Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Untangling Alzheimers Actx Complimentary Copy full books in PDF, epub, and Kindle. Read online Untangling Alzheimers Actx Complimentary Copy ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Anne Brown Rodgers
Publisher :
ISBN 13 :
Total Pages : 80 pages
Book Rating : 4.:/5 (277 download)
Download or read book Alzheimer's Disease written by Anne Brown Rodgers and published by . This book was released on 2008 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jesus Avila
Publisher : Frontiers E-books
ISBN 13 : 288919261X
Total Pages : 114 pages
Book Rating : 4.8/5 (891 download)
Download or read book Tau oligomers written by Jesus Avila and published by Frontiers E-books. This book was released on 2014-08-18 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.
Author : Jason Karlawish
Publisher : St. Martin's Press
ISBN 13 : 1250218748
Total Pages : 269 pages
Book Rating : 4.2/5 (52 download)
Download or read book The Problem of Alzheimer's written by Jason Karlawish and published by St. Martin's Press. This book was released on 2021-02-23 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: A definitive and compelling book on one of today's most prevalent illnesses. In 2020, an estimated 5.8 million Americans had Alzheimer’s, and more than half a million died because of the disease and its devastating complications. 16 million caregivers are responsible for paying as much as half of the $226 billion annual costs of their care. As more people live beyond their seventies and eighties, the number of patients will rise to an estimated 13.8 million by 2050. Part case studies, part meditation on the past, present and future of the disease, The Problem of Alzheimer's traces Alzheimer’s from its beginnings to its recognition as a crisis. While it is an unambiguous account of decades of missed opportunities and our health care systems’ failures to take action, it tells the story of the biomedical breakthroughs that may allow Alzheimer’s to finally be prevented and treated by medicine and also presents an argument for how we can live with dementia: the ways patients can reclaim their autonomy and redefine their sense of self, how families can support their loved ones, and the innovative reforms we can make as a society that would give caregivers and patients better quality of life. Rich in science, history, and characters, The Problem of Alzheimer's takes us inside laboratories, patients' homes, caregivers’ support groups, progressive care communities, and Jason Karlawish's own practice at the Penn Memory Center.
Author : David Baker
Publisher : Bookbaby
ISBN 13 : 9781098392741
Total Pages : 230 pages
Book Rating : 4.3/5 (927 download)
Download or read book Death Is No Excuse written by David Baker and published by Bookbaby. This book was released on 2021-11-02 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Death Is No Excuse is an insightful roadmap through the legal potholes of unplanned death and disability, offered by a veteran attorney who's handled the worst of these cases for over forty years. It's a plain-spoken, surprisingly entertaining guide to everything you need to know about planning for death or disability, as well as other calamities that can occur along the way, be they divorce, avoidable tax burdens or getting ripped off as you toddle into old age.
Author : Claudia Perez-Cruz
Publisher : Frontiers Media SA
ISBN 13 : 2889197190
Total Pages : 78 pages
Book Rating : 4.8/5 (891 download)
Download or read book Nutrition and Prevention of Alzheimer's Disease written by Claudia Perez-Cruz and published by Frontiers Media SA. This book was released on 2015-12-18 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: Altered metabolism is known to be associated with a higher incidence of Alzheimer´s disease (AD). Diabetes type 2, obesity, and metabolic syndrome are considered risk factors for the development of dementias, including AD. These metabolic diseases may have a genetic predisposition, but most of them are caused by environmental factors and life-style. Most research has focused on the effect of a high-fat diet (HFD) and sweetened beverages that induce obesity. Importantly, a HFD can also trigger oxidative stress, neuro-inflammation and cognitive decline. Less is known, however, about beneficial effects of diet on cognition, such as slowing the progression or preventing AD by ingesting whole fruits, vegetables, fish and oil. It is important to highlight the difference between vitamin/mineral supplements and whole food, as it appears that the former are clinically ineffective, while multiple ingredients in the latter act synergistically to improve cognition. As AD is a disease of slow progression, therapies should start several decades before clinical symptoms can be observed; one strategy can be the ingestion of healthy food in those subjects with one or more risk factors (genetic, environmental, life-style) already in their 40s, just when some brain metabolic disturbances start to develop. This dietary therapy can overcome the increased reactive oxygen species, protein deposition and synaptic failure, characteristic of AD. This research topic will cover a range of research articles, case studies, opinion and mini-reviews, all focused on describing the damaging effects of an industrial diet on cognition as well as on highlighting the beneficial effects of a healthy diet to prevent AD. We believe that we still have time to fight against the negative impact of our industrialized cultures, and adopt better eating habits, increase exercise and slow down our life style to prevent increasing dementia in the aging population. Also, all these topics has been a product of intensives investigations, with a great life hope, and we hope you all enjoy reading this e-book.
Author : Julian Jaynes
Publisher : Houghton Mifflin Harcourt
ISBN 13 : 0547527543
Total Pages : 580 pages
Book Rating : 4.5/5 (475 download)
Download or read book The Origin of Consciousness in the Breakdown of the Bicameral Mind written by Julian Jaynes and published by Houghton Mifflin Harcourt. This book was released on 2000-08-15 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: National Book Award Finalist: “This man’s ideas may be the most influential, not to say controversial, of the second half of the twentieth century.”—Columbus Dispatch At the heart of this classic, seminal book is Julian Jaynes's still-controversial thesis that human consciousness did not begin far back in animal evolution but instead is a learned process that came about only three thousand years ago and is still developing. The implications of this revolutionary scientific paradigm extend into virtually every aspect of our psychology, our history and culture, our religion—and indeed our future. “Don’t be put off by the academic title of Julian Jaynes’s The Origin of Consciousness in the Breakdown of the Bicameral Mind. Its prose is always lucid and often lyrical…he unfolds his case with the utmost intellectual rigor.”—The New York Times “When Julian Jaynes . . . speculates that until late in the twentieth millennium BC men had no consciousness but were automatically obeying the voices of the gods, we are astounded but compelled to follow this remarkable thesis.”—John Updike, The New Yorker “He is as startling as Freud was in The Interpretation of Dreams, and Jaynes is equally as adept at forcing a new view of known human behavior.”—American Journal of Psychiatry
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030916785X
Total Pages : 223 pages
Book Rating : 4.3/5 (91 download)
Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.
Author : Dale Bredesen
Publisher : Penguin
ISBN 13 : 0735216207
Total Pages : 322 pages
Book Rating : 4.7/5 (352 download)
Download or read book The End of Alzheimer's written by Dale Bredesen and published by Penguin. This book was released on 2017-08-22 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: The instant New York Times and Wall Street Journal bestseller A groundbreaking plan to prevent and reverse Alzheimer’s Disease that fundamentally changes how we understand cognitive decline. Everyone knows someone who has survived cancer, but until now no one knows anyone who has survived Alzheimer's Disease. In this paradigm shifting book, Dale Bredesen, MD, offers real hope to anyone looking to prevent and even reverse Alzheimer's Disease and cognitive decline. Revealing that AD is not one condition, as it is currently treated, but three, The End of Alzheimer’s outlines 36 metabolic factors (micronutrients, hormone levels, sleep) that can trigger "downsizing" in the brain. The protocol shows us how to rebalance these factors using lifestyle modifications like taking B12, eliminating gluten, or improving oral hygiene. The results are impressive. Of the first ten patients on the protocol, nine displayed significant improvement with 3-6 months; since then the protocol has yielded similar results with hundreds more. Now, The End of Alzheimer’s brings new hope to a broad audience of patients, caregivers, physicians, and treatment centers with a fascinating look inside the science and a complete step-by-step plan that fundamentally changes how we treat and even think about AD.
Author : Richard Powers
Publisher : Harper Collins
ISBN 13 : 1443422924
Total Pages : 308 pages
Book Rating : 4.4/5 (434 download)
Download or read book Orfeo written by Richard Powers and published by Harper Collins. This book was released on 2014-01-21 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author of the National Book Award winner and Pulitzer Prize finalist The Echo Maker, Richard Powers “may well be one of the smartest novelists now writing” (LOS ANGELES TIMES BOOK REVIEW) Seventy-year-old avant-garde composer Peter Els opens the door one evening to find the police on his doorstep. His home DIY microbiology lab--the latest experiment in his lifelong attempt to extract music from rich patterns beyond the ear’s ability to hear--has come to the attention of Homeland Security. Panicked by the raid on his house, Els turns fugitive, waiting for the evidence to clear him and for the alarm surrounding his activities to blow over. His days in hiding provoke memories of a turbulent century of musical turf wars and cause Els to reflect on a life spent chasing after transcendent sounds to the bewilderment of an indifferent public. As the national hysteria for safety erupts again in the face of this latest threat, Els--the “Bioterrorist Bach”--feeling the noose around him tighten, embarks on a cross-country trip to visit the people in his past who have most shaped his failed musical journey. Through the help of these people--his ex-wife, his daughter and his long-time artistic collaborator-- Els comes up with a plan to turn this disastrous collision with the security state into one last, resonant artwork that might reach an audience beyond his wildest dreams. Inspired by Steve Kurtz, the bio-artist wrongly arrested for terrorism by the FBI, Orfeo probes the boundary between stifling safety and reckless, releasing danger. It explores the varieties of human hunger, in particular the desire to hear more and to make meaning where there is none. Finally, the book is a meditation on that most endangered and priceless of human resources: attention.
Author : Ruth Ozeki
Publisher : Penguin
ISBN 13 : 1101606258
Total Pages : 621 pages
Book Rating : 4.1/5 (16 download)
Download or read book A Tale for the Time Being written by Ruth Ozeki and published by Penguin. This book was released on 2013-03-12 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: A brilliant, unforgettable novel from bestselling author Ruth Ozeki, author of The Book of Form and Emptiness Finalist for the Booker Prize and the National Book Critics Circle Award “A time being is someone who lives in time, and that means you, and me, and every one of us who is, or was, or ever will be.” In Tokyo, sixteen-year-old Nao has decided there’s only one escape from her aching loneliness and her classmates’ bullying. But before she ends it all, Nao first plans to document the life of her great grandmother, a Buddhist nun who’s lived more than a century. A diary is Nao’s only solace—and will touch lives in ways she can scarcely imagine. Across the Pacific, we meet Ruth, a novelist living on a remote island who discovers a collection of artifacts washed ashore in a Hello Kitty lunchbox—possibly debris from the devastating 2011 tsunami. As the mystery of its contents unfolds, Ruth is pulled into the past, into Nao’s drama and her unknown fate, and forward into her own future. Full of Ozeki’s signature humor and deeply engaged with the relationship between writer and reader, past and present, fact and fiction, quantum physics, history, and myth, A Tale for the Time Being is a brilliantly inventive, beguiling story of our shared humanity and the search for home.
Author : Daniel Laskowitz
Publisher : CRC Press
ISBN 13 : 1498766579
Total Pages : 388 pages
Book Rating : 4.4/5 (987 download)
Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Author : Karin Tanabe
Publisher : Simon and Schuster
ISBN 13 : 1451695608
Total Pages : 370 pages
Book Rating : 4.4/5 (516 download)
Download or read book The List written by Karin Tanabe and published by Simon and Schuster. This book was released on 2013-02-05 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meet Adrienne Brown, a twenty-eight-year-old Wellesley College grad who recently left her glamorous job at Town & Country for a spot at the Capitolist. Known simply as the List to Beltway insiders, it’s the only media outlet in D.C. that’s actually on the rise. Taking the job means accepting a painful pay cut, giving up perks like free Louboutins, and moving back in with her parents, but Adrienne is certain that her new position will be the making of her career. And it is—but not at all in the way that she expects. The Capitolist runs at an insane pace: Adrienne’s up before five in the morning, writing ten stories a day (sometimes on her BlackBerry, often during her commute), and answering every email within three minutes. Just when it seems like the frenetic workload is going to break her, she stumbles upon a juicy political affair, involving a very public senator—and her most competitive colleague. Discovering that there’s much more to the relationship than meets the eye, Adrienne realizes she’s got the scoop of a lifetime. But should she go public with the story? Inspired by Washington insider Karin Tanabe’s experiences at Politico, The List is a riveting debut novel bursting with behind-the-scenes details about what happens when media and politics collide.
Author : Daniel T. Willingham
Publisher : John Wiley & Sons
ISBN 13 : 0470730455
Total Pages : 324 pages
Book Rating : 4.4/5 (77 download)
Download or read book Why Don't Students Like School? written by Daniel T. Willingham and published by John Wiley & Sons. This book was released on 2009-06-10 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Easy-to-apply, scientifically-based approaches for engaging students in the classroom Cognitive scientist Dan Willingham focuses his acclaimed research on the biological and cognitive basis of learning. His book will help teachers improve their practice by explaining how they and their students think and learn. It reveals-the importance of story, emotion, memory, context, and routine in building knowledge and creating lasting learning experiences. Nine, easy-to-understand principles with clear applications for the classroom Includes surprising findings, such as that intelligence is malleable, and that you cannot develop "thinking skills" without facts How an understanding of the brain's workings can help teachers hone their teaching skills "Mr. Willingham's answers apply just as well outside the classroom. Corporate trainers, marketers and, not least, parents -anyone who cares about how we learn-should find his book valuable reading." —Wall Street Journal
Author : Knut Schroeder
Publisher : John Wiley & Sons
ISBN 13 : 0470664703
Total Pages : 638 pages
Book Rating : 4.4/5 (76 download)
Download or read book Diagnosing Your Health Symptoms For Dummies written by Knut Schroeder and published by John Wiley & Sons. This book was released on 2010-09-02 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by an experienced family doctor and packed with practical and sound advice, Diagnosing Your Health Symptoms For Dummies is a reference for everyone who wants to find out when they do and don't need to worry about their health. It will cover over 100 common, important, potentially serious and often worrying symptoms and emergencies, such as headaches, chest pain, dizziness, fever, bleeding, tiredness or stress. This reassuring guide will also include guidance on how to perform basic physical assessments, as well as a run through of key first aid techniques. Perfect for both allaying fears and encouraging those with serious symptoms to seek professional advice, this guide will be an essential family health bible. Diagnosing Your Health Symptoms FD includes: Part I: Spotting and Assessing Illness: The Basics Chapter 1: Thinking about Medicine Chapter 2: Dealing with Medical Problems Chapter 3: Conducting a Symptom Check Chapter 4: Looking for Out For Signs of Illness Part II: Looking at Emergencies and ‘All-Over' Symptoms Chapter 5: Coping with Medical Emergencies Chapter 6: Approaching Non-Specific Symptoms Chapter 7: Symptoms Affecting the Wider Body Part III: From top to toe: looking at specific areas of the body Chapter 8: Look at Me! Sussing Out Skin Problems Chapter 9: Trouble at the Top: Symptoms Around the Head and Problems with the Senses Chapter 10: Close to Your Heart: Exploring Chest Problems Chapter 11: Untangling Tummy and Bowel Problems Chapter 12: Getting Lower: Urinary and Other Disturbances ‘Down There' Chapter 13: Bones and Groans Part IV: Dealing with health problems in people close to you Chapter 14: Spotting Illness in Your Baby Chapter 15: Illness in Your Toddler or Pre-School Child Chapter 16: Problems in Your School-Age Kids Chapter 17: Dealing with Adolescent Problems Chapter 18: Understanding Women's Troubles Chapter 19: Looking at Some Specific Men's Issues Chapter 20: Dealing with Common Later Life Problems Part V: Spotting mental health problems Chapter 21: Tackling Anxiety, Depression and Stress Chapter 22: Approaching Unusual Thoughts and Behaviour Chapter 23: Addressing Alcohol and Drug Problems Part VI: The part of tens Chapter 24: Ten First Aid Essentials: Helping Yourself and Others Chapter 25: Ten Reliable Health Websites Chapter 26: Ten Medical Tests you May Need Glossary: 100 Useful Medical Terms
Author : Olivier Godefroy
Publisher : Cambridge University Press
ISBN 13 : 1139461893
Total Pages : 637 pages
Book Rating : 4.1/5 (394 download)
Download or read book The Behavioral and Cognitive Neurology of Stroke written by Olivier Godefroy and published by Cambridge University Press. This book was released on 2007-01-18 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: The care of stroke patients has changed dramatically. As well as improvements in the emergency care of the condition, there have been marked advances in our understanding, management and rehabilitation of residual deficits. This book is about the care of stroke patients, focusing on behavioural and cognitive problems. It provides a comprehensive review of the field covering the diagnostic value of these conditions, in the acute and later phases, their requirements in terms of treatment and management and the likelihood and significance of long-term disability. This book will appeal to all clinicians involved in the care of stroke patients, as well as to neuropsychologists, other rehabilitation therapists and research scientists investigating the underlying neuroscience.
Author : Mousumi Mutsuddi
Publisher : Springer Nature
ISBN 13 : 981132218X
Total Pages : 470 pages
Book Rating : 4.8/5 (113 download)
Download or read book Insights into Human Neurodegeneration: Lessons Learnt from Drosophila written by Mousumi Mutsuddi and published by Springer Nature. This book was released on 2019-12-05 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is aimed at generating an updated reservoir of scientific endeavors undertaken to unravel the complicated yet intriguing topic of neurodegeneration. Scientists from Europe, USA and India who are experts in the field of neurodegenerative diseases have contributed to this book. This book will help readers gain insight into the recent knowledge obtained from Drosophila model, in understanding the molecular mechanisms underlying neurodegenerative disorders and also unravel novel scopes for therapeutic interventions. Different methodologies available to create humanized fly models that faithfully reflects the pathogenicities associated with particular disorders have been described here. It also includes information on the exciting area of neural stem cells. A brief discussion on neurofibrillary tangles, precedes the elaborate description of lessons learnt from Drosophila about Alzheimer's, Parkinson’s, Spinomuscular Atrophy, Huntington’s diseases, RNA expansion disorders and Hereditary Spastic Paraplegia. We have concluded the book with the use of Drosophila for identifying pharmacological therapies for neurodegenerative disorders. The wide range of topics covered here will not only be relevant for beginners who are new to the concept of the extensive utility of Drosophila as a model to study human disorders; but will also be an important contribution to the scientific community, with an insight into the paradigm shift in our understanding of neurodegenerative disorders. Completed with informative tables and communicative illustrations this book will keep the readers glued and intrigued. We have comprehensively anthologized the lessons learnt on neurodegeneration from Drosophila and have thus provided an insight into the multidimensional aspects of pathogenicities of majority of the neurodegenerative disorders.
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309049393
Total Pages : 636 pages
Book Rating : 4.3/5 (9 download)
Download or read book Reducing Risks for Mental Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 1994-01-01 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: The understanding of how to reduce risk factors for mental disorders has expanded remarkably as a result of recent scientific advances. This study, mandated by Congress, reviews those advances in the context of current research and provides a targeted definition of prevention and a conceptual framework that emphasizes risk reduction. Highlighting opportunities for and barriers to interventions, the book draws on successful models for the prevention of cardiovascular disease, injuries, and smoking. In addition, it reviews the risk factors associated with Alzheimer's disease, schizophrenia, alcohol abuse and dependence, depressive disorders, and conduct disorders and evaluates current illustrative prevention programs. The models and examination provide a framework for the design, application, and evaluation of interventions intended to prevent mental disorders and the transfer of knowledge about prevention from research to clinical practice. The book presents a focused research agenda, with recommendations on how to develop effective intervention programs, create a cadre of prevention researchers, and improve coordination among federal agencies.
