Analysis Of Progestin Effects On Hepatocyte Growth Factor Signaling Pathways In Relation To Proliferation And Alveolar Morphogenesis Of Normal Mammary Epithelial Cells In Vitro

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Analysis of Progestin Effects on Hepatocyte Growth Factor Signaling Pathways in Relation to Proliferation and Alveolar Morphogenesis of Normal Mammary Epithelial Cells in Vitro

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)

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Book Synopsis Analysis of Progestin Effects on Hepatocyte Growth Factor Signaling Pathways in Relation to Proliferation and Alveolar Morphogenesis of Normal Mammary Epithelial Cells in Vitro by :

Download or read book Analysis of Progestin Effects on Hepatocyte Growth Factor Signaling Pathways in Relation to Proliferation and Alveolar Morphogenesis of Normal Mammary Epithelial Cells in Vitro written by and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progestin action in the normal adult mammary gland has a major role in the formation of the alveolar bud structure during development and pregnancy. We have determined that for P-induced proliferation and morphogenesis to occur, the presence of hepatocyte growth factor (HGF) is required. When added alone to mouse primary cultures from adult virgin mice, HGF induces proliferation and a ductal morphology. With the addition of P we observe increased proliferation and an alveolar-like morphogenesis similar to that seen in response to P in the in vivo gland. We have therefore proposed to study the effects of P on HGF/c-met signaling in an in vitro, serum free, three dimensional primary culture system using mammary epithelial cells. During the first year of this proposal methods for western blotting against c-Met were adapted for use in our culture system. The levels of c-Met were examined in response to the proposed treatments by immunostaining, showing that it is unlikely that the effects of HGF and progestins are mediated through changes in receptor expression. The effect of HCF and progestin treatment was also examined in pubertal mouse mammary epithelial organoids and did not exhibit the synergistic effect of HGF and progestin seen in adult mammary epithelial organoids.

Analysis of Progestin Effects on Hepatocycte Growth Factor Signaling Pathways in Relation to Proliferation and Alveolar Morpgogensis [i.e. Morphogenesis] of Normal Mammary Epithelial Cells in Vitro

Download Analysis of Progestin Effects on Hepatocycte Growth Factor Signaling Pathways in Relation to Proliferation and Alveolar Morpgogensis [i.e. Morphogenesis] of Normal Mammary Epithelial Cells in Vitro PDF Online Free

Author : Kyle Thomas Smith
Publisher :
ISBN 13 :
Total Pages : 202 pages
Book Rating : 4.3/5 (129 download)

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Book Synopsis Analysis of Progestin Effects on Hepatocycte Growth Factor Signaling Pathways in Relation to Proliferation and Alveolar Morpgogensis [i.e. Morphogenesis] of Normal Mammary Epithelial Cells in Vitro by : Kyle Thomas Smith

Download or read book Analysis of Progestin Effects on Hepatocycte Growth Factor Signaling Pathways in Relation to Proliferation and Alveolar Morpgogensis [i.e. Morphogenesis] of Normal Mammary Epithelial Cells in Vitro written by Kyle Thomas Smith and published by . This book was released on 2005 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Progestins and the Mammary Gland

Author : Orla M. Conneely
Publisher : Springer Science & Business Media
ISBN 13 : 3540734937
Total Pages : 211 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Progestins and the Mammary Gland by : Orla M. Conneely

Download or read book Progestins and the Mammary Gland written by Orla M. Conneely and published by Springer Science & Business Media. This book was released on 2008-03-27 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progestins play a key role in reproductive endocrinology and as pharmaceutical drugs for contraception and in combined hormone therapy. To further our understanding of progestin action in the mammary gland, an international symposium, attended by leading researchers from academia and industry, was held in Berlin, 21–23 March 2007. Genetic mouse models helped to elucidate the role of progestins, both in normal breast development and in disease. Mechanistic molecular studies inspired the design of new progestins with improved tissue selectivity. In addition, the clinical impact of progesterone receptor agonists and antagonists for the prevention and treatment of breast cancer was discussed.

The Role of Mammary Epithelial-stromal Cell Interactions in Relation to Growth Regulation by Estrogen and Progestin

Author : Shiqing Wang
Publisher :
ISBN 13 :
Total Pages : 268 pages
Book Rating : 4.3/5 (129 download)

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Book Synopsis The Role of Mammary Epithelial-stromal Cell Interactions in Relation to Growth Regulation by Estrogen and Progestin by : Shiqing Wang

Download or read book The Role of Mammary Epithelial-stromal Cell Interactions in Relation to Growth Regulation by Estrogen and Progestin written by Shiqing Wang and published by . This book was released on 1994 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1900 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2002 with total page 1900 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

The Uterus

Author : Henry J. Norris
Publisher :
ISBN 13 :
Total Pages : 588 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Uterus by : Henry J. Norris

Download or read book The Uterus written by Henry J. Norris and published by . This book was released on 1973 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Intercellular Signalling in the Mammary Gland

Author : C.H. Knight
Publisher : Springer Science & Business Media
ISBN 13 : 146151973X
Total Pages : 296 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Intercellular Signalling in the Mammary Gland by : C.H. Knight

Download or read book Intercellular Signalling in the Mammary Gland written by C.H. Knight and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: All being done, we went to Mrs Shipmans, who is a great butter-woman; and I did see there the most of milke and cream, and the cleanest, that I ever saw in my life (29 May 1661). Among others, Sir Wm. Petty did tell me that in good earnest, he hath in his will left such parts of his estate to him that could invent such and such things -as among others, that could discover truly the way of milk coming into the breasts of a woman ... (22 March 1665). My wife tells me that she hears that my poor aunt James hath had her breast cut off here in tow- her breast having long been out of order (5 May 1665). From the Diary of Samuel Pepys, published as The Shorter Pepys (edited by R. Latham), Penguin Books (1987) The long-standing ultimate importance of research on the mammary gland is illustrated by the importance attached to cows' milk for human consumption, to human lactation and to breast cancer by Samuel Pepys and his contemporaries in the middle of the 17th century. Research has tended to develop in isolation in these three areas of continuing contemporary importance largely because in most countries, the underlying science of agricultural productivity is funded separately from the underlying science of human health and welfare.

Basic Medical Endocrinology

Author : H. Maurice Goodman
Publisher : Lippincott Williams & Wilkins
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Basic Medical Endocrinology by : H. Maurice Goodman

Download or read book Basic Medical Endocrinology written by H. Maurice Goodman and published by Lippincott Williams & Wilkins. This book was released on 1994 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Human Endometrium

Author : Carlo Bulletti
Publisher :
ISBN 13 :
Total Pages : 522 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis The Human Endometrium by : Carlo Bulletti

Download or read book The Human Endometrium written by Carlo Bulletti and published by . This book was released on 1994 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structural, biochemical and clinical events related to menstruation, implantation, parturition, endometriosis, abnormal uterine bleeding and endometrial cancer are discussed in this comprehensive volume on the biological functions of the endometrium. New topics, such as the biochemical and molecular mechanisms regulating maternal embryonic interaction, are explored, and gynecologic endoscopy and therapeutic tools are discussed. The proceedings of the first conference is also available from the Academy, as volume 622 of The Annals of The New York Academy of Science.

Embryo and Fetal Pathology

Author : Enid Gilbert-Barness
Publisher : Cambridge University Press
ISBN 13 : 9781139451741
Total Pages : 706 pages
Book Rating : 4.4/5 (517 download)

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Book Synopsis Embryo and Fetal Pathology by : Enid Gilbert-Barness

Download or read book Embryo and Fetal Pathology written by Enid Gilbert-Barness and published by Cambridge University Press. This book was released on 2004-05-31 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exhaustively illustrated in color with over 1000 photographs, figures, histopathology slides, and sonographs, this uniquely authoritative atlas provides the clinician with a visual guide to diagnosing congenital anomalies, both common and rare, in every organ system in the human fetus. It covers the full range of embryo and fetal pathology, from point of death, autopsy and ultrasound, through specific syndromes, intrauterine problems, organ and system defects to multiple births and conjoined twins. Gross pathologic findings are correlated with sonographic features in order that the reader may confirm visually the diagnosis of congenital abnormalities for all organ systems. Obstetricians, perinatologists, neonatologists, geneticists, anatomic pathologists, and all practitioners of maternal-fetal medicine will find this atlas an invaluable resource.

Endocrinology of Pregnancy

Author : Fuller W. Bazer
Publisher : Springer Science & Business Media
ISBN 13 : 1461218047
Total Pages : 579 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Endocrinology of Pregnancy by : Fuller W. Bazer

Download or read book Endocrinology of Pregnancy written by Fuller W. Bazer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, cutting-edge review of the complex interactions between maternal and fetal-placental tissues that control the establishment and maintenance of pregnancy, the proper development of the fetus, the birth process, and the behavioral aspects of bonding between mother and newborn. Expert researchers review the endocrine and physiological events that culminate in the delivery of offspring, and provide a solid base of comparative information on the menstrual cycle of primates, including humans. They also discuss the sources and functions of both steroid and protein hormones from the placenta and the details of their effects on uterine function, placental development, fetal growth and well-being, and maternal responses to pregnancy. This book will become the standard reference source not only for reproductive scientists, but also for those clinicians who want better to understand the complex factors that affect pregnancy-and their pregnant patients.

Management of Breast Diseases

Author : Ismail Jatoi
Publisher : Springer
ISBN 13 : 9783540697428
Total Pages : 664 pages
Book Rating : 4.6/5 (974 download)

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Book Synopsis Management of Breast Diseases by : Ismail Jatoi

Download or read book Management of Breast Diseases written by Ismail Jatoi and published by Springer. This book was released on 2009-12-18 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2002, Lippincott published the Manual of Breast Diseases, edited by Professor Ismail Jatoi. The current book, Management of Breast Diseases, is an adaptation of that manual, with Professor Manfred Kaufmann of the Goethe-University of Frankfurt serving as co-editor. Most of the chapters from the original manual have been either extensively revised or discarded, and several new chapters added. This text contains more material than the original manual, but it is still intended as a basic guide for the wide spectrum of clinicians (surgeons, gynecologists, oncologists, radiation onco- gists, internists, general practitioners) who treat breast diseases, both benign and malignant. To compile this text, we assembled experts from throughout the world. Thus, this text provides not only a broad overview of breast diseases, but also highlights diff- ent perspectives from different parts of the world. Yet, it is worth noting that the management of breast cancer is now largely predicated on evidence-based medicine. Several large, randomized prospective trials have demonstrated the ef? cacy of breast cancer screening and chemoprevention. Other large trials have addressed the impact of systemic therapy, radiotherapy, and variations in local therapy on breast cancer mortality. Many of these landmark trials are discussed in this text, and they clearly have had a bene? cial effect. Indeed, since about 1990, breast cancer mortality rates have declined substantially in most industrialized countries, and this trend is expected to continue in the years ahead.

Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis

Author : Padma V. Devarajan
Publisher : Springer Nature
ISBN 13 : 3030291685
Total Pages : 560 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis by : Padma V. Devarajan

Download or read book Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis written by Padma V. Devarajan and published by Springer Nature. This book was released on 2019-11-09 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book elaborates on drug delivery targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in , Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. As a result, many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also emphasize commercial products, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. Finally, we briefly discuss the regulatory and toxicity issues that may be associated specifically with the RME approach of intracellular drug delivery.

Endocrine and Biochemical Development of the Fetus and Neonate

Author : Jose M. Cuezva
Publisher : Springer Science & Business Media
ISBN 13 : 1461595673
Total Pages : 311 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Endocrine and Biochemical Development of the Fetus and Neonate by : Jose M. Cuezva

Download or read book Endocrine and Biochemical Development of the Fetus and Neonate written by Jose M. Cuezva and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: The annual meeting of the Perinatal Biochemical Group of the Spanish Biochemical Society held in Madrid on December 15-16, 1989, provided an excellent opportunity to bring together a group of distinguished investigators both from Spain and from abroad with a common interest in developmental endocrinology and biochemistry. The aim of the symposium was to present and discuss the most recent developments in the areas of endocrine and biochemical processes critical to normal growth and maturation of the newborn. To achieve a high degree of interaction among the participants, subject reviews as well as short communications were include in the program. The reviews provided in-depth information on selected important topics. The purpose of short communications was two fold: (i) to provide a forum to discuss on-going investigations on related areas; and (ii) to present opportunities for active participation by young investigators. This format proved very successful in generating fruitful discussions among the participants. Taken together the review chapters and the short communications have resulted in a coherent and unified subject presentation. Advances in biochemistry, molecular biology and cell biology have provided not only new and exciting experimental approaches but also have opened up new directions in the investigation of differentiation and developmental processes at cellular, molecular and biochemical levels during the early stages of growth and maturation. In recent years a wealth of information in these areas of development has emerged at a rapid rate.

The Primate Endometrium

Author : Carlo Bulletti
Publisher :
ISBN 13 :
Total Pages : 520 pages
Book Rating : 4.X/5 (1 download)

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Book Synopsis The Primate Endometrium by : Carlo Bulletti

Download or read book The Primate Endometrium written by Carlo Bulletti and published by . This book was released on 1991 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Tissue-Specific Cell Signaling

Author : Joana Vieira Silva
Publisher : Springer Nature
ISBN 13 : 3030444368
Total Pages : 444 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Tissue-Specific Cell Signaling by : Joana Vieira Silva

Download or read book Tissue-Specific Cell Signaling written by Joana Vieira Silva and published by Springer Nature. This book was released on 2020-05-29 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal transduction comprises the intracellular biochemical signals which induce the appropriate cell response to an external stimulus. The players in signal transduction are diverse, from small molecules as first messengers, to proteins, receptors, transcription factors, among many others. The different signaling pathways and the crosstalk between them originates the unique signaling profile of every cell type in the human body. The cell signaling specificity depends on several aspects including protein composition, subcellular localization and complexes and gene promoters. This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. This information can be of great value for health science researchers, professionals and students to understand key pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors. Chapter 3 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Mesenchymal-Epithelial Interactions in Neural Development

Author : Joachim R. Wolff
Publisher : Springer Science & Business Media
ISBN 13 : 364271837X
Total Pages : 424 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Mesenchymal-Epithelial Interactions in Neural Development by : Joachim R. Wolff

Download or read book Mesenchymal-Epithelial Interactions in Neural Development written by Joachim R. Wolff and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on the NATO Advanced Research Workshop on "Mesenchymal-Epithelial Interactions in Neural Development" which was held in Berlin during March 1986. The idea that it may be the time for this workshop arose from a discussion among the organizers who met at a conference in Innsbruck. During the twenties, Spemann demonstrated that, in vertebrates, the formation of neuroepithelium depends on the induction by specific mesodermal derivatives. This was about the first time that mesenchymal-epithelial interactions had been recognized as an important mechanism in the development of an epithelial organ. Since then two things had become clear: 1) The identity and role of molecules, elaborated at mesenchymal-neuroepithelial interfaces had been partially elucidated in spinal cord and peripheral nerve ontogeny but, until recently, had been ignored in studies on the development of the brain. 2) In many-non-neural epithelia, the surrounding mesenchyme regulates such fundamental developmental steps as, for example, cell proliferation, morphogenesis and cell differentia tion, and there is no reason to exclude similar influences and interactions from brain development. It seemed to us that the importance and implications of many of these findings had not been appreciated by many developmental neurobiologists and that an attempt should be made to initiate discussions and exchange of ideas among different groups of scientists involved in extracellular matrix (ECM) research. This turned out to be a formidable task because of the great diversity of disciplines contributing findings to this active field.