“What is Damage suppressor Protein?-A Tardigrade (water bear)-Unique DNA-associated Protein improves Radiotolerance in Human-cultured cells.’’

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Author :
Publisher : Dr.Hakim Saboowala
ISBN 13 :
Total Pages : 45 pages
Book Rating : 4./5 ( download)

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Book Synopsis “What is Damage suppressor Protein?-A Tardigrade (water bear)-Unique DNA-associated Protein improves Radiotolerance in Human-cultured cells.’’ by : Dr.Hakim Saboowala

Download or read book “What is Damage suppressor Protein?-A Tardigrade (water bear)-Unique DNA-associated Protein improves Radiotolerance in Human-cultured cells.’’ written by Dr.Hakim Saboowala and published by Dr.Hakim Saboowala. This book was released on 2020-02-02 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic DNA (Genomic deoxyribonucleic acid is chromosomal DNA, in contrast to extra-chromosomal DNAs like plasmids, abbreviated as gDNA) stores all genetic information and is indispensable for maintenance of normal cellular activity and propagation. Radiation causes severe DNA lesions, including double-strand breaks, and leads to genome instability and even lethality. Regardless of the toxicity of radiation, some organisms exhibit extraordinary tolerance against radiation. · These organisms are supposed to possess special mechanisms to mitigate radiation-induced DNA damages. Extensive study using radio-tolerant bacteria suggested that effective protection of proteins and enhanced DNA repair system play important roles in tolerability against high-dose radiation. Recent studies using an extremotolerant animal, the tardigrade, provides new evidence that a tardigrade-unique DNA-associating protein, termed Dsup, suppresses the occurrence of DNA breaks by radiation in human-cultured cells. An attempt has been made in this Booklet to provide a brief summary of the current knowledge on extremely radiotolerant animals, and present novel insights from the tardigrade research, which expand our understanding on molecular mechanism of exceptional radio-tolerability. ……. Dr. H. K. Saboowala.M.B.(BoM) M.R.S.H.(London)

Biotechnological Applications of Extremophilic Microorganisms

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Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110424339
Total Pages : 424 pages
Book Rating : 4.1/5 (14 download)

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Book Synopsis Biotechnological Applications of Extremophilic Microorganisms by : Natuschka M. Lee

Download or read book Biotechnological Applications of Extremophilic Microorganisms written by Natuschka M. Lee and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-10-26 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a broad overview how extremophiles can be used in biotechnology, including for the production and degradation of compounds. It reviews various recent discoveries and applications related to a large variety of extremophiles, considering both prokaryotes as well as eukaryotes.

The Impact of the Space Environment on Microbial Growth and Behavior

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Publisher : Frontiers Media SA
ISBN 13 : 2832547141
Total Pages : 160 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis The Impact of the Space Environment on Microbial Growth and Behavior by : Camilla Urbaniak

Download or read book The Impact of the Space Environment on Microbial Growth and Behavior written by Camilla Urbaniak and published by Frontiers Media SA. This book was released on 2024-04-02 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microorganisms play an important role in life on Earth and can adapt and survive in harsh and changing environments. Their aptitude to thrive under hostile conditions is reflected by their survival and activity in some of the most extreme environments on Earth and their presence and growth in low earth orbit and outer space. Spaceflight and the space environment have a unique set of stressors compared to Earth (microgravity, galactic cosmic radiation, solar UV radiation, space vacuum, thermal extremes) that microbes are exposed to, but how they adapt and respond is still poorly understood. Studies to date, though, have shown that these responses can range from being beneficial for human exploration to negatively impact long duration missions. Hence, investigating the reaction of microorganisms to space conditions, the alterations in their physiology and virulence, not only helps shed light on the molecular basis of tolerance, but has implications for both space exploration and astrobiological missions.

Radiobiology Textbook

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Publisher : Springer Nature
ISBN 13 : 3031188101
Total Pages : 687 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis Radiobiology Textbook by : Sarah Baatout

Download or read book Radiobiology Textbook written by Sarah Baatout and published by Springer Nature. This book was released on 2023-09-23 with total page 687 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access textbook focuses on the various aspects of radiobiology. The goal of radiobiological research is to better understand the effects of radiation exposure at the cellular and molecular levels in order to determine the impact on health. This book offers a unique perspective, by covering not only radiation biology but also radiation physics, radiation oncology, radiotherapy, radiochemistry, radiopharmacy, nuclear medicine, space radiation biology & physics, environmental and human radiation protection, nuclear emergency planning, molecular biology and bioinformatics, as well as the ethical, legal and social considerations related to radiobiology. This range of disciplines contributes to making radiobiology a broad and rather complex topic. This textbook is intended to provide a solid foundation to those interested in the basics and practice of radiobiological science. It is a learning resource, meeting the needs of students, scientists and medical staff with an interest in this rapidly evolving discipline, as well as a teaching tool, with accompanying teaching material to help educators.

Water Bears: The Biology of Tardigrades

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Publisher : Springer
ISBN 13 : 3319957023
Total Pages : 419 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Water Bears: The Biology of Tardigrades by : Ralph O. Schill

Download or read book Water Bears: The Biology of Tardigrades written by Ralph O. Schill and published by Springer. This book was released on 2019-02-14 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering extensive information on tardigrades, this volume begins with a chapter on the history of tardigrades, from the first description by Goeze in 1773, until 1929, when the most comprehensive monographic approach by E. Marcus was published. Tardigrades’ organ systems, including their integument, body cavity, digestive, muscular, nervous and reproductive systems, as well as their overall external morphology, are summarized in the second chapter. Subsequent chapters present the current state of knowledge on tardigrade phylogeny, biogeography, paleontology, cytology and cytogenetics. In addition, the book provides insights into the ecology of tardigrades in marine, freshwater and terrestrial habitats. The reproduction, development and life cycles are summarized and the extraordinary environmental adaptations of encystment and cyclomorphosis, desiccation tolerance, freezing tolerance and radiation tolerance are discussed in detail. Further chapters provide an overview of key approaches in molecular tardigrade studies and describe techniques for sampling and sample processing. The book closes with a list of tardigrade taxa up to a sub-generic level, including the type species of each genus, the numbers of lower taxa in each taxon, and the main environments in which the taxa were found. Given its depth of coverage, the volume offers an invaluable resource for scientists from various disciplines who plan to research tardigrades, and for all others who are interested in these fascinating animals.

Physiological and Biotechnological Aspects of Extremophiles

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Publisher : Academic Press
ISBN 13 : 0128183233
Total Pages : 388 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Physiological and Biotechnological Aspects of Extremophiles by : Richa Salwan

Download or read book Physiological and Biotechnological Aspects of Extremophiles written by Richa Salwan and published by Academic Press. This book was released on 2020-06-04 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiological and Biotechnological Aspects of Extremophiles highlights the current and topical areas of research in this rapidly growing field. Expert authors from around the world provide the latest insights into the mechanisms of these fascinating organisms use to survive.The vast majority of extremophiles are microbes which include archaea, bacteria and some eukaryotes. These microbes live under chemical and physical extremes that are usually lethal to cellular molecules, yet they manage to survive and even thrive. Extremophiles have important practical uses. They are a valuable source of industrially important enzymes and recent research has revealed novel mechanisms and biomolecular structures with a broad range of potential applications in biotechnology, biomining, and bioremediation.Aimed at research scientists, students, microbiologists, and biotechnologists, this book is an essential reading for scientists working with extremophiles and a recommended reference text for anyone interested in the microbiology, bioprospecting, biomining, biofuels, and extremozymes of these organisms. Shows the implications of the physiological adaptations of microbes from extreme habitats that are largely contributed by their biomolecules from basic to applied research Provides in-depth knowledge of genomic plasticity and proteome of different extremophiles Gives detailed and comprehensive insight about use of genetic engineering as well as genome editing for industrial applications

Human Enhancements for Space Missions

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Publisher : Springer
ISBN 13 : 9783030420352
Total Pages : 270 pages
Book Rating : 4.4/5 (23 download)

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Book Synopsis Human Enhancements for Space Missions by : Konrad Szocik

Download or read book Human Enhancements for Space Missions written by Konrad Szocik and published by Springer. This book was released on 2020-10-04 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a collection of chapters, which address various contexts and challenges of the idea of human enhancement for the purposes of human space missions. The authors discuss pros and cons of mostly biological enhancement of human astronauts operating in hostile space environments, but also ethical and theological aspects are addressed. In contrast to the idea and program of human enhancement on Earth, human enhancement in space is considered a serious and necessary option. This book aims at scholars in the following fields: ethics and philosophy, space policy, public policy, as well as biologists and psychologists.

Evo-Devo: Non-model Species in Cell and Developmental Biology

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Publisher : Springer Nature
ISBN 13 : 3030234592
Total Pages : 551 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Evo-Devo: Non-model Species in Cell and Developmental Biology by : Waclaw Tworzydlo

Download or read book Evo-Devo: Non-model Species in Cell and Developmental Biology written by Waclaw Tworzydlo and published by Springer Nature. This book was released on 2019-10-09 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evolutionary developmental biology or evo-devo is a field of biological research that compares the underlying mechanisms of developmental processes in different organisms to infer the ancestral condition of these processes and elucidate how they have evolved. It addresses questions about the developmental bases of evolutionary changes and evolution of developmental processes. The book’s content is divided into three parts, the first of which discusses the theoretical background of evo-devo. The second part highlights new and emerging model organisms in the evo-devo field, while the third and last part explores the evo-devo approach in a broad comparative context. To the best of our knowledge, no other book combines these three evo-devo aspects: theoretical considerations, a comprehensive list of emerging model species, and comparative analyses of developmental processes. Given its scope, the book will offer readers a new perspective on the natural diversity of processes at work in cells and during the development of various animal groups, and expand the horizons of seasoned and young researchers alike.

Ecology and Evolution of Cancer

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Publisher : Academic Press
ISBN 13 : 0128043806
Total Pages : 292 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Ecology and Evolution of Cancer by : Beata Ujvari

Download or read book Ecology and Evolution of Cancer written by Beata Ujvari and published by Academic Press. This book was released on 2017-02-08 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies

Adaptive Oncogenesis

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Publisher : Harvard University Press
ISBN 13 : 0674545397
Total Pages : 289 pages
Book Rating : 4.6/5 (745 download)

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Book Synopsis Adaptive Oncogenesis by : James DeGregori

Download or read book Adaptive Oncogenesis written by James DeGregori and published by Harvard University Press. This book was released on 2018-03-09 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancerÕs occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the bodyÕs tissues. His theory ties cancerÕs progression, or lack thereof, to evolved strategies to maximize reproductive success. Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genesÑbut not much longer. These mechanisms engender a tissue environment that favors normal stem cells over precancerous ones. Healthy tissues thwart cancer cellsÕ ability to outcompete their precancerous rivals. But as our tissues age or accumulate damage from exposures such as smoking, normal stem cells find themselves less optimized to their ecosystem. Cancer-causing mutations can now help cells adapt to these altered tissue environments, and thus outcompete normal cells. Just as changes in a speciesÕ habitat favor the evolution of new species, changes in tissue environments favor the growth of cancerous cells. DeGregoriÕs perspective goes far in explaining who gets cancer, when it appears, and why. While we cannot avoid mutations, it may be possible to sustain our tissuesÕ natural and effective system of defense, even in the face of aging or harmful exposures. For those interested in learning how cancers arise within the human body, the insights in Adaptive Oncogenesis offer a compelling perspective.

Protein Dimerization and Oligomerization in Biology

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Publisher : Springer Science & Business Media
ISBN 13 : 1461432294
Total Pages : 184 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Protein Dimerization and Oligomerization in Biology by : Jacqueline M. Matthews

Download or read book Protein Dimerization and Oligomerization in Biology written by Jacqueline M. Matthews and published by Springer Science & Business Media. This book was released on 2012-09-04 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.

Polyextremophiles

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Publisher : Springer
ISBN 13 : 9789400792401
Total Pages : 0 pages
Book Rating : 4.7/5 (924 download)

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Book Synopsis Polyextremophiles by : Joseph Seckbach

Download or read book Polyextremophiles written by Joseph Seckbach and published by Springer. This book was released on 2015-06-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many Microorganisms and some macro-organisms can live under extreme conditions. For example, high and low temperature, acidic and alkaline conditions, high salt areas, high pressure, toxic compounds, high level of ionizing radiation, anoxia and absence of light, etc. Many organisms inhabit environments characterized by more than one form of stress (Polyextremophiles). Among them are those who live in hypersaline and alkaline, hot and acidic, cold/hot and high hydrostatic pressure, etc. Polyextremophiles found in desert regions have to copy with intense UV irradiation and desiccation, high as well as low temperatures, and low availability of water and nutrients. This book provides novel results of application to polyextremophiles research ranging from nanotechnology to synthetic biology to the origin of life and beyond.

Plant Functional Genomics

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Publisher : Humana
ISBN 13 : 9781493924431
Total Pages : 0 pages
Book Rating : 4.9/5 (244 download)

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Book Synopsis Plant Functional Genomics by : Jose M. Alonso

Download or read book Plant Functional Genomics written by Jose M. Alonso and published by Humana. This book was released on 2015-03-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume discusses the revolutionary development of faster and less expensive DNA sequencing technologies from the past 10 years and focuses on general technologies that can be utilized by a wide array of plant biologists to address specific questions in their favorite model systems. This book is organized into five parts. Part I examines the tools and methods required for identifying epigenetic and conformational changes at the whole-genome level. Part II presents approaches used to determine key aspects of a gene’s function, such as techniques used to identify and characterize gene regulatory networks. This is followed by a discussion of tools used to analyze the levels of mRNA, mRNA translation rates and metabolites. Part III features a compilation of forward and reverse genetic approaches that include recent implementation of high-throughput sequencing in classical methodologies such as QTL mapping. The final two parts explore strategies to facilitate and accelerate the generation and testing of functional DNA elements and basic computational tools used to facilitate the use of systems biology approached by a broad spectrum of plant researchers. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls. Practical and timely, Plant Functional Genomics: Methods and Protocols, Second Edition highlights the latest developments in DNA sequencing technologies that are likely to continue shaping the future of functional genomics.

Arthropod Relationships

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Publisher : Springer Science & Business Media
ISBN 13 : 9780412754203
Total Pages : 444 pages
Book Rating : 4.7/5 (542 download)

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Book Synopsis Arthropod Relationships by : Richard A. Fortey

Download or read book Arthropod Relationships written by Richard A. Fortey and published by Springer Science & Business Media. This book was released on 1997-12-31 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: The arthropods contain more species than any other animal group, but the evolutionary pathways which led to their current diversity are still an issue of controversy. Arthropod Relationships provides an overview of our current understanding, responding to the new data arising from sequencing DNA, the discovery of new Cambrian fossils as direct evidence of early arthropod history, and developmental genetics. These new areas of research have stimulated a reconsideration of classical morphology and embryology. Arthropod Relationships is the first synthesis of the current debate to emerge: not since the volume edited by Gupta was published in 1979 has the arthropod phylogeny debate been, considered in this depth and breadth. Leaders in the various branches of arthropod biology have contributed to this volume. Chapters focus progressively from the general issues to the specific problems involving particular groups, and thence to a consideration of embryology and genetics. This wide range of disciplines is drawn on to approach an understanding of arthropod relationships, and to provide the most timely account of arthropod phylogeny. This book should be read by evolutionary biologists, palaeontologists, developmental geneticists and invertebrate zoologists. It will have a special interest for post-graduate students working in these fields.

Prebiotic Chemistry

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Publisher : Springer
ISBN 13 : 9783642066146
Total Pages : 0 pages
Book Rating : 4.0/5 (661 download)

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Book Synopsis Prebiotic Chemistry by : Peter Walde

Download or read book Prebiotic Chemistry written by Peter Walde and published by Springer. This book was released on 2010-02-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: D.W. Deamer, J.P. Dworkin: Chemistry and Physics of Primitive Membranes.- R.Saladino, C. Crestini, G. Costanzo, E. DiMauro: On the Prebiotic Synthesis of Nucleobases, Nucleotides, Oligonucleotides, Pre-RNA and Pre-DNA Molecules.- R. Pascal, L. Boiteau, A. Commeyras: From the Prebiotic Synthesis of alpha-Amino Acids Towards a Primitive Translation Apparatus for the Synthesis of Peptides.- I. Weissbuch, L: Leiserowitz, M. Lahav: Stochastic "Mirror-Symmetry Breaking" via Self-Assembly, Reactivity and Amplification of Chirality: Relevance to Abiotic Conditions.- E. Szathmáry, M.Santos, C. Fernando: Evolutionary Potential and Requirements for Minimal Protocells

Artemia: Basic and Applied Biology

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Publisher : Springer Science & Business Media
ISBN 13 : 940170791X
Total Pages : 416 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Artemia: Basic and Applied Biology by : Th.J. Abatzopoulos

Download or read book Artemia: Basic and Applied Biology written by Th.J. Abatzopoulos and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objectives of this volume are to present an up-to-date (literature survey up to 2001) account of the biology of Artemia focusing particularly upon the major advances in knowledge and understanding achieved in the last fifteen or so years and emphasising the operational and functional linkage between the biological phenomena described and the ability of this unusual animal to thrive in extreme environments. Artemia is a genus of anostracan crustaceans, popularly known as brine shrimps. These animals are inhabitants of saline environments which are too extreme for the many species which readily predate them if opportunity offers. They are, thus, effectively inhabitants of extreme (hypersaline) habitats, but at the same time are able to tolerate physiologically large changes in salinity, ionic composition, temperature and oxygen tension. Brine shrimp are gener ally thought of as tropical and subtropical, but are also found in regions where temperatures are very low for substantial periods such as Tibet, Siberia and the Atacama desert. They have, thus, great powers of adaptation and are of interest for this capacity alone. The earliest scientific reference to brine shrimp is in 1756, when Schlosser reported their existence in the saltpans of Lymington, England. These saltpans no longer exist and brine shrimp are not found in Britain today. Later, Linnaeus named the brine shrimp Cancer salinus and later still, Leach used the name Artemia salina. The strong effect which the salinity of the medium exerts on the morphological development of Artemia is now widely recognised.

The Biology of Tardigrades

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Publisher : Portland Press, London
ISBN 13 :
Total Pages : 208 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis The Biology of Tardigrades by : Ian M. Kinchin

Download or read book The Biology of Tardigrades written by Ian M. Kinchin and published by Portland Press, London. This book was released on 1994 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Biology of Tardigrades is the only modern comprehensive account of marine and freshwater tardigrades. It contains the first taxonomic review for over a decade in addition to covering every aspect of their biology.