Advanced Research In Sclerosis

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Multiple Sclerosis

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309072859
Total Pages : 457 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Multiple Sclerosis by : Institute of Medicine

Download or read book Multiple Sclerosis written by Institute of Medicine and published by National Academies Press. This book was released on 2001-08-10 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.

Autoimmune Neurology

Author :
Publisher : Elsevier
ISBN 13 : 0444634460
Total Pages : 569 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Autoimmune Neurology by :

Download or read book Autoimmune Neurology written by and published by Elsevier. This book was released on 2016-03-11 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. - Includes comprehensive coverage of autoimmune neurology - Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders - Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities

Translational Methods for Multiple Sclerosis Research

Author : Sergiu Groppa
Publisher : Humana
ISBN 13 : 9781071612125
Total Pages : 335 pages
Book Rating : 4.6/5 (121 download)

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Book Synopsis Translational Methods for Multiple Sclerosis Research by : Sergiu Groppa

Download or read book Translational Methods for Multiple Sclerosis Research written by Sergiu Groppa and published by Humana. This book was released on 2021-08-03 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the recent advances in the study of translational paths in central inflammation and focuses on ongoing pathophysiological processes and the transition between inflammatory stages and progressive states with neurodegeneration. Chapters cover topics such as pathophysiological hallmarks of neuroinflammation from tissue damage to reorganization; connecting studies of mouse models; and investigations of humans with multiple sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Translational Methods for Multiple Sclerosis Research is a valuable resource for researchers who want to learn more about this chronic ad progressive disease, and pave the way for new advancements.

Advanced Concepts in Multiple Sclerosis Nursing Care

Author : June Halper, MSN, APN-C, MSCN, FAAN
Publisher : Demos Medical Publishing
ISBN 13 : 1935281062
Total Pages : 307 pages
Book Rating : 4.9/5 (352 download)

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Book Synopsis Advanced Concepts in Multiple Sclerosis Nursing Care by : June Halper, MSN, APN-C, MSCN, FAAN

Download or read book Advanced Concepts in Multiple Sclerosis Nursing Care written by June Halper, MSN, APN-C, MSCN, FAAN and published by Demos Medical Publishing. This book was released on 2007-11-16 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nurse plays a vital role as an educator, care provider, and advocate for patients and families affected by multiple sclerosis (MS). The companion book to an earlier work, Comprehensive Nursing Care in Multiple Sclerosis, Advanced Concepts in Multiple Sclerosis Nursing Care, 2nd Edition examines complex issues in MS management and reflects a new philosophy of MS care: one of empowerment. The focus is on the numerous settings in which MS nurses practice, as well as their many roles and responsibilities in managing this highly variable disease. It will provide the reader with an updated view of MS along with a greater understanding of its lifelong impact. Special features of the second edition include: A new chapter on sustaining hope in MS patients A new chapter on treatment of acute exacerbations A new chapter on emerging intravenous therapies Expanded sections on pain, depression, and skin care with frequent injections The book is divided into sections dealing with the disease itself, advanced practice requirements for nurses, and advanced symptom management. Contributors to Advanced Concepts in Multiple Sclerosis Nursing Care, 2nd Edition are nurse clinicians and researchers who work in geographically diverse practice settings throughout North America and Europe. The book will provide nurses with tools and strategies to improve the lives affected by multiple sclerosis and to reinforce the role of the nurse in managing it.

Neurodegeneration in Multiple Sclerosis

Author : M. Filippi
Publisher : Springer Science & Business Media
ISBN 13 : 8847003911
Total Pages : 233 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Neurodegeneration in Multiple Sclerosis by : M. Filippi

Download or read book Neurodegeneration in Multiple Sclerosis written by M. Filippi and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.

Quantitative Magnetic Resonance Imaging

Author : Nicole Seiberlich
Publisher : Academic Press
ISBN 13 : 0128170581
Total Pages : 1094 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Quantitative Magnetic Resonance Imaging by : Nicole Seiberlich

Download or read book Quantitative Magnetic Resonance Imaging written by Nicole Seiberlich and published by Academic Press. This book was released on 2020-11-18 with total page 1094 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Magnetic Resonance Imaging is a 'go-to' reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: - The basic physics behind tissue property mapping - How to implement basic pulse sequences for the quantitative measurement of tissue properties - The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* - The pros and cons for different approaches to mapping perfusion - The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor - maps and more complex representations of diffusion - How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed - How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance - Fingerprinting can be used to accelerate or improve tissue property mapping schemes - How tissue property mapping is used clinically in different organs - Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds - Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements - Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges - Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches

Multiple Sclerosis

Author : T. Jock Murray, MD
Publisher : Demos Medical Publishing
ISBN 13 : 193455927X
Total Pages : 594 pages
Book Rating : 4.9/5 (345 download)

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Book Synopsis Multiple Sclerosis by : T. Jock Murray, MD

Download or read book Multiple Sclerosis written by T. Jock Murray, MD and published by Demos Medical Publishing. This book was released on 2004-12-01 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Sclerosis: The History of a Disease won a 2005 ForeWord Book of the Year Silver Medal! The basic facts about multiple sclerosis are well known: it is the most common neurologic disease of young adults, usually beginning with episodic attacks of neurologic symptoms, then entering a progressive phase some years later. Its onset has an average age of 30, and occurs in about 1 in 500 individuals of European ancestry living primarily in temperate climates. There appears to be a complex interaction between a genetic predisposition and an environmental trigger that initiates the disease. But these facts do not convey the impact of the disease on the people whose lives it affects. In this elegantly written and comprehensive history, we meet individuals who suffered with MS in the centuries before the disease had a name, including blessed Lidwina of Holland, who took joy from her misery, believing that she was sent to accept suffering for the sins of others; Augustus d'Est, grandson of George III and cousin of Queen Victoria, whose case shows how someone with access to the best of medical care of the age was understood and managed; and Heinrich Heine, the great German poet, who also had access to all medical services that were available, but who progressed into his mattress grave in two decades, aware of the loss of physical ability while still able to compose great poetry to the end. From these early cases the author demonstrates how progress in diagnosing and managing multiple sclerosis has paralleled the development of medical science, from the early developments in modern studies of anatomy and pathology, to the framing of the disease in the nineteenth century, and eventually to modern diagnosis and treatment. From beginning to end, Dr. Murray takes us on a fascinating journey of discovery, in the process showing how the evolution of our understanding of multiple sclerosis has been part of the greater history of medical knowledge.

Curing MS

Author : Howard L. Weiner, M.D.
Publisher : Harmony
ISBN 13 : 0307420523
Total Pages : 354 pages
Book Rating : 4.3/5 (74 download)

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Book Synopsis Curing MS by : Howard L. Weiner, M.D.

Download or read book Curing MS written by Howard L. Weiner, M.D. and published by Harmony. This book was released on 2007-12-18 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: What causes multiple sclerosis? When will there be a cure? Dr. Howard Weiner has spent nearly three decades trying to find answers to the mysteries of multiple sclerosis, an utterly confounding and debilitating disease that afflicts almost half a million Americans. Curing MS is his moving, personal account of the long-term scientific quest to pinpoint the origins of the disease and to find a breakthrough treatment for its victims. Dr. Weiner has been at the cutting edge of MS research and drug development, and he describes in clear and illuminating detail the science behind the symptoms and how new drugs may hold the key to "taming the monster." From the "Twenty-one Points" of MS--a concise breakdown of the knowns and unknowns of the disease--to stories from the frontlines of laboratories and hospitals, Curing MS offers a message of hope about new treatments and makes a powerful argument that a cure can--and will--be found.

Magnetic Resonance Spectroscopy in Multiple Sclerosis

Author : M. Filippi
Publisher : Springer Science & Business Media
ISBN 13 : 884702109X
Total Pages : 180 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Magnetic Resonance Spectroscopy in Multiple Sclerosis by : M. Filippi

Download or read book Magnetic Resonance Spectroscopy in Multiple Sclerosis written by M. Filippi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have witnessed dramatic advances in the development and use of magnetic resonance imaging (MRI) techniques that can provide quantitative measures with some degree of pathological specificity for the heterogeneous substrates of multiple sclerosis (MS). Magnetic resonance spectroscopy (MRS) is one of the most promising of these techniques. Thanks to MRS, axonal damage is no longer considered an end-stage phenomenon typical of only the most destructive lesions and the most unfortunate cases, but rather as a major component of the MS pathology of lesions and normal-appearing white matter at all the phases of the disease. This new concept is rapidly changing our understanding of MS pathophysiology and, as a consequence, the therapeutic strategies to modify the disease course favorably. Many of the authors have pionereed the use of MRS in MS, thus contributing to the foundation of the "axonal hypothesis".

Multiple Sclerosis Therapeutics

Author : Jeffrey A. Cohen
Publisher : Cambridge University Press
ISBN 13 : 1139502379
Total Pages : 771 pages
Book Rating : 4.1/5 (395 download)

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Book Synopsis Multiple Sclerosis Therapeutics by : Jeffrey A. Cohen

Download or read book Multiple Sclerosis Therapeutics written by Jeffrey A. Cohen and published by Cambridge University Press. This book was released on 2011-10-20 with total page 771 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews the current state of clinical trial methods in multiple sclerosis treatment, providing investigators, sponsors and specialists with current knowledge of outcome measures and study designs for disease and symptom management. The status of the rapidly evolving field of disease-modifying drugs is presented, with emphasis on the most promising therapies currently being tested. Experts discuss disease and symptom management for MS subtypes, including neuromyelitis optica and pediatric MS. In addition, key scientific advances in MS pathology, genetics, immunology and epidemiology are presented. The fourth edition has been extensively revised, featuring more than 50% new material. All chapters have been substantially updated to provide current information on rapidly evolving topics and this volume contains 15 new chapters, reflecting the growth of the field in recent years. This book is an essential reference for practitioners caring for MS patients, investigators planning or conducting clinical trials, and clinical trial sponsors.

Multiple Sclerosis

Author : Ian S. Zagon
Publisher :
ISBN 13 : 9780994438133
Total Pages : 137 pages
Book Rating : 4.4/5 (381 download)

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Book Synopsis Multiple Sclerosis by : Ian S. Zagon

Download or read book Multiple Sclerosis written by Ian S. Zagon and published by . This book was released on 2017 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Multiple Sclerosis and Related Disorders

Author : Robert J. Fox, MD
Publisher : Springer Publishing Company
ISBN 13 : 0826125948
Total Pages : 441 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis Multiple Sclerosis and Related Disorders by : Robert J. Fox, MD

Download or read book Multiple Sclerosis and Related Disorders written by Robert J. Fox, MD and published by Springer Publishing Company. This book was released on 2018-08-28 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revised and updated second edition of Multiple Sclerosis and Related Disorders: Clinical Guide to Diagnosis, Medical Management, and Rehabilitation, the only comprehensive but practical source of core information on multiple sclerosis and other demyelinating disorders. Intended as a ready reference for clinicians who provide ongoing care to MS patients, this book combines evidence-based science with experience-based guidance to present current standards and management protocols from leading MS centers. Beginning with the scientific underpinnings of MS for clinicians, the book proceeds through diagnosis, including initial symptoms, diagnostic criteria and classification, imaging, and differential diagnosis, and onto approved treatments for the various MS types and emerging therapies. Later parts of the book discuss symptom management and rehabilitation with chapters focusing on specific side effects, along with considerations for special populations, comorbidities, societal and family issues, and related autoimmune disorders that are often mistaken for MS. Throughout, chapters include lists of Key Points both for clinicians and for patients and families, and management pearls are boxed for quick reference and clinical utility. Illustrations, tables, algorithms, assessment scales, and up-to-date MRI imaging enrich the text, making this a wide-ranging clinical reference for all members of the MS care team. New to the Second Edition: Includes summary recommendations from new AAN practice guidelines for use of DMTs All chapters updated to reflect the latest literature and diagnostic criteria Five entirely new chapters added to expand coverage of treatment, rehabilitation and symptom management, and special issues related to MS Treatment section has been completely revised to better capture current approaches to disease modifying therapies, with separate chapters devoted to injection and oral therapies, infusion therapies, and treatments for progressive forms of MS Related autoimmune diseases section significantly expanded to include transverse myelitis, autoimmune encephalitis, and neurosarcoidosis

Systemic Sclerosis - Recent Advances and New Perspectives

Author : Katja Perdan Pirkmajer
Publisher : BoD – Books on Demand
ISBN 13 : 1837696705
Total Pages : 132 pages
Book Rating : 4.8/5 (376 download)

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Book Synopsis Systemic Sclerosis - Recent Advances and New Perspectives by : Katja Perdan Pirkmajer

Download or read book Systemic Sclerosis - Recent Advances and New Perspectives written by Katja Perdan Pirkmajer and published by BoD – Books on Demand. This book was released on 2024-05-15 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic sclerosis (SSc) is a multisystem autoimmune disease involving vasculopathy and immune activation that leads to the deposition of extracellular matrix and the development of fibrosis, resulting in cardinal clinical problems. Systemic Sclerosis - Recent Advances and New Perspectives provides a comprehensive overview of the pathophysiology, diagnosis, and specific management of the clinical manifestations of SSc. The book addresses the current understanding of the causes and consequences of inflammatory activation, chromosomal instability, and activating factors. Special emphasis is placed on diagnosis, from the recognition of very early systemic sclerosis and consideration of its treatment to diagnostic methods for microvascular and pulmonary involvement. It also highlights the less life-threatening but very common manifestations of bone and skeletal muscle involvement, which affect patient quality of life.

Neuroimmunological Diseases

Author : Susumu Kusunoki
Publisher : Springer
ISBN 13 : 4431555943
Total Pages : 292 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Neuroimmunological Diseases by : Susumu Kusunoki

Download or read book Neuroimmunological Diseases written by Susumu Kusunoki and published by Springer. This book was released on 2016-06-24 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a detailed review of the remarkable advances that have been made in research on the pathogenesis of a number of neuroimmunological diseases, as well as outlining novel treatments including the use of monoclonal antibodies. Written by renowned experts who have made major contributions in the field, such as identifying neuromyelitis optica as an immunopathological clinical condition, identifying the role of ganglioside and ganglioside-complex antibodies in Guillain-Barré syndrome, and developing a novel treatment for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome, the book summarizes recent advances in basic and clinical research. Neuroimmunological Diseases is a useful resource for not only researchers but also neurologists who are engaged in the management of neuroimmunological diseases.

McAlpine's Multiple Sclerosis

Author : Alastair Compston
Publisher :
ISBN 13 :
Total Pages : 620 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis McAlpine's Multiple Sclerosis by : Alastair Compston

Download or read book McAlpine's Multiple Sclerosis written by Alastair Compston and published by . This book was released on 1998 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the latest edition of the classic book on the subject of multiple sclerosis. An international group of authors has been involved in updating this edition which features more information on imaging and investigations, and a new chapter on neurobiology and glial development.

Brain and Spinal Cord Atrophy in Multiple Sclerosis

Author : Robert Zivadinov
Publisher : Nova Publishers
ISBN 13 : 9781594541605
Total Pages : 220 pages
Book Rating : 4.5/5 (416 download)

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Book Synopsis Brain and Spinal Cord Atrophy in Multiple Sclerosis by : Robert Zivadinov

Download or read book Brain and Spinal Cord Atrophy in Multiple Sclerosis written by Robert Zivadinov and published by Nova Publishers. This book was released on 2005 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended for general neurologists as well as specialists in multiple sclerosis (MS) and imaging, this book provides comprehensive discussion of central nervous system (CNS) atrophy involving the brain and spinal cord, and both the chapter authors and topics have been selected to provide state-of-the-art reviews. Key issues covered in the book include pathogenesis and its mechanisms, technical aspects of MRI measurement, the relationship between CNS atrophy and other MRI metrics, clinical relevance, the association with neurobehavioral and genetic-immunologic components of MS, and the effects of disease-modifying therapies on tissue atrophy. Pros and cons of different technical approaches are discussed critically. Special attention is devoted to CNS atrophy as a clinically relevant biologic marker of the MS disease process.

Amyotrophic Lateral Sclerosis

Author : Lina Machtoub
Publisher : CRC Press
ISBN 13 : 9814463051
Total Pages : 157 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Amyotrophic Lateral Sclerosis by : Lina Machtoub

Download or read book Amyotrophic Lateral Sclerosis written by Lina Machtoub and published by CRC Press. This book was released on 2016-01-05 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, the implication of biocompatible nanotechnologies has set the stage for an evolutionary leap in diagnostic imaging and therapy. In this scope, the book presents a comprehensive overview of the possible causes, diagnostic criteria, and treatment assessments of amyotrophic lateral sclerosis, and presents the recent findings using innovative