Autophagy and Senescence in Cancer Therapy

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Author :
Publisher : Academic Press
ISBN 13 : 0128241594
Total Pages : 384 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Autophagy and Senescence in Cancer Therapy by :

Download or read book Autophagy and Senescence in Cancer Therapy written by and published by Academic Press. This book was released on 2021-04-13 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more. Addresses the relationship between autophagy and senescence in cancer therapy Covers autophagy and senescence in tumor dormancy Explores autophagy and senescence in disease recurrence

Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889454223
Total Pages : 111 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy by : Patrizia Agostinis

Download or read book Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy written by Patrizia Agostinis and published by Frontiers Media SA. This book was released on 2018-02-19 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macroautophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, has emerged as a key process modulating tumorigenesis, tumor–stroma interactions, and cancer therapy. An impressive number of studies over the past decade have unraveled the plastic role of autophagy during tumor development and dissemination. The discoveries that autophagy may either support or repress neoplastic growth and contextually favor or weaken resistance and impact antitumor immunity have spurred efforts from many laboratories trying to conceptualize the complex role of autophagy in cancer using cellular and preclinical models. This complexity is further accentuated by recent findings highlighting that various autophagy-related genes have roles beyond this catabolic mechanism and interface with oncogenic pathways, other trafficking and degradation mechanisms and the cell death machinery. From a therapeutic perspective, knowledge of how autophagy modulates the tumor microenvironment is crucial to devise autophagy-targeting strategies using smart combination of drugs or anticancer modalities. This eBook contains a collection of reviews by autophagy researchers and provides a background to the state-of-the-art in the field of autophagy in cancer, focusing on various aspects of autophagy regulation ranging from its molecular components to its cell autonomous role, e.g. in cell division and oncogenesis, miRNAs regulation, cross-talk with cell death pathways as well as cell non-autonomous role, e.g. in secretion, interface with tumor stroma and clinical prospects of autophagy-based biomarkers and autophagy modulators in anticancer therapy. This eBook is part of the TransAutophagy initiative to better understand the clinical implications of autophagy in cancer.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

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Author :
Publisher : Academic Press
ISBN 13 : 0128121475
Total Pages : 622 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by : M. A. Hayat

Download or read book Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging written by M. A. Hayat and published by Academic Press. This book was released on 2017-09-07 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 12 discusses and details almost all aspects of the autophagy machinery in the context of health, cancer and other pathologies. Autophagy is more widely accepted as beneficial given its role in eliminating ‘toxic assets’ and promoting cell viability, hence, it has emerged as a new and potent modulator of disease progression that is both scientifically intriguing and clinically relevant. As the latest release in the Autophagy book series, users will find a detailed explanation of the role of molecular mechanisms. Presents the most advanced information regarding the role of the autophagic system in life and death States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities Summarizes the most up-to-date findings on how autophagy is executed and regulated at the molecular level and how its disruption can lead to disease Authored by global leaders in the field, bringing the broadest, most expert coverage available

Advances in Cancer Research

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Author :
Publisher : Elsevier
ISBN 13 : 0443192812
Total Pages : 332 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Advances in Cancer Research by :

Download or read book Advances in Cancer Research written by and published by Elsevier. This book was released on 2023-09-12 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, Volume 160, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research, with this updated edition covering PFKP: More Than Phosphofructokinase, Setting sail: maneuvering SHP2 activity and its effects in cancer, Mechanical factors driving cancer progression, Microsomal Glutathione Transferase 1 in Cancer and the Regulation of Ferroptosis, Lnc-ing epigenetic mechanisms with autophagy and cancer drug resistance, Head and Neck Cancer Treatment in the Era of Molecular Medicine, Applications of Tissue-Specific and Cancer-Selective Gene Promoters for Cancer Diagnosis and Therapy, and more. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

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Author :
Publisher : Academic Press
ISBN 13 : 0128094273
Total Pages : 430 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by : M. A. Hayat

Download or read book Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging written by M. A. Hayat and published by Academic Press. This book was released on 2016-12-28 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Apoptosis, Senescence and Cancer

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1597452211
Total Pages : 596 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Apoptosis, Senescence and Cancer by : David A. Gewirtz

Download or read book Apoptosis, Senescence and Cancer written by David A. Gewirtz and published by Springer Science & Business Media. This book was released on 2007-10-23 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides insight into established practices and research into apoptosis and senescence. The volume thoroughly examines novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics that still hold mysteries for researchers. In total, this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment, both in the initial stages of the disease as well as in disease recurrence.

Senolytics in Disease, Ageing and Longevity

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Author :
Publisher : Springer Nature
ISBN 13 : 3030449033
Total Pages : 226 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Senolytics in Disease, Ageing and Longevity by : Daniel Muñoz-Espin

Download or read book Senolytics in Disease, Ageing and Longevity written by Daniel Muñoz-Espin and published by Springer Nature. This book was released on 2020-04-27 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. First documented in the 1960s, the concept of cellular senescence as an underlying cause of ageing has been established in the course of the last decade. Using genetically engineered mouse models, researchers have demonstrated that the selective elimination of senescent cells can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic diseases resulting in organ dysfunction; the integrity of the musculoskeletal system; and cancer. Some senolytic agents have already progressed into trials. These include UBX0101 for the treatment of osteoarthritis (now in phase II), a cocktail of dasatinib and quercetin for the management of idiopathic pulmonary fibrosis and chronic kidney disease, and ABT-263 in combination with senescence-inducing chemotherapies for the treatment of advanced solid tumours. In addition, the book discusses pathways to early phase clinical trials and translational approaches in medicine and ageing, highlighting new opportunities as well as current limitations, challenges and alternatives. Given its scope, it will benefit a broad audience of advanced educators, researchers, graduate students and practitioners.

Novel Cancer Treatments based on Autophagy Modulation

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889668738
Total Pages : 236 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Novel Cancer Treatments based on Autophagy Modulation by : Marco Cordani

Download or read book Novel Cancer Treatments based on Autophagy Modulation written by Marco Cordani and published by Frontiers Media SA. This book was released on 2021-06-11 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Tumor Cell Metabolism and Autophagy as Therapeutic Targets

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Publisher : Frontiers Media SA
ISBN 13 : 2889665003
Total Pages : 233 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Tumor Cell Metabolism and Autophagy as Therapeutic Targets by : Carlos Pérez-Plasencia

Download or read book Tumor Cell Metabolism and Autophagy as Therapeutic Targets written by Carlos Pérez-Plasencia and published by Frontiers Media SA. This book was released on 2021-02-24 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Senescence

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 9535134612
Total Pages : 167 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Senescence by : Jolanta Dorszewska

Download or read book Senescence written by Jolanta Dorszewska and published by BoD – Books on Demand. This book was released on 2017-08-30 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the second half of the twentieth century, life expectancy was prolonged, and the number of elderly people increased. The effect of population aging increases in the frequency of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, epilepsy, and stroke. Also, a higher incidence of infections, autoimmune diseases, and malignant cancers is observed in elderly people. The aging process is difficult to define. Are physiological changes in elderly people controlled by specific genes? Is aging process a pathophysiology affecting different organs with different severity? Finding answers to these questions may help prevent age-related diseases and improve the quality of life of old people. This book was made as a compendium on contemporary challenges in senescence.

Targeting autophagy in cancer therapy: Focus on small-molecule modulators and new strategies

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832515746
Total Pages : 158 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Targeting autophagy in cancer therapy: Focus on small-molecule modulators and new strategies by : Chen Yi

Download or read book Targeting autophagy in cancer therapy: Focus on small-molecule modulators and new strategies written by Chen Yi and published by Frontiers Media SA. This book was released on 2023-04-17 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Autophagy in tumor and tumor microenvironment

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Author :
Publisher : Springer Nature
ISBN 13 : 9811569304
Total Pages : 284 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Autophagy in tumor and tumor microenvironment by : Sujit Kumar Bhutia

Download or read book Autophagy in tumor and tumor microenvironment written by Sujit Kumar Bhutia and published by Springer Nature. This book was released on 2020-10-24 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.

Geriatric Oncology

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Publisher : Springer
ISBN 13 : 9783319574141
Total Pages : 1150 pages
Book Rating : 4.5/5 (741 download)

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Book Synopsis Geriatric Oncology by : Martine Extermann

Download or read book Geriatric Oncology written by Martine Extermann and published by Springer. This book was released on 2020-01-30 with total page 1150 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended as a comprehensive resource for clinicians and researchers seeking in-depth information on geriatric oncology. The coverage encompasses epidemiology, the biology and (patho)physiology of aging and cancer, geriatric assessment and management, hematologic malignancies, solid tumors, issues in patient care, and research methods. Since cancer is a disease of aging and people are living longer, most cancer patients are now aged 70 and older. Yet the more we age, the more diverse we become in terms of our health, biologic fitness, and cancer behavior. Typically, however, general oncology clinical trials address only a selected healthier and younger population of patients. Geriatric oncology is the area of oncology that addresses these issues but while a wealth of knowledge has been accumulated, information is often difficult to retrieve or insufficiently detailed. The SpringerReference program, in which this book is published, offers an ideal format for overcoming these limitations since it combines thorough coverage with access to living editions constantly updated chapter by chapter via a dynamic peer-review process, ensuring that information remains current and pertinent.

Targeting Autophagy in Cancer Therapy

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Author :
Publisher : Springer
ISBN 13 : 3319427407
Total Pages : 141 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Targeting Autophagy in Cancer Therapy by : Jin-Ming Yang

Download or read book Targeting Autophagy in Cancer Therapy written by Jin-Ming Yang and published by Springer. This book was released on 2016-09-02 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will detail the current state and perspectives of autophagy-based cancer therapy. Covering a wide range of topics, it will include an overview of autophagy as a therapeutic target in cancer, autophagy modulators as cancer therapeutic agents, implications of micro-RNA-regulated autophagy in cancer therapy, modulation of autophagy through targeting PI3 kinase in cancer therapy, targeting autophagy in cancer stem cells, and roles of autophagy in cancer immunotherapy. In addition, the volume will review applications of system biology and bioinformatics approaches to discovering cancer therapeutic targets in the autophagy regulatory network. The volume will be beneficial for a variety of basic and clinical scientists, including cancer biologists, autophagy researchers, pharmacologists, and clinical oncologists who wish to delve more deeply into this field of cancer research. This volume will be the first book to focus solely on autophagy as a target in cancer therapy. As well, it will comprehensively discuss the roles of autophagy in most currently available cancer treatments.

Cell Death

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Publisher : BoD – Books on Demand
ISBN 13 : 9535122363
Total Pages : 448 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Cell Death by : Tobias Ntuli

Download or read book Cell Death written by Tobias Ntuli and published by BoD – Books on Demand. This book was released on 2015-12-16 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.

Autophagy in Immune Response: Impact on Cancer Immunotherapy

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Author :
Publisher : Academic Press
ISBN 13 : 0128196092
Total Pages : 242 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Autophagy in Immune Response: Impact on Cancer Immunotherapy by : Salem Chouaib

Download or read book Autophagy in Immune Response: Impact on Cancer Immunotherapy written by Salem Chouaib and published by Academic Press. This book was released on 2020-05-25 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy in Immune Response: Impact on Cancer Immunotherapy focuses on the status and future directions of autophagy with respect to different aspects of its interaction with the immune system and immunotherapy. The book takes scientific research in autophagy a step further by presenting reputable information on the topic and offering integrated content with advancements in autophagy, from cell biology and biochemical research, to clinical treatments. This book is a valuable source for cancer researchers, oncologists, graduate students and several members of biomedical field who are interested in learning more on the relationship between autophagy and immunotherapies. Presents updated knowledge on autophagy at the basic level and its potential use in cancer treatment Offers the first book to cover autophagy at the interface of cell biology, immunology and tumor biology Provides a wealth of information on the topic in a coherent and comprehensive collection of contributions by world renowned scientists and investigators

Targeting redox regulation and autophagy systems for cancer therapy

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832516688
Total Pages : 185 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Targeting redox regulation and autophagy systems for cancer therapy by : Junmin Zhang

Download or read book Targeting redox regulation and autophagy systems for cancer therapy written by Junmin Zhang and published by Frontiers Media SA. This book was released on 2023-03-03 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: