Use Of A Listeria Monocytogenes Protein To Stimulate Immune Responses And Anti Tumor Effects

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Use of a Listeria Monocytogenes Protein to Stimulate Immune Responses and Anti-tumor Effects

Author : Amber Leigh Ortiz
Publisher :
ISBN 13 : 9780355601480
Total Pages : 149 pages
Book Rating : 4.6/5 (14 download)

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Book Synopsis Use of a Listeria Monocytogenes Protein to Stimulate Immune Responses and Anti-tumor Effects by : Amber Leigh Ortiz

Download or read book Use of a Listeria Monocytogenes Protein to Stimulate Immune Responses and Anti-tumor Effects written by Amber Leigh Ortiz and published by . This book was released on 2017 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural killer (NK) cells are a type of innate immune cell that secrete IFN when activated. IFN has pro-inflammatory effects and can act on tumor cells to kill them or inhibit their proliferation. NK cells can also exert direct anti-tumor cytolytic activity. Previous work showed that the Listeria monocytogenes (Lm) p60 protein indirectly promotes activation of NK cells to mediate cytokine production. The p60 protein contains two divergent LysM domains and one SH3 domain. The LysM1 domain is responsible for the immune stimulatory activity of the p60 protein and is present with the SH3 domain in a fragment of p60 termed "L1S." Like p60, recombinant L1S binds dendritic cells (DC) to stimulate their secretion of cytokines such as interleukin-18 (IL-18) and license them to promote activation of NK cells. The studies in this thesis investigated the nature of immune cell activation by L1S in vitro and in vivo through direct lung instillation. I found that instillation with wildtype L1S induced recruitment of inflammatory neutrophils and promoted accumulation of activated, IFN-producing, NK cells with increased cytolytic activity. I further showed that instillation of tumor-bearing mice with wildtype L1S protein significantly reduced burdens of established tumors. IFN and NK cells were required for these therapeutic effects. Further studies utilized simulated structure analysis and site-directed mutagenesis to explore the effects of specific amino acids in the LysM1 domain on the function of recombinant L1S protein. Specific amino acids in the LysM1 region were identified as critical for eliciting NK cell activity. Thus, my studies have improved our understanding of L1S immunostimulatory function and demonstrated its potential in vivo use for stimulation of NK cell anti-tumor responses.

Inflammasome Activation Impairs Cell-mediated Immunity to Listeria Monocytogenes

Author : Erin M. Theisen
Publisher :
ISBN 13 :
Total Pages : 398 pages
Book Rating : 4.:/5 (1 download)

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Book Synopsis Inflammasome Activation Impairs Cell-mediated Immunity to Listeria Monocytogenes by : Erin M. Theisen

Download or read book Inflammasome Activation Impairs Cell-mediated Immunity to Listeria Monocytogenes written by Erin M. Theisen and published by . This book was released on 2017 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Recombinant Listeria Monocytogenes as an Anti-tumor Vaccine and a Probe to Study Innate and Acquired Immunity

Author : Kevin Wendell Bruhn
Publisher :
ISBN 13 :
Total Pages : 400 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Recombinant Listeria Monocytogenes as an Anti-tumor Vaccine and a Probe to Study Innate and Acquired Immunity by : Kevin Wendell Bruhn

Download or read book Recombinant Listeria Monocytogenes as an Anti-tumor Vaccine and a Probe to Study Innate and Acquired Immunity written by Kevin Wendell Bruhn and published by . This book was released on 2004 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Immunity to Listeria Monocytogenes

Author : E R Unanue
Publisher : Academic Press
ISBN 13 : 0123945909
Total Pages : 206 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Immunity to Listeria Monocytogenes by : E R Unanue

Download or read book Immunity to Listeria Monocytogenes written by E R Unanue and published by Academic Press. This book was released on 2012-01-24 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. Contributions from leading authorities Informs and updates on all the latest developments in the field

Mechanisms of Listeria Monocytogenes-mediated Modulation of Tumor Growth

Author : Amy Margaret Fulton
Publisher :
ISBN 13 :
Total Pages : 268 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Mechanisms of Listeria Monocytogenes-mediated Modulation of Tumor Growth by : Amy Margaret Fulton

Download or read book Mechanisms of Listeria Monocytogenes-mediated Modulation of Tumor Growth written by Amy Margaret Fulton and published by . This book was released on 1977 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Janeway's Immunobiology

Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Listeria monocytogenes: Pathogenesis and Host Response

Author : Howard Goldfine
Publisher : Springer Science & Business Media
ISBN 13 : 038749376X
Total Pages : 292 pages
Book Rating : 4.3/5 (874 download)

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Book Synopsis Listeria monocytogenes: Pathogenesis and Host Response by : Howard Goldfine

Download or read book Listeria monocytogenes: Pathogenesis and Host Response written by Howard Goldfine and published by Springer Science & Business Media. This book was released on 2007-06-24 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past twenty years Listeria monocytogenes has emerged as one of the most intensely studied bacterial pathogens. New windows are constantly being opened into the complexity of host cell biology and the interplay of the signals connecting the various cells and organs involved in the host response. This volume includes research from studies at the molecular level on the pathogenesis of Listeria monocytogenes and the response of the host to its infections.

Bugs as Drugs

Author : Robert A. Britton
Publisher : John Wiley & Sons
ISBN 13 : 1555819702
Total Pages : 514 pages
Book Rating : 4.5/5 (558 download)

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Book Synopsis Bugs as Drugs by : Robert A. Britton

Download or read book Bugs as Drugs written by Robert A. Britton and published by John Wiley & Sons. This book was released on 2020-07-02 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examining the enormous potential of microbiome manipulation to improve health Associations between the composition of the intestinal microbiome and many human diseases, including inflammatory bowel disease, cardiovascular disease, metabolic disorders, and cancer, have been elegantly described in the past decade. Now, whole-genome sequencing, bioinformatics, and precision gene-editing techniques are being combined with centuries-old therapies, such as fecal microbiota transplantation, to translate current research into new diagnostics and therapeutics to treat complex diseases. Bugs as Drugs provides a much-needed overview of microbes in therapies and will serve as an excellent resource for scientists and clinicians as they carry out research and clinical studies on investigating the roles the microbiota plays in health and disease. In Bugs as Drugs, editors Robert A. Britton and Patrice D. Cani have assembled a fascinating collection of reviews that chart the history, current efforts, and future prospects of using microorganisms to fight disease and improve health. Sections cover traditional uses of probiotics, next-generation microbial therapeutics, controlling infectious diseases, and indirect strategies for manipulating the host microbiome. Topics presented include: How well-established probiotics support and improve host health by improving the composition of the intestinal microbiota of the host and by modulating the host immune response. The use of gene editing and recombinant DNA techniques to create tailored probiotics and to characterize next-generation beneficial microbes. For example, engineering that improves the anti-inflammatory profile of probiotics can reduce the number of colonic polyps formed, and lactobacilli can be transformed into targeted delivery systems carrying therapeutic proteins or bioengineered bacteriophage. The association of specific microbiota composition with colorectal cancer, liver diseases, osteoporosis, and inflammatory bowel disease. The gut microbiota has been proposed to serve as an organ involved in regulation of inflammation, immune function, and energy homeostasis. Fecal microbiota transplantation as a promising treatment for numerous diseases beyond C. difficile infection. Practical considerations for using fecal microbiota transplantation are provided, while it is acknowledged that more high-quality evidence is needed to ascertain the importance of strain specificity in positive treatment outcomes. Because systems biology approaches and synthetic engineering of microbes are now high-throughput and cost-effective, a much wider range of therapeutic possibilities can be explored and vetted.

The New Microbiology

Author : Pascale Cossart
Publisher : John Wiley & Sons
ISBN 13 : 1683670116
Total Pages : 200 pages
Book Rating : 4.6/5 (836 download)

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Book Synopsis The New Microbiology by : Pascale Cossart

Download or read book The New Microbiology written by Pascale Cossart and published by John Wiley & Sons. This book was released on 2020-07-10 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbiology has undergone radical changes over the past few decades, ushering in an exciting new era in science. In The New Microbiology, Pascale Cossart tells a splendid story about the revolution in microbiology, especially in bacteriology. This story has wide-ranging implications for human health and medicine, agriculture, environmental science, and our understanding of evolution. The revolution results from the powerful tools of molecular and cellular biology, genomics, and bioinformatics, which have yielded amazing discoveries, from entire genome sequences to video of bacteria invading host cells. This book is for both scientists and especially nonscientists who would like to learn more about the extraordinary world of bacteria. Dr. Cossart's overview of the field of microbiology research, from infectious disease history to the ongoing scientific revolution resulting from CRISPR technologies, is presented in four parts. New concepts in microbiology introduces the world of bacteria and some recent discoveries about how they live, such as the role of regulatory RNAs including riboswitches, the CRISPR defense system, and resistance to antibiotics. Sociomicrobiology: the social lives of bacteria helps us see the new paradigm by which scientists view bacteria as highly social creatures that communicate in many ways, for example in the assemblies that reside in our intestine or in the environment. The biology of infections reviews some of history's worst epidemics and describes current and emerging infectious diseases, the organisms that cause them, and how they produce an infection. Bacteria as tools introduces us to molecules derived from microbes that scientists have harnessed in the service of research and medicine, including the CRISPR/Cas9 genome-editing technology. The New Microbiology takes us on a journey through a remarkable revolution in science that is occurring here and now.

RNA Interference

Author : Mouldy Sioud
Publisher : Humana
ISBN 13 : 9781493948918
Total Pages : 0 pages
Book Rating : 4.9/5 (489 download)

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Book Synopsis RNA Interference by : Mouldy Sioud

Download or read book RNA Interference written by Mouldy Sioud and published by Humana. This book was released on 2016-09-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA Interference: Challenges and Therapeutic Opportunities provides readers with recent advances in siRNA design, delivery, targeting and methods to minimize siRNA’s unwanted effects. Preclinical and clinical use of synthetic siRNAs, the roles of miRNAs in cancer and the promise of extracellular miRNAs for diagnosis are also covered in this meticulous collection, along with novel methods for identifying endogenous siRNAs and the annotation of small RNA transcriptomes. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory. Comprehensive and cutting-edge, RNA Interference: Challenges and Therapeutic Opportunities will aid researchers, clinicians, teachers and biotechnologists interested in the power of RNA-based therapies.

Mucosal Vaccines

Author : Hiroshi Kiyono
Publisher : Elsevier
ISBN 13 : 0080537057
Total Pages : 501 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Mucosal Vaccines by : Hiroshi Kiyono

Download or read book Mucosal Vaccines written by Hiroshi Kiyono and published by Elsevier. This book was released on 1996-10-23 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. Provides the latest views on mucosal vaccines Applies basic principles to the development of new vaccines Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases Unique and user-friendly organization

CRISPR-Cas Systems

Author : Rodolphe Barrangou
Publisher : Springer Science & Business Media
ISBN 13 : 364234657X
Total Pages : 300 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis CRISPR-Cas Systems by : Rodolphe Barrangou

Download or read book CRISPR-Cas Systems written by Rodolphe Barrangou and published by Springer Science & Business Media. This book was released on 2012-12-13 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

Treating Infectious Diseases in a Microbial World

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309180686
Total Pages : 102 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Treating Infectious Diseases in a Microbial World by : National Research Council

Download or read book Treating Infectious Diseases in a Microbial World written by National Research Council and published by National Academies Press. This book was released on 2006-01-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

The Immune Response

Author : Tak W. Mak
Publisher : Academic Press
ISBN 13 : 0080534481
Total Pages : 1217 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Immune Response by : Tak W. Mak

Download or read book The Immune Response written by Tak W. Mak and published by Academic Press. This book was released on 2005-11-11 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences. Current and thorough 30 chapter reference reviewed by luminaries in the field Unique ‘single voice' ensures consistency of definitions and concepts Comprehensive and elegant illustrations bring key concepts to life Provides historical context to allow fuller understanding of key issues Introductory chapters 1-4 serve as an ‘Immunology Primer' before topics are discussed in more detail

Oncoimmunology

Author : Laurence Zitvogel
Publisher : Springer
ISBN 13 : 3319624318
Total Pages : 700 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Oncoimmunology by : Laurence Zitvogel

Download or read book Oncoimmunology written by Laurence Zitvogel and published by Springer. This book was released on 2017-12-13 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.

Toll-Like Receptors (TLRs) and Innate Immunity

Author : Stefan Bauer
Publisher : Springer Science & Business Media
ISBN 13 : 3540721673
Total Pages : 243 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Toll-Like Receptors (TLRs) and Innate Immunity by : Stefan Bauer

Download or read book Toll-Like Receptors (TLRs) and Innate Immunity written by Stefan Bauer and published by Springer Science & Business Media. This book was released on 2007-12-11 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.

Current Strategies in Cancer Gene Therapy

Author : Wolfgang Walther
Publisher : Springer
ISBN 13 : 3319429345
Total Pages : 124 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Current Strategies in Cancer Gene Therapy by : Wolfgang Walther

Download or read book Current Strategies in Cancer Gene Therapy written by Wolfgang Walther and published by Springer. This book was released on 2017-01-17 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well as in gene suppression and miRNA therapies. Many of the described strategies focus on the generation of more efficient and specific means of attack at known and novel cellular targets associated with tumor development and progression. The book also details parallel improvements in vector design, vector delivery, and therapeutic efficacy. It offers readers a stimulating, broad overview of advances in the field, linking experimental strategies to their clinical applications.