Book Synopsis Towards The Total Synthesis Of Terpenoid Natural Products by :
Download or read book Towards The Total Synthesis Of Terpenoid Natural Products written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The construction of diverse molecular architecture conceived and created by Nature, continues to be the most exiting and challenging task to the practitioners of organic synthesis. As a result of refinement in isolation and purification techniques, recent advances in the spectroscopic methods particularly two-dimensional NMR spectroscopy and routine use of single crystal X-ray crystallography, the isolation and structural elucidation of the complex natural products has become a routine exercise. Even those natural products which are present in minute quantity, are being unraveled from the newer and exotic sources such as marine flora and fauna, microbial organisms and insect world. This has been a big boon for the synthetic organic chemists, providing them with increasing number of exciting objectives. The recent advances in the field of natural product synthesis testify to the organic chemists endeavors to meet these emerging challenges. Nature's expertise and virtuosity in creating a phenomenal array of carbocyclic frameworks is most notably highlighted in the terpenoid group of natural products. Indeed, the number and type of carbocyclic skeleta among terpenes continues to grow unabated as more and more natural products are being routinely isolated from the various sources. Thus, various polycyclic natural products bearing new and novel fused assemblies of five, six, seven and eight membered rings and replete with dense functionalization and stereogenic centers are being regularly encountered. The present investigation represents synthetic efforts towards some novel and recently isolated terpenoid natural products. Two main themes have been pursued. The first involves the construction of a functionalized hydroazulene framework employing RCM as the key step and its further elaboration to the 5,7,6-tricyclic framework present in diterpene guanacastepene-A and 5,11-fused bicyclic system present in neodolabellane diterpenes. The second theme explores the synthetic ve.