Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Trans 10 Cis 12 Conjugated Linoleic Acid Alters Lipid Metabolism And Induces Apoptosis In 3t3 L1 Preadipocytes
Download Trans 10 Cis 12 Conjugated Linoleic Acid Alters Lipid Metabolism And Induces Apoptosis In 3t3 L1 Preadipocytes full books in PDF, epub, and Kindle. Read online Trans 10 Cis 12 Conjugated Linoleic Acid Alters Lipid Metabolism And Induces Apoptosis In 3t3 L1 Preadipocytes ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Trans-10, CIS-12 Conjugated Linoleic Acid Alters Lipid Metabolism and Induces Apoptosis in 3T3-L1 Preadipocytes by : Mary Elizabeth Evans
Download or read book Trans-10, CIS-12 Conjugated Linoleic Acid Alters Lipid Metabolism and Induces Apoptosis in 3T3-L1 Preadipocytes written by Mary Elizabeth Evans and published by . This book was released on 2001 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms by which Conjugated Linoleic Acid Causes Human Adipocyte Delipidation by : Soonkyu Chung
Download or read book Mechanisms by which Conjugated Linoleic Acid Causes Human Adipocyte Delipidation written by Soonkyu Chung and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Obesity is an important health issue, having risen to epidemic proportions in the U.S. Use of conjugated linoleic acid (CLA), positional and geometric isomers of linoleic acid, has received recent attention due to its potential health benefits including the reduction of fat mass in animals. However, the effectiveness and safety of CLA consumption in humans remains unclear. Our group previously reported that trans-10, cis-12 CLA impaired the conversion of preadipocytes into lipid-filled adipocytes (e.g., differentiation) and caused adipocyte delipidation that involved inflammatory cytokines in a human cell model. However, the isomer-specific mechanism for these events was unknown. Thus, this research examined mechanisms by which trans-10, cis-12 CLA induced adipocyte delipidation, inflammation, and insulin resistance in primary cultures of human adipocytes. Delipidation of adipocytes by trans-10, cis-12 CLA was accompanied by increased lipolysis and changes in the morphology of lipid droplets and the expression and localization of proteins regulating lipid droplet metabolism. This process involved the translational control of adipose differentiated related protein (ADRP) through activation of mTOR/p70S6K/S6 signaling and transcriptional control of perilipin A. Prior to these morphological changes, it was shown that trans-10, cis-12 CLA promoted nuclear factor κB (NFκB) and mitogen activated protein kinase (MAPK) activation and subsequent induction of interleukin (IL)-6 which were, at least in part, responsible for trans-10, cis-12 CLA-mediated suppression of peroxisome proliferator activated receptor gamma (PPAR)γ target gene expression and insulin sensitivity in human adipocytes. The essential role of NFκB on CLA-induced inflammation was confirmed by using RNA interference. Further studies were conducted examining the localization and characterization of the inflammatory response, including the type of cells involved, using lipopolysaccharide (LPS) as the inflammatory agent. It was demonstrated that LPS-induced, NFκB-dependent proinflammatory cytokine expression was predominantly from preadipocytes, which led to, at least in part, the suppression of PPAR activity and adipogenic gene expression and insulin sensitivity. Collectively, these data support the emerging concept that adipose tissue is a dynamic endocrine organ with the capacity to generate inflammatory signals that impact glucose and lipid metabolism. Furthermore, human preadipocytes have the capacity to generate these inflammatory signals induced by trans-10, cis-12 CLA and LPS, subsequently causing insulin resistance in neighboring adipocytes. These studies also revealed that NFκB- and MAPK-signaling mediate inflammation and insulin resistance induced by CLA and LPS. Thus, although the trans-10, cis-12 isomer of CLA may decrease the size and lipid content of human adipocytes, it may also cause insulin resistance, which is a hallmark of type 2 diabetes."--Abstract from author supplied metadata.
Book Synopsis Encyclopedia of Dietary Supplements by : Paul M. Coates
Download or read book Encyclopedia of Dietary Supplements written by Paul M. Coates and published by CRC Press. This book was released on 2010-06-25 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Dietary Supplements presents peer-reviewed, objective entries that rigorously examine the most significant scientific research on basic chemical, preclinical, and clinical data. Designed for healthcare professionals, researchers, and health-conscious consumers, it presents evidence-based information on the major vitamin and mineral micronutrients, herbs, botanicals, phytochemicals, and other bioactive preparations. Supplements covered include: Vitamins, beta-carotene, niacin, and folate Omega-3 and omega-6 fatty acids, isoflavones, and quercetin Calcium, copper, iron, and phosphorus 5-hydroxytryptophan, glutamine, and L-arginine St. John's Wort, ginkgo biloba, green tea, kava, and noni Androstenedione, DHEA, and melatonin Coenzyme Q10 and S-adenosylmethionine Shiitake, maitake, reishi, and cordiceps With nearly 100 entries contributed by renowned subject-specific experts, the book serves as a scientific checkpoint for the many OTC supplements carried in today's nutritional products marketplace. Also Available Online This Taylor & Francis encyclopedia is also available through online subscription, offering a variety of extra benefits for researchers, students, and librarians, including: Citation tracking and alerts Active reference linking Saved searches and marked lists HTML and PDF format options Contact Taylor and Francis for more information or to inquire about subscription options and print/online combination packages. US: (Tel) 1.888.318.2367; (E-mail) [email protected] International: (Tel) +44 (0) 20 7017 6062; (E-mail) [email protected]
Book Synopsis Effect of Trans-10, Cis-12-conjugated Linoleic Acid on Activation of Peroxisome Proliferator-activated Receptor B and Metabolic Outcomes in 3T3-L1 Adipocytes by : Celeste Gauthreaux Koster
Download or read book Effect of Trans-10, Cis-12-conjugated Linoleic Acid on Activation of Peroxisome Proliferator-activated Receptor B and Metabolic Outcomes in 3T3-L1 Adipocytes written by Celeste Gauthreaux Koster and published by . This book was released on 2005 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Chronic treatment with the dietary fatty acid, trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) reduces body fat in growing mice and inhibits adipogenesis in several adipocyte cell models. Here, we show that t10c12-CLA (100uM) and arachidonic acid (100uM) preferentially activate PPARB in both the PPARB/PPRE-TK-Luc reporter system and PPARB-GAL4/UAS-TK-Lucreporter system significantly (P
Book Synopsis Functional Genomic Characterization of the Anti-adipogenic Effects of Trans 10, Cis 12-conjugated Linoleic Acid (t10c12-CLA) in a Polygenic Obese Line of Mice by : Ralph Lee House
Download or read book Functional Genomic Characterization of the Anti-adipogenic Effects of Trans 10, Cis 12-conjugated Linoleic Acid (t10c12-CLA) in a Polygenic Obese Line of Mice written by Ralph Lee House and published by . This book was released on 2004 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keywords: apoptosis, metabolism, de-lipidation, lipid, conjugated linoleic acid, Obesity.
Book Synopsis Effect of Dietary Conjugated Linoleic Acid (CLA) on the Fatty Acid Status in Chicken and Meat Quality by : Min Du
Download or read book Effect of Dietary Conjugated Linoleic Acid (CLA) on the Fatty Acid Status in Chicken and Meat Quality written by Min Du and published by . This book was released on 2001 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation includes studies on the effect of dietary CLA on the growth, fat accumulation and fatty acid status of chicken, and chicken meat quality as influenced by irradiation. Results showed that dietary CLA did not have significant effects on the growth rate and feed efficiency in chicken. And high levels of dietary CLA slightly reduced the whole body fat content. High ratio of dietary CLA can incorporate into chicken meat and egg yolk. Dietary CLA reduced the concentration of monounsaturated fatty acids. The concentration of polyunsaturated fatty acids, including arachidonic acid, linolenic acid and linolenic acid, also reduced as the dietary CLA level increased. However, when the dietary level of linolenic acid in diet was high, dietary CLA stimulated the synthesis of DHA and EPA, which might directly relate to the biological effects of CLA. High level of dietary CLA influenced the quality of meat, which was slightly harder and drier compared to the control meat. Dietary CLA significantly improved the oxidative stability of chicken meat. The reason for the improved oxidative and color stability of meat patties during storage should be due to the reduced unsaturated fatty acid content in chicken muscles, which improved lipid and color stability and reduced volatile production in both irradiated and nonirradiated meat during storage. Irradiation greatly increased the volatile production and induced a metal-like off-odor in chicken rolls, and dietary CLA had synergistic effect on this metal-like off-odor. Irradiation also increased the redness of chicken rolls. Consumers had a preference for the color of irradiated chicken rolls, while their reactions to the flavor of irradiated chicken rolls were quite negative.
Book Synopsis Anti-adipogenic Mechanism of Conjugated Linoleic Acid by : Kihwa Kang
Download or read book Anti-adipogenic Mechanism of Conjugated Linoleic Acid written by Kihwa Kang and published by . This book was released on 2003 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Japanese Association for Animal Cell Technology. Meeting Publisher :Springer Science & Business Media ISBN 13 :9781402002717 Total Pages :508 pages Book Rating :4.0/5 (27 download)
Book Synopsis Animal Cell Technology: Basic & Applied Aspects by : Japanese Association for Animal Cell Technology. Meeting
Download or read book Animal Cell Technology: Basic & Applied Aspects written by Japanese Association for Animal Cell Technology. Meeting and published by Springer Science & Business Media. This book was released on 2002-04-30 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Thirteenth Annual Meeting of the Japanese Association for Animal Cell Technology (JAACT), Fukuoka-Karatsu, November 16-21, 2000
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1836 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Effects of Conjugated Linoleic Acids on Lipid Metabolism in Lactating Dairy Cows by : Lance Hall Baumgard
Download or read book Effects of Conjugated Linoleic Acids on Lipid Metabolism in Lactating Dairy Cows written by Lance Hall Baumgard and published by . This book was released on 2002 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Conjugated Linoleic Acid and Human Health by : Eileen F. Murphy
Download or read book Conjugated Linoleic Acid and Human Health written by Eileen F. Murphy and published by . This book was released on 2007 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conjugated linoleic acid (CLA), and its individual isomers, have been suggested to possess numerous health effects. Some of these effects appear to be isomer-specific and the underlying mechanisms are unclear. The application of transcriptomic approaches offers the potential to gain valuable insights into the mechanisms of action of CLA. The present work describes a number of studies using transcriptomic approaches, in which clear isomer-specific effects of CLA on intestinal Ca transport, carcinogensis and lipid metabolism were observed. In relation to the observed enhancement of Ca absorption, trans-10, cis-12 CLA increased paracellular Ca transport, which was associated with changes in the expression of genes encoding components of the tight-junction. In contrast, the trans-10, sis-12 CLA-mediated increase in transcellular Ca transport did not appear to relate to consistent changes in expression of the key genes encoding mediators of this route. Furthermore, trans-10, cis-12 CLA did not augment the effect of 1,25(OH)2D3-mediated transcellular transport, suggesting that its effect on this route of Ca transport are mediated through alternative mechanisms. Beyond its effect on Ca transport, the isomer-specific effects of CLA on global gene expression profiles in Caco-2 cells were investigated. In the first such study, to our knowledge, genome-wide analysis showed that trans-10, cis-12 CLA altered the expression of 918 genes in Caco-2 cells, whereas cis-9, trans-11 CLA had no effect on gene expression. While a number of expression patterns in relation to the chemopreventative mechanisms of trans-10, cis-12 CLA in colon cancer were highlighted, potential adverse effects related to intestinal HDL biogenesis and glucose metabolism were evident in the Caco-2 cells. Thus, the use of transcriptomics provides valuable insights into the possible mechanisms of action of CLA in gut cell function and health. An investigation of the effects of CLA supplementation on global gene expression at the shole-body level, using peripheral blood mononuclear cells (PBMC) from healthy adult males, showed altered expression of genes involved in glycogen and haem metabolism and prostaglandin synthesis. However, additional studies are required to further the understanding of the ability of changes in gene expression of PBMC to relate to whole-body effects associated with CLA. While these approaches increase our mechanistic understanding of the role of CLA in health, further research is required to determine the efficacy and safety of CLA in human health and its potential as a functional food ingredient.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2003 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Obesity by : George A. Bray
Download or read book Handbook of Obesity written by George A. Bray and published by CRC Press. This book was released on 2003-12-05 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: With rates of obesity soaring to epidemic proportions, this reference strives to unearth new treatment regimens and pharmaceuticals for the prevention and treatment of obesity. Offering the latest recommendations and research from the most respected leaders in the field, the Second Edition compiles the most noteworthy studies on the evaluation and
Book Synopsis Animal Cell Technology: Basic & Applied Aspects by : Sanetaka Shirahata
Download or read book Animal Cell Technology: Basic & Applied Aspects written by Sanetaka Shirahata and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal cell technology is a growing discipline of cell biology, which aims not only to understand structures, functions, and behaviours of differentiated animal cells but also to ascertain their ability to be used for industrial and medical purposes. The goal of animal cell technology includes accomplishments of clonal expansion of differentiated cells with useful ability, optimisation of their culture conditions, modulation of their ability for production of medically and pharmaceutically important proteins, and the application of animal cells to gene therapy, artificial organs, and functional foods. This volume gives the reader a complete review of the present state of the art in Japan and other countries where this field is well advanced. The Proceedings will be useful for cell biologists, biochemists, molecular biologists, immunologists, biochemical engineers, and other disciplines related to animal cell culture, working in either academic environments or in industries of biotechnology and pharmacy.
Book Synopsis Regulation of Adiposity by Dietary Conjugated Linoleic Acid by : Xiaofang Xu
Download or read book Regulation of Adiposity by Dietary Conjugated Linoleic Acid written by Xiaofang Xu and published by . This book was released on 2002 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Index Medicus written by and published by . This book was released on 2003 with total page 1902 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Cancer Research written by and published by . This book was released on 2002-08 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt:
