Tumor Dormancy Quiescence And Senescence Vol 3

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Tumor Dormancy, Quiescence, and Senescence, Vol. 3

Author : M.A. Hayat
Publisher : Springer
ISBN 13 : 9401793255
Total Pages : 160 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Tumor Dormancy, Quiescence, and Senescence, Vol. 3 by : M.A. Hayat

Download or read book Tumor Dormancy, Quiescence, and Senescence, Vol. 3 written by M.A. Hayat and published by Springer. This book was released on 2014-09-12 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third volume in the series Tumor Dormancy, Quiescence, and Senescence discusses the role of tumor dormancy and senescence in a number of diseases, including breast cancer, ovarian cancer and leukemia. The contents are organized under five subheadings: General Applications, Role in Breast Cancer, Role in Ovarian Cancer, Role in Leukemia and Role in Cardiovascular Disease. The first section includes basic information on the definition of dormancy, how cells become senescent and what they do, along with an appraisal of the current state of research on dormancy. Section Two explores dormancy in breast cancer, including the progression of hormone-dependent mammary tumors after dormancy. Section Three details the resistance of Type II ovarian tumors, in which the resistant tumor cell population persists after chemotherapy in a state of dormancy, with recurrent tumors arising upon transformation of such dormant cells back to malignant growth. This section explains how lineage, histological subtypes and grade influence the differential response of ovarian cancer resistance to platinum drugs. The fourth section explores leukemia, discussing regulation of the promyelocytic leukemia protein and its role in premature senescence. The final section explores the role of senescence and autophagy in age-related cardiovascular diseases and the observation that autophagy seems to retard cardiac senescence. Like the two preceding volumes in the series, Volume 3 stands out for its comprehensive approach, its roster of some 26 expert contributors representing seven different countries and its up-to-date review of leading-edge technology and methods.

Tumor Dormancy, Quiescence, and Senescence, Volume 1

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9400759584
Total Pages : 332 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Tumor Dormancy, Quiescence, and Senescence, Volume 1 by : M.A. Hayat

Download or read book Tumor Dormancy, Quiescence, and Senescence, Volume 1 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a particular emphasis on tumor dormancy in breast, lung, prostate, and liver cancers, as well as in melanoma, this first volume of a new Springer series focuses on the interrelationship between biological processes of aging and tumors—both dormant and quiescent. With detail supplied by numerous international researchers at the forefront of cancer research, the book examines a host of differing aspects of the topic. Featured contributions analyze the role of the quiescent state in regulating hematopoietic and muscle stem cells. They also explore the mediation, by the kinase, in the reversible quiescent state of a subset of ovarian, pancreatic, and colon cancers. The book includes key research on the molecular mechanisms underlying stress-induced cellular senescence, in addition to those governing the accumulation of reactive oxygen species, and the induction of premature senescence. It also provides information on suppressing cellular senescence in the most common, and most aggressive malignant primary brain tumor in humans, glioblastoma multiforme. With comprehensive and cutting-edge information on therapeutic interventions and on the correct diagnosis of relevant neoplasms, and with numerous color illustrations, this is the most up-to-date assessment of current medical knowledge in this crucial area of medical research.

Tumor Dormancy, Quiescence, and Senescence, Volume 2

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9400777264
Total Pages : 336 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Tumor Dormancy, Quiescence, and Senescence, Volume 2 by : M.A. Hayat

Download or read book Tumor Dormancy, Quiescence, and Senescence, Volume 2 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2013-11-29 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases such as breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M. A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor. Taking a broad and varied perspective, this volume was written by 70 contributors representing 11 countries.

Human Cell Transformation

Author : Johng S. Rhim
Publisher : Springer Nature
ISBN 13 : 3030222543
Total Pages : 246 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Human Cell Transformation by : Johng S. Rhim

Download or read book Human Cell Transformation written by Johng S. Rhim and published by Springer Nature. This book was released on 2019-10-01 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, part contributed volume, part proceedings, discusses state-of-the-art advances on human cell transformation in cell models for the study of cancer and aging. Several of the chapters are from the Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging conference that was held in June 2018 at McGill University. The authors represent international expertise on a wide variety of topics ranging from different types of cancer (prostate, bone, breast, etc.) to tumor microenvironment, tumor progression, homogeneity, and possible therapies and treatments.

Autophagy and Senescence in Cancer Therapy

Author :
Publisher : Academic Press
ISBN 13 : 0128241594
Total Pages : 384 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Autophagy and Senescence in Cancer Therapy by :

Download or read book Autophagy and Senescence in Cancer Therapy written by and published by Academic Press. This book was released on 2021-04-13 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more. - Addresses the relationship between autophagy and senescence in cancer therapy - Covers autophagy and senescence in tumor dormancy - Explores autophagy and senescence in disease recurrence

Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cells

Author : Carlos Hermano J. Pinheiro
Publisher : Frontiers Media SA
ISBN 13 : 2889198324
Total Pages : 261 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cells by : Carlos Hermano J. Pinheiro

Download or read book Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cells written by Carlos Hermano J. Pinheiro and published by Frontiers Media SA. This book was released on 2016-05-25 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: The search for knowledge on cellular and molecular mechanisms involved in skeletal muscle mass homeostasis and regeneration is an exciting scientific area and extremely important to develop therapeutic strategies for neuromuscular disorders and conditions related to muscle wasting. The mechanisms involved in the regulation of skeletal muscle mass and regeneration consist of molecular signaling pathways modulating protein synthesis and degradation, bioenergetics alterations and preserved function of muscle stem cells. In the last years, different kinds of stem cells has been reported to be localized into skeletal muscle (satellite cells, mesoangioblasts, progenitor interstitial cells and others) or migrate from non-muscle sites, such as bone marrow, to muscle tissue in response to injury. In addition, myogenic progenitor cells are also activated in skeletal muscle wasting disorders. The goal of this research topic is to highlight the available knowledge regarding skeletal muscle and stem cell biology in the context of both physiological and pathological conditions. Our purpose herein is to facilitate better dissemination of research into skeletal muscle physiology field. Frontiers in Physiology is a journal indexed in: PubMed Central, Scopus, Google Scholar, DOAJ, CrossRef.

Advances in Stem Cell Aging

Author : K.L. Rudolph
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318021717
Total Pages : 135 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Advances in Stem Cell Aging by : K.L. Rudolph

Download or read book Advances in Stem Cell Aging written by K.L. Rudolph and published by Karger Medical and Scientific Publishers. This book was released on 2012-09-27 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including leukemia and colorectal cancer. Stem cells are the most long-lived cells in the proliferative compartment of mammalian tissues. Therefore, stem cells have an increased risk of acquiring mutations that could ultimately lead to the transformation of tissue stem cells.This publication presents the current knowledge in the field of stem cell aging, which was discussed at the Else Kröner-Fresenius Symposium on Advances in Stem Cell Aging in 2011. It will be of special interest to scientists working on stem cell research, aging, regeneration, and cancer as well as physicians and scientists specializing in geriatric medicine, internal medicine, and surgery.

Cellular Quiescence

Author : H. Daniel Lacorazza
Publisher : Humana Press
ISBN 13 : 9781493973705
Total Pages : 303 pages
Book Rating : 4.9/5 (737 download)

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Book Synopsis Cellular Quiescence by : H. Daniel Lacorazza

Download or read book Cellular Quiescence written by H. Daniel Lacorazza and published by Humana Press. This book was released on 2017-10-18 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores methods and protocols that aim to increase our understanding of how cells enter a quiescent state during homeostasis and how cells exit quiescence and re-enter differentiating cell divisions to restore damaged tissues, essential for developing new approaches in regenerative medicine in the future. The chapters in this book were designed to address cellular quiescence in prokaryote and eukaryote organisms, detection of quiescence (Hoechst/pyronin Y, FUCCI, CFSE, BrdU, H2B-GFP, CyTOF), quiescence in stem cells (skin, intestinal, neuronal, hematopoietic), genomic regulation (gene expression, transcription factors, lncRNA, RNA methylation), as well as analysis of the heterogeneity of quiescence by computer modeling. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cellular Quiescence: Methods and Protocols offers a broad view of basic and cutting-edge technology to inspire research in this emerging field of cell biology.

Chromatin Readers in Health and Disease

Author : Olivier Binda
Publisher : Academic Press
ISBN 13 : 0323903142
Total Pages : 422 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Chromatin Readers in Health and Disease by : Olivier Binda

Download or read book Chromatin Readers in Health and Disease written by Olivier Binda and published by Academic Press. This book was released on 2023-09-22 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Readers in Health and Disease, Volume 35, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chromatin readers regulate access to genetic information, and how their aberrant regulation can contribute to human pathologies. Chromatin readers discussed include 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR, BRCT, bromodomains and Kac readers, chromodomains and chromobarrel readers, citrullination readers, macrodomains and poly-ADP-ribose readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor and TTD, UDR and ubiquitin, WD40, YEATS (crotonyl reader), MBD, SRA, and Methyl-RNA readers.In the book, more than a dozen leaders in the field examine a range of protein readers, their relationship to human disease, and the early therapeutics that act as chromatin signaling factors to treat cancers and Huntington's disease, among other disorders. - Enables researchers and clinicians to understand chromatin signaling mechanisms that regulate gene expression through chromatin readers - Highlights the role of chromatin readers in a variety of human pathologies, as well as early therapeutics that act on chromatin signaling - Includes chapter contributions from international leaders in the field

Cancer Cell Dormancy

Author : Marco Montagner
Publisher : Springer Nature
ISBN 13 : 1071638823
Total Pages : 230 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Cancer Cell Dormancy by : Marco Montagner

Download or read book Cancer Cell Dormancy written by Marco Montagner and published by Springer Nature. This book was released on with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Cancer Stem Cell Niche

Author : Susie Nilsson
Publisher : Academic Press
ISBN 13 : 0323853250
Total Pages : 246 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis The Cancer Stem Cell Niche by : Susie Nilsson

Download or read book The Cancer Stem Cell Niche written by Susie Nilsson and published by Academic Press. This book was released on 2021-02-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche

Phospholipases in Physiology and Pathology

Author : Sajal Chakraborti
Publisher : Elsevier
ISBN 13 : 0323956882
Total Pages : 2974 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Phospholipases in Physiology and Pathology by : Sajal Chakraborti

Download or read book Phospholipases in Physiology and Pathology written by Sajal Chakraborti and published by Elsevier. This book was released on 2023-08-17 with total page 2974 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phospholipases in Physiology and Pathology presents a comprehensive overview on the physiology and pathology of phospholipases. This seven-volume set considers the biochemical and molecular mechanisms of normal and abnormal cell function upon dysregulation of phospholipases in different diseases. Volumes cover signal transduction mechanisms, implications in cancer, infectious diseases, neural diseases, cardiovascular diseases and other diseases, implications in inflammation, apoptosis, gene expression and non-coding RNAs, the role of natural and synthetic compounds, and stem cell therapies, nanotechnology-based therapies, and more. Together, these volumes give researchers critical insight on the mechanistic and therapeutic aspects of phospholipases. - Discusses the biochemical and molecular mechanisms of normal and abnormal cell function in different disease processes - Covers a wide range of basic and translational research appropriate for scientists engaged in studying the regulation of phospholipases from interdisciplinary perspectives - Features state-of-the-art chapter contributions from international leaders in the field

Insect Diapause

Author : David L. Denlinger
Publisher : Cambridge University Press
ISBN 13 : 1108755186
Total Pages : 465 pages
Book Rating : 4.1/5 (87 download)

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Book Synopsis Insect Diapause by : David L. Denlinger

Download or read book Insect Diapause written by David L. Denlinger and published by Cambridge University Press. This book was released on 2022-02-03 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our highly seasonal world restricts insect activity to brief portions of the year. This feature necessitates a sophisticated interpretation of seasonal changes and enactment of mechanisms for bringing development to a halt and then reinitiating it when the inimical season is past. The dormant state of diapause serves to bridge the unfavourable seasons, and its timing provides a powerful mechanism for synchronizing insect development. This book explores how seasonal signals are monitored and used by insects to enact specific molecular pathways that generate the diapause phenotype. The broad perspective offered here scales from the ecological to the molecular and thus provides a comprehensive view of this exciting and vibrant research field, offering insights on topics ranging from pest management, evolution, speciation, climate change and disease transmission, to human health, as well as analogies with other forms of invertebrate dormancy and mammalian hibernation.

Tumor Microenvironment and Cellular Stress

Author : Constantinos Koumenis
Publisher : Springer Science & Business Media
ISBN 13 : 146145915X
Total Pages : 293 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Tumor Microenvironment and Cellular Stress by : Constantinos Koumenis

Download or read book Tumor Microenvironment and Cellular Stress written by Constantinos Koumenis and published by Springer Science & Business Media. This book was released on 2013-11-23 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.

The Drosophila Model in Cancer

Author : Wu-Min Deng
Publisher : Springer Nature
ISBN 13 : 3030236293
Total Pages : 251 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis The Drosophila Model in Cancer by : Wu-Min Deng

Download or read book The Drosophila Model in Cancer written by Wu-Min Deng and published by Springer Nature. This book was released on 2019-09-13 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.

Tumor Progression and Therapeutic Resistance

Author : Wafik S. El-Deiry
Publisher :
ISBN 13 :
Total Pages : 222 pages
Book Rating : 4.X/5 (3 download)

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Book Synopsis Tumor Progression and Therapeutic Resistance by : Wafik S. El-Deiry

Download or read book Tumor Progression and Therapeutic Resistance written by Wafik S. El-Deiry and published by . This book was released on 2005 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the entire breadth of translational cancer research and brings together members of academia and industry in the expectation of accelerating interactions and progress in the field. A variety of key topics are presented, beginning with discovery of molecular targets and pathways (oncogene, cell survival, tumor suppression, cell death), host-neoplasm interactions (cell adhesion, matrix proteases), early detection, monitoring progression, understanding tumor progression and metastasis, immune surveillance, in vivo molecular imaging, animal models, drug discovery including chemistry, high-throughput assays, mechanism determination, target validation, therapeutic window and some progress in clinical trials for more advanced agents and targets.

Cancer Stem Cell Resistance to Targeted Therapy

Author : Cristina Maccalli
Publisher : Springer
ISBN 13 : 9783030166267
Total Pages : 256 pages
Book Rating : 4.1/5 (662 download)

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Book Synopsis Cancer Stem Cell Resistance to Targeted Therapy by : Cristina Maccalli

Download or read book Cancer Stem Cell Resistance to Targeted Therapy written by Cristina Maccalli and published by Springer. This book was released on 2020-08-14 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents an up-dated summary of the state of the art of the characterization of cancer stem cell/ cancer initiating cell (CSC/CIC) properties. An overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.