Tnf Pathophysiology

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TNF Pathophysiology

Author : G. Kollias
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805593848
Total Pages : 223 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis TNF Pathophysiology by : G. Kollias

Download or read book TNF Pathophysiology written by G. Kollias and published by Karger Medical and Scientific Publishers. This book was released on 2010-02-18 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: TNF is a multifunctional proinflammatory cytokine central to the development and homeostasis of the immune system and a regulator of cell activation, differentiation and death. Recent decades have seen an enormous scientific and clinical interest in the function of TNF in physiology and disease. A vast amount of data has been accumulated at the biochemical, molecular and cellular level, establishing TNF as a prototype for in-depth understanding of the physiological and pathogenic functions of cytokines. This volume covers several current aspects of TNF regulation and function, including transcriptional and posttranscriptional control mechanisms, cellular modes of action, signaling networks that mediate its effect, involvement in pathogenesis and clinical outcomes of TNF antagonists. It combines basic science at the molecular and cellular level with research in animal models of disease and clinical findings to provide a comprehensive review of recent developments in TNF biology. A thorough understanding of the mechanisms by which this key molecular player is produced and functions to regulate cell biology, immunity and disease postulates novel paradigms on how genes contribute to the development and physiology of biological systems. This book is mandatory reading for molecular and cell biologists, immunologists and clinicians interested in TNF function.

TNF Pathophysiology

Author : George Kollias
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 380559383X
Total Pages : 223 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis TNF Pathophysiology by : George Kollias

Download or read book TNF Pathophysiology written by George Kollias and published by Karger Medical and Scientific Publishers. This book was released on 2010-01-01 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: TNF is a multifunctional proinflammatory cytokine central to the development and homeostasis of the immune system and a regulator of cell activation, differentiation and death. Recent decades have seen an enormous scientific and clinical interest in the function of TNF in physiology and disease. A vast amount of data has been accumulated at the biochemical, molecular and cellular level, establishing TNF as a prototype for in-depth understanding of the physiological and pathogenic functions of cytokines. This volume covers several current aspects of TNF regulation and function, including transcriptional and posttranscriptional control mechanisms, cellular modes of action, signaling networks that mediate its effect, involvement in pathogenesis and clinical outcomes of TNF antagonists. It combines basic science at the molecular and cellular level with research in animal models of disease and clinical findings to provide a comprehensive review of recent developments in TNF biology. A thorough understanding of the mechanisms by which this key molecular player is produced and functions to regulate cell biology, immunity and disease postulates novel paradigms on how genes contribute to the development and physiology of biological systems.

Cellular Pathophysiology

Author : Mohammed M. Sayeed
Publisher : CRC Press
ISBN 13 : 9780849340611
Total Pages : 186 pages
Book Rating : 4.3/5 (46 download)

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Book Synopsis Cellular Pathophysiology by : Mohammed M. Sayeed

Download or read book Cellular Pathophysiology written by Mohammed M. Sayeed and published by CRC Press. This book was released on 1989-05-31 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, there has been increased research on cellular pathophysiology in animal and tissue models simulating human disease processes. The result of this research, which has been carried out primarily by physiologists, pharmacologists, biochemists, anatomists, pathologists, and clinicians, is now presented in this forum. A better understanding of how cellular, subcellular and molecular mechanisms initiate and progressively intensify organic/systemic disease processes is important in the development of rational therapies against these disease processes.

Surgical Pathophysiology

Author : A. Aasen
Publisher : CRC Press
ISBN 13 : 9783718650385
Total Pages : 480 pages
Book Rating : 4.6/5 (53 download)

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Book Synopsis Surgical Pathophysiology by : A. Aasen

Download or read book Surgical Pathophysiology written by A. Aasen and published by CRC Press. This book was released on 1991-05-13 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pathophysiology of Shock, Sepsis, and Organ Failure

Author : Günther Schlag
Publisher : Springer Science & Business Media
ISBN 13 : 3642767362
Total Pages : 1180 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Pathophysiology of Shock, Sepsis, and Organ Failure by : Günther Schlag

Download or read book Pathophysiology of Shock, Sepsis, and Organ Failure written by Günther Schlag and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1180 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book current knowledge of the pathophysiology of shock, sepsis and multi organ failure is presented. The rapid progress which has been made and the results achieved in intensive care medicine are based on sound basic research, which is duly reflected in these chapters. Multiorgan failure is the foremost cause of postoperative and posttraumatic death and many complex mechanisms are involved. Only with a good foundation of basic research can abnormalities in the physiological, biochemical, and morphological course of shock be recognized and the necessary conclusions for treatment drawn. Therapy must proceed from profound knowledge of the multi variant physiological events in order to influence shock, sepsis and organ failure. Although numerous possibilities for therapy have arisen from pharmaceutical research in recent years, they are beyond the scope of this book and are not discussed here. To gain a better understanding of the pathophysiological events it was necessary to examine and to describe different models that simulate and reproduce these events. Here we describe the causative agents (shock) and the consequences (sepsis, organ failure) in two main sections, divided on the basis of their pathophysiology.

Crosstalk between Peripheral and Local Immune Response in the Pathophysiology of Stroke and Neurodegeneration Diseases

Author : Yuanjian Fang
Publisher : Frontiers Media SA
ISBN 13 : 2832541461
Total Pages : 363 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Crosstalk between Peripheral and Local Immune Response in the Pathophysiology of Stroke and Neurodegeneration Diseases by : Yuanjian Fang

Download or read book Crosstalk between Peripheral and Local Immune Response in the Pathophysiology of Stroke and Neurodegeneration Diseases written by Yuanjian Fang and published by Frontiers Media SA. This book was released on 2023-12-27 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Metabolic Syndrome Pathophysiology

Author : Undurti N. Das
Publisher : John Wiley & Sons
ISBN 13 : 0813815533
Total Pages : 282 pages
Book Rating : 4.8/5 (138 download)

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Book Synopsis Metabolic Syndrome Pathophysiology by : Undurti N. Das

Download or read book Metabolic Syndrome Pathophysiology written by Undurti N. Das and published by John Wiley & Sons. This book was released on 2010-02-23 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids provides current research exploring the links among insulin, insulin receptors, polyunsaturated fatty acids, brain growth and disease. Specific interactions of essential fatty acids and polyunsaturated fatty acids in brain development and several disease groups are described. The role of inflammation in disease and how fatty acids regulate low-systemic inflammation are examined and explained. Metabolic and neurologic dynamics are presented to provide a linkage between the presence of omega-3 and omega-6 and protection against diseases and conditions such as diabetes mellitus, obesity, autoimmune diseases and hypertension.

Biomarker Exploration in Neuropsychiatry: Understanding of the Pathophysiology and Therapeutic Implications

Author : HuaLin Cai
Publisher : Frontiers Media SA
ISBN 13 : 2889716902
Total Pages : 173 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Biomarker Exploration in Neuropsychiatry: Understanding of the Pathophysiology and Therapeutic Implications by : HuaLin Cai

Download or read book Biomarker Exploration in Neuropsychiatry: Understanding of the Pathophysiology and Therapeutic Implications written by HuaLin Cai and published by Frontiers Media SA. This book was released on 2021-11-25 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Role of Oxidative Stress in Pathophysiology of Diseases

Author : Pawan K. Maurya
Publisher : Springer Nature
ISBN 13 : 9811515689
Total Pages : 297 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Role of Oxidative Stress in Pathophysiology of Diseases by : Pawan K. Maurya

Download or read book Role of Oxidative Stress in Pathophysiology of Diseases written by Pawan K. Maurya and published by Springer Nature. This book was released on 2020-06-15 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress.

Essentials of Pathophysiology

Author : Carol Porth
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1582557241
Total Pages : 1280 pages
Book Rating : 4.5/5 (825 download)

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Book Synopsis Essentials of Pathophysiology by : Carol Porth

Download or read book Essentials of Pathophysiology written by Carol Porth and published by Lippincott Williams & Wilkins. This book was released on 2011 with total page 1280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Porth Pathophysiology: understanding made easy, delivered however you need it. Porth's "Essentials of Pathophysiology" 3e delivers exceptional student understanding and comprehension of pathophysiology. An expanded, robust and flexible suite of supplements makes it easy for you to select the best course resources, so you can meet your students' changing needs. For both discrete and hybrid courses, the flexibility and power of Porth allows you to customize the amount of pathophysiology that you need for effective teaching and learning. Including a resource DVD with text!

Liver Pathophysiology

Author : Pablo Muriel
Publisher : Academic Press
ISBN 13 : 0128043210
Total Pages : 914 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Liver Pathophysiology by : Pablo Muriel

Download or read book Liver Pathophysiology written by Pablo Muriel and published by Academic Press. This book was released on 2017-03-02 with total page 914 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. Provides in vivo and in vitro models to study human liver pathology. Explains the beneficial effects of antioxidants on liver diseases. Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.

Recent Advances in the Pathophysiology of Gastro-intestinal and Liver Diseases

Author : J. P. Galmiche
Publisher : John Libbey Eurotext
ISBN 13 : 9782742001804
Total Pages : 288 pages
Book Rating : 4.0/5 (18 download)

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Book Synopsis Recent Advances in the Pathophysiology of Gastro-intestinal and Liver Diseases by : J. P. Galmiche

Download or read book Recent Advances in the Pathophysiology of Gastro-intestinal and Liver Diseases written by J. P. Galmiche and published by John Libbey Eurotext. This book was released on 1997 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Postgraduate Course 1997, Nantes, 3 to 7 July. In January 1997, John Libbey Eurotext first published this course organised by the European Association of Gastroenterology and Endoscopy (EAGE) for young doctors and researchers, and given by the leading European specialists in the field. As well as the annual course, EAGE also wanted to hold provincial courses with a high scientific content. This is the course given by Professors Galmiche and Gournay last July in Nantes. The aim of these lectures is to present the latest advances in basic and clinical research into gastroenterology and hepatology.

Physiology and Pathophysiology of Temperature Regulation

Author : Clark M Blatteis
Publisher : World Scientific
ISBN 13 : 9814497290
Total Pages : 308 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Physiology and Pathophysiology of Temperature Regulation by : Clark M Blatteis

Download or read book Physiology and Pathophysiology of Temperature Regulation written by Clark M Blatteis and published by World Scientific. This book was released on 1998-06-15 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a user-friendly monograph designed for medical students as well as graduate students and postdoctoral trainees in medicine and other health-related sciences who need a comprehensive overview of thermoregulation. It presents the bases of the modern concepts in thermal physiology and pathophysiology, bringing together the disciplines encompassed by this highly integrative field — physiology, anatomy, biophysics, molecular and cellular biology, pharmacology, neuroscience, pathology, medicine, and others — into a clear and concise form that can be read comfortably in a relatively short time. This text was conceived by the Commission on Thermal Physiology of the International Union of Physiological Sciences in response to its concern over the inadequate and outdated coverage of this topic in traditional textbooks. The membership of this Commission comprises international experts in each of the subfields of thermal physiology, with extensive research and teaching experience in their respective specialties. They are the authors of the chapters of this indispendable textbook. Contents:Thermal Physiology: Brief History and Perspectives (A S Milton)Body Temperature (C M Blatteis)Biophysics of Heat Exchange between Body and Environment (J Werner)Heat Production Mechanisms: Shivering (L Jansky)Heat Production Mechanisms: Nonshivering Thermogenesis and Brown Adipose Tissue (B Cannon & J Nedergaard)Heat Loss Mechanisms (T Morimoto)Neural Thermal Reception and Regulation of Body Temperature (J A Boulant)Thermiatrics and Behavior (M Cabanac)Temperature Regulation in Exercise (B N Johannsen & H Kaciuba-Uscilko)Body Temperature and Age: Thermoregulation in the Neonates (H P Laburn)Body Temperature and Age: Thermoregulation in the Elderly (K E Cooper)Fever (C M Blatteis)Thermoregulatory Consequences of Prolonged Exposure to Thermal Extremes: Prolonged Exposure to Heat (M Horowitz)Thermoregulatory Consequences of Prolonged Exposure to Thermal Extremes: Cold Adaptation (E Zeisberger)Pathophysiological Consequences of Exposure to Thermal Extremes: Pathophysiology of Hyperthermia (M Horowitz & J R S Hales)Pathophysiological Consequences of Exposure to Thermal Extremes: Hypothermia and Cold Injuries in Man (J B Mercer)Temperature Regulation in Special Situations (C M Blatteis) Readership: Researchers and students in physiology, biochemistry, biomedical engineering, neural networks, paediatrics, pharmacology/pharmacy, surgery and toxicology. keywords:Thermometry;Body Temperature;Thermogenesis;Heat Loss;Heat Exchange;Nervous Control of Body Temperature;Fever;Aging;Thermal Extremes;Thermoregulatory Behaviour “… this book is an excellent resource. It provides the reader with basic, applied, and clinically relevant material on the most pertinent aspects of thermal physiology … even a neophyte will find aspects of this book fascinating and understandable.” The Physiologist “Most chapters are superbly written, beautifully illustrated, and highly informative … This book is a bargain, and one that those interested in thermophysiology will treasure.” The Quarterly Review of Biology

Etiology and Pathophysiology of Parkinson's Disease

Author : Md, Frcpc, Frcp (hon), Abdul Qayyum Rana
Publisher : BoD – Books on Demand
ISBN 13 : 9533074620
Total Pages : 556 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Etiology and Pathophysiology of Parkinson's Disease by : Md, Frcpc, Frcp (hon), Abdul Qayyum Rana

Download or read book Etiology and Pathophysiology of Parkinson's Disease written by Md, Frcpc, Frcp (hon), Abdul Qayyum Rana and published by BoD – Books on Demand. This book was released on 2011-10-12 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book about Parkinson's disease provides a detailed account of etiology and pathophysiology of Parkinson's disease, a complicated neurological condition. Environmental and genetic factors involved in the causation of Parkinson's disease have been discussed in detail. This book can be used by basic scientists as well as researchers. Neuroscience fellows and life science readers can also obtain sufficient information. Beside genetic factors, other pathophysiological aspects of Parkinson's disease have been discussed in detail. Up to date information about the changes in various neurotransmitters, inflammatory responses, oxidative pathways and biomarkers has been described at length. Each section has been written by one or more faculty members of well known academic institutions. Thus, this book brings forth both clinical and basic science aspects of Parkinson's disease.

Pathogenesis of Systemic Lupus Erythematosus

Author : Alberta Hoi
Publisher : Springer Nature
ISBN 13 : 3030851613
Total Pages : 192 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Pathogenesis of Systemic Lupus Erythematosus by : Alberta Hoi

Download or read book Pathogenesis of Systemic Lupus Erythematosus written by Alberta Hoi and published by Springer Nature. This book was released on 2021-11-15 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.

Myokines, Adipokines, Cytokines in Muscle Pathophysiology

Author : Valentina Di Felice
Publisher : Frontiers Media SA
ISBN 13 : 2889662721
Total Pages : 256 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Myokines, Adipokines, Cytokines in Muscle Pathophysiology by : Valentina Di Felice

Download or read book Myokines, Adipokines, Cytokines in Muscle Pathophysiology written by Valentina Di Felice and published by Frontiers Media SA. This book was released on 2020-12-24 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response

Author :
Publisher : Frontiers Media SA
ISBN 13 : 288974101X
Total Pages : 1671 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response by :

Download or read book Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response written by and published by Frontiers Media SA. This book was released on 2023-01-25 with total page 1671 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume I.A An outbreak of a respiratory disease first reported in Wuhan, China in December 2019 and the causative agent was discovered in January 2020 to be a novel betacoronovirus of the same subgenus as SARS-CoV and named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) has rapidly disseminated worldwide, with clinical manifestations ranging from mild respiratory symptoms to severe pneumonia and a fatality rate estimated around 2%. Person to person transmission is occurring both in the community and healthcare settings. The World Health Organization (WHO) has recently declared the COVID-19 epidemic a public health emergency of international concern. The ongoing outbreak presents many clinical and public health management challenges due to limited understanding of viral pathogenesis, risk factors for infection, natural history of disease including clinical presentation and outcomes, prognostic factors for severe illness, period of infectivity, modes and extent of virus inter-human transmission, as well as effective preventive measures and public health response and containment interventions. There are no antiviral treatment nor vaccine available but fast track research and development efforts including clinical therapeutic trials are ongoing across the world. Managing this serious epidemic requires the appropriate deployment of limited human resources across all cadres of health care and public health staff, including clinical, laboratory, managerial and epidemiological data analysis and risk assessment experts. It presents challenges around public communication and messaging around risk, with the potential for misinformation and disinformation. Therefore, integrated operational research and intervention, learning from experiences across different fields and settings should contribute towards better understanding and managing COVID-19. This Research Topic aims to highlight interdisciplinary research approaches deployed during the COVID-19 epidemic, addressing knowledge gaps and generating evidence for its improved management and control. It will incorporate critical, theoretically informed and empirically grounded original research contributions using diverse approaches, experimental, observational and intervention studies, conceptual framing, expert opinions and reviews from across the world. The Research Topic proposes a multi-dimensional approach to improving the management of COVID-19 with scientific contributions from all areas of virology, immunology, clinical microbiology, epidemiology, therapeutics, communications as well as infection prevention and public health risk assessment and management studies.