The Role Of The L Type Voltage Gated Calcium Channel Casubscript V12 In Skeletal Muscle Development And Fiber Type Specification

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Voltage-Gated Calcium Channels

Author : Gerald W. Zamponi
Publisher : Springer Science & Business Media
ISBN 13 : 9780306478406
Total Pages : 402 pages
Book Rating : 4.4/5 (784 download)

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Book Synopsis Voltage-Gated Calcium Channels by : Gerald W. Zamponi

Download or read book Voltage-Gated Calcium Channels written by Gerald W. Zamponi and published by Springer Science & Business Media. This book was released on 2005-02-10 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Voltage Gated Calcium Channels is the first comprehensive book in the calcium channel field, encompassing over thirty years of progress towards our understanding of calcium channel structure, function, regulation, physiology, pharmacology, and genetics. This book balances contributions from many of the leading authorities in the calcium channel field with fresh perspectives from risings stars in the area, taking into account the most recent literature and concepts. This is the only all-encompassing calcium channel book currently available, and is an essential resource for academic researchers at all levels in the areas neuroscience, biophysics, and cardiovascular sciences, as well as to researchers in the drug discovery area.

Calcium Channels

Author : L. Donald Partridge
Publisher : CRC Press
ISBN 13 : 9780849388071
Total Pages : 510 pages
Book Rating : 4.3/5 (88 download)

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Book Synopsis Calcium Channels by : L. Donald Partridge

Download or read book Calcium Channels written by L. Donald Partridge and published by CRC Press. This book was released on 1991-07-03 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most comprehensive compendium of information available on calcium channels Calcium channels are a common component of the membranes of a wide range of excitable cells, and their presence is crucial to the functioning of these cells. This book presents a current review of the biophysics, physiology, pharmacology, and clinical role of calcium channels. Chapters discussing the biophysics of calcium channels include topics in ion permeation, channel activation, channel inactivation, and second messenger modulation. The chapters on physiology cover excitation-contraction coupling, excitation-secretion coupling, sensory transduction, regulation of electrical activity, and the regulation of cell growth and development. Issues discussed in the pharmacology chapters of the book include the effects of permeant and inhibitory inorganic ions, blocking and activating effects of organic ions, and the regulatory effects of naturally occurring compounds. The chapters exploring the clinical aspects of calcium channels examine topics such as the modulation of calcium channels in the treatment of ischemic heart disease, cardiomyopathies, hypertension, cardiac arrhythmias, peripheral vascular diseases, platelet-related disorders, neurological disorders, and psychiatric disorders. Physicians neuroscientists, and pharmacologists should consider this book essential to their reference collections.

Calcium Channel Pharmacology

Author : Stefan I. McDonough
Publisher : Springer Science & Business Media
ISBN 13 : 1441992545
Total Pages : 427 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Calcium Channel Pharmacology by : Stefan I. McDonough

Download or read book Calcium Channel Pharmacology written by Stefan I. McDonough and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Voltage-gated calcium channels are critical regulators of cytoplasmic levels of calcium, the universal signaling ion. As such, calcium channels trigger a wide range of cellular functions, from muscle contraction to neurotransmitter secretion, and are important players in human disease. Prominent in the nervous, cardiovascular, and endocrine systems, members of the calcium channel family are targets for existing antihypertensive and anticonvulsant drugs. In addition, they are emerging targets for drugs to treat an extraordinarily diverse group of disorders, including pain, cerebral ischemia, cardiac arrhythmia, and migraine. This book reviews the compounds that target individual calcium channel subtypes and the cellular and behavioral functions governed by each different channel. It contains information for basic scientists using calcium channel antagonists as experimental tools, for behavioralists studying animal models of human disease, and for pharmaceutical scientists interested in creating the next generation of calcium channel-targeted drugs. Several factors make an entire book on calcium channel pharmacology timely.

Low-voltage-activated T-type Calcium Channels

Author : Richard W. Tsien
Publisher :
ISBN 13 :
Total Pages : 420 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Low-voltage-activated T-type Calcium Channels by : Richard W. Tsien

Download or read book Low-voltage-activated T-type Calcium Channels written by Richard W. Tsien and published by . This book was released on 1998 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pathologies of Calcium Channels

Author : Norbert Weiss
Publisher : Springer Science & Business Media
ISBN 13 : 3642402828
Total Pages : 725 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Pathologies of Calcium Channels by : Norbert Weiss

Download or read book Pathologies of Calcium Channels written by Norbert Weiss and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium ions represent Mother Nature’s ‘ion-of-choice’ for regulating fundamental physiological functions, as they initiate a new life at the time of fertilization and guide subsequent developmental and physiological functions of the human body. Calcium channels, which act as gated pathways for the movement of calcium ions across the membranes, play a central part in the initiation of calcium signals, and defects in calcium channel function have been found to result in a plethora of human diseases, referred to as the calcium channelopathies. Pathologies of Calcium Channels brings together leading international experts to discuss our current understanding of human diseases associated with the various calcium channels, from their molecular basis to potential future therapeutic targeting of calcium channels.

T-type Calcium Channels in Basic and Clinical Science

Author : Stephen W. Schaffer
Publisher : Springer
ISBN 13 : 3709114136
Total Pages : 158 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis T-type Calcium Channels in Basic and Clinical Science by : Stephen W. Schaffer

Download or read book T-type Calcium Channels in Basic and Clinical Science written by Stephen W. Schaffer and published by Springer. This book was released on 2014-11-26 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: T-type calcium channels are prevalent in every organ of the body, and are believed to play a part in a variety of physiological processes, including contraction, shape change, secretion, endo- and exocytosis, cell proliferation and differentiation, modulation of enzyme function, and cell cycle progression. As such, research on the roles of these channels in a wide range of diseases has attracted increasing attention in recent years. The purpose of this book is to present a series of unique and comprehensive reviews of our current understanding of T-type calcium channels at the level of the basic sciences as well as the clinical sciences. For key organ systems, information is provided on the correlation between the molecular, biophysical and pharmacological properties of the channels, their cellular mechanisms, and their potential roles in the pathogenesis of various diseases. The compilation presents both commonplace and less well-known findings on these channels in a format designed to appeal to both casual readers and specialists in basic and clinical research on these transporters.

The Calcium Channel: Structure, Function and Implications

Author : Martin Morad
Publisher : Springer Science & Business Media
ISBN 13 : 3642739148
Total Pages : 662 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis The Calcium Channel: Structure, Function and Implications by : Martin Morad

Download or read book The Calcium Channel: Structure, Function and Implications written by Martin Morad and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to summarize experimental results from the new, rapidly expanding field of research into the calcium channel in cell membrane. Calcium is an ubiquitous messenger of various cellular functions. Its fundamental role in the regulation of cardiac contractions has long been recognized. Drugs counteracting some actions of calcium ions, namely calcium antagonists, have since become essential to research. In the last decade it has been established that calcium ions reach their target intracellular system by passing through specialized calcium channels in the membrane. Recently improved experimental techniques combined with the discovery of highly specific Ca channel ligands have dramatically enlarged our knowledge of the molecular structure and function of such channels. The contributions by leading world specialists shed new light on both basic science and possible clinical implications for cardiovascular pharmacology, endocrinology and neuropharmacology.

Calcium Signaling

Author : Martin Morad
Publisher : John Wiley & Sons
ISBN 13 : 9781586031572
Total Pages : 292 pages
Book Rating : 4.0/5 (315 download)

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Book Synopsis Calcium Signaling by : Martin Morad

Download or read book Calcium Signaling written by Martin Morad and published by John Wiley & Sons. This book was released on 2001 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The processes that use or regulate calcium as a biological signal to transmit information or initiate functions such as exocytosis signaling and contraction are highly developed and specialized for the functional needs of a particular tissue. A large number of cellular proteins have developed to recognize or transmit biological calcium signals. Technology has advanced such that it is possible to identify the molecular structure of these proteins and determine particular motifs involved in recognizing and regulating calcium, among other things. One of the major advances has been the recognition that calcium signaling often occurs in the inter-molecular nano-domains surrounding the signaling protein rather than in the global cytoplasmic spaces. This book is organized in five parts. It deals with cardiac and skeletal muscle calcium signaling; the variability in the regulation of calcium channel, both structurally and hormonally; calcium signaling in neurons; the role of mitochondria in calcium signaling; and various other calcium-regulated or calcium-transporting proteins.

Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle

Author : George B. Frank
Publisher : Springer Science & Business Media
ISBN 13 : 1461533627
Total Pages : 450 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle by : George B. Frank

Download or read book Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle written by George B. Frank and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Third International Symposium on Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle, organized by George Frank, C. Paul Bianchi, and Henk E. DJ. ter Keurs, was held in Banff Centre, Banff, Alberta, Canada during June 26 to June 30, 1991. The theme of these symposia has been to recognize the similarities and dissimilarities of excitation-contraction coupling in skeletal, cardiac, and smooth muscle. Cross fertilization of concepts of excitation-contraction coupling in these three types of muscle has occurred since the early studies in the late fifties and early sixties on skeletal muscle. Investigators in each field meet only at specialized symposia which exclude investigators in the other fields. The purpose of the symposia has been to bring together international investigators studying excitation-contraction coupling in skeletal, cardiac, and smooth muscle so that we may learn from each other and hence provide a more global concept of excitation-contraction. The Third International Symposia has accomplished its objective as we recognize that calcium channels of the sarcolemma and the sarcoplasmic reticulum play key essential roles in excitation-contraction coupling in all three types of muscles. In skeletal muscle the recognition that E-C coupling consists of two parallel mechanisms, one dependent upon a dihydropyridine voltage-sensitive sensors coupled to calcium release from the terminal cisternae via the ryanodine sensitive channel in the foot structure of the triad.

Pharmacological Control of Calcium and Potassium Homeostasis

Author : T. Godfraind
Publisher : Springer Science & Business Media
ISBN 13 : 9401101175
Total Pages : 280 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Pharmacological Control of Calcium and Potassium Homeostasis by : T. Godfraind

Download or read book Pharmacological Control of Calcium and Potassium Homeostasis written by T. Godfraind and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the number of drugs acting on calcium and potassium channels grows, there is a need for a continuous reappraisal of the cellular machinery controlling them. The present volume provides an update on the basic knowledge, the molecular targets of the two channels, and the importance the drugs that bind them have as pharmacological tools and therapeutic agents. This work was presented at the 6th International Symposium on PHARMACOLOGICAL CONTROL OF CALCIUM AND POTASSIUM HOMEOSTASIS: BIOLOGICAL, THERAPEUTICAL, AND CLINICAL ASPECTS, in Florence (Italy) on October 4-6, 1994. Because of the recent advances in the field, discussions on potassium channels were included for the first time. At least six classes of voltage-dependent calcium channels have been defined based on their physiological and pharmacological properties. Among them, L-type channels, mediating long lasting currents, are better characterized. Calcium homeostasis within the cell is not only regulated by calcium channels; intracellular calcium stores, in particular a pool contained in the lumen of specialized areas of the endoplasmic reticulum, are rapidly exchanged with the cytoplasm and playa key role in the control of calcium homeostasis. This area, however, has not yet been exploited from a therapeutic point of view. Potassium channels are present in virtually every cell type, excitable and nonexcitable, and are distinguished by structural, biophysical, and pharmacological criteria. Different classes including voltage-gated, ligand-gated, AP-sensitive, and G-protein coupled among others, have been defined by their primary regulatory and gating mechanisms.