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Ultrasound Assisted Optical Elastography For Measurement Of Mechanical Properties Of Soft Tissue Mimicking Phantoms
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Book Synopsis Ultrasound Assisted Optical Elastography For Measurement Of Mechanical Properties Of Soft Tissue Mimicking Phantoms by :
Download or read book Ultrasound Assisted Optical Elastography For Measurement Of Mechanical Properties Of Soft Tissue Mimicking Phantoms written by and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This work describes the development of an optical probe for measuring movement of tissue particles deep inside which are loaded by an ultrasound remote palpation device. The principle of the method is that ultrasound force which can be applied inside the tissue makes the tissue particles vibrate and this vibration phase-modulates the light intercepting the insoniified region which results in a modulated speckle intensity on detection outside the object. This speckle intensity modulation detected through the measured intensity autocorrelation is a measure of the vibration amplitude. Since the vibration amplitude is related to the local elastic properties of the medium, the measured modulation depth in intensity autocorrelation can be used to map the elastic property in the insonified region. In this work, first the ultrasound induced force is calculated for both plane and focused ultrasound beams, and converted to amplitude of vibration and refractive index modulation, solving the forward elastography equation. Light propagation inside an insonified object is modelled using Monte Carlo simulation and the amplitude and intensity correlations are computed. The modulation depth on the autocorrelation is estimated and shown that it is inversely correlated to the local elastic modulus and optical absorption coefficient. It is further shown that whereas the variation in modulation depth is linear with respect to absorption coefficient, the same variation with elastic property is nonlinear. These results are verified experimentally in a tissue mimicking phantom. The phantom was constructed out of poly vinyl alcohol(PVA) whose optical, mechanical and acoustic properties are independently controlled. It is also shown that for loading with focused ultrasound beam the displacement is almost along the ultrasound transducer axis and therefore the contribution from refractive index modulation alone can be ascertained by probing the insonified perpendicular to the transducer axis.
Book Synopsis Ultrasound Elastography for Biomedical Applications and Medicine by : Ivan Z. Nenadic
Download or read book Ultrasound Elastography for Biomedical Applications and Medicine written by Ivan Z. Nenadic and published by John Wiley & Sons. This book was released on 2019-01-22 with total page 613 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultrasound Elastography for Biomedical Applications and Medicine Ivan Z. Nenadic, Matthew W. Urban, James F. Greenleaf, Mayo Clinic Ultrasound Research Laboratory, Mayo Clinic College of Medicine, USA Jean-Luc Gennisson, Miguel Bernal, Mickael Tanter, Institut Langevin – Ondes et Images, ESPCI ParisTech CNRS, France Covers all major developments and techniques of Ultrasound Elastography and biomedical applications The field of ultrasound elastography has developed various techniques with the potential to diagnose and track the progression of diseases such as breast and thyroid cancer, liver and kidney fibrosis, congestive heart failure, and atherosclerosis. Having emerged in the last decade, ultrasound elastography is a medical imaging modality that can noninvasively measure and map the elastic and viscous properties of soft tissues. Ultrasound Elastography for Biomedical Applications and Medicine covers the basic physics of ultrasound wave propagation and the interaction of ultrasound with various media. The book introduces tissue elastography, covers the history of the field, details the various methods that have been developed by research groups across the world, and describes its novel applications, particularly in shear wave elastography. Key features: Covers all major developments and techniques of ultrasound elastography and biomedical applications. Contributions from the pioneers of the field secure the most complete coverage of ultrasound elastography available. The book is essential reading for researchers and engineers working in ultrasound and elastography, as well as biomedical engineering students and those working in the field of biomechanics.
Book Synopsis Quantitative Ultrasound in Soft Tissues by : Jonathan Mamou
Download or read book Quantitative Ultrasound in Soft Tissues written by Jonathan Mamou and published by Springer Science & Business Media. This book was released on 2013-09-26 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to parallel advances in signal processing and computer hardware in the last 15 years, quantitative ultrasound techniques have reached maturity, allowing for the construction of quantitative maps or images of soft tissues. This book will focus on 5 modern research topics related to quantitative ultrasound of soft tissues: - Spectral-based methods for tissue characterization, tissue typing, cancer detection, etc.; - Envelope statistics analysis as a means of quantifying and imaging tissue properties; - Ultrasound elastography for quantifying elastic properties of tissues (several clinical ultrasound scanners now display elastography images); - Scanning acoustic microscopy for forming images of mechanical properties of soft tissues with micron resolution (desktop size scanners are now available); and - Ultrasound computer tomography for breast cancer imaging (new ultrasound tomography systems have been developed and are currently under evaluation clinically).
Book Synopsis Passive Elastography by : Ali Zorgani
Download or read book Passive Elastography written by Ali Zorgani and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this thesis was the development of a new approach called passive elastography. This approach is inspired from noise correlation methods well developed in seismology and time reversal technics in acoustics. Passive elastography uses shear waves naturally induced in the human body to extract its mechanical properties of soft tissue. The feasibility of this method was tested in several applications. First in ultrasound, slow frame rate ultrasound scanner was used to monitor high intensity focused ultrasound treatment on porcine pancreas. Then, an ultrafast ultrasound scanner was used to retrieve shear wave speed map in a calibrated phantom and in-vivo. Second, Magnetic resonance elastography was implemented to image natural motion in the brain of healthy volunteers and conduct shear wavelength tomography. Third, of ophthalmological and dermatological applications, optical coherence passive elastography was tested in a phantom and a cornea of healthy mouse. Also, a fully optical setup was established to image surface wave for elastography applications. Finally, the resolution limit of elastography was measured using and ultrasound ultrafast scanner.
Book Synopsis Dynamic Optical Coherence Elastography by : José Fernando Zvietcovich Zegarra
Download or read book Dynamic Optical Coherence Elastography written by José Fernando Zvietcovich Zegarra and published by . This book was released on 2020 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Dynamic optical coherence elastography (OCE) is a functional imaging modality which leverages the propagation of mechanical waves in order to estimate the mechanical properties of tissues. It is very useful since it does not require (i) a priori knowledge of force/stress, (ii) mandatory direct contact between the mechanical loading source and the tissue under study, and (iii) large deformation of tissues. Therefore, dynamic OCE shows promise for non-contact, in situ, and in vivo mechanical characterization of tissues with applications in laboratory and clinical studies. To date, the impact of using transient/continuous temporal excitation produced by one/multiple loading sources on the effectiveness of OCE methods for the elastic characterization of tissues has not been fully explored. Further, due to the small field of view of optical coherence tomography (OCT) (~ 2 mm along depth), the complexity of boundary conditions of tissues (such as heterogeneous, composite, or plate-shaped media), and the excitation wavelength (typically between 0.1 mm 10 mm), surface acoustic waves (SAW) are the dominant perturbation. These diminish the capability of OCE methods to estimate depth-dependent tissue elasticity information (such as in layered or composite materials). Moreover, the estimation of viscous parameters in addition to the classic elastic modulus is of great interest since it can provide useful information of disease stages. However, most OCE methods assume a rheological model of tissues and utilize only frequency-dependent wave speed measurements, disregarding valuable information given by the wave attenuation process. Finally, the exploration of novel dynamic OCE techniques to address the aforementioned issues, including the aberration of waves in heterogeneous and anisotropic media and the multiple wave reflections produced by irregular boundary conditions, is highly desired. In this thesis, a comparative study of transient and continuous dynamic OCE methods and estimators when using one or two vibration sources is conducted. Resolution, accuracy error, precision error, and contrast-to-noise ratio are the selected metrics for evaluating the performance of each method in numerical simulations and experiments in tissue-mimicking phantoms. Furthermore, a novel OCE method based on reverberant shear wave fields in elastic media is presented. This method arose as a response to the limitations found in the comparative study developed previously. Numerical simulations and experiments in ex vivo porcine cornea demonstrate the capabilities of the proposed technique for layered material elastic characterization compared to SAW-based OCE methods. Subsequently, a novel technique for the viscoelastic characterization of tissues by propagating Gaussian-shape transient waves using acoustic radiation force (ARF) excitation is developed. Experimental results in viscoelastic tissue-mimicking phantoms validated the proposed approach, accounting for dispersion, distortion, and attenuation of transient waves while not assuming any rheological model for tissue characterization. In addition, a study on longitudinal shear waves generated using a disk-shaped glass plate for the elastic characterization of heterogeneous distributed media is presented. Numerical simulations and experiments in tissue-mimicking phantoms demonstrate the capabilities and difficulties of such waves in detecting vertically and horizontally distributed materials. Preliminary experiments in mouse brain tissue are conducted followed by a discussion on future implementations of this method for in vivo mouse brain elastography studies. Finally, the elastography of small substructures in rabbit cornea produced by localized laser-induced refractive index change (LIRIC treatment) using OCE techniques is explored. In addition, the study of anisotropic tissues (chicken tibialis muscle and porcine brain) using non-contact ARF excitation is conducted. In these studies, a transverse isotropic mechanical model is used and validated. In summary, we have (i) conducted a series of studies using numerical simulations and tissue-mimicking phantoms to understand the nature, properties, and capabilities of mechanical waves for the elastography of tissues; (ii) developed a set of novel dynamic OCE approaches that are capable of detecting subtle changes (>13% change in elastic properties) within tissues, and with a spatial resolution as low as 120 um along lateral axis and 55.5 um along depth axis; and (iii) applied these approaches to the study of tissues with different boundary conditions (composite plate-shaped media such as cornea, mouse in situ brain tissue, etc.) and diverse mechanical properties (viscoelastic, heterogeneous, and anisotropic tissues)"--Pages xviii-xxi.
Book Synopsis Magnetic Resonance Elastography by : Sudhakar K. Venkatesh
Download or read book Magnetic Resonance Elastography written by Sudhakar K. Venkatesh and published by Springer. This book was released on 2014-10-01 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to cover the groundbreaking development and clinical applications of Magnetic Resonance Elastography, this book is essential for all practitioners interested in this revolutionary diagnostic modality. The book is divided into three sections. The first covers the history of MRE. The second covers technique and clinical applications of MRE in the liver with respect to fibrosis, liver masses, and other diseases. Case descriptions are presented to give the reader a hands-on approach. The final section presents the techniques, sequence and preliminary results of applications in other areas of the body including muscle, brain, lung, heart, and breast.
Book Synopsis Cardiovascular Engineering by : Dyah Ekashanti Octorina Dewi
Download or read book Cardiovascular Engineering written by Dyah Ekashanti Octorina Dewi and published by Springer Nature. This book was released on 2019-08-21 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights recent technological advances, reviews and applications in the field of cardiovascular engineering, including medical imaging, signal processing and informatics, biomechanics, as well as biomaterials. It discusses the use of biomaterials and 3D printing for tissue-engineered heart valves, and also presents a unique combination of engineering and clinical approaches to solve cardiovascular problems. This book is a valuable resource for students, lecturers and researchers in the field of biomedical engineering.
Book Synopsis Optical Coherence Elastography by : Brendan F. Kennedy
Download or read book Optical Coherence Elastography written by Brendan F. Kennedy and published by . This book was released on 2021 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Elastography: Imaging Tissue Mechanics on the Micro-Scale provides a unique and practical overview of this important new fi eld, which has seen tremendous growth in the last decade. Using optical coherence tomography (OCT) to measure sample deformation, optical coherence elastography (OCE) provides visualization of the three-dimensional, micro-scale mechanical properties of tissues and biomaterials and has shown distinct promise for application across clinical medicine, biology, and tissue engineering. This timely book provides: -- Detailed coverage of the key elements required for the successful implementation of OCE techniques, particularly OCT imaging, mechanical deformation, and image processing -- Synthesis of theory, methodology, and applications in one resource -- Detailed discussion of the historical context within which OCE has evolved, particularly regarding ultrasound elastography and magnetic resonance elastography -- Perspectives on likely future developments in OCE This book is an invaluable resource for graduate students and researchers in biophotonics and tissue engineering and for professionals working with OCT and elastography.
Book Synopsis Ultrasound Elastography and Characterization of Soft Tissue Mimicking Phantoms by : Rachel Morehouse
Download or read book Ultrasound Elastography and Characterization of Soft Tissue Mimicking Phantoms written by Rachel Morehouse and published by . This book was released on 2010 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nonlinear Theory of Sound Beams by : N.S. Bakhvalov
Download or read book Nonlinear Theory of Sound Beams written by N.S. Bakhvalov and published by American Institute of Physics. This book was released on 1987 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Ultrasound Elastography by : Hossein Khodadadi
Download or read book Ultrasound Elastography written by Hossein Khodadadi and published by . This book was released on 2018 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultrasound elastography involves measuring the mechanical properties of tissue, and has many applications in diagnostics and intervention. Ultrasound elastography techniques mainly target obtaining strain images from raw Radio-Frequency (RF) echo field produced by ultrasound machine without adding any hardware. A common step in different elastography methods is imaging the tissue while it undergoes deformation and estimating the displacement field from the images. A popular next step is to estimate tissue strain, which gives clues into the underlying tissue elasticity modulus. To estimate the strain, one should compute the gradient of the displacement image, which amplifies the noise. The noise is commonly minimized by least square estimation of the gradient from multiple displacement measurements, which reduces the noise by sacrificing image resolution. The first part of this thesis propose a new method which adaptively adjusts the level and orientation of the smoothing strain images using two different mechanisms. First, the precision of the displacement field decreases significantly in the regions with high signal decorrelation, which requires increasing the smoothness. Second, smoothing the strain field at the boundaries between different tissue types blurs the edges, which can render small targets invisible. To minimize blurring and noise, we perform anisotropic smoothing and perform smoothing parallel to the direction of the edges. The first mechanism ensures that textures/variations in the strain image reflect underlying tissue properties and are not caused by errors in the displacement estimation. The second mechanism keeps the edges between different tissue structures sharp while minimizing the noise. The second part of this thesis introduces a 2D strain imaging technique called SHORTCUT (meSHing Of gRadienT in DP for direCt Ultrasound elasTography) based on minimizing a cost function. The cost function incorporates similarity of echo amplitudes and tissue continuity. The proposed technique is fast, robust and accurate and it directly produces the strain images from RF data using a novel dynamic programming (DP) configuration. Unlike the standard DP algorithm which discretizes the decision space (displacement field) and search in the space of piecewise constant functions, the proposed DP discretizes the gradient of the decision space (strain field) and search the space of continuous piecewise linear functions. Eliminating the displacement differentiation block and performing a global search instead of local search which exist in all of the available strain estimation techniques result in substantial improvement in SNR, CNR and accuracy of the estimations. The effectiveness of the proposed methods is investigated through simulation data, phantom experiments, and in vivo patient data.
Book Synopsis Imaging the Mechanical Properties of Tissue with Ultrasound by : Mark Louis Palmeri
Download or read book Imaging the Mechanical Properties of Tissue with Ultrasound written by Mark Louis Palmeri and published by . This book was released on 2005 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis AN INVESTIGATION OF UNCERTAINTY IN ULTRASONIC ELASTOGRAPHY by :
Download or read book AN INVESTIGATION OF UNCERTAINTY IN ULTRASONIC ELASTOGRAPHY written by and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract : Ultrasonic elastography (UE) is a set of ultrasonic imaging techniques used to noninvasively quantify material properties of soft tissues. UE comes in two major forms, strain elastography (SE), in which compressional force is used to produce strain images of human tissues, and shear wave elastography (SWE) in which dynamic excitation is used to induce shear waves and (typically group) shear wave speeds (SWS) are collected from their propagation. Clinical interest in UE lies in its potential for noninvasive screening for pathologies with associated biomechanical property changes, such as breast lesion classification and staging of liver fibrosis. The diagnostic utility of UE hinges on its ability to consistently detect and characterize the underlying mechanical properties of diseased and healthy tissues. A fair amount of analysis and effort has been invested in investigating signal processing and measurement related uncertainty in SWE and SE. Comparatively less attention has been paid to investigating the uncertainty associated with the complex and multifaceted continuum biomechanics that underlies the response of tissue to an UE measurement. This dissertation contains my contributions toward delineating the role of several of these biomechanical facets on UE measurements. Its chapters are composed of a collection of five articles. In the first article, we investigated the contrast transfer characteristics of an advanced form of SE called viscoelastic imaging through mechanical simulations, which was found to be influenced by the non-viscous material characteristics. This motivated a follow up simulation study were we applied a systematic design-of-experiments based approach to determine the material and user dependent factors that most strongly influence traditional SE contrast. We found that along with the initial elasticity of the tissue, elastic nonlinearity and precompression seem to play substantial roles in SE contrast. The other three articles contain my contributions to SWE. Here, a robust approach to SWS estimation based on the method-of-characteristics solution to the 1D elastic wave equation was developed. I also contribute to the theoretical development of acoustoelastic analysis in SWE. From these efforts, it was found that only certain material models could accurately represent SWS along multiple principle axis of deformation and that acoustoelastic analysis can be applied to understanding SWE measurements in the presence of fluid-induced deformation.
Book Synopsis Diagnostic Ultrasound Imaging: Inside Out by : Thomas L. Szabo
Download or read book Diagnostic Ultrasound Imaging: Inside Out written by Thomas L. Szabo and published by Academic Press. This book was released on 2013-12-05 with total page 829 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnostic Ultrasound Imaging provides a unified description of the physical principles of ultrasound imaging, signal processing, systems and measurements. This comprehensive reference is a core resource for both graduate students and engineers in medical ultrasound research and design. With continuing rapid technological development of ultrasound in medical diagnosis, it is a critical subject for biomedical engineers, clinical and healthcare engineers and practitioners, medical physicists, and related professionals in the fields of signal and image processing. The book contains 17 new and updated chapters covering the fundamentals and latest advances in the area, and includes four appendices, 450 figures (60 available in color on the companion website), and almost 1,500 references. In addition to the continual influx of readers entering the field of ultrasound worldwide who need the broad grounding in the core technologies of ultrasound, this book provides those already working in these areas with clear and comprehensive expositions of these key new topics as well as introductions to state-of-the-art innovations in this field. - Enables practicing engineers, students and clinical professionals to understand the essential physics and signal processing techniques behind modern imaging systems as well as introducing the latest developments that will shape medical ultrasound in the future - Suitable for both newcomers and experienced readers, the practical, progressively organized applied approach is supported by hands-on MATLAB® code and worked examples that enable readers to understand the principles underlying diagnostic and therapeutic ultrasound - Covers the new important developments in the use of medical ultrasound: elastography and high-intensity therapeutic ultrasound. Many new developments are comprehensively reviewed and explained, including aberration correction, acoustic measurements, acoustic radiation force imaging, alternate imaging architectures, bioeffects: diagnostic to therapeutic, Fourier transform imaging, multimode imaging, plane wave compounding, research platforms, synthetic aperture, vector Doppler, transient shear wave elastography, ultrafast imaging and Doppler, functional ultrasound and viscoelastic models
Author :American Institute of Ultrasound in Medicine. Technical Standards Committee Publisher : ISBN 13 :9781930047211 Total Pages :14 pages Book Rating :4.0/5 (472 download)
Book Synopsis Methods for Specifying Acoustic Properties of Tissue Mimicking Phantoms and Objects by : American Institute of Ultrasound in Medicine. Technical Standards Committee
Download or read book Methods for Specifying Acoustic Properties of Tissue Mimicking Phantoms and Objects written by American Institute of Ultrasound in Medicine. Technical Standards Committee and published by . This book was released on 1995-01-01 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Real-time Regularized Tracking of Shear-Wave in Ultrasound Elastography by : Mahmoud Derakhshan Horeh
Download or read book Real-time Regularized Tracking of Shear-Wave in Ultrasound Elastography written by Mahmoud Derakhshan Horeh and published by . This book was released on 2017 with total page 87 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elastography is a convenient and affordable method for imaging mechanical properties of tissue, which are often correlated with pathologies. An emerging novel elastography technique applies an external acoustic radiation force (ARF) to generate shear-wave in the tissue which are then tracked using ultrasound imaging. Accurate tracking of the small tissue motion (referred to as tissue displacement) is a critical step in shear-wave elastography, but is challenging due to various sources of noise in the ultrasound data. I formulate tissue displacement estimation as an optimization problem and propose two computationally efficient approaches to estimate the displacement field. The first algorithm is referred to as dynamic programming analytic minimization (DPAM), which utilizes first order Taylor series expansion of the highly nonlinear cost function to allow for its efficient optimization. DPAM was previously proposed for quasi-static elastography and I extend the approach to shear-wave elastography. The second algorithm is a novel technique that exploits second-order Taylor expansion of the non-linear cost function. I call the new algorithm as second-order analytic minimization elastography (SESAME). I compare DMAP and SESAME to the standard normalizedCross Correlation (NCC) approach in the context of estimating displacement and elasticity of the medium for shear-wave elastography (SWE). The results of micrometer-order displacement estimation in a uniform simulation phantom illustrate that SESAME outperforms DPAM, which in turn outperforms NCC in terms of signal to noise ratio (SNR) and jitter. In addition, the relative difference between true and reconstructed shear modulus (averaged over several excitations focusing at different focal depths with different scatterers realizations at each depth) is approximately 3.41%, 1.12% and 1.01%, respectively, for NCC, DPAM and SESAME. The performance of the proposed methods is also assessed with real data acquired using a tissue-mimicking phantom, wherein, in comparison to NCC, DPAM and SESAME improve the SNR of displacement by 7.6 dB and 9.5 dB, respectively. Experimental results on a tissue-mimicking phantom also show that shear modulus reconstruction is more accurate with DPAM and SESAME in comparison with NCC.
Author :American Institute of Ultrasound in Medicine. Technical Standards Committee Publisher : ISBN 13 :9781932962321 Total Pages :24 pages Book Rating :4.9/5 (623 download)
Book Synopsis Methods for Specifying Acoustic Properties of Tissue Mimicking Phantoms and Objects by : American Institute of Ultrasound in Medicine. Technical Standards Committee
Download or read book Methods for Specifying Acoustic Properties of Tissue Mimicking Phantoms and Objects written by American Institute of Ultrasound in Medicine. Technical Standards Committee and published by . This book was released on with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:
