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Thrombin
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Book Synopsis The Chemical Biology of Thrombin by : Roger L. Lundblad
Download or read book The Chemical Biology of Thrombin written by Roger L. Lundblad and published by . This book was released on 2023-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Biology of Thrombin is a comprehensive review of thrombin as regulatory protease, perhaps one of the most important enzymes in hemostasis. It focuses on work from 1970's to the present time. Thrombin has some emerging therapeutic uses such the treatment of pseudoaneurysms and an important role in the extravascular space.
Book Synopsis Laboratory Techniques in Thrombosis — a Manual by : J. Jespersen
Download or read book Laboratory Techniques in Thrombosis — a Manual written by J. Jespersen and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of this manual appeared in 1992 and was entitled ECAT Assay Procedures. It was the result of a unique cooperation between experts brought together by the European Concerted Action on Thrombosis and Disabilities (ECAT). The Concerted Action was at that time under the auspices of the Commission of the European Union. The second edition, like the first edition, deals with diagnostic tests within the field of thrombosis. However, the second edition has a broader scope because it is no longer limited by the frontiers of ECAT. Experts allover the world, in and outside ECAT, have contributed to this edition. The editors are very grateful for their contributions. The need for a new edition is obvious. Since 1992 new assays have been introduced for research, diagnosis, and therapy of thrombosis; for other assays improvements have been suggested, while a few others became redundant. The editors waived the radioimmunoassays of ~-thrombog1obulin and platelet factor 4 due to the fact that the kits required for these assays are rarely, or no longer, available. Also the PAI-1 activity assay was waived as it is liable to many inconsistencies and to large variations. A list of names and addresses of manufacturers marketing the kits and reagents has been compiled, together with a list of the recommended nomenclature of quantities in thrombosis and haemostasis, in order to facilitate the use of the updated version. These lists have been carefully compiled by Johannes J. Sidelmann, PhD, Department of Clinical Biochemistry in Esbjerg, Denmark.
Author :Michael E. Maragoudakis Publisher :Springer Science & Business Media ISBN 13 :038709637X Total Pages :272 pages Book Rating :4.3/5 (87 download)
Book Synopsis Thrombin by : Michael E. Maragoudakis
Download or read book Thrombin written by Michael E. Maragoudakis and published by Springer Science & Business Media. This book was released on 2010-04-02 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: In addition to its central role in blood coagulation, it has become increasingly apparent that thrombin and thrombin receptors are involved in many other physiological processes and can contribute to a variety of disease states such as tumor progression and metastasis, inflammation, neurological disorders and cardiovascular complications. This book is a collection of reviews of up-to-date information on the above topics by leaders in these fields. This book will be of value to researchers and academic professionals both in basic and clinical science who are interested in the fields of biochemistry, biophysics, cell biology, pharmacology, cancer, inflammation, angiogenesis, cardiovascular system and neuronal system. These areas of research are prime target areas for drug development by many pharmaceutical and biotechnology companies.
Book Synopsis The Chemical Biology of Thrombin by : Roger L. Lundblad
Download or read book The Chemical Biology of Thrombin written by Roger L. Lundblad and published by CRC Press. This book was released on 2022-05-01 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive review of thrombin, especially as regulatory protease. The ready availability of highly purified thrombin has stimulated rapid advances in the cell biology of this important macromolecule. The text focuses on research findings from the discovery of thrombin by Andrew Buchanan in 1842 to the present. A substantial amount of this work was conducted by the author and his colleagues. His work on the purification of thrombin was seminal to much subsequent work on thrombin. This volume provides a framework for future studies now made possible by the discovery of the importance of exosites in the physiology of thrombin function. The current work describes the process of the development of an oral inhibitor of thrombin used in the prevention of thrombosis. Key Features Reviews the history of Thrombin (Fibrin Ferment) Documents the relation of protein engineering and chemical modification in the study of thrombin Summarizes the interaction of thrombin with fibrinogen and fibrin Outlines the role of exosites in thrombin function Describes the development of an oral inhibitor for thrombin
Download or read book Thrombin written by Lawrence J. Berliner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on thrombin structure and function has progressed significantly over the past three decades. We are continually discovering new functions f()r this enzyme in biology. Yet, until quite recently, a full, detailed, three dimensional picture of its structure was difficult to attain. We believe that this text represents a turning point and, more appropriately, a new start ing point for thrombin studies. Our goal for this text is to present a thorough and rounded-out coverage of thrombin chemistry and biochem istry in order to provide the biochemist and physiologist with an excellent desk reference on almost any thrombin-related problem. This volume is organized into three general thrombin topic areas: Structure, Biochemistry, and Physiology. In Part 1, Structure, we open with the complete three-dimensional x-ray structures of two inhibited human thrombin complexes, one of which is the thrombin-hirudin com plex. These complexes are also addressed in the chapter on structural studies in solution, which include NMR, ESR, and fluorescence. Part 2, Biochemistry, includes chapters on synthetic thrombin inhibitors, protein inhibitors (e.g., antithrombin III, hirudin), and thrombin interactions with factor XIII. Part 3, Physiology, covers such topics as chemotactic activities, interactions with cell surfaces, and the vascular endothelium.
Book Synopsis The Design of Synthetic Inhibitors of Thrombin by : Goran Claeson
Download or read book The Design of Synthetic Inhibitors of Thrombin written by Goran Claeson and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: In one generation, the numerous factors involved in blood coagulation have become real protein entities, isolated in pure form, expressed by recombinant DNA techniques, and subjected to structure elucidation by the modem methods of physical chemistry, viz. , X-ray diffraction, and NMR, ESR and fluorescence spectroscopy. The major milestone in this field was the breakthrough achieved by W. Bode, R. Huber and their colleagues in 1989 in of human a-thrombin, inhibited with D-Phe-Pro-Arg determining the crystal structure chioromethyl ketone. The availability of this structure will greatly facilitate the interpretation of experiments designed to gain an understanding of the interatomic interactions between this enzyme and fibrinogen and its other substrates. At the same time, it provides a rational basis for the design and synthesis of inhibitors of thrombin, the subject of this symposium. The symposium was organized in four sessions: (1) Structural features of the interaction of thrombin with substrates and inhibitors, (2) Synthetic inhibitors, (3) Hirudin and its analogues, and (4) Pharmacological and clinical considerations. This book contains summaries of most of the papers presented, and takes its rigbful place among two others that provide a comprehensive picture of our current knowledge about thrombin, viz. the 1977 volume entitled "Chemistry and Biology of Thrombin", edited by R. L. Lundblad, J. W. Fenton II, and K. G. Mann, and the 1992 volume entitled "Thrombin: Structure and Function", edited by L. J. Berliner.
Book Synopsis Advances in thrombin generation by : Romy De Laat-Kremers
Download or read book Advances in thrombin generation written by Romy De Laat-Kremers and published by Frontiers Media SA. This book was released on 2023-04-26 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Recent Developments in the Field of Thrombin Inhibitors by : Jorg Struzebecher
Download or read book Recent Developments in the Field of Thrombin Inhibitors written by Jorg Struzebecher and published by CRC Press. This book was released on 1995-03 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Misch's Avoiding Complications in Oral Implantology by : Carl E. Misch
Download or read book Misch's Avoiding Complications in Oral Implantology written by Carl E. Misch and published by Elsevier Health Sciences. This book was released on 2017-03-24 with total page 907 pages. Available in PDF, EPUB and Kindle. Book excerpt: See how to effectively manage ALL dental implant complications throughout ALL phases of treatment! Avoiding Complications in Oral Implantology provides evidence-based management protocols for a wide range of implant problems such as placement complications, malpositioning, bleeding, infection, and nerve injuries. Hundreds of high-quality, full-color photos and illustrations clearly demonstrate the complications and their resolution. Edited by Carl Misch and Randolph Resnik — both well-known names in dental implantology and prosthodontics — and with a team of expert contributors, this authoritative guide helps you handle the implant-related complications that can occur as more and more patients choose dental implants. Expert authors are joined by a panel of recognized leaders in implant dentistry — many of whom are associated with the Misch International Implant Institute — to share their extensive experience with handling complications through all phases of treatment. Comprehensive approach to complications that occur in the different phases of oral implantology provides the knowledge and skills you need to handle treatment planning, implant placement, post-operative complications, prostheses-related complications, and more. Over 1,000 images include full-color clinical photographs, radiographs, line drawings, and diagrams, clearly demonstrating complications, procedures, and outcomes. Management protocols developed by world-renowned dental implantologists provide a proven system and authoritative guidance in managing complications with dental implants. Evidence-based solutions make it easier to manage a wide variety of clinical problems associated with dental implants, with state-of-the-art guidance supported by the best available research.
Book Synopsis Consultative Hemostasis and Thrombosis E-Book by : Craig S. Kitchens
Download or read book Consultative Hemostasis and Thrombosis E-Book written by Craig S. Kitchens and published by Elsevier Health Sciences. This book was released on 2013-02-20 with total page 843 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique clinical focus makes Consultative Hemostasis and Thrombosis, 3rd Edition your go-to guide for quick, practical answers on managing the full range of bleeding and clotting disorders. Emphasizing real-world problems and solutions, Dr. Craig S. Kitchens, Dr. Barbara A. Konkle, and Dr. Craig M. Kessler provide all the clinical guidance you need to make optimal decisions on behalf of your patients and promote the best possible outcomes. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Efficiently look up concise descriptions of each condition, its associated symptoms, laboratory findings, diagnosis, differential diagnosis, and treatment. Get the latest information on hot topics such as Disseminated Intravascular Coagulation, Thrombophilia, Clinical and Laboratory Assessment and Management, Thrombotic -Thrombocytopenic Purpura, and Heparin-Induced Thrombocytopenia. Apply today’s newest therapies, including those that are quickly becoming standard in this fast-changing field. Meet the needs of specific patient groups with a new chapter on Bleeding and the Management of Hemorrhagic Disorders in Pregnancy and an extensively updated chapter on Thrombosis and Cancer. Zero in on key information with a new user-friendly design, and all-new full-color format, abundant laboratory protocols, and at-a-glance tables and charts throughout.
Book Synopsis Trauma Induced Coagulopathy by : Hunter B. Moore
Download or read book Trauma Induced Coagulopathy written by Hunter B. Moore and published by Springer Nature. This book was released on 2020-10-12 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities. Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.
Book Synopsis Essential Guide to Blood Coagulation by : Margareta Blombäck
Download or read book Essential Guide to Blood Coagulation written by Margareta Blombäck and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide to laboratory diagnosis and treatment of hemostatic disorders. This concise book covers all you need to know to manage thrombotic and bleeding disorders, distilling the most clinically up-to-date information, and including the latest treatment strategies for key conditions and diseases. Essential Guide to Blood Coagulation covers both the stable and the acute stages of hereditary and acquired bleeding and thrombotic disorders. Faced with a bleeding patient, it may be difficult to determine whether blood loss is due to a local factor or an underlying hemostatic defect. There are a range of laboratory tests which can be performed to identify the cause of bleeding in a patient. This book highlights the tests that can be used in the laboratory to aid diagnosis. Originally published in Swedish, Essential Guide to Blood Coagulation, has been revised to include the latest treatment strategies available for patients and will help clinicians to expand their knowledge of hemostatic disorders.
Book Synopsis Synthesis of Best-Seller Drugs by : Ruben Vardanyan
Download or read book Synthesis of Best-Seller Drugs written by Ruben Vardanyan and published by Academic Press. This book was released on 2016-01-07 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation
Book Synopsis Hematopathology and Coagulation by : Amer Wahed
Download or read book Hematopathology and Coagulation written by Amer Wahed and published by Cambridge University Press. This book was released on 2017-05-27 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides questions and answers to test readers' knowledge of hematopathology and coagulation, for use when preparing for the American Board of Pathology exams.
Book Synopsis Pediatric Hematology by : Robert Wynn
Download or read book Pediatric Hematology written by Robert Wynn and published by Cambridge University Press. This book was released on 2017-02-16 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: A succinct summary of the key principles and facts that guide the everyday practice of modern, clinical paediatric hematology. Covering all the information necessary for examinations in the topic, this book is ideal for postgraduates studying paediatric hematology, as well as for junior doctors in training.
Book Synopsis Rodak's Hematology - E-Book by : Elaine M. Keohane
Download or read book Rodak's Hematology - E-Book written by Elaine M. Keohane and published by Elsevier Health Sciences. This book was released on 2019-02-22 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: Make sure you are thoroughly prepared to work in a clinical lab. Rodak’s Hematology: Clinical Principles and Applications, 6th Edition uses hundreds of full-color photomicrographs to help you understand the essentials of hematology. This new edition shows how to accurately identify cells, simplifies hemostasis and thrombosis concepts, and covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins. Easy to follow and understand, this book also covers key topics including: working in a hematology lab; complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics; the parts and functions of the cell; and laboratory testing of blood cells and body fluid cells. UPDATED nearly 700 full-color illustrations and photomicrographs make it easier for you to visualize hematology concepts and show what you’ll encounter in the lab, with images appearing near their mentions in the text to minimize flipping pages back and forth. UPDATED content throughout text reflects latest information on hematology. Instructions for lab procedures include sources of possible errors along with comments. Hematology instruments are described, compared, and contrasted. Case studies in each chapter provide opportunities to apply hematology concepts to real-life scenarios. Hematology/hemostasis reference ranges are listed on the inside front and back covers for quick reference. A bulleted summary makes it easy for you to review the important points in every chapter. Learning objectives begin each chapter and indicate what you should achieve, with review questions appearing at the end. A glossary of key terms makes it easy to find and learn definitions. NEW! Additional content on cell structure and receptors helps you learn to identify these organisms. NEW! New chapter on Introduction to Hematology Malignancies provides and overview of diagnostic technology and techniques used in the lab.
Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
