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Author : Lei Dong
Publisher : Frontiers Media SA
ISBN 13 : 2889748030
Total Pages : 120 pages
Book Rating : 4.8/5 (897 download)
Download or read book The Roles of Oncogenic Phosphatase/Kinase in Tumors written by Lei Dong and published by Frontiers Media SA. This book was released on 2022-03-29 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sangdun Choi
Publisher : Springer
ISBN 13 : 9781493968008
Total Pages : 6330 pages
Book Rating : 4.9/5 (68 download)
Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.
Author : Benjamin G. Neel
Publisher : Springer
ISBN 13 : 1493936492
Total Pages : 362 pages
Book Rating : 4.4/5 (939 download)
Download or read book Protein Tyrosine Phosphatases in Cancer written by Benjamin G. Neel and published by Springer. This book was released on 2016-08-05 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts. Protein Tyrosine Phosphatases in Cancer,from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry.
Author : Yahwardiah Siregar
Publisher : Inst za onkologiju i radiol
ISBN 13 : 9535108581
Total Pages : 497 pages
Book Rating : 4.5/5 (351 download)
Download or read book Oncogene and Cancer written by Yahwardiah Siregar and published by Inst za onkologiju i radiol. This book was released on 2013-01-24 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes a course of cancer growth starting from normal cells to cancerous form and the genomic instability, the cancer treatment as well as its prevention in form of the invention of a vaccine. Some diseases are also discussed in detail, such as breast cancer, leucaemia, cervical cancer, and glioma. Understanding cancer through its molecular mechanism is needed to reduce the cancer incidence. How to treat cancer more effectively and the problems like drug resistance and metastasis are very clearly illustrated in this publication as well as some research result that could be used to treat the cancer patients in the very near future. The book was divided into six main sections: 1. HER2 Carcinogenesis: Etiology, Treatment and Prevention; 2. DNA Repair Mechanism and Cancer; 3. New Approach to Cancer Mechanism; 4. New Role of Oncogenes and Tumor Suppressor Genes; 5. Non Coding RNA and Micro RNA in Tumorigenesis; 6. Oncogenes for Transcription Factors
Author : E. J. Corey
Publisher : John Wiley & Sons
ISBN 13 : 1394207085
Total Pages : 404 pages
Book Rating : 4.3/5 (942 download)
Download or read book Molecules Engineered Against Oncogenic Proteins and Cancer written by E. J. Corey and published by John Wiley & Sons. This book was released on 2023-09-06 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecules Engineered Against Oncogenic Proteins and Cancer A comprehensive review of the latest molecular advances in cancer treatment Featuring 91 total small molecule kinase/KRAS inhibitors, 80 of which are FDA-approved, Molecules Engineered Against Oncogenic Proteins and Cancer documents the recent scientific advances that have transformed one of medicine’s most challenging areas—cancer treatment. Most of these inhibitors specifically block oncogene-induced carcinogenic proteins with results that have dramatically advanced the treatment of cancer. In addition, the structural formulas of more than 100 kinase/KRAS inhibitors in clinical trials are presented. With a very well-known chemist as an author, Molecules Engineered Against Oncogenic Proteins and Cancer includes information on: Each molecule’s structure, function of the kinase target and relevance to cancer, the drug discovery process, and molecular details of drug action Mutated protein kinases as oncoproteins and targets for inhibition, along with the details of discovery for each antitumor antikinase agent History of oncoprotein inhibitors and their role in advancing the treatment and understanding of cancer The discovery process as a whole, effective strategies for innovation, ongoing challenges, and a glimpse of the future of the field Combining the most significant recent discoveries in a unique and useful way, Molecules Engineered Against Oncogenic Proteins and Cancer is an essential resource for researchers and students in bioscience, medicine, chemistry, and oncology as well as for those at industrial companies involved in therapeutic discovery.
Author : David A. Frank
Publisher : Springer Science & Business Media
ISBN 13 : 1402073402
Total Pages : 358 pages
Book Rating : 4.4/5 (2 download)
Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Author : Manfred Wirth
Publisher : Walter de Gruyter
ISBN 13 : 3110807270
Total Pages : 220 pages
Book Rating : 4.1/5 (18 download)
Download or read book Molecular Biology of Prostate Cancer written by Manfred Wirth and published by Walter de Gruyter. This book was released on 2013-05-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Caitlin M. O'Connor
Publisher :
ISBN 13 :
Total Pages : 186 pages
Book Rating : 4.:/5 (112 download)
Download or read book Mechanisms Governing the Tumor Suppressive Functions of the A-alpha Subunit of Protein Phosphatase 2A written by Caitlin M. O'Connor and published by . This book was released on 2019 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular signaling through reversible phosphorylation is an essential process of communication which allows cells to identify and respond to their microenvironment and is coordinated in a manner regulated both in time and space. This process is balanced by the opposing actions of phosphatases and kinases. Highlighting the importance of maintaining balanced cellular signaling, altered cellular signaling is dysregulated is multiple disease contexts. In particular, one of the hallmarks of cancer is sustained proliferative signaling, often through the dysregulation of phosphorylation. Work completed over the past several years has shown an important role for phosphatases in cellular transformation and disease progression. In particular, Protein Phosphatase 2A (PP2A) functions as a tumor suppressor by negatively regulating multiple oncogenic signaling pathways responsible for driving cancer progression. The canonical PP2A holoenzyme is comprised of a scaffolding subunit (PP2A A-alpha/beta), which serves as the platform for the binding of both the catalytic C subunit and one regulatory B subunit.While it has been established the PP2A holoenzyme and the A-alpha scaffold have tumor suppressive functions, the mechanisms responsible for these activities had not been well explored. The research presented in this dissertation sought to provide insight into the mechanisms of the tumor suppressive functions of the PP2A A-alpha scaffolding subunit by studying how mutations and deletions of this protein affect function. We showed how the most recurrent PP2A A-alpha mutation, R183W, altered holoenzyme formation, the downstream consequences on cellular signaling and decreased response to MEK inhibitors. Additionally, we investigated the functional consequences of homozygous deletion of the A-alpha subunit and identified that complete deletion of A-alpha is not tumor suppressive due to a compensatory upregulation of the A-beta scaffolding subunit. Collectively, these studies offer unique insight into the mechanisms inactivating PP2A A-alpha in patient tumors and provide an understanding of the essential nature of PP2A signaling in cellular homeostasis.
Author : David Labbé
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (98 download)
Download or read book Deciphering the Regulation and Role of Protein Tyrosine Phosphatase 1B in Prostate Cancer written by David Labbé and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Despite the early diagnosis and efficient treatment of most early-stage tumors, prostate cancer (PCa) remains the second leading cause of cancer-related deaths in North American men. This reflects the use of androgen deprivation therapy, initially described in 1941, as the standard treatment for patients diagnosed with advanced disease despite the eventual development of incurable castration-resistant metastatic cancer. Therefore there is an urgent need for novel and innovative approaches to effectively treat this disease. Elevated tyrosine phosphorylation is a major contributor to tumor progression. As such, many tyrosine kinase inhibitors are presently being tested for the treatment of advanced PCa in clinical trials. However, one largely unexplored mechanism in prostate tumorigenesis is the regulation of tyrosine phosphorylation by classical protein tyrosine phosphatases. Owing to the putative oncogenic role of the protein tyrosine phosphatase 1B (PTP1B) in various cancers, the objective of my doctoral research was to investigate its regulation and role in PCa. First, we identified the androgen receptor (AR) as a critical regulator of PTPN1 (encoding PTP1B) transcription in human PCa cell lines and human PCa tissues. Importantly, we described PTP1B as a tumor promoter in these cell lines, particularly when the AR signaling axis was activated. Second, we described the frequent amplification of a chromosomal region within the hereditary PCa genetic-susceptibility locus located on chromosome 20 (HPC20) in metastatic tumors. Interestingly, PTPN1 is included in the maximal common amplified region, which is frequently co-amplified with the AR. This coordinated copy number gain might result in a synergistic increase in the transcription of most genes located on the amplicon as many are AR-regulated. Finally, using prostate-specific PTEN-null mice, we demonstrated that genetic depletion of PTPN1 results in a slightly more aggressive phenotype when mice are fed a regular chow diet. Strikingly, when mice are fed a high fat diet, PTPN1 knockout mice exhibited a dramatic increase in the number of microinvasive lesions that then progress to fully invasive carcinoma. In summary, the data presented herein identifies PTPN1 as a context-dependent PCa gene that can act as an oncogene when the AR signaling axis is activated, or as a tumor suppressor in PTEN-null tumors. These results suggest that parameters such as genetic alterations and diet should be taken into consideration when designing new clinical trials for PTP1B inhibitors in cancer." --
Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Author : Thorsten Cramer
Publisher : Springer
ISBN 13 : 3319421182
Total Pages : 272 pages
Book Rating : 4.3/5 (194 download)
Download or read book Metabolism in Cancer written by Thorsten Cramer and published by Springer. This book was released on 2016-08-24 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.
Author : Robert Clarke
Publisher : Springer
ISBN 13 : 303005067X
Total Pages : 220 pages
Book Rating : 4.0/5 (3 download)
Download or read book The Unfolded Protein Response in Cancer written by Robert Clarke and published by Springer. This book was released on 2019-03-01 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.
Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author : Juliana Dushanova
Publisher : IntechOpen
ISBN 13 : 9789533078762
Total Pages : 606 pages
Book Rating : 4.0/5 (787 download)
Download or read book Mechanisms in Parkinson's Disease written by Juliana Dushanova and published by IntechOpen. This book was released on 2012-02-08 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular mechanisms that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD pathogenesis. Previously implicated culprits in PD neurodegeneration, mitochondrial dysfunction, and oxidative stress may also act in part by causing the accumulation of misfolded proteins, in addition to producing other deleterious events in dopaminergic neurons. Neurotoxin-based models have been important in elucidating the molecular cascade of cell death in dopaminergic neurons. PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process.
Author : Francesc Posas
Publisher : Springer Science & Business Media
ISBN 13 : 3540755691
Total Pages : 322 pages
Book Rating : 4.5/5 (47 download)
Download or read book Stress-Activated Protein Kinases written by Francesc Posas and published by Springer Science & Business Media. This book was released on 2008-01-24 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book leading researchers in the field discuss the state-of-the-art of many aspects of SAPK signaling in various systems from yeast to mammals. These include various chapters on regulatory mechanisms as well as the contribution of the SAPK signaling pathways to processes such as gene expression, metabolism, cell cycle regulation, immune responses and tumorigenesis. Written by international experts, the book will appeal to cell biologists and biochemists.
Author : Takamatsu no Miya Hi Gan Kenkyū Kikin. International Symposium
Publisher : Taylor & Francis Group
ISBN 13 : 9780748400171
Total Pages : 342 pages
Book Rating : 4.4/5 (1 download)
Download or read book Genetic Basis for Carcinogenesis written by Takamatsu no Miya Hi Gan Kenkyū Kikin. International Symposium and published by Taylor & Francis Group. This book was released on 1990 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together the latest studies on various aspects of molecular oncology. It emphasizes the current view that oncogenes and suppressor genes need to be discussed in the same context.
Author : Stuart K. Calderwood
Publisher : Springer Science & Business Media
ISBN 13 : 1402064012
Total Pages : 399 pages
Book Rating : 4.4/5 (2 download)
Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood and published by Springer Science & Business Media. This book was released on 2007-09-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
