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Translational Approaches To Autism Spectrum Disorder
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Book Synopsis Translational Approaches to Autism Spectrum Disorder by : Maria de los Angeles Robinson-Agramonte
Download or read book Translational Approaches to Autism Spectrum Disorder written by Maria de los Angeles Robinson-Agramonte and published by Springer. This book was released on 2015-06-10 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses and synthesizes recent basic, translational, and clinical research with the goal of understanding the mechanisms behind autism spectrum disorder (ASD) and how they lead to altered brain function and behavior. Bringing clarity to these mechanisms will lead to more effective therapies for the various heterogeneous pathologies that comprise ASD. Currently there are few, if any, proven therapies for the majority of the disorders. Among the topic addressed are neural plasticity, neuroimmunology, neuroinflammation, neuroimaging, and appropriate animal and genetic models.
Book Synopsis Neurochemistry in Autism Spectrum Disorder by : Alice Marie Sybille Durieux
Download or read book Neurochemistry in Autism Spectrum Disorder written by Alice Marie Sybille Durieux and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Translational and Clinical Research in Autism Spectrum Disorders by : Paul Spencer
Download or read book Translational and Clinical Research in Autism Spectrum Disorders written by Paul Spencer and published by American Medical Publishers. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects how a person perceives and interacts with others, leading to problems in social interaction and communication. Limited and repetitive patterns of conduct are also part of the disorder. While autism is a lifelong disease, the extent to which these challenges limit a person's capacity to function varies from person to person. The term 'spectrum disorders' signifies the wide variety of symptoms and severity associated with autism. Genetic factors are primarily the reason for the disorder's occurrence. ASD appears early in childhood and is related to social, scholastic, and occupational challenges. Autism signs appear as early as the first year of life. Some of the complications linked with the disease include difficulties in school and successful learning, work issues, inability to live independently, social isolation, and family stress. This book is a collection of translational and clinical researches on autism. The readers would gain knowledge that would broaden their perspective about autism spectrum disorders.
Book Synopsis Pharmacological Modulation of Excitation - Inhibition Balance in Autism Spectrum Disorders by : Laura Ann Ajram
Download or read book Pharmacological Modulation of Excitation - Inhibition Balance in Autism Spectrum Disorders written by Laura Ann Ajram and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: However, riluzole had no measurable effect on glutamate nor GABA efflux in either wild type, or Neurexinl a knock out rats. Overall, I have, for the first time, identified that E-1 balance at both the intracellular and functional level may be shifted in adult men with ASD, and that the brain in ASD is pharmacologically different to that of controls. This has implications for future drug discovery in ASD and the results of this thesis could be translated forwards to enhance future clinical trial design. Further to this, I found the Neurexinl a knock out rat to have a comparable baseline biology to the human condition, which may support its use in future studies of back-translate these findings. Such work will be necessary to further understand EI pharmacology in ASD, and further validate E-I balance as a tractable therapeutic treatment target for this increasingly prevalent condition.
Book Synopsis The Neuroscience of Autism Spectrum Disorders by : Joseph D. Buxbaum
Download or read book The Neuroscience of Autism Spectrum Disorders written by Joseph D. Buxbaum and published by Academic Press. This book was released on 2012-10-25 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available
Download or read book Autism written by and published by Academic Press. This book was released on 2020-07-23 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism, Volume 173 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. Chapters in this new release include updates on atypical brain development in autism spectrum disorder, predicting early diagnosis of autism spectrum disorder using neural and behavioral measures, the roles of the endocannabinoid system in autism spectrum disorder, the neurobiology of sensory processing in autism spectrum disorder, the effects of oxytocin administration on individuals with ASD, resting-state abnormalities of posterior cingulate in autism spectrum disorder, and more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field
Book Synopsis A Time for Metabolism and Hormones by : Paolo Sassone-Corsi
Download or read book A Time for Metabolism and Hormones written by Paolo Sassone-Corsi and published by Springer. This book was released on 2016-04-04 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.
Book Synopsis Autism Service Delivery by : Florence D. DiGennaro Reed
Download or read book Autism Service Delivery written by Florence D. DiGennaro Reed and published by Springer. This book was released on 2015-09-09 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines ways in which service delivery to individuals with autism can be improved from both ends of the basic-applied research spectrum. It introduces the concept of translational scholarship and examines real-world value in developing relevant interventions. Each area of coverage reviews current findings on autism from basic research and, then, discusses the latest applied research literature to create a roadmap for researchers, clinicians, and scientist-practitioners to develop new, effective strategies as children, adolescents, and adults with autism continue to learn and grow. Featured coverage includes: Why practice needs science and how science informs practice. The social learning disorder of stimulus salience in autism. Assessment and treatment of problem behaviors associated with transitions. Understanding persistence and improving treatment through behavioral momentum theory. The behavioral economics of reinforcer value. Increasing tolerance for delay with children and adults with autism. Autism Service Delivery is an essential resource for researchers, clinicians and scientist-practitioners, and graduate students in the fields of developmental psychology, behavioral therapy, social work, clinical child and school psychology, occupational therapy, and speech pathology.
Book Synopsis Research Approaches to Supporting Students on the Autism Spectrum in Inclusive Schools by : Suzanne Carrington
Download or read book Research Approaches to Supporting Students on the Autism Spectrum in Inclusive Schools written by Suzanne Carrington and published by Routledge. This book was released on 2021-05-18 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will support researchers in the field of education disability by outlining inclusive research approaches and their challenges, outcomes, and impact. Each chapter reports on school/university-based research supporting inclusion for young people on the autism spectrum. This research has been developed in Australian schools with students, families, teachers, and specialists. The intent of this approach is to mobilise new knowledge to the benefit of all students, including students on the autism spectrum, their families, teachers, and school communities. This book showcases how research can be more inclusive with a move to collaborative, participatory, and co-produced research that will impact on young people, families, and educators. The authors highlight the complex challenges and the positive outcomes of conducting research in inclusive ways and provide detailed practical strategies for researchers. Inclusive education is socially, emotionally, and academically beneficial for all students and positively impacts on respectful attitudes to difference. This book provides a groundbreaking approach to research that by design is inclusive and therefore provides an invaluable opportunity for building the foundations of an inclusive society for all. This book will be invaluable to researchers, educators, and professional learning in schools.
Book Synopsis Behavior Analysis by : Henry S. Roane
Download or read book Behavior Analysis written by Henry S. Roane and published by Guilford Publications. This book was released on 2024-01-26 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Throughout this text, many of the research paradigms and methodologies across experimental analysis of behavior (EAB) and applied behavior analysis (ABA) are presented within the "bench-to-bedside" approach of translational research described by the National Institutes of Health. The first few chapters of the text introduce underlying core tenets of behaviorism as well as core characteristics and methods that define the field of behavior analysis. The next several chapters of the book introduce the reader to some of the foundational principles of behavior analysis, with coverage from both the EAB and ABA perspectives. The final chapters of the book cover topics for which there has been ample basic, applied, and translational research conducted. The text concludes with a chapter on ethics, which includes content related to ethical issues in research, ethical issues in clinical practice, and the ethical use of nonhuman animals and special populations in research"--
Book Synopsis Autism Spectrum Disorders by : Dianne Zager
Download or read book Autism Spectrum Disorders written by Dianne Zager and published by Routledge. This book was released on 2004-09-22 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of autism has been growing at an unprecedented rate in recent years. In addition to an actual rise in the number of classic DSM-IV cases, broadened diagnostic criteria have uncovered a wider range of autistic behaviors and ability levels. The third edition of this well-known text continues the mission of its predecessors--to present a comprehensive, readable, up-to-date overview of the field of autism, one that links research, theory, and practice in ways that are accessible to both practitioners and parents. Key features include: *Expanded Coverage--To accommodate the recent explosion of research, the book has been expanded from 11 to 14 chapters that examine the impact of autism on the individual and the family from infancy through adulthood. *Expertise--Internationally recognized experts offer cutting-edge treatment and educational information on topics such as early diagnosis, medical treatment, assessment, educational methods, language development, behavior regulation, and family support. *Neurobiological Research--Comprehensive medical research and treatment chapters provide an understandable overview of neurobiological research and current treatments including when and how medication can be employed as part of a treatment plan. *Focus on Early Years--Old sections I and III have been combined and a new 3-chapter section on early identification and intervention added. *Focus on Parents and Families--In addition to a chapter on the evolving role of families, a new chapter addresses family needs during the preschool years. *Integration of Assessment and Intervention--The chapters on assessment and intervention have been reorganized and more closely integrated in keeping with current thinking about their inter-relatedness. *Future Directions--Two chapters discuss emerging directions in this exploding field and how to make informed decisions among a variety of approaches. This book is appropriate for anyone--students, practitioners, or parents--who must provide care for an autistic child.
Book Synopsis Translational Anatomy and Cell Biology of Autism Spectrum Disorder by : Michael J. Schmeisser
Download or read book Translational Anatomy and Cell Biology of Autism Spectrum Disorder written by Michael J. Schmeisser and published by Springer. This book was released on 2017-05-25 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism spectrum disorder (ASD) affects approximately 1 % of the human population and is characterized by a core symptomatology including deficits in social interaction and repetitive patterns of behaviour plus various co-morbidities. Although a lot of progress has been made to uncover underlying causes and mechanisms throughout the last decade, we are still at the very beginning to understand this enormously complex neurodevelopmental condition. This special volume is focused on translational anatomy and cell biology of ASD. International experts from the field including several members of the EU-AIMS initiative launched by the European Union to develop novel treatments for ASD have contributed chapters on several topics covering all crucial aspects of translational ASD research with a special emphasis on ASD model systems including stem cells and animals. Primary objective is to clarify how anatomical and cell biological phenotypes of ASD will help to translate basic mechanisms to clinical practice and to efficiently treat affected individuals in the near future.
Book Synopsis Frontiers In Autism Research: New Horizons For Diagnosis And Treatment by : Valerie W Hu
Download or read book Frontiers In Autism Research: New Horizons For Diagnosis And Treatment written by Valerie W Hu and published by World Scientific. This book was released on 2014-05-09 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the emerging and expanding areas of research on ASD and their potential to lead to better diagnosis and more effective therapies. These areas include innovative and integrative approaches to genetic/genomic analyses and investigations of epigenetic contributions, including the role of noncoding RNAs, DNA methylation, alternative splicing, RNA editing, and faulty translation in gene regulation and expression, metabolic and immune dysfunction, co-morbidities, as well as hormonal and gene-environment interactions that may increase risk for ASD.Within each chapter, experts review cutting-edge research as well as provide their perspective on the future of research in their respective areas, including the challenges involved and the types of studies or advances that are necessary to move the field forward to achieve predicted translational goals.Contributors: Argel Aguilar-Valles, Evdokia Anagnostou, Emma Ashwin, Bonnie Auyeung, Kelly M Bakulski, Simon Baron-Cohen, Margaret L Bauman, Donna Betts, Chad A Bousman, Daniel B Campbell, Manuel F Casanova, Bhismadev Chakrabarti, Gursharan Chana, Abha Chauhan, Ved Chauhan, Jessica DeWitt, Keith W Dunaway, Alal Eran, Ian P Everall, M Daniele Fallin, Richard E Frye, Piers Gillett, Matthew Ginsberg, Christos G Gkogkas, Rhonda J Greenhaw, Simon G Gregory, Elena L Grigorenko, Feng Gu, Rebecca Harmer, Martha Herbert, Valerie W Hu, Karen L Jones, Petra Kern, Arkady Khoutorsky, Rebecca Knickmeyer, Isaac S Kohane, Louis M Kunkel, Janine M LaSalle, Michael V Lombardo, Deepali Mankad, Marvin Natowicz, Laura Nicholls, Christos Pantelis, Natalia Rakhlin, Radhika Ramadas, Daniel A Rossignol, Tewarit Sarachana, Stephen W Scherer, Gabriela Schmulevich, Ayten Shah, Frank R Sharp, Alison B Singer, Efstratios Skafidas, Estate M Sokhadze, Nahum Sonenberg, Boryana Stamova, Zohreh Talebizadeh, Renee Testa, Judy Van de Water, Irina Voineagu, Daniel Williams, Ryan K C Yuen, Daniela Zantomio.
Book Synopsis Autism Spectrum Disorder by : Michael Fitzgerald
Download or read book Autism Spectrum Disorder written by Michael Fitzgerald and published by BoD – Books on Demand. This book was released on 2015-04-02 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book starts with a new sub category of Autism Criminal Autistic Psychopathy and school shootings. It focuses on a number of interventions, including speech and language pathology, speech and language assessment instruments, occupational therapy, improving functional language development in autism with natural gestures, communication boards etc as well as helping people with autism using the pictorial support, training of concepts of significant others, theory of mind, social concepts and a conceptual model for empowering families of children with autism cross culturally. It also examines the issue of hyperandrogenism and evidence-based treatments of autism. In terms of assessment, it focuses on psychological and biological assessment including neurotransmitters systems, structural and functional brain imaging, coping strategies of parents, examines the intertwining of language impairment, specific language impairment and ASD, as well as implicit and spontaneous Theory of Mind reading in ASD. In terms of aetiology, it focuses on genetic factors, epigenetics, synaptic vesicles, toxicity during neurodevelopment, immune system and sex differences. It also examines the link between social cognitive anatomical and neurophysiologic biomarkers and candidate genes. This book will be relevant to all mental health professionals because autism occurs in all the different areas of psychiatry and professionals who will find it helpful will be psychiatrists, psychologists, social workers, nurses, teachers and all those working with persons with Autism including parents who nowadays are interested in knowing more and more, at a detailed level about their children or adults with autism.
Book Synopsis Neural and Synaptic Defects in Autism Spectrum Disorders by : Hansen Wang
Download or read book Neural and Synaptic Defects in Autism Spectrum Disorders written by Hansen Wang and published by Frontiers Media SA. This book was released on 2015-07-07 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism spectrum disorders (ASDs) are a group of genetically and clinically heterogeneous neurodevelopmental disorders characterized by impaired reciprocal social interactions and communication, and restricted and repetitive patterns of behaviors and interests. Studies in genetics, neurobiology and systems biology are providing insights into the pathogenesis of ASDs. Investigation of neural and synaptic defects in ASDs not only sheds light on the molecular and cellular mechanisms that govern the function of the central nervous system, but may lead to the discovery of potential therapeutic targets for autism and other cognitive disorders. Our Research Topic which constitutes this e-book documents the recent development and ideas in the study of pathogenesis and treatment of ASDs, with an emphasis on syndromic disorders such as fragile X and Rett syndromes. In addition, model systems and methodological approaches with translational relevance to autism are covered herein. We hope that the Research Topic will enhance the global knowledge base in the autism research community and foster new research directions in autism related biology.
Book Synopsis Autism Spectrum Disorders by : David Amaral
Download or read book Autism Spectrum Disorders written by David Amaral and published by Oxford University Press. This book was released on 2011-05-01 with total page 1445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism is an emerging area of basic and clinical research, and has only recently been recognized as a major topic in biomedical research. Approximately 1 in 150 children are diagnosed as autistic, so it is also an intense growth area in behavioral and educational treatments. Financial resources have begun to be raised for more comprehensive research and an increasing number of scientists are becoming involved in autism research. In many respects, autism has become a model for conducting translational research on a psychiatric disorder. This text provides a comprehensive summary of all current knowledge related to the behavioral, experiential, and biomedical features of the autism spectrum disorders including major behavioral and cognitive syndromology, common co-morbid conditions, neuropathology, neuroimmunology, and other neurological correlates such as seizures, allergy and immunology, gastroenterology, infectious disease, and epidemiology. Edited by three leading researchers, this volume contains over 80 chapters and nine shorter commentaries by thought leaders in the field, making the book a virtual "who's who" of autism research. This carefully developed book is a comprehensive and authoritative reference for what we know in this area as well as a guidepost for the next several years in all areas of autism research.
Book Synopsis Addressing Underserved Populations in Autism Spectrum Research by : Matthew Bennett
Download or read book Addressing Underserved Populations in Autism Spectrum Research written by Matthew Bennett and published by Emerald Group Publishing. This book was released on 2022-07-07 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addressing Underserved Populations in Autism Spectrum Research highlights five areas of autism spectrum research that currently lack a substantial body of literature. These include, autistic seniors, autistic women, fathers raising autistic children, autistics with intellectual disabilities, and autistics from ethnic minorities.
