Ubiquitin Family Modifiers And The Proteasome

Download Ubiquitin Family Modifiers And The Proteasome full books in PDF, epub, and Kindle. Read online Ubiquitin Family Modifiers And The Proteasome ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Ubiquitin Family Modifiers and the Proteasome

Author : R. Jürgen Dohmen
Publisher : Humana Press
ISBN 13 : 9781493959051
Total Pages : 666 pages
Book Rating : 4.9/5 (59 download)

DOWNLOAD NOW!

Book Synopsis Ubiquitin Family Modifiers and the Proteasome by : R. Jürgen Dohmen

Download or read book Ubiquitin Family Modifiers and the Proteasome written by R. Jürgen Dohmen and published by Humana Press. This book was released on 2016-08-23 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ubiquitin-proteasome system (UPS) and ubiquitin-related modifiers are not only involved in cellular protein quality control but also in the regulation of many fundamental cellular processes/pathways as well as in their disease-relevant aberrations. Ubiquitin Family Modifiers and Proteasome: Reviews and Protocols presents both novel developments in UPS research and important methods related to the main recent advances in the field of ubiquitin family modifiers. Divided into five convenient sections, this volume focuses on the enzymology and substrate identification of ubiquitin family modifiers, the recognition and chain formation of these modifiers, the analysis of proteasome biogenesis and function, protein quality control, and finally the use of small molecules and strategies to study or manipulate the function of the UPS and of ubiquitin family modifiers, respectively. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Ubiquitin Family Modifiers and Proteasome: Reviews and Protocols will be of great use to investigators and students engaged in both basic and applied research in life sciences.

Conjugation and Deconjugation of Ubiquitin Family Modifiers

Author : Marcus Groettrup
Publisher : Springer Science & Business Media
ISBN 13 : 1441966765
Total Pages : 270 pages
Book Rating : 4.4/5 (419 download)

DOWNLOAD NOW!

Book Synopsis Conjugation and Deconjugation of Ubiquitin Family Modifiers by : Marcus Groettrup

Download or read book Conjugation and Deconjugation of Ubiquitin Family Modifiers written by Marcus Groettrup and published by Springer Science & Business Media. This book was released on 2011-01-11 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: † 1 a a 4 † 17 10 15 ubiquitin; and of 16 VCP 17 18 20 33 34 34 36 p domain. 41 42 42 43 P U 42 47 binding. C. elegans 16 In 21 22 50 51 52 53 13 and UFD 4 10 of Cdc48. 18 30 of Ufd2. COFACTORS 47 23 13 47 47 47 72 15 15 and of Spt23 p90. Ufd2 and Cdc48. In C. elegans 74 16 75 75 76 76 Ufd2 25 54 54 7 56 p47 7 7 80 30 30 81 82 82 but and CD3 26 DUB COFACTORS 30 UFD3 OTU1 4 Cdc48 30 4 OLE1. 15 27 87 REFERENCES 30 REGULATION OF UBIQUITIN MONOUBIQUITINATION UBIQUITINATION 1 32 7 S) d 33 12 13 14 15 18 19 15 20 21 35 15 15 27 15 31 32 31 33 36 monoubiquitination of pol pol 34 37 34 monoubiquitination. 20 35 trans 3 15 REFERENCES by monoubiquitination. Mol Cell; 2009. UBIQUITIN LIGASE ACTIVITY BY Nedd 1 2 of 41 5 6 8 fold. 9 13 14 edd 43 18 18 K M and k 18 22 23 K M 24 25 K M 26 edd 45 18 27 K M K D 18 25 . 8 10 M 21 28 MECHANISM AND REGULATION OF CRLs 34 41 34 edd 47 48 S. pombe 49 51 p27 and I by SCF and SCF 57 58 59 60 CTD CTD CTD CTD in Cul5 CTD CTD CTD 60 18

Ubiquitin and the Biology of the Cell

Author : Jan-Michael Peters
Publisher : Springer Science & Business Media
ISBN 13 : 0306456494
Total Pages : 498 pages
Book Rating : 4.3/5 (64 download)

DOWNLOAD NOW!

Book Synopsis Ubiquitin and the Biology of the Cell by : Jan-Michael Peters

Download or read book Ubiquitin and the Biology of the Cell written by Jan-Michael Peters and published by Springer Science & Business Media. This book was released on 1998-05-31 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last several years have been a landmark period in the ubiquitin field. The breadth of ubiquitin's roles in cell biology was first sketched, and the importance of ubiquitin-dependent proteolysis as a regulatory mechanism gained general acceptance. The many strands of work that led to this new perception are re counted in this book. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M. Rechsteiner (ed. ), Ubiquitin, Plenum Press, 1988]. In this span, students of the cell cycle, transcription, signal transduction, protein sorting, neuropathology, cancer, virology, and immunology have attempted to chart the role of ubi quit in in their particular experimental systems, and this integration of the field into cell biology as a whole continues at a remarkable pace. We hope that for active researchers in the field as well as for newcomers and those on the fence, this book will prove helpful for its breadth, historical perspective, and practical tips. Structural data are now available on many of the components of the ubiquitin pathway. The structures have provided basic insights into the unusual biochemical mechanisms of ubiquitination and proteasome-mediated proteolysis. Because high-speed computer graphics can convey structures more effectively than print media, we have supplemented the figures of the book with a Worldwide Web site that can display the structures in a flexible, viewer-controlled format.

The Ubiquitin System

Author : Milton J. Schlesinger
Publisher : Cold Spring Harbor Laboratory Press
ISBN 13 :
Total Pages : 218 pages
Book Rating : 4.:/5 (319 download)

DOWNLOAD NOW!

Book Synopsis The Ubiquitin System by : Milton J. Schlesinger

Download or read book The Ubiquitin System written by Milton J. Schlesinger and published by Cold Spring Harbor Laboratory Press. This book was released on 1988 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Ubiquitin Proteasome System

Author : Matthew Summers
Publisher : BoD – Books on Demand
ISBN 13 : 1838804900
Total Pages : 228 pages
Book Rating : 4.8/5 (388 download)

DOWNLOAD NOW!

Book Synopsis Ubiquitin Proteasome System by : Matthew Summers

Download or read book Ubiquitin Proteasome System written by Matthew Summers and published by BoD – Books on Demand. This book was released on 2019-06-19 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.

Ubiquitin and Ubiquitin-like Protein Modifiers

Author :
Publisher : Academic Press
ISBN 13 : 0128163607
Total Pages : 432 pages
Book Rating : 4.1/5 (281 download)

DOWNLOAD NOW!

Book Synopsis Ubiquitin and Ubiquitin-like Protein Modifiers by :

Download or read book Ubiquitin and Ubiquitin-like Protein Modifiers written by and published by Academic Press. This book was released on 2019-03-06 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ubiquitination and Protein Stability - Part A Volume 618, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this updated volume presenting interesting chapter written by an international board of authors. Topics of note in this new release include the Preparation of ubiquitinated nucleosomes with native and non-hydrolyzable linkages, Methods to measure ubiquitin chain length and linkage, Genetic approaches to study the yeast ubiquitin system, Enzymatic preparation of monoubiquitinated proteins, Methods to distinguish the function of ubiquitin in autophagy and the proteasome pathway, the Purification and characterization of enzyme activity of USPs, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in this series on enzymology - Updated release includes the latest information on methods to measure ubiquitin chain length and linkage, genetic approaches to study the yeast ubiquitin system, amongst many other timely topics

Ubiquitin

Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1838804323
Total Pages : 126 pages
Book Rating : 4.8/5 (388 download)

DOWNLOAD NOW!

Book Synopsis Ubiquitin by :

Download or read book Ubiquitin written by and published by BoD – Books on Demand. This book was released on 2020-12-09 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain the balance between protein synthesis and degradation in a cell and tissue. Moreover, deubiquitinating enzymes can remove the attached ubiquitin chain, which results in a reverse ubiquitination-deubiquitination process involved in multiple biological processes in a cell and tissue. The changes of components in the ubiquitin-proteasome pathway are associated with multiple pathophysiological processes, such as cancers and neurodegenerative diseases. This book presents the new advances in concepts, analytical methodology, and application of ubiquitin-proteasome pathway for clarification of molecular mechanisms and discovery of new therapeutic targets and drugs in different diseases.

Ubiquitin-Proteasome Protocols

Author : Cam Patterson
Publisher : Springer Science & Business Media
ISBN 13 : 1592598951
Total Pages : 376 pages
Book Rating : 4.5/5 (925 download)

DOWNLOAD NOW!

Book Synopsis Ubiquitin-Proteasome Protocols by : Cam Patterson

Download or read book Ubiquitin-Proteasome Protocols written by Cam Patterson and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of cutting-edge techniques for studying ubiquitin-dependent protein degradation via the proteasome. The topics covered range broadly from basic biochemistry to cellular assays to discovery techniques using mass spectrometric analysis. These biochemical and cellular methods are necessary to explore the ubiquitin-proteasome system and ubiquitin-proteasome-dependent functions. State-of-the-art and user-friendly, Ubiquitin-Proteasome Protocols offers novice and experienced bench scientists alike a thorough compendium of readily reproducible techniques that will accelerate discovery, enhance productivity, and permit manipulation of the system for varied research purposes.

Cell Biology of the Ubiquitin-Proteasome System

Author : R. John Mayer
Publisher : John Wiley & Sons
ISBN 13 : 352762029X
Total Pages : 252 pages
Book Rating : 4.5/5 (276 download)

DOWNLOAD NOW!

Book Synopsis Cell Biology of the Ubiquitin-Proteasome System by : R. John Mayer

Download or read book Cell Biology of the Ubiquitin-Proteasome System written by R. John Mayer and published by John Wiley & Sons. This book was released on 2008-06-25 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third of four volumes discusses the role of ubiquitin-mediated protein breakdown in cellular regulation and physiology. Required reading for molecular biologists, cell biologists and physiologists with an interest in the topic.

The Ubiquitin Proteasome System

Author : Thibault Mayor
Publisher : Humana
ISBN 13 : 9781493993710
Total Pages : 413 pages
Book Rating : 4.9/5 (937 download)

DOWNLOAD NOW!

Book Synopsis The Ubiquitin Proteasome System by : Thibault Mayor

Download or read book The Ubiquitin Proteasome System written by Thibault Mayor and published by Humana. This book was released on 2019-10-06 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: “This volume explores numerous techniques used to study the ubiquitin proteasome system. The chapters in this book are organized into five parts and cover topics such as determining the mechanisms of action for E2s, E3s, and DUB enzymes; the latest advances to study the formation of poly-ubiquitin chains as well as their linkage types; the binding partners of proteins in the UPS; methods for structure determination by x-ray crystallography, cryo electron microscopy and SAXS; screening assays to select for degrons or modulators of E3s and DUBs; proteomics approaches in the ubiquitin field and methods to study 26S proteasome function. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and authoritative, The Ubiquitin Proteasome System: Methods and Protocols is a valuable resource for both experienced and novice scientists who are interested in expanding their knowledge in this field.

Ubiquitin Proteasome System

Author : Aldrin V. Gomes
Publisher :
ISBN 13 : 9781536135190
Total Pages : 287 pages
Book Rating : 4.1/5 (351 download)

DOWNLOAD NOW!

Book Synopsis Ubiquitin Proteasome System by : Aldrin V. Gomes

Download or read book Ubiquitin Proteasome System written by Aldrin V. Gomes and published by . This book was released on 2018 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, major advancements in our understanding of the ubiquitin-proteasome system (UPS) have occurred. This book focuses on recent trends in the UPS. The UPS is possibly the most complex of all intracellular pathways - as close to 7% of all genes in the human genome make up part of the UPS. This complex system serves as an essential role in intracellular protein degradation, and because of its critical function, improper functioning of the UPS is associated with nearly all know diseases, including cancer, cardiovascular disease, and neurological diseases. The proteolytic component of the UPS is the proteasome, a multicatalytic complex found in the nucleus and cytoplasm. Another form of the proteasome, the immunoproteasome, is less abundant than the constitutive proteasome, but is important in immune response and degradation of oxidized proteins, and recent research suggests that it may be important in longevity. The articles in this book discuss recent findings which indicate that mutations in proteins involved with the UPS are associated with genetic diseases such as familial dilated cardiomyopathy, Nakajo syndrome, and spinal muscular atrophy (X-linked). Some chapters also discuss recent results which suggest that the UPS is heavily regulated by post-translational modifications such as phosphorylation, acetylation, and methylation. The UPS is also heavily regulated by ubiquitination itself. This book contains a research article using PubMed bibliometric data to present current research trends in the UPS. Articles are written so that no one tissue is emphasized to allow readers from any discipline to benefit from this information.

The Ubiquitin Proteasome System

Author : Thibault Mayor
Publisher :
ISBN 13 : 9781493987061
Total Pages : 413 pages
Book Rating : 4.9/5 (87 download)

DOWNLOAD NOW!

Book Synopsis The Ubiquitin Proteasome System by : Thibault Mayor

Download or read book The Ubiquitin Proteasome System written by Thibault Mayor and published by . This book was released on 2018 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores numerous techniques used to study the ubiquitin proteasome system. The chapters in this book are organized into five parts and cover topics such as determining the mechanisms of action for E2s, E3s, and DUB enzymes; the latest advances to study the formation of poly-ubiquitin chains as well as their linkage types; the binding partners of proteins in the UPS; methods for structure determination by x-ray crystallography, cryo electron microscopy and SAXS; screening assays to select for degrons or modulators of E3s and DUBs; proteomics approaches in the ubiquitin field and methods to study 26S proteasome function. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and authoritative, The Ubiquitin Proteasome System: Methods and Protocols is a valuable resource for both experienced and novice scientists who are interested in expanding their knowledge in this field.

Auxin Molecular Biology

Author : Cathérine Perrot-Rechenmann
Publisher : Springer Science & Business Media
ISBN 13 : 9401003777
Total Pages : 181 pages
Book Rating : 4.4/5 (1 download)

DOWNLOAD NOW!

Book Synopsis Auxin Molecular Biology by : Cathérine Perrot-Rechenmann

Download or read book Auxin Molecular Biology written by Cathérine Perrot-Rechenmann and published by Springer Science & Business Media. This book was released on 2011-06-27 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: The plant hormone auxin plays a fundamental role in the growth and development of plants. Researchers from across the globe are currently attempting to unravel the molecular mechanisms by which auxin controls such diverse processes as cell division, cell elongation, and differentiation. Research questions on auxin action are being addressed using state-of-the-art techniques that are available to cell biologists, geneticists, molecular biologists, biochemists, and physiologists. This text highlights many of the major topics that were covered in a recent workshop that was specifically focused on research into the mechanisms of auxin action. The articles in this text give a current update of the research findings on auxin biosynthesis, metabolism and transport; evolutionary patterns; auxin perception, signal transduction and physiology; auxin-regulated gene expression and protein degradation pathway in auxin responses; and cross-talk between auxin and other plant signalling pathways.

Plant Resistance to Viruses

Author : David Evered
Publisher : John Wiley & Sons
ISBN 13 : 0470513578
Total Pages : 226 pages
Book Rating : 4.4/5 (75 download)

DOWNLOAD NOW!

Book Synopsis Plant Resistance to Viruses by : David Evered

Download or read book Plant Resistance to Viruses written by David Evered and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concern about the environmental consequences of the widespread use of pesticides has increased, and evidence of pesticide-resistant virus vectors have continued to emerge. This volume presents a timely survey of the mechanisms of plant resistance and examines current developments in breeding for resistance, with particular emphasis on advances in genetic engineering which allow for the incorporation of viral genetic material into plants. Discusses the mechanisms of innate resistance in strains of tobacco, tomato, and cowpea; various aspects of induced resistance, including the characterization and roles of the pathogenesis-related proteins; antiviral substances and their comparison with interferon; and cross-protection between plant virus strains. Also presents several papers which evaluate the status of genetic engineering as it relates to breeding resistant plants. Among these are discussions of the potential use of plant viruses as gene vectors, gene coding for viral coat protein, satellite RNA, and antisense RNA, and practical issues such as the durability of resistant crop plants in the field.

Muscle Atrophy

Author : Junjie Xiao
Publisher : Springer
ISBN 13 : 9811314357
Total Pages : 618 pages
Book Rating : 4.8/5 (113 download)

DOWNLOAD NOW!

Book Synopsis Muscle Atrophy by : Junjie Xiao

Download or read book Muscle Atrophy written by Junjie Xiao and published by Springer. This book was released on 2018-11-02 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thirdly, the book reviews the molecular mechanisms of muscle atrophy, including protein degradation and synthesis pathways, noncoding RNAs, inflammatory signaling, oxidative stress, mitochondria signaling, etc. Fourthly, it highlights the pathophysiological mechanisms of muscle atrophy in aging and disease. The book’s fifth and final part covers the diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy. The book will appeal to a broad readership including scientists, undergraduate and graduate students in medicine and cell biology.

Protein Degradation

Author : R. John Mayer
Publisher : Wiley-VCH
ISBN 13 : 9783527314355
Total Pages : 252 pages
Book Rating : 4.3/5 (143 download)

DOWNLOAD NOW!

Book Synopsis Protein Degradation by : R. John Mayer

Download or read book Protein Degradation written by R. John Mayer and published by Wiley-VCH. This book was released on 2006-10-27 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation. The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway. Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, it also presents the latest results on novel members of the ubiquitin superfamily and their role in cellular regulation. Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

SUMOylation and Ubiquitination

Author : Van G. Wilson
Publisher :
ISBN 13 : 9781912530120
Total Pages : 512 pages
Book Rating : 4.5/5 (31 download)

DOWNLOAD NOW!

Book Synopsis SUMOylation and Ubiquitination by : Van G. Wilson

Download or read book SUMOylation and Ubiquitination written by Van G. Wilson and published by . This book was released on 2019-09 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most proteins undergo post-translational modifications altering physical and chemical properties, folding, conformation distribution, stability, activity and function. Ubiquitin and SUMOs are related small proteins that are members of the large ubiquitin superfamily of post-translational modifiers. Written by highly respected leaders in their fields under the expert guidance of the editor, this volume covers the principles of ubiquitination and SUMOylation, presents detailed reviews of current and emerging concepts and highlights new advances in all areas of SUMOylation and ubiquitination. Topics of note include: the ubiquitin superfamily, the ubiquitin toolbox, onco viral exploitation of the SUMO system, small molecule modulators of desumoylation, mass spectrometry, global proteomic profiling of SUMO and ubiquitin, biotin-based approaches, genetic screening, SUMOylation networks in humans, targets for ubiquitin ligases, regulation of p53, protein homeostasis, miRNAs, DNA replication, DNA damage response, telomere biology, intracellular trafficking, regulation of angiogenesis, brain ischemia, autophagy, assembly and activity, antiviral defense, HIV infection, amyloid and amyloid-like proteins, plant immunity. This comprehensive and up-to-date book is the definitive reference volume on all aspects of SUMOylation and ubiquitination and is an essential acquisition for anyone involved in this area of biology.