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The Wild Mouse In Immunology
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Book Synopsis The Wild Mouse in Immunology by : Michael Potter
Download or read book The Wild Mouse in Immunology written by Michael Potter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume of "Current Topics in Microbiology and Immunology" is a series of papers on subjects that are relevant to the growing use of 'wild mice' in immunological, microbiological and genetical research. 'Wild mice' is a jargonistic term that is used chiefly in the laboratory to refer to the naturally living forms of house mice (Mus musculus) and also other species closely related to M. musculus. This group of species is designated by systematists as the genus Mus. Immunologists began 20 years ago to study the polymorphisms of 1mmunoglobulins and major histocompatibility complex antigens in wild mice. An extrordinary extension of the highly polymorphic array of phenotypes known in inbred mice was encountered. Breeding stocks of wild mice were brought into the laboratory. This included not only M. musculus but a)so many of the available species in the genus Mus-from Southeast Asia ~nd Europe. This availability led to other comparisons of 'wild' and inbred mice and the discovery of other new and interesting phenotypes and genotypes. It became apparent that inbred strains of mice provided only a limited window for viewing the genetic diversity of Mus musculus.
Book Synopsis Microbiome in Human Health and Disease by : Pallaval Veera Bramhachari
Download or read book Microbiome in Human Health and Disease written by Pallaval Veera Bramhachari and published by Springer Nature. This book was released on 2021-10-18 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture & environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture & environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture & environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe & plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead. Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinking—the capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science.This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.
Book Synopsis Wild Immunology—The Answers Are Out There by : Gregory M. Woods
Download or read book Wild Immunology—The Answers Are Out There written by Gregory M. Woods and published by Frontiers Media SA. This book was released on 2019-03-20 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Go into partnership with nature; she does more than half the work and asks none of the fee.” - Martin H. Fisher. Nature has undertaken an immense amount of work throughout evolution. The evolutionary process has provided a power of information that can address key questions such as - Which immune molecules and pathways are conserved across species? Which molecules and pathways are exploited by pathogens to cause disease? What methods can be broadly used or readily adapted for wild immunology? How does co-infection and exposure to a dynamic environment affect immunity? Section 1 addresses these questions through an evolutionary approach. Laboratory mice have been instrumental in dissecting the nuances of the immune system. The first paper investigates the immunology of wild mice and reviews how evolution and ecology sculpt differences in the immune responses of wild mice and laboratory mice. A better understanding of wild immunology is required and sets the scene for the subsequent papers. Although nature doesn't ask for a fee, it is appropriate that nature is repaid in one form or another. The translational theme of the second section incorporates papers that translate wild immunology back to nature. But any non-human, non-laboratory mouse research environment is hindered by a lack of research tools, hence the underlying theme throughout the second section. Physiological resource allocation is carefully balanced according to the most important needs of the body. Tissue homeostasis can involve trade-offs between energy requirements of the host and compensatory mechanisms to respond to infection. The third section comprises a collection of papers that employ novel strategies to understand how the immune system is compensated under challenging physiological situations. Technology has provided substantial advances in understanding the immune system at cellular and molecular levels. The specificity of these tools (e.g. monoclonal antibodies) often limits the study to a specific species or strain. A consequence of similar genetic sequences or cross-reactivity is that the technology can be adapted to wild species. Section 4 provides two examples of probing wild immunology by adapting technology developed for laboratory species.
Book Synopsis Genetics in Wild Mice by : Kazuo Moriwaki
Download or read book Genetics in Wild Mice written by Kazuo Moriwaki and published by . This book was released on 1994 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Origins of Inbred Mice by : Herbert C. III Morse
Download or read book Origins of Inbred Mice written by Herbert C. III Morse and published by Elsevier. This book was released on 2012-12-02 with total page 737 pages. Available in PDF, EPUB and Kindle. Book excerpt: Origins of Inbred Mice documents the proceedings of a symposium on the state of knowledge on inbred mice held in Bethesda, Maryland, in 1978. The book is organized into seven parts. Part I provides introductory remarks on the history of the development of inbred mice. Part II contains papers that examine mutations of inbred strains of mice. Part III contains studies dealing with viruses that affect inbred mice, including those that cause leukemia and mammary tumors. Part IV examines histocompatibility genes and their antigens; cell surface antigens of mouse leukemia; the characteristics of genes of the Tla region of the mouse; and the use of recombinant inbred strains in gene mapping. Part V presents studies on differences among sublines of inbred mouse strains. The papers in Part VI focus on wild mice, covering their classification and biochemical polymorphisms. Finally, Part VIII discusses the viruses, T locus, and histocompatibility antigens of wild mice.
Book Synopsis The Mouse in Biomedical Research by :
Download or read book The Mouse in Biomedical Research written by and published by Academic Press. This book was released on 2006-12-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In no other species of animal has such a wealth of experimental data been utilized for scientific pursuits. Now in its Second Edition, this Four Volume Set is dedicated to the understanding of the mouse and its role in scientific research. This valuable compendium serves as a standard reference source of information for students embarking on scientific careers, specialists in laboratory animal science, technicians in both animal care and research, and the broad scientific community. This set is also sold individually and covers History, Wild Mice, and Genetics; Diseases; Normative Biology, Husbandry, and Models; and Immunology. Volume 1: History, Wild Mice, and Genetics KEY FEATURES: . A primer for scientists new to the field of mouse research . Information about the history, biology and genomics of the laboratory mouse (Mus musculus) . Mouse origins and relationships covered in chapters on history, evolutionary taxonomy and wild mice . Mouse genetics and genomics discussed in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome . Use of the mouse as a model system for basic biomedical research described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation Volume 2: Diseases KEY FEATURES: . New format by discussing specific disease causing microorganisms versus the format used in the first edition which discussed infectious diseases affecting specific organs and tissues . Consists of 26 chapters subdivided into RNA viruses and DNA viruses, mycotic, and parasitic infections. . Provides updates on pathogenesis, epidemiology and prevention of previously recognized murine pathogens . Offers information on newly recognized disease-causing organisms: mouse parvovirus, cilia associated respiratory bacilli and Helicobacter Volume 3: Normative Biology, Husbandry, and Models KEY FEATURES: . Encompasses 23 chapters with a broad overview on the laboratory mouse's normative biology, husbandry, and its use as a model in biomedical research. . Includes chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. . Discusses management, nutrition, gnotobiotics and disease surveillance . Provides analysis of the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases Volume 4: Immunology KEY FEATURES: . A complete new addition to this series, dedicated to mouse immunology including both the innate and adaptive immune systems . Based on the mouse as a choice model when studying immunity in man-arguably more is known about the immune system in mice than any other species except man . Chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells NEW TO THIS EDITION: * Over 50% new material * Each volume contains 4-color page inserts with indispensable figures * Greatly expanded sections on genetics including: the mouse genome, gene mapping, and gene therapy * Information on newly recognized disease-causing organisms, such as mouse parvovirus and Helicobacter * A volume entirely devoted to mouse immunology * New section on stem cell biology * Each of the four volumes are available individually
Book Synopsis Mouse Models of Innate Immunity by : Irving C. Allen
Download or read book Mouse Models of Innate Immunity written by Irving C. Allen and published by Humana Press. This book was released on 2013-07-04 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: The innate immune system represents a critical arm of the immune response by providing immediate and robust host defense; however, human studies of its function are often limited by ethical, logistical, and technical obstacles. In Mouse Models of Innate Immunity: Methods and Protocols, experts in the field explore the design and execution of experiments used to thoroughly evaluate critical elements associated with the host innate immune response. The volume opens with methods that are essential for collecting and assessing various primary cells that are highly relevant to innate immunity, and it continues with in vivo protocols commonly used to evaluate the innate immune response in the mouse, including mouse models of respiratory infection, gastrointestinal inflammation, fungal and parasitic diseases, sepsis, and HIV-1 infection. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Mouse Models of Innate Immunity: Methods and Protocols will serve the research community by providing expert advice and protocols that allow both experienced and novice investigators to successfully plan, implement, and assess disease processes associated with the innate immune response.
Book Synopsis Nutrient Requirements of Laboratory Animals, by : National Research Council
Download or read book Nutrient Requirements of Laboratory Animals, written by National Research Council and published by National Academies Press. This book was released on 1995-02-01 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparationâ€"including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.
Book Synopsis The Mouse in Biomedical Research by :
Download or read book The Mouse in Biomedical Research written by and published by Elsevier. This book was released on 2006-12-04 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: History, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research.
Book Synopsis Cytokine Knockouts by : Giamila Fantuzzi
Download or read book Cytokine Knockouts written by Giamila Fantuzzi and published by Springer Science & Business Media. This book was released on 2003-07-30 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.
Book Synopsis Immunology Of Nude Mice by : Miroslav Holub
Download or read book Immunology Of Nude Mice written by Miroslav Holub and published by CRC Press. This book was released on 2020-03-25 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1989, Immunology of Nude Mice presents a discussion of the nature of this viable laboratory mutant. This new volume updates all immunological information contained in the sparse literature concerning nude mice. It comprehensively explores some of the fre-quent questions associated with nude mice, such as if the mutant is really athymic or if the thymic defect causes all of the other deviations from brain to gonads. The practical consequences of hairlessness of the mutant are also consid-ered. Illustrated with original photographs and tables doc-umenting novel facts in immunology and physiology of nude mice, this publication is valuable for investigators and stu-dents entering the field.
Book Synopsis Analysis of Biological Networks by : Björn H. Junker
Download or read book Analysis of Biological Networks written by Björn H. Junker and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introduction to biological networks and methods for their analysis Analysis of Biological Networks is the first book of its kind to provide readers with a comprehensive introduction to the structural analysis of biological networks at the interface of biology and computer science. The book begins with a brief overview of biological networks and graph theory/graph algorithms and goes on to explore: global network properties, network centralities, network motifs, network clustering, Petri nets, signal transduction and gene regulation networks, protein interaction networks, metabolic networks, phylogenetic networks, ecological networks, and correlation networks. Analysis of Biological Networks is a self-contained introduction to this important research topic, assumes no expert knowledge in computer science or biology, and is accessible to professionals and students alike. Each chapter concludes with a summary of main points and with exercises for readers to test their understanding of the material presented. Additionally, an FTP site with links to author-provided data for the book is available for deeper study. This book is suitable as a resource for researchers in computer science, biology, bioinformatics, advanced biochemistry, and the life sciences, and also serves as an ideal reference text for graduate-level courses in bioinformatics and biological research.
Book Synopsis Advances in Network Clustering and Blockmodeling by : Patrick Doreian
Download or read book Advances in Network Clustering and Blockmodeling written by Patrick Doreian and published by John Wiley & Sons. This book was released on 2020-02-03 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an overview of the developments and advances in the field of network clustering and blockmodeling over the last 10 years This book offers an integrated treatment of network clustering and blockmodeling, covering all of the newest approaches and methods that have been developed over the last decade. Presented in a comprehensive manner, it offers the foundations for understanding network structures and processes, and features a wide variety of new techniques addressing issues that occur during the partitioning of networks across multiple disciplines such as community detection, blockmodeling of valued networks, role assignment, and stochastic blockmodeling. Written by a team of international experts in the field, Advances in Network Clustering and Blockmodeling offers a plethora of diverse perspectives covering topics such as: bibliometric analyses of the network clustering literature; clustering approaches to networks; label propagation for clustering; and treating missing network data before partitioning. It also examines the partitioning of signed networks, multimode networks, and linked networks. A chapter on structured networks and coarsegrained descriptions is presented, along with another on scientific coauthorship networks. The book finishes with a section covering conclusions and directions for future work. In addition, the editors provide numerous tables, figures, case studies, examples, datasets, and more. Offers a clear and insightful look at the state of the art in network clustering and blockmodeling Provides an excellent mix of mathematical rigor and practical application in a comprehensive manner Presents a suite of new methods, procedures, algorithms for partitioning networks, as well as new techniques for visualizing matrix arrays Features numerous examples throughout, enabling readers to gain a better understanding of research methods and to conduct their own research effectively Written by leading contributors in the field of spatial networks analysis Advances in Network Clustering and Blockmodeling is an ideal book for graduate and undergraduate students taking courses on network analysis or working with networks using real data. It will also benefit researchers and practitioners interested in network analysis.
Book Synopsis Standards of Mouse Model Phenotyping by : Martin Hrabé de Angelis
Download or read book Standards of Mouse Model Phenotyping written by Martin Hrabé de Angelis and published by John Wiley & Sons. This book was released on 2009-09-03 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book in the field of mouse genetics to provide comprehensive and standardized methods for the characterization of laboratory mice. The editor is Director of the German Mouse Clinic and member of the Project Committee of the German National Genome Research Network and provides here a brief introduction to the mouse as a model for diseases and functional analysis of genes and proteins. Throughout, he focuses on the characterization of mouse models using the latest phenotyping methods, with the different areas presented in a clearly structured and easily accessible manner.
Book Synopsis Biology of the Mouse Histocompatibility-2 Complex by : J. de Klein
Download or read book Biology of the Mouse Histocompatibility-2 Complex written by J. de Klein and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Somewhere I heard a story of a bridge and a painter. The bridge was enormous and was made all of metal, and the painter's job was to keep it from rusting. He would start at one end and slowly proceed, day by day, month by month, toward the other end, painting the bridge. But no sooner would he finish with the painting than the bridge would begin to rust again. The rust, too, would start at one end and slowly proceed toward the other end, systematically destroying the painter's endeavor. And so the painter would return to where he had started, and begin painting again, slowly proceeding toward the other end of the bridge, always just one step ahead of the rust. And if the story is true, the painter might still be painting that bridge-a modern Sisyphus! During the writing of this book, the story of the painter and his bridge kept coming to mind. The field the book covers has been developing so rapidly that, like the painter, I too had to return to where I had started and fight the rust of obsolescence. But unlike the painter, I had a deadline to meet, which constituted a point of no return. And so, sending off this manuscript, I have no choice but to watch the fruits of my endeavor be overtaken by the rust.
Book Synopsis The Mouse in Biomedical Research: History, genetics, and wild mice by :
Download or read book The Mouse in Biomedical Research: History, genetics, and wild mice written by and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis ILAR News by : Institute of Laboratory Animal Resources (U.S.)
Download or read book ILAR News written by Institute of Laboratory Animal Resources (U.S.) and published by . This book was released on 1984 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
