Transcriptional Corepressors

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Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression

Author : Martin L. Privalsky
Publisher : Springer Science & Business Media
ISBN 13 : 3662105950
Total Pages : 202 pages
Book Rating : 4.6/5 (621 download)

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Book Synopsis Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression by : Martin L. Privalsky

Download or read book Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression written by Martin L. Privalsky and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Corepressors are newly discovered assemblies of proteins that play essential roles in eukaryotic gene regulation. Recent discoveries about corepressors have provided new insights into the molecular basis of gene regulation, and have established surprising connections between the mechanisms of action of a wide variety of transcriptional regulators. The reviews in this volume critically discuss the nature, mechanisms of action, and physiological roles of corepressors in a diverse assortment of biological systems. Both basic and clinical investigators will be able to find relevant information. The comprehensive nature of the compilation, and the breadth of the reviews, are intended to provide the reader with an excellent introduction to the newly emergent and rapidly-growing field of corepressor research. A valuable and detailed reference guide.

Transcriptional Corepressors

Author : Martin L. Privalsky
Publisher :
ISBN 13 : 9783662105962
Total Pages : 212 pages
Book Rating : 4.1/5 (59 download)

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Book Synopsis Transcriptional Corepressors by : Martin L. Privalsky

Download or read book Transcriptional Corepressors written by Martin L. Privalsky and published by . This book was released on 2014-01-15 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Smad Signal Transduction

Author : Peter Dijke
Publisher : Springer Science & Business Media
ISBN 13 : 1402047096
Total Pages : 489 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Smad Signal Transduction by : Peter Dijke

Download or read book Smad Signal Transduction written by Peter Dijke and published by Springer Science & Business Media. This book was released on 2007-05-10 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive book on Smad signal transduction. Forward looking reviews of Smads are provided in a series of 22 cutting-edge chapters. The book is written for an audience with basic understanding of molecular and cell biology. This volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided.

Drosphila Zinc Finger Protein Schnurri Recruits Multiple Transcriptional Corepressors to Repress Transcription

Author : Yi Cai
Publisher :
ISBN 13 :
Total Pages : 198 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Drosphila Zinc Finger Protein Schnurri Recruits Multiple Transcriptional Corepressors to Repress Transcription by : Yi Cai

Download or read book Drosphila Zinc Finger Protein Schnurri Recruits Multiple Transcriptional Corepressors to Repress Transcription written by Yi Cai and published by . This book was released on 2007 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chromatin Remodeling Complexes and Transcriptional Coregulators

Author :
Publisher : Elsevier
ISBN 13 : 0443160082
Total Pages : 210 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Chromatin Remodeling Complexes and Transcriptional Coregulators by :

Download or read book Chromatin Remodeling Complexes and Transcriptional Coregulators written by and published by Elsevier. This book was released on 2023-10-01 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Remodeling Complexes and Transcriptional Coregulators, Volume 53, the latest release in The Enzymes series highlights new advances in the field, with interesting new chapters that cover Perspectives on Chromatin Remodeling, The functions of ISWI-type remodelers in yeast, Conserved mechanisms of NuRD function in hematopoietic gene expression, The SIN3 complex as a metabolic epigenetic regulator, Soft repression and chromatin modification by conserved transcriptional corepressors, The NPAC-LSD2 complex in nucleosome demethylation, Role of intrinsically disordered domains in transcriptional regulation, and Regulation of the Recovery of Cancer from Therapy Exposure by Noncoding RNAs. Provides the authority and expertise of leading contributors from an international board of authors Updated release includes the latest information on Chromatin remodeling complexes and transcriptional coregulators Presents the latest release in The Enzymes series

Transcriptional Control of Neural Crest Development

Author : Brian Nelms
Publisher : Biota Publishing
ISBN 13 : 1615040498
Total Pages : 246 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Transcriptional Control of Neural Crest Development by : Brian Nelms

Download or read book Transcriptional Control of Neural Crest Development written by Brian Nelms and published by Biota Publishing. This book was released on 2010-02-01 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the body, and to smooth muscle of the great arteries of the heart. For these cells to correctly progress from an unspecifi ed, nonmigratory population to a wide array of dynamic, differentiated cell types—some of which retain stem cell characteristics presumably to replenish these derivatives—requires a complex network of molecular switches to control the gene programs giving these cells their defi ning structural, enzymatic, migratory, and signaling capacities. This review will bring together current knowledge of neural crest-specifi c transcription factors governing these progressions throughout the course of development. A more thorough understanding of the mechanisms of transcriptional control in differentiation will aid in strategies designed to push undifferentiated cells toward a particular lineage, and unraveling these processes will help toward reprogramming cells from a differentiated to a more naive state. Table of Contents: Introduction / AP Genes / bHLH Genes / ETS Genes / Fox Genes / Homeobox Genes / Hox Genes / Lim Genes / Pax Genes / POU Domain Genes / RAR/RXR Genes / Smad Genes / Sox Genes / Zinc Finger Genes / Other Miscellaneous Genes / References / Author Biographies

Human Biochemistry

Author : Gerald Litwack
Publisher : Academic Press
ISBN 13 : 032391053X
Total Pages : 883 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Human Biochemistry by : Gerald Litwack

Download or read book Human Biochemistry written by Gerald Litwack and published by Academic Press. This book was released on 2021-11-28 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more. Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers. Presents an update on a past edition winner of the 2018 Most Promising New Textbook (College) Award (Texty) from the Textbook and Academic Authors Association and the PROSE Award of the Association of American Publishers Provides a fully updated resource on current research in human and medical biochemistry Includes clinical case studies, applications, chapter summaries and review-based questions Adopts a practice-based approach, reflecting the needs of both researchers and clinically oriented readers

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protein Complexes that Modify Chromatin

Author : Jerry L. Workman
Publisher : Springer Science & Business Media
ISBN 13 : 3642557473
Total Pages : 298 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Protein Complexes that Modify Chromatin by : Jerry L. Workman

Download or read book Protein Complexes that Modify Chromatin written by Jerry L. Workman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene expression and that the challenge to the cell would be to rescue specific sequences from these structures. The exten sive packaging of inactive DNA was considered the primary difference between eukaryotic and prokaryotic genomes and except for that point both would be similarly regulated by cis-acting sequences and trans acting factors. Our view of eukaryotic chromosomes has evolved dra matically over the last decade. The picture of chromosomes that is emerging is that of dynamic breathing organelles actively regulating the flow of genetic information from the genome. Indeed chromatin is so fluid that even maintaining gene quiescence is an active process and is tightly regulated. Chromatin dynamics is a consequence of protein complexes that modify histones, remove histone modifications, mobi lize nucleosomes or stabilize nucleosomes. Awide variety of such com plexes have now been described. Some are abundant and may play glo bal roles in chromosome fluidity and function. Others are more rare and specialized for specific functions at discreet loci. Moreover, several complexes share biochemical activities and genetic studies suggest overlapping functions in vivo. Many components of these complexes were first revealed in genetic screens, while others were discovered by novel cell biological or biochemical approaches.

Mechanisms in Transcriptional Regulation

Author : Albert J. Courey
Publisher : John Wiley & Sons
ISBN 13 : 1444300458
Total Pages : 248 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis Mechanisms in Transcriptional Regulation by : Albert J. Courey

Download or read book Mechanisms in Transcriptional Regulation written by Albert J. Courey and published by John Wiley & Sons. This book was released on 2009-01-22 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms in Transcriptional Regulation provides a concisediscussion of the fundamental concepts in transcription and itsregulation. Covers RNA polymerases, transcriptional machinery, mechanismsof transcriptional activation, the histone code hypothesis, theepigenetic control of transcription, and combinatorial control insignaling and development Features over 80 figures available to download online Chapters include comprehensive reading lists, boxeshighlighting theoretical concepts and experimental methods andproblems designed to build and test understanding

CtBP Family Proteins

Author : G. Chinnadurai
Publisher : Springer Science & Business Media
ISBN 13 : 0387399739
Total Pages : 131 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis CtBP Family Proteins by : G. Chinnadurai

Download or read book CtBP Family Proteins written by G. Chinnadurai and published by Springer Science & Business Media. This book was released on 2008-05-07 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Ctbp family proteins are multifunctional. They predominantly function as transcriptional corepressors in the nucleus by recruiting various histone modifying enzymes such as histone deacetylases, histone methylases and a histone demethylase. This book is a comprehensive monograph on the Ctbp family proteins.

Desk Reference for Hematology

Author : N.K. Shinton
Publisher : CRC Press
ISBN 13 : 142000512X
Total Pages : 1030 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Desk Reference for Hematology by : N.K. Shinton

Download or read book Desk Reference for Hematology written by N.K. Shinton and published by CRC Press. This book was released on 2007-12-19 with total page 1030 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cross between a dictionary and an encyclopedia, Desk Reference for Hematology, Second Edition presents a concise yet thorough examination of hematology and its relationship with other systems and disorders. The 1500 alphabetically listed articles provide quick and easy access to expert information, the 150 tables put precise data at your f

The Regulatory Genome in Adaptation, Evolution, Development, and Disease

Author : Moyra Smith
Publisher : Elsevier
ISBN 13 : 0443153531
Total Pages : 420 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis The Regulatory Genome in Adaptation, Evolution, Development, and Disease by : Moyra Smith

Download or read book The Regulatory Genome in Adaptation, Evolution, Development, and Disease written by Moyra Smith and published by Elsevier. This book was released on 2023-03-10 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Regulatory Genome in Adaptation, Evolution, Development, and Disease synthesizes insights from recent genomic and gene expression studies across organisms, from humans to plants, animals, and single cell life, exploring common roles gene regulation plays in adaptive evolution, developmental biology and susceptibility to disease. The book sheds light on gene regulation across evolutionary timelines, illuminating new areas of focus and future research. Chapters consider key elements in gene expression regulation, fundamentals of genomic alterations over time, and in response to environmental and local conditions, epigenetics in adaptive evolution, and adaptive gene regulation in healthy processes and developmental biology, and in disease biology. Throughout the book, a comparative approach is adopted across organisms to highlight common evolutionary themes and genome diversity revealed by recent sequencing and GWAS studies, as well as how this informs our understanding of human adaptive evolution. The book finishes by detailing how we can use this knowledge to impact disease outcomes and healthy human metabolism, development, and physiology. Reviews key elements in the regulation of gene expression and modes of studying gene regulation across evolutionary timelines Adopts a cross-species view, synthesizing recent sequencing and GWAS studies across organisms to draw out fresh meaning and highlight pathways for future research Considers altered gene expression associated with developmental defects and disease, as well as healthy biology and physiology, and our adaptive response to disease influence

Epigenetics and Regeneration

Author :
Publisher : Academic Press
ISBN 13 : 0128148802
Total Pages : 541 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Epigenetics and Regeneration by :

Download or read book Epigenetics and Regeneration written by and published by Academic Press. This book was released on 2019-05-24 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming. As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics. Provides a foundational overview of epigenetics in regenerative medicine Examines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practice Offers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathways Features chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine

Epigenetics in Human Disease

Author : Trygve O. Tollefsbol
Publisher : Academic Press
ISBN 13 : 0123884152
Total Pages : 618 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Epigenetics in Human Disease by : Trygve O. Tollefsbol

Download or read book Epigenetics in Human Disease written by Trygve O. Tollefsbol and published by Academic Press. This book was released on 2012-07-26 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Aldosterone-Mineralocorticoid Receptor

Author : Brian Harvey
Publisher : BoD – Books on Demand
ISBN 13 : 1839621982
Total Pages : 302 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Aldosterone-Mineralocorticoid Receptor by : Brian Harvey

Download or read book Aldosterone-Mineralocorticoid Receptor written by Brian Harvey and published by BoD – Books on Demand. This book was released on 2019-09-25 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book assembles review chapters from 16 European ADMIRE laboratories providing the latest insights into mechanisms of aldosterone synthesis/secretion, aldosterone/MR physiology and signaling, and the pathophysiological roles of aldosterone/MR activation.

Transcription Factors and Human Disease

Author : Gregg L. Semenza
Publisher : Oxford Monographs on Medical G
ISBN 13 : 9780195112399
Total Pages : 396 pages
Book Rating : 4.1/5 (123 download)

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Book Synopsis Transcription Factors and Human Disease by : Gregg L. Semenza

Download or read book Transcription Factors and Human Disease written by Gregg L. Semenza and published by Oxford Monographs on Medical G. This book was released on 1998 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several general principles have emerged from the study of human transcription factors. First, germline mutations in genes encoding transcription factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations involving many of the same genes contribute to tumorigenesis. Third, transcriptional regulatory mechanisms demonstrate remarkable evolutionary conservation. Fourth, prenatal development and postnatal physiology are unified by the demonstration that a single transription factor can control the proliferation of progenitor cells during development and the expression within the differentiated cells of gene products that participate in specific physiologic responses. Transcription Factors and Human Disease presents the basic science of transcriptional regulation and then describes inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites. The involvement of transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is briefly discussed. The effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessive inheritance patterns, and disease pathogenesis are also explored. This book thus provides a direct connection between molecular defects in transcriptional regulation and human pathophysiology.