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Author : Wolfgang Michael Rohn
Publisher :
ISBN 13 :
Total Pages : 226 pages
Book Rating : 4.:/5 (395 download)
Download or read book Transcriptional Regulation of Class II MHC Gene Expression in Astrocytes written by Wolfgang Michael Rohn and published by . This book was released on 1998 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yi-Ju Lee
Publisher :
ISBN 13 :
Total Pages : 358 pages
Book Rating : 4.:/5 (369 download)
Download or read book Signaling Mechanisms Involved in Class II Major Histocompatibility Complex Gene Expression in Astrocytes written by Yi-Ju Lee and published by . This book was released on 1996 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Erica Lynn Scott
Publisher :
ISBN 13 :
Total Pages : 98 pages
Book Rating : 4.:/5 (381 download)
Download or read book Transcriptional Regulation of MHC Class II Genes in Trophoblast Cells written by Erica Lynn Scott and published by . This book was released on 1997 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Li Zhu
Publisher :
ISBN 13 :
Total Pages : 258 pages
Book Rating : 4.F/5 ( download)
Download or read book Molecular Regulation of the MHC Class II-associated Invariant Chain Gene (Ii) Expression written by Li Zhu and published by . This book was released on 1990 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jyotsna Nath
Publisher :
ISBN 13 :
Total Pages : 72 pages
Book Rating : 4.:/5 (195 download)
Download or read book Regulation of the Class II MHC Gene Expression by Macrophages from BCGr and BCGs Mice and the Regulation of Surface Expression of Class II Molecules by PGE2 written by Jyotsna Nath and published by . This book was released on 1988 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 139 pages
Book Rating : 4.:/5 (232 download)
Download or read book Transcriptional Regulation of CD40 and Class II MHC Molecules in Macrophages and Microglia by Statins written by and published by . This book was released on 2008 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 123 pages
Book Rating : 4.:/5 (155 download)
Download or read book Chromatin Regulation of MHC Class II Expression written by and published by . This book was released on 2007 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: The eukaryotic cell, DNA is assembled into higher order structure to allow the packaging of genetic material into the confined space within the cell nucleus. Chromatin remodeling must occur too allow transcription factors binding and the activation of gene expression. Class II transactivator (CIITA) is the master regulator of MHC class II expression and it has been shown to participate in chromatin remodeling at the MHC class II promoter. We found that in several tumor cell lines (Colon 26 and RJ2.2.5), MHC class II expression is silenced and can be induced by treatment with the histone deacetylase inhibitor Trichostatin A (TSA) in the absence of CIITA. Although Colon 26 contains an intrinsic, active IFN-[gamma] pathway, TSA pretreatment inhibited the IFN-[gamma] induced STAT-1 phosphorylation suggesting a different TSA activation pathway from that induced by IFN-[gamma]. Chromatin immunoprecipitation (ChIP) assays demonstrated similar patterns of histone modification changes upon IFN-[gamma] (CIITA-dependent) and TSA (CIITA-independent) stimulation. Both IFN-[gamma] and TSA treated cells demonstrated an enhancement of markers associated with active gene expression (Acetylated histone H3 and H4 and trimethylated H3 lysine 4) at the MHC class II promoter while the level of the repressive state marker, trimethylated H3 lysine 9, was decreased. Unlike other histone modifications, enhanced trimethylated H3 lysine 36 was detected at the 3'region but not the promoter of the MHC class II gene in both IFN-[gamma] inducible (HeLa) and TSA inducible (RJ2.2.5) cell lines. Such differential localization of the histone modifications suggests that each mark may be involved in the different phases of the transcription process. H3K79me2 remained unchanged and at low level after IFN-[gamma] (HeLa) or TSA (RJ2.2.5) treatment when compared to the MHC class II expressing cell line Raji. However, H3K79 methylation can be rescued by the reconstitution of CIITA expression in the CIITA deficient cell line RJ2.2.5 by stable transfection. Together, our data suggests that TSA treatment can replace the function of CIITA in activating MHC class II expression. Although IFN-[gamma] and TSA induced MHC class II expression through different regulatory pathways, both resulted in similar patterns of histone modifications and chromatin remodeling. Lastly, CIITA may be crucial for the recruitment of histone methyltransferase to the MHC class II gene.
Author : Hongquan Zhang
Publisher :
ISBN 13 :
Total Pages : 208 pages
Book Rating : 4.:/5 (478 download)
Download or read book Regulation of MHC Class II and IL-8 Gene Expression by RB written by Hongquan Zhang and published by . This book was released on 2000 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 588 pages
Book Rating : 4.:/5 (94 download)
Download or read book Transcriptional Regulation of Class II MHC Genes in Malignant Melanoma and Other Transformed Cell Lines written by and published by . This book was released on 1994 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Shihe Hou
Publisher :
ISBN 13 :
Total Pages : 199 pages
Book Rating : 4.:/5 (244 download)
Download or read book Transcriptional Regulation of MHC Class I Genes in Adenovirus Transformed Cells written by Shihe Hou and published by . This book was released on 2002 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ann C. Morris
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (142 download)
Download or read book Regulation of MHC Class II Gene Expression at the Fetal-maternal Interface written by Ann C. Morris and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Brian D. Gulbransen
Publisher : Biota Publishing
ISBN 13 : 1615046615
Total Pages : 72 pages
Book Rating : 4.6/5 (15 download)
Download or read book Enteric Glia written by Brian D. Gulbransen and published by Biota Publishing. This book was released on 2014-07-01 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enteric nervous system (ENS) is a complex neural network embedded in the gut wall that orchestrates the reflex behaviors of the intestine. The ENS is often referred to as the “little brain” in the gut because the ENS is more similar in size, complexity and autonomy to the central nervous system (CNS) than other components of the autonomic nervous system. Like the brain, the ENS is composed of neurons that are surrounded by glial cells. Enteric glia are a unique type of peripheral glia that are similar to astrocytes of the CNS. Yet enteric glial cells also differ from astrocytes in many important ways. The roles of enteric glial cell populations in the gut are beginning to come to light and recent evidence implicates enteric glia in almost every aspect of gastrointestinal physiology and pathophysiology. However, elucidating the exact mechanisms by which enteric glia influence gastrointestinal physiology and identifying how those roles are altered during gastrointestinal pathophysiology remain areas of intense research. The purpose of this e-book is to provide an introduction to enteric glial cells and to act as a resource for ongoing studies on this fascinating population of glia. Table of Contents: Introduction / A Historical Perspective on Enteric Glia / Enteric Glia: The Astroglia of the Gut / Molecular Composition of Enteric Glia / Development of Enteric Glia / Functional Roles of Enteric Glia / Enteric Glia and Disease Processes in the Gut / Concluding Remarks / References / Author Biography
Download or read book The Role of S7, a Subunit of the 19S Proteasome, in the Transcriptional Regulation of MHC II written by and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Induction of an adaptive, or antigen specific, immune response is critical for eliminating most infections. Pathogen clearance is accomplished primarily, by the actions of CD4+ T cells through their ability to recognize foreign antigens presented at the cell surface by major histocompatibility class II (MHC II) molecules. Consequently, the capacity to regulate expression of MHC molecules is essential to control the adaptive immune response. MHC molecules are regulated at the level of transcription by a master regulator, the class II transcriptional activator, CIITA. Thus, the expression of MHC II is directly related to proper CIITA activity. This thesis focuses on the novel role of S7, an ATPase subunit of the 19S proteasome, in the transcriptional regulation of CIITA and MHC II molecules.
Author : G. Eric Blair
Publisher : Cambridge University Press
ISBN 13 : 9780521495783
Total Pages : 462 pages
Book Rating : 4.4/5 (957 download)
Download or read book Modulation of MHC Antigen Expression and Disease written by G. Eric Blair and published by Cambridge University Press. This book was released on 1995-11-09 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumor and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, viral oncology, cancer biology and autoimmunity). There is a strong emphasis on situations where MHC expression is modulated (either stimulated or repressed). The book's major themes are: the mechanisms of MHC expression--explored at several levels including the transcription and translation of MHC genes and the insertion of MHC protein molecules into plasma membranes; the effect of cytokines on MHC expression--both in the etiology of certain diseases and in possible immunotherapeutic approaches to disease; and the use of gene therapy to modify MHC expression in cancer cells, and thereby cause tumor rejection. This book will be valuable to researchers and clinicians in molecular biology, immunology, oncology, and virology.
Author :
Publisher :
ISBN 13 :
Total Pages : 1844 pages
Book Rating : 4.3/5 (243 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1844 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Author :
Publisher :
ISBN 13 :
Total Pages : 1390 pages
Book Rating : 4.:/5 (31 download)
Download or read book The Journal of Immunology written by and published by . This book was released on 1998 with total page 1390 pages. Available in PDF, EPUB and Kindle. Book excerpt:
