book Synopsis Handbook of Viral Bioterrorism and Biodefense by : E. de Clercq

Download or read book Handbook of Viral Bioterrorism and Biodefense written by E. de Clercq and published by Elsevier. This book was released on 2003-04-17 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: The atrocities of 11 September 2001 and the more recent casualties due to anthrax bioterrorism have dramatically emphasized the potential danger of biological warfare and bioterrorism. The editors of "Antiviral Research" have taken the initiative to edit a special issue of the Journal, focusing on Viral Bioterrorism and Biodefense. It is the first time in history that a special volume has been dedicated to this topic, which in view of the current circumstances is timely, appropriate and relevant. To what extent could viruses be "weaponized", i.e. turned into biological weapons, and used for biowarfare, which viruses would lend themselves for this purpose, how should we estimate the risk and the consequences, which diagnostic measures should be taken, and how should we react prophylactically, and, if needed, therapeutically?

Antiviral Drugs

Author : Wieslaw M. Kazmierski
Publisher : John Wiley & Sons
ISBN 13 : 0470934689
Total Pages : 472 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Antiviral Drugs by : Wieslaw M. Kazmierski

Download or read book Antiviral Drugs written by Wieslaw M. Kazmierski and published by John Wiley & Sons. This book was released on 2011-07-08 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on new small molecule approaches to combat viral infections. The chapters describe the discovery and development from bench through the clinic of relatively recently-approved antiviral drugs and compounds in advanced clinical development. Organized by a virus (such as HIV, HCV, RSV, influenza, HBV and CMV) and written by top academic and industrial authorities in the field, the book provides a unique opportunity to study, understand and apply discovery and development principles and learning without the need for an individual to research, analyze and synthesize all immense sourcing references. Topics showcase challenges and solutions of issues encountered, offering tremendous experience accumulated over many years of research that will be particularly useful to basic and bench scientists as well as clinicians as they continue discovering and developing new drugs and therapies.

Virus Taxonomy

Author : Frederik A Murphy
Publisher :
ISBN 13 : 9783709166086
Total Pages : 600 pages
Book Rating : 4.1/5 (66 download)

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Book Synopsis Virus Taxonomy by : Frederik A Murphy

Download or read book Virus Taxonomy written by Frederik A Murphy and published by . This book was released on 1995-05-03 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemotherapy of Viral Infections

Author : P E. Came
Publisher : Springer Science & Business Media
ISBN 13 : 3642684874
Total Pages : 580 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Chemotherapy of Viral Infections by : P E. Came

Download or read book Chemotherapy of Viral Infections written by P E. Came and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: " . . . the motto for the therapeutics of the future will have to be de sedibus et causis pharmacorum. " P. EHRLICH, 1909 Exciting events in the basic disciplines of virology, immunology, and pharmacology continue to advance the understanding of the pathogenesis and control of virus diseases. At the same time, the rational development of antiviral agents is attracting, to an increasing extent, the interest of workers in other disciplines. Improvements in technology facilitate the definition of potential target sites for antiviral intervention and unmask new viral and host genes. The outcome is a further steady development of new antiviral agents which approach the "magic bullets" first proposed by PAUL EHRLICH. Remarkable advances in protein synthetic methods that yield polypeptides which inhibit active sites of viral proteins have aided substantially in the basic and clinical study of these antiviral agents. In addition, the extremely rapid progression in recombinant DNA techniques, leading to the synthesis of large quantities of gene products, is also increasing our opportunities at a dashing pace. New information and developing technology facilitate research on the mechanism of action, toxicity, pharmacokinetics, and pharmacodynamics of new agents. The list of clinically effective antiviral agents is expanding and the number of potentially useful compounds is growing rapidly. This book is a combined theoretical text and practical manual which, it is hoped, will be of use to all who have an interest in virus diseases, particularly scientists, physicians and graduate students.

Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats

Author : Paul F. Torrence
Publisher : John Wiley & Sons
ISBN 13 : 0471716707
Total Pages : 440 pages
Book Rating : 4.4/5 (717 download)

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Book Synopsis Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats by : Paul F. Torrence

Download or read book Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats written by Paul F. Torrence and published by John Wiley & Sons. This book was released on 2005-08-05 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antiviral Drug Discovery gives readers a cutting-edge view of how chemical concepts are being mobilized to develop novel approaches that will effectively confront emerging diseases and biowarfare. Among the many topics discussed are smallpox, the Ebola virus, influenza, SARS, arenaviruses and flaviviruses. Each chapter discusses hypothetical strategies for the discovery of relevant antiviral agents, recent findings related to biochemistry or drug discovery, and advances in the further development of established leads in the area. Timely and informative, this book clearly delineates the efforts being made to develop new and effective broad-spectrum antiviral agents.