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Transcriptional And Post Transcriptional Regulation Of Oncogenes And Tumor Suppressor Genes And Their Role In Solid Cancer Metastasis
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Book Synopsis Transcriptional and Post-transcriptional Regulation of Oncogenes and Tumor-suppressor Genes and Their Role in Solid Cancer Metastasis by : Giridhar Mudduluru
Download or read book Transcriptional and Post-transcriptional Regulation of Oncogenes and Tumor-suppressor Genes and Their Role in Solid Cancer Metastasis written by Giridhar Mudduluru and published by . This book was released on 2012 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Tumor Suppressor Genes in Human Cancer by : David E. Fisher
Download or read book Tumor Suppressor Genes in Human Cancer written by David E. Fisher and published by Springer Science & Business Media. This book was released on 2000-10-26 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.
Book Synopsis Oncogenes as Transcriptional Regulators by : Moshe Yaniv
Download or read book Oncogenes as Transcriptional Regulators written by Moshe Yaniv and published by Birkhäuser. This book was released on 2013-12-01 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intensive study of molecular events leading to cellular transformation in tissue culture or in intact organisms culminated in the identification of 100 or more genes that can be defined as oncogenes or tumor suppressor genes. Functionally, these genes can be divided into several classes, each involved in a different step in transmission of signals from the exterior of the cell to the nucleus. The first oncogenes to be biochemically character ized included membrane receptors for growth factors, growth factors themselves, protein kinases or small GTP binding proteins involved in signal transduction. Later, the development of techniques to study pro teins-DNA interaction in eucaryotes and the isolation and characterization of many promoter and enhancer sequences revealed that a number of the classical retroviral oncogenes were indeed transcription factors. In paral lel, the rapid progress in the identification and cloning of chromosomal translocations in human and animal malignancies and the increased reper toire of known transcription factors families revealed that many other transcription factors can playa critical role in cancer. A more recent devel opment concerns tumor suppressor genes. The realization that human tumors are frequently associated with a loss of function of one or several genes is also one of the landmarks of cancer research in the last 15 years. Again, as we will see below, some of these genes encode transcription factors. It is becoming increasingly difficult to cover in a single monograph all oncogenes and tumor suppressor genes.
Book Synopsis The Oncogene and Tumour Suppressor Gene Factsbook by : Robin Hesketh
Download or read book The Oncogene and Tumour Suppressor Gene Factsbook written by Robin Hesketh and published by Elsevier. This book was released on 1997-07-11 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of The Oncogene and Tumour Suppressor Gene FactsBook has been completely revised, updated, and expanded by 60%. The book contains more than 80 entries on oncogenes including JUN, MYC, and RAS, as well as DNA tumour viruses, tumour suppressor genes, including p53, retinoblastoma, BRCA1, BRCA2, VHL, F2FL, and essential material on angiogenesis and metastasis, apoptosis, cell cycle control, and gene therapy. - Includes much new data on this fast-moving field, including newly discovered oncogenes - Summarizes the clinical association and molecular properties of all known oncogenes and tumor suppression genes - Contains more than 2000 terms for reference and further research - Revised to included signaling pathways, apoptosis, and metastasis
Book Synopsis Oncogenes as Transcriptional Regulators by : Moshe Yaniv
Download or read book Oncogenes as Transcriptional Regulators written by Moshe Yaniv and published by Birkhäuser. This book was released on 2013-11-27 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intensive study of molecular events leading to cellular transformation in tissue culture or in intact organisms culminated in the identification of 100 or more genes that can be defined as oncogenes or tumor suppressor genes. Functionally, these genes can be divided into several classes, each involved in a different step in transmission of signals from the exterior of the cell to the nucleus. The first oncogenes to be biochemically character ized included membrane receptors for growth factors, growth factors themselves, protein kinases or small GTP binding proteins involved in signal transduction. Later, the development of techniques to study pro teins-DNA interaction in eucaryotes and the isolation and characterization of many promoter and enhancer sequences revealed that a number of the classical retroviral oncogenes were indeed transcription factors. In paral lel, the rapid progress in the identification and cloning of chromosomal translocations in human and animal malignancies and the increased reper toire of known transcription factors families revealed that many other transcription factors can playa critical role in cancer. A more recent devel opment concerns tumor suppressor genes. The realization that human tumors are frequently associated with a loss of function of one or several genes is also one of the landmarks of cancer research in the last 15 years. Again, as we will see below, some of these genes encode transcription factors. It is becoming increasingly difficult to cover in a single monograph all oncogenes and tumor suppressor genes.
Book Synopsis Oncogenes and Tumor Suppressor Genes in Human Malignancies by : Christopher Benz
Download or read book Oncogenes and Tumor Suppressor Genes in Human Malignancies written by Christopher Benz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Oncogenes (1989) focused on several of the better known transforming mechanisms and surveyed a spectrum of solid tumors and hematologic malignancies. Several of the nearly 50 known oncogenes most relevant to human disease were examined. In contrast, this volume presents a very different profile and balance of subject material that reflects the rapidly changing field of molecular oncology and its newly emerging concepts. Among the most important discoveries of the past 4 years are the identification of nearly a dozen different tumor suppressor genes and the finding of an entirely new class of cancer-causing gene (bcl-2) that acts by inhibiting cell death rather than stimulating cell proliferation. This edition begins by reviewing selected malignancies in which our earlier search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function genetic abnormalities, as well as autocrine and paracrine growth factor loops known to regulate tumor physiology and malignant cell behavior. Curiously, many of these genetic and functional abnormalities are shared by several different tumor types and are not uniformly present in all tumors of the same type. This observation brings up molecular questions about the tissue-specific determinants that underlie individual cancers and also gives added impetus to the suggestion that molecular abnormalities (referred to as tumor markers) be included among the histopathologic features used for clinical diagnosis and manage ment.
Book Synopsis Oncogene and Cancer by : Yahwardiah Siregar
Download or read book Oncogene and Cancer written by Yahwardiah Siregar and published by Inst za onkologiju i radiol. This book was released on 2013-01-24 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes a course of cancer growth starting from normal cells to cancerous form and the genomic instability, the cancer treatment as well as its prevention in form of the invention of a vaccine. Some diseases are also discussed in detail, such as breast cancer, leucaemia, cervical cancer, and glioma. Understanding cancer through its molecular mechanism is needed to reduce the cancer incidence. How to treat cancer more effectively and the problems like drug resistance and metastasis are very clearly illustrated in this publication as well as some research result that could be used to treat the cancer patients in the very near future. The book was divided into six main sections: 1. HER2 Carcinogenesis: Etiology, Treatment and Prevention; 2. DNA Repair Mechanism and Cancer; 3. New Approach to Cancer Mechanism; 4. New Role of Oncogenes and Tumor Suppressor Genes; 5. Non Coding RNA and Micro RNA in Tumorigenesis; 6. Oncogenes for Transcription Factors
Book Synopsis New Developments in Metastasis Suppressor Research by : Paul Jackson
Download or read book New Developments in Metastasis Suppressor Research written by Paul Jackson and published by Nova Publishers. This book was released on 2007 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: The spread of cancer cells from their organ of origin to distant tissues is called metastasis. Cancer metastasis is the main cause of death from cancer, and in many cases is difficult to detect or treat. The process by which tumour cells become metastatic is complex and involves many stages, including detachment of cells from the main tumour mass, degradation of the surrounding extra-cellular matrix, invasion into nearby blood vessels, travel and survival through the circulatory system, attachment to a vessel wall, extra-vasation, degradation of the extra-cellular matrix into a distant tissue/organ, and the development of a novel blood supply. In order to accomplish this process, the cells acquire characteristics which are important for each stage. Recently, a class of genes known as metastasis suppressors' has been the subject of intense investigation. For some metastasis suppressor genes, there is strong evidence from both in vitro and in vivo studies to demonstrate key roles in the metastatic process, for others data is much more limited, and their importance uncertain. In this book, chapters are devoted to providing up-to-date summaries of our understanding of individual metastasis suppressor genes. Each is written by a leading authority in the study of that gene. Topics covered include discussions on how each metastasis suppressor was discovered, the mechanisms underlying their loss of expression in tumours and tumour cell lines, their proposed molecular functions, and the consequences to a tumour cell of the loss of this function. This compilation aims to provide, in a single volume, comprehensive information that will be valuable to all scientists working in cancer research, to students needing to understand molecular events that regulate tumour progression and the acquisition of metastasis, and to clinicians who might wish to know more of the roles of potentially new markers for cancer diagnosis and prognosis.
Book Synopsis Tumor Suppressor Genes by : Katherine R. Polinsky
Download or read book Tumor Suppressor Genes written by Katherine R. Polinsky and published by Nova Publishers. This book was released on 2007 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: A tumour suppressor gene is a gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. A mutation or deletion of such a gene will increase the probability of the formation of a tumor. Unlike oncogenes, tumor suppressor genes generally follow the 'two-hit hypothesis', which implies that both alleles that code for a particular gene must be affected before an effect is manifested. This is due to the fact that if only one allele for the gene is damaged, the second can still produce the correct protein. However, there are cases where mutations in only one allele will cause an effect. A notable example is the gene that codes for p53. Tumor suppressor genes, or more precisely, the proteins for which they code, either have a dampening or repressive effect on the regulation of the cell cycle or promote apoptosis, and sometimes do both. This book presents new and important research from throughout the world.
Book Synopsis Tumor Suppressor Genes by : Wafik S. El-Deiry
Download or read book Tumor Suppressor Genes written by Wafik S. El-Deiry and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has become clear that tumors result from excessive cell proliferation and a corresponding reduction in cell death caused by the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emp- sis has shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and TSGs function in the same pathways, providing positive and negative growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Mu- tions in tumor suppressor genes have been identified in familial cancer syndromes, and the same genes in many cases have been found to be mutationally inactivated in sporadically occurring cancers. In their normal state, TSGs control cancer development and progression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pa- ways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access not only the powerful tools now available to discover these genes, but also their links to cell biology and growth control.
Book Synopsis Post-Transcriptional Regulation of Proto-Oncogene C-fms in Breast Cancer by : Ho-Hyung Woo
Download or read book Post-Transcriptional Regulation of Proto-Oncogene C-fms in Breast Cancer written by Ho-Hyung Woo and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Tumor Suppressor Genes by : Wafik S. El-Deiry
Download or read book Tumor Suppressor Genes written by Wafik S. El-Deiry and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has become clear that tumors arise from excessive cell proliferation and a c- responding reduction in cell death. Tumors result from the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emphasis shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and tumor suppressor genes function in the same pathways, providing positive and ne- tive growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Tumor suppressor genes are mutated in hereditary cancer syndromes, as well as somatically in nonhereditary cancers. In their normal state, TSGs control cancer development and p- gression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pathways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access the powerful tools now available to discover these genes, as well as their links to cell biology and growth control.
Book Synopsis Gene Regulation and Therapeutics for Cancer by : Surinder K. Batra
Download or read book Gene Regulation and Therapeutics for Cancer written by Surinder K. Batra and published by CRC Press. This book was released on 2021-03-22 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Differential gene regulation and targeted therapy are the critical aspects of several cancers. This book covers specific gene regulation and targeted therapies in different malignancies. It offers a comprehensive assessment of the transcriptional dysregulation in cancer, and considers some examples of transcriptional regulators as definitive oncogenic drivers in solid tumors, followed by a brief discussion of transcriptional effectors of the programs they drive, and discusses its specific targets. Most targeted therapeutics developed to date have been directed against a limited set of oncogenic drivers, exemplified by those encoding cell surface or cytoplasmic kinases that function in intracellular signaling cascades.
Book Synopsis Oncogenes As Transcriptional Regulators by : Moshe Yaniv
Download or read book Oncogenes As Transcriptional Regulators written by Moshe Yaniv and published by Springer Science & Business Media. This book was released on 1997 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1 E2Fs and the Retinoblastoma Protein Family.- 2 Signalling to the C-terminus of p53.- 3 Chromosome Translocations Generating Chimeric Transcription Factors, Unique Genetic Events with Pleiotropic Cellular Consequences.- 4 The Runt Domain Transcription Factor, PEBP2/CBF, and its Involvement in Human Leukemia.- 5 EBNA2: A Viral Transcription Factor Essential for the Immortalization of Human B Lymphocytes by the Epstein-Barr Virus (EBV).
Book Synopsis Transcriptional Regulation in Cancers and Metabolic Diseases by : Wen Zhou
Download or read book Transcriptional Regulation in Cancers and Metabolic Diseases written by Wen Zhou and published by Frontiers Media SA. This book was released on 2015-12-04 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: The transcription factor (TF) mediated regulation of gene expression is a process fundamental to all biological and physiological processes. Genetic changes and epigenetic modifications of TFs affect target gene expression during the formation of malignant cells. Extensive work has been done on the critical TFs in various disease models. Despite the success of numerous TF-targeted therapies, there remain significant hurdles understanding the mechanisms, transcriptional targets and networks of physiologic pathways that govern TF action. This effort is now beginning to produce exciting new avenues of research. A clinically relevant topic for genetic change of TF is the mutant isoforms of p53, the most famous tumor suppressor. The p53 mutations either results in loss of function, or acting as dominant negative for wild-type protein, or ‘gain of function’ specifically promoting cancer survival. The gain of function is achieved by shifting p53 binding partner proteins, or changed genomic binding landscape leading to a cancer-promoting transcriptome. Another example of genetic change of TF causing malignancy is the AML-ETO fusion protein in the human t(8;21)-leukemia. The fusion protein is an active TF, and more interestingly, new studies link the disease causing role of AML-ETO to the unique transcriptome in the hematopoietic stem cells. Nuclear receptors (NR) are a group of ligand-dependent TFs governing the expression of genes involved in a broad range of reproductive, developmental and metabolic programs. Genetic changes and epigenetic modifications of NRs lead to cancers and metabolic diseases. Androgen receptor (AR), estrogen receptor (ER) and progesterone receptor (PR) are well studied NRs in prostate, breast and endometrial cancers. The development in sequencing technology and computational genomics enable us to investigate the transcription programs of these master TFs in an unprecedented level. This Research Topic aims to present the most up-to-date progress in the field of transcription regulation in cancers and metabolic diseases.
Author :Nicholas B. La Thangue Publisher :Springer Science & Business Media ISBN 13 :1592591531 Total Pages :358 pages Book Rating :4.5/5 (925 download)
Book Synopsis Targets for Cancer Chemotherapy by : Nicholas B. La Thangue
Download or read book Targets for Cancer Chemotherapy written by Nicholas B. La Thangue and published by Springer Science & Business Media. This book was released on 2002-04-03 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins, a panel of leading basic researchers, pharmaceutical scientists, and clinical oncologists explain in detail the therapeutically-relevant protein targets that contribute to cancer pathology and spell out their implications for cancer drug discovery and clinical application. The authors identify and illuminate selected transcription factor oncoproteins and tumor suppressors, together with nuclear proteins that are central to the phenotype of the tumor cell involved in chromatin control. The emphasis is on new targets and approaches to cancer treatment derived from the cancer cell cycle, gene control targets, and angiogenesis.
Book Synopsis Oncogenes and Carcinogenesis by : Pinar Erkekoglu
Download or read book Oncogenes and Carcinogenesis written by Pinar Erkekoglu and published by BoD – Books on Demand. This book was released on 2019-03-06 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncogenes are mutated and/or overexpressed at high levels in tumor cells. Tumors of the lung, breast, pancreas, and colon may display specific oncogenetic features. These tumors have been largely associated with exposure to environmental carcinogens and a variety of biological agents, including viruses. These carcinogens can induce specific genetic and epigenetic alterations in these tissues, leading to aberrant functioning of oncogenes and tumor suppressor genes. On the microRNAs (miRNAs) there are significant modifiers of both transcription and translation of oncogenes in carcinogenesis. In the last 50 years, several oncogenes and microRNAs related to these oncogenes have been identified in different types of human cancers. It is now clear that high expression of oncogenes, DNA damage response, and regulation of the cell cycle are related to the circadian clock. This book will mainly focus on the expressions of different oncogenes in breast, colon, and lung cancers. Moreover, readers will gain qualified scientific knowledge of the alterations in miRNAs in different types of cancers and the effects of the circadian clock on the expression of oncogenes in carcinogenesis.
