WHO consolidated guidelines on tuberculosis. Module 3

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Publisher : World Health Organization
ISBN 13 : 924000730X
Total Pages : 106 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO consolidated guidelines on tuberculosis. Module 3 by : World Health Organization

Download or read book WHO consolidated guidelines on tuberculosis. Module 3 written by World Health Organization and published by World Health Organization. This book was released on 2020-06-22 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: The political declaration of the first United Nations (UN) high-level meeting on tuberculosis (TB) calls countries to diagnose and treat 40 million people with TB globally between 2018 and 2022. Traditionally, in most countries, TB diagnosis has been performed using sputum-smear microscopy, a method developed more than 100 years ago, with suboptimal sensitivity. In recent years new technologies have emerged based on the detection of mycobacterial DNA or mycobacterial antigens. Over the past decade the World Health Organization (WHO) has published a number of guidelines developed by WHO-convened Guideline Development Groups (GDGs), using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to summarize the evidence and to formulate policy recommendations and accompanying remarks. The present document "WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection" consolidates five guidelines developed by WHO between 2016 and 2020. Earlier guidelines on diagnostics that were not developed according to the GRADE approach have not been included in this document. The WHO Consolidated Guidelines on Tuberculosis will group all TB recommendations in one document and will be complemented by matching modules of an operational handbook. The handbook will provide practical advice on how to put in place the recommendations at the scale needed to achieve national and global impact. A range of new diagnostic technologies have been endorsed by WHO during the past decade. These are listed below: - real-time polymerase chain reaction (PCR) assays - for example, Xpert MTB/RIF(r) (Ultra) (cartridge-based) and TruenatTM (chip-based);- line probe assays (LPAs) - for example, GenoType(r) MTBDRplus v1 and v2, GenoscholarTM NTM+MDRTB II and GenoType(r) MTBDRsl;- loop-mediated isothermal amplification (LAMP) - for example, TB-LAMP; and- antigen detection in a lateral flow format (biomarker-based detection) - for example, Alere DetermineTM TB LAM Ag. The present "WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection" provides background, justification and recommendations on these technologies. The document includes new recommendations on molecular assays intended as initial tests for the diagnosis of pulmonary and extrapulmonary TB and rifampicin resistance in adults and children.

WHO consolidated guidelines on tuberculosis. Module 3

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Publisher : World Health Organization
ISBN 13 : 9240089489
Total Pages : 184 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO consolidated guidelines on tuberculosis. Module 3 by : World Health Organization

Download or read book WHO consolidated guidelines on tuberculosis. Module 3 written by World Health Organization and published by World Health Organization. This book was released on 2024-03-08 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: The “WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection, third edition” is the latest document replacing the one issued in 2021. This latest edition includes new recommendations on the use of a new class of diagnostic technologies: targeted next-generation sequencing (NGS) tests for the diagnosis of drug-resistant tuberculosis (TB). The recommendations provide a novel approach for the rapid detection of drug resistance to new anti-TB drugs using the latest technologies. The consolidated guideline provides background, justification and recommendations on these and earlier endorsed TB diagnostic technologies. This document is accompanied by the “WHO operational handbook on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection, third edition”, which aims at facilitating the implementation of the WHO recommendations by the Member States, technical partners, and others involved in managing patients with TB and DR-TB.

WHO consolidated guidelines on tuberculosis. Module 3

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Publisher : World Health Organization
ISBN 13 : 9240029419
Total Pages : 164 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO consolidated guidelines on tuberculosis. Module 3 by : World Health Organization

Download or read book WHO consolidated guidelines on tuberculosis. Module 3 written by World Health Organization and published by World Health Organization. This book was released on 2021-07-05 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: The "WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection 2021 update" is the latest document replacing the one issued in 2020. Three new nucleic acid amplification test (NAAT) classes are endorsed by WHO and included in the latest consolidated guideline: 1. moderate complexity automated NAATs, recommended for the initial detection of TB and resistance to rifampicin and isoniazid, providing more options for early diagnosis of TB and rifampicin-resistant TB but also addressing an important gap in the rapid diagnosis of isoniazid-resistant and rifampicin-susceptible TB;2. low complexity automated NAATs, recommended for the detection of resistance to isoniazid and second-line anti-TB agents, which will improve access to testing of resistance to fluoroquinolones at peripheral level; and3. high complexity reverse hybridization-based NAATs, recommended for the detection of pyrazinamide resistance, representing the first molecular tests for resistance determination to this drug. The consolidated guideline provides background, justification and recommendations on these and earlier endorsed TB diagnostic technologies. This document is accompanied by the "WHO operational handbook on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection 2021 update", which aims at facilitating the implementation of the WHO recommendations by the Member States, technical partners, and others involved in managing patients with TB and DR-TB.

WHO consolidated guidelines on tuberculosis. Module 3

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Publisher : World Health Organization
ISBN 13 : 9240056084
Total Pages : 68 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO consolidated guidelines on tuberculosis. Module 3 by : World Health Organization

Download or read book WHO consolidated guidelines on tuberculosis. Module 3 written by World Health Organization and published by World Health Organization. This book was released on 2022-08-12 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: The consolidated and updated guidelines in the current Module 3: Diagnosis. Tests for TB infection brings together, without modifications, all valid and evidence-based recommendations from the 2011 and 2020 guideline updates and adds a new section based on the recent round of guidelines development in 2022 – the recommendations on M. tuberculosis antigen-based skin tests for the diagnosis of TB infection.

WHO consolidated guidelines on tuberculosis. Module 2

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Publisher : World Health Organization
ISBN 13 : 9240022678
Total Pages : 68 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO consolidated guidelines on tuberculosis. Module 2 by : World Health Organization

Download or read book WHO consolidated guidelines on tuberculosis. Module 2 written by World Health Organization and published by World Health Organization. This book was released on 2021-03-22 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: The WHO consolidated guidelines on tuberculosis. Module 2: screening – systematic screening for tuberculosis disease is an updated and consolidated summary of WHO recommendations on systematic screening for tuberculosis (TB) disease, containing 17 recommendations for populations in which TB screening should be conducted and tools to be used for TB screening. TB screening is strongly recommendations for household and close contacts of individuals with TB, people living with HIV, miners exposed to silica dust, and prisoners. In addition, screening is conditionally recommended for people with risk factors for TB attending health care, and for communities with risk factors for TB and limited access to care (e.g. homeless, urban poor, refugees, migrants). General population screening is recommended in high-burden settings (0.5% prevalence or higher). Symptoms, chest radiography (CXR), and molecular WHO-recommended rapid diagnostic tests for TB are recommended as screening tools for all adults eligible for screening. Computer-aided detection programmes are recommended as alternatives to human interpretation of CXR in settings where trained personnel are scarce. For people living with HIV, C-reactive protein is also a good screening tool. This guideline document is accompanied by an operational handbook, the WHO operational handbook on tuberculosis. Module 2: screening – systematic screening for tuberculosis disease, that presents principles of screening, steps in planning and implementing a screening programme, and algorithm options for screening different populations.

WHO consolidated guidelines on tuberculosis. Module 4

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Publisher : World Health Organization
ISBN 13 : 924004812X
Total Pages : 72 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO consolidated guidelines on tuberculosis. Module 4 by : World Health Organization

Download or read book WHO consolidated guidelines on tuberculosis. Module 4 written by World Health Organization and published by World Health Organization. This book was released on 2022-04-30 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: Between 2011 and 2019, WHO has developed and issued evidence-based policy recommendations on the treatment and care of patients with DR-TB. These policy recommendations have been presented in several WHO documents and their associated annexes, including the WHO Consolidated Guidelines on Drug Resistant Tuberculosis Treatment, issued by WHO in March 2019. The policy recommendations in each of these guidelines have been developed by WHO-convened Guideline Development Groups, using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach to summarize the evidence, and formulate policy recommendations and accompanying remarks. The present WHO Consolidated Guidelines on Tuberculosis, Module 4: Treatment - Drug-Resistant Tuberculosis Treatment includes a comprehensive set of WHO recommendations for the treatment and care of DR-TB. The document includes two new recommendations, one on the composition of shorter regimens and one on the use of the BPaL regimen (i.e. bedaquiline, pretomanid and linezolid). In addition, the consolidated guidelines include existing recommendations on treatment regimens for isoniazid-resistant TB and MDR/RR-TB, including longer regimens, culture monitoring of patients on treatment, the timing of antiretroviral therapy (ART) in MDR/RR-TB patients infected with the human immunodeficiency virus (HIV), the use of surgery for patients receiving MDR-TB treatment, and optimal models of patient support and care. The guidelines are to be used primarily in national TB programmes, or their equivalents in Ministries of Health, and for other policy-makers and technical organizations working on TB and infectious diseases in public and private sectors and in the community.

WHO consolidated guidelines on tuberculosis. Module 4

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Publisher : World Health Organization
ISBN 13 : 9240007040
Total Pages : 120 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO consolidated guidelines on tuberculosis. Module 4 by : World Health Organization

Download or read book WHO consolidated guidelines on tuberculosis. Module 4 written by World Health Organization and published by World Health Organization. This book was released on 2020-06-15 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: BACKGROUND: Tuberculosis (TB) strains with drug resistance (DR-TB) are more difficult to treat than drug-susceptible ones, and threaten global progress towards the targets set by the End TB Strategy of the World Health Organization (WHO). WHO estimates that about half a million cases of multi-drug or rifampicin resistant (MDR/RR-TB) are estimated to occur each year. However, only one third were estimated to have accessed effective treatment and of those, just over half had a successful treatment outcome. Therefore, there is a pressing need for evidence-based policy recommendations on the treatment and care of patients with DR-TB, based on the most recent and comprehensive evidence available. In this regard, the WHO Consolidated Guidelines on Tuberculosis, Module 4: Treatment - Drug-Resistant Tuberculosis Treatment fulfills the mandate of WHO to inform health care professionals in Member States on how to improve treatment and care for patients with DR-TB. The 2020 recommendations on drug resistant TB treatment are contained in the second module to be released under the rubric of WHO Consolidated Guidelines on Tuberculosis (Module 4: Treatment). The WHO Consolidated Guidelines on Tuberculosis will group all TB recommendations in one document and will be complemented by matching modules of a consolidated operational handbook. The operational handbook will provide practical advice on how to put in place the recommendations at the scale needed to achieve national and global impact. OVERVIEW: Between 2011 and 2019, WHO has developed and issued evidence-based policy recommendations on the treatment and care of patients with DR-TB. These policy recommendations have been presented in several WHO documents and their associated annexes, including the WHO Consolidated Guidelines on Drug Resistant Tuberculosis Treatment, issued by WHO in March 2019. The policy recommendations in each of these guidelines have been developed by WHO-convened Guideline Development Groups, using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach to summarize the evidence, and formulate policy recommendations and accompanying remarks. The present WHO Consolidated Guidelines on Tuberculosis, Module 4: Treatment - Drug-Resistant Tuberculosis Treatment includes a comprehensive set of WHO recommendations for the treatment and care of DR-TB. The document includes two new recommendations, one on the composition of shorter regimens and one on the use of the BPaL regimen (i.e. bedaquiline, pretomanid and linezolid). In addition, the consolidated guidelines include existing recommendations on treatment regimens for isoniazid-resistant TB and MDR/RR-TB, including longer regimens, culture monitoring of patients on treatment, the timing of antiretroviral therapy (ART) in MDR/RR-TB patients infected with the human immunodeficiency virus (HIV), the use of surgery for patients receiving MDR-TB treatment, and optimal models of patient support and care. The guidelines are to be used primarily in national TB programmes, or their equivalents in Ministries of Health, and for other policy-makers and technical organizations working on TB and infectious diseases in public and private sectors and in the community.

WHO consolidated guidelines on tuberculosis. Module 4

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Publisher : World Health Organization
ISBN 13 : 9240063129
Total Pages : 134 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO consolidated guidelines on tuberculosis. Module 4 by : World Health Organization

Download or read book WHO consolidated guidelines on tuberculosis. Module 4 written by World Health Organization and published by World Health Organization. This book was released on 2022-11-30 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:

WHO consolidated guidelines on drug-resistant tuberculosis treatment

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Publisher : World Health Organization
ISBN 13 : 9789241550529
Total Pages : 0 pages
Book Rating : 4.5/5 (55 download)

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Book Synopsis WHO consolidated guidelines on drug-resistant tuberculosis treatment by : World Health Organization

Download or read book WHO consolidated guidelines on drug-resistant tuberculosis treatment written by World Health Organization and published by World Health Organization. This book was released on 2018-11-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tuberculosis (TB) strains with drug resistance (DR-TB) are more difficult to treat than drug-susceptible ones, and threaten global progress towards the targets set by the End TB Strategy of the World Health Organization (WHO). There is thus a critical need for evidence-based policy recommendations on the treatment and care of patients with DR-TB, based on the most recent and comprehensive evidence available. In this regard, the WHO consolidated guidelines on drug-resistant tuberculosis treatment fulfil the mandate of WHO to inform health professionals in Member States on how to improve treatment and care for patients with DR-TB. Between 2011 and 2018, WHO has developed and issued evidence-based policy recommendations on the treatment and care of patients with DR-TB. These policy recommendations have been presented in several WHO documents and their associated annexes, including the WHO treatment guidelines for multidrug- and rifampicin-resistant tuberculosis, 2018 update, issued by WHO in December 2018. The policy recommendations in each of these guidelines have been developed by WHO-convened Guideline Development Groups (GDGs), using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach to summarize the evidence, and formulate policy recommendations and accompanying remarks. The present Consolidated guidelines include a comprehensive set of WHO recommendations for the treatment and care of DR-TB, derived from these WHO guidelines documents. The consolidated guidelines include policy recommendations on treatment regimens for isoniazid-resistant TB (Hr-TB) and MDR/RR-TB, including longer and shorter regimens, culture monitoring of patients on treatment, the timing of antiretroviral therapy (ART) in MDR/RR-TB patients infected with the human immunodeficiency virus (HIV), use of surgery for patients receiving MDR-TB treatment, and optimal models of patient support and care.

WHO operational handbook on tuberculosis. Module 3

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Publisher : World Health Organization
ISBN 13 : 9240007288
Total Pages : 96 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO operational handbook on tuberculosis. Module 3 by : World Health Organization

Download or read book WHO operational handbook on tuberculosis. Module 3 written by World Health Organization and published by World Health Organization. This book was released on 2020-06-22 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:

WHO consolidated guidelines on tuberculosis. Module 6

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Publisher : World Health Organization
ISBN 13 : 9240087001
Total Pages : 90 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO consolidated guidelines on tuberculosis. Module 6 by : World Health Organization

Download or read book WHO consolidated guidelines on tuberculosis. Module 6 written by World Health Organization and published by World Health Organization. This book was released on 2024-04-22 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addressing comorbidities and risk factors for tuberculosis (TB) is a crucial component of the World Health Organization (WHO)’s End TB Strategy. These consolidated guidelines on tuberculosis. Module 6: tuberculosis and comorbidities summarize the latest WHO recommendations on TB and key comorbidities. It is a living document and will include a separate section for each of the key TB comorbidities or health-related risk factors. This first edition focuses on interventions to address HIV-associated TB and is an update of the WHO policy on collaborative TB/HIV activities: guidelines for national programmes and other stakeholders. People with HIV are 12–16 times more likely to develop TB disease, have poorer TB treatment outcomes and have three-fold higher mortality during TB treatment compared to people without HIV. Despite advances in the screening, diagnosis, treatment and prevention of TB disease, TB remains the leading cause of death among people with HIV worldwide. These consolidated guidelines are intended for use by people working in ministries of health, particularly TB programmes and the relevant departments or programmes responsible for comorbidities and health-related risk factors for TB, as well as programmes addressing mental health and lung health, implementing partners including technical and funding agencies, civil society and representatives of affected communities, clinicians and public health practitioners.

Disease Control Priorities, Third Edition (Volume 6)

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Author :
Publisher : World Bank Publications
ISBN 13 : 1464805253
Total Pages : 1027 pages
Book Rating : 4.4/5 (648 download)

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Book Synopsis Disease Control Priorities, Third Edition (Volume 6) by : King K. Holmes

Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

WHO operational handbook on tuberculosis. Module 3

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Publisher : World Health Organization
ISBN 13 : 9240030581
Total Pages : 172 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO operational handbook on tuberculosis. Module 3 by :

Download or read book WHO operational handbook on tuberculosis. Module 3 written by and published by World Health Organization. This book was released on 2021-07-06 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Guidelines on the Management of Latent Tuberculosis Infection

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Publisher : World Health Organization
ISBN 13 : 9241548908
Total Pages : 38 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Guidelines on the Management of Latent Tuberculosis Infection by : WHO

Download or read book Guidelines on the Management of Latent Tuberculosis Infection written by WHO and published by World Health Organization. This book was released on 2015-01-15 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: BACKGROUND: Latent tuberculosis infection (LTBI), defined as a state of persistent immune response to prior-acquired Mycobacterium tuberculosis antigens without evidence of clinically manifested active TB, affects about one-third of the world's population. Approximately 10% of people with LTBI will develop active TB disease in their lifetime, with the majority developing it within the first five years after initial infection. Currently available treatments have an efficacy ranging from 60% to 90%. Systematic testing and treatment of LTBI in at-risk populations is a critical component of WHO's eight-point framework adapted from the End TB Strategy to target pre-elimination and, ultimately, elimination in low incidence countries. OVERVIEW: Recognizing the importance of expanding the response to LTBI, in 2014 WHO developed Guidelines on the Management of Latent Tuberculosis Infection. The guidelines are primarily targeted at high-income or upper middle-income countries with an estimated TB incidence rate of less than 100 per 100 000 population, because they are most likely to benefit from it due to their current TB epidemiology and resource availability. The overall objective of the guidelines is to provide public health approach guidance on evidence-based practices for testing, treating and managing LTBI in individuals with the highest risk of progression to active disease. Specific objectives include identifying and prioritizing at-risk population groups for targeted intervention of LTBI testing and treatment, including defining an algorithm, and recommending specific treatment options. The guidelines are expected to provide the basis and rationale for the development of national guidelines for LTBI management based on available resources, epidemiology of TB including intensity of transmission, the health-care delivery system of the country, and other national and local determinants.

WHO operational handbook on tuberculosis. Module 3

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Publisher : World Health Organization
ISBN 13 : 9240058346
Total Pages : 92 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO operational handbook on tuberculosis. Module 3 by : World Health Organization

Download or read book WHO operational handbook on tuberculosis. Module 3 written by World Health Organization and published by World Health Organization. This book was released on 2022-09-30 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:

WHO consolidated guidelines on tuberculosis

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Publisher : World Health Organization
ISBN 13 : 9240055886
Total Pages : 60 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO consolidated guidelines on tuberculosis by : World Health Organization

Download or read book WHO consolidated guidelines on tuberculosis written by World Health Organization and published by World Health Organization. This book was released on 2022-08-12 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the targets of the Sustainable Development Goals (SDGs) for the period 2015-2030 is to end the global TB epidemic. In line with this target, the WHO End TB Strategy, approved by the World Health Assembly in 2014, calls for a 90% reduction in TB deaths and an 80% decrease in the TB incidence rate by 2030. The strategy emphasizes the need for prevention across all approaches, including infection prevention and control (IPC) in health care services and other settings where the risk of Mycobacterium tuberculosis transmission is high. IPC practices are vital to reduce the risk of M. tuberculosis transmission, by reducing the concentration of infectious droplet nuclei in the air and the exposure of susceptible individuals to such aerosols. Initial WHO recommendations on TB IPC focused primarily on decreasing the risk of transmission in health care facilities in resource-limited settings.17,18 These initial recommendations were then expanded in 2009 to provide further guidance on the use of specific measures for health care facilities, congregate settings and households. After the 2009 guidelines had been in effect for almost 10 years, the need for an update was anticipated, to provide a revised evidence assessment, reinforcing earlier recommendations and linking to core components of effective IPC programmes overall. The present updated guidelines also stress the importance of implementing IPC measures in a systematic and objective way that prioritizes consideration of the hierarchy of IPC controls.

WHO consolidated guidelines on tuberculosis. Module 4

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Publisher : World Health Organization
ISBN 13 : 9240047719
Total Pages : 60 pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis WHO consolidated guidelines on tuberculosis. Module 4 by : World Health Organization

Download or read book WHO consolidated guidelines on tuberculosis. Module 4 written by World Health Organization and published by World Health Organization. This book was released on 2022-04-30 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: