The Role Of Evidence In Risk Characterization

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Science and Judgment in Risk Assessment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030904894X
Total Pages : 668 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Science and Judgment in Risk Assessment by : National Research Council

Download or read book Science and Judgment in Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 1994-01-01 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: The public depends on competent risk assessment from the federal government and the scientific community to grapple with the threat of pollution. When risk reports turn out to be overblownâ€"or when risks are overlookedâ€"public skepticism abounds. This comprehensive and readable book explores how the U.S. Environmental Protection Agency (EPA) can improve its risk assessment practices, with a focus on implementation of the 1990 Clean Air Act Amendments. With a wealth of detailed information, pertinent examples, and revealing analysis, the volume explores the "default option" and other basic concepts. It offers two views of EPA operations: The first examines how EPA currently assesses exposure to hazardous air pollutants, evaluates the toxicity of a substance, and characterizes the risk to the public. The second, more holistic, view explores how EPA can improve in several critical areas of risk assessment by focusing on cross-cutting themes and incorporating more scientific judgment. This comprehensive volume will be important to the EPA and other agencies, risk managers, environmental advocates, scientists, faculty, students, and concerned individuals.

The Role of Evidence in Risk Characterization

Author : Peter M. Wiedemann
Publisher : John Wiley & Sons
ISBN 13 : 9783527320486
Total Pages : 248 pages
Book Rating : 4.3/5 (24 download)

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Book Synopsis The Role of Evidence in Risk Characterization by : Peter M. Wiedemann

Download or read book The Role of Evidence in Risk Characterization written by Peter M. Wiedemann and published by John Wiley & Sons. This book was released on 2008-07-29 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the few books to focus on the critical problem of the correct characterization of conflicting data for an adequate risk evaluation, this title comprehensively covers the different approaches in various research areas in the US and in Europe, while also considering the ethical implications of risk evaluation. In addition, special attention is paid to the sensitive topic of potential health risks through electromagnetic fields. Written by leading experts in the field, this is an indispensable resource for policy makers and professionals in health risk assessment.

Issues in Risk Assessment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309047862
Total Pages : 375 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Issues in Risk Assessment by : National Research Council

Download or read book Issues in Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 1993-02-01 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume. The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures. The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.

Science and Decisions

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309120462
Total Pages : 422 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Science and Decisions by : National Research Council

Download or read book Science and Decisions written by National Research Council and published by National Academies Press. This book was released on 2009-03-24 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.

Risk Assessment in the Federal Government

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309033497
Total Pages : 206 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Risk Assessment in the Federal Government by : National Research Council

Download or read book Risk Assessment in the Federal Government written by National Research Council and published by National Academies Press. This book was released on 1983-02-01 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: The regulation of potentially hazardous substances has become a controversial issue. This volume evaluates past efforts to develop and use risk assessment guidelines, reviews the experience of regulatory agencies with different administrative arrangements for risk assessment, and evaluates various proposals to modify procedures. The book's conclusions and recommendations can be applied across the entire field of environmental health.

Possible Health Effects of Exposure to Residential Electric and Magnetic Fields

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309054478
Total Pages : 379 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Possible Health Effects of Exposure to Residential Electric and Magnetic Fields by : National Research Council

Download or read book Possible Health Effects of Exposure to Residential Electric and Magnetic Fields written by National Research Council and published by National Academies Press. This book was released on 1997-03-18 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Can the electric and magnetic fields (EMF) to which people are routinely exposed cause health effects? This volume assesses the data and draws conclusions about the consequences of human exposure to EMF. The committee examines what is known about three kinds of health effects associated with EMF: cancer, primarily childhood leukemia; reproduction and development; and neurobiological effects. This book provides a detailed discussion of hazard identification, dose-response assessment, exposure assessment, and risk characterization for each. Possible Health Effects of Exposure to Residential Electric and Magnetic Fields also discusses the tools available to measure exposure, common types of exposures, and what is known about the effects of exposure. The committee looks at correlations between EMF exposure and carcinogenesis, mutagenesis, neurobehavioral effects, reproductive and developmental effects, effects on melatonin and other neurochemicals, and effects on bone healing and stimulated cell growth.

EPA 630/R

Author :
Publisher :
ISBN 13 :
Total Pages : 94 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis EPA 630/R by :

Download or read book EPA 630/R written by and published by . This book was released on 1998 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309211964
Total Pages : 204 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde by : National Research Council

Download or read book Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde written by National Research Council and published by National Academies Press. This book was released on 2011-05-31 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in come foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Intergated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process.

Microbiological Risk Assessment in Food Processing

Author : M. Brown
Publisher : Elsevier
ISBN 13 : 1855736683
Total Pages : 320 pages
Book Rating : 4.8/5 (557 download)

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Book Synopsis Microbiological Risk Assessment in Food Processing by : M. Brown

Download or read book Microbiological Risk Assessment in Food Processing written by M. Brown and published by Elsevier. This book was released on 2002-09-26 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbiological risk assessment (MRA) is one of the most important recent developments in food safety management. Adopted by Codex Alimentarius and many other international bodies, it provides a structured way of identifying and assessing microbiological risks in food. Edited by two leading authorities, and with contributions by international experts in the field, Microbiological risk assessment provides a detailed coverage of the key steps in MRA and how it can be used to improve food safety. The book begins by placing MRA within the broader context of the evolution of international food safety standards. Part one introduces the key steps in MRA methodology. A series of chapters discusses each step, starting with hazard identification and characterisation before going on to consider exposure assessment and risk characterisation. Given its importance, risk communication is also covered. Part two then considers how MRA can be implemented in practice. There are chapters on implementing the results of a microbiological risk assessment and on the qualitative and quantitative tools available in carrying out a MRA. It also discusses the relationship of MRA to the use of microbiological criteria and another key tool in food safety management, Hazard Analysis and Critical Control Point (HACCP) systems. With its authoritative coverage of both principles and key issues in implementation, Microbiological risk assessment in food processing is a standard work on one of the most important aspects of food safety management. Provides a detailed coverage of the key steps in microbiological risk assessment (MRA) and how it can be used to improve food safety Places MRA within the broader context of the evolution of international food safety standards Introduces the key steps in MRA methodology, considers exposure assessment and risk characterisation, and covers risk communication

Phthalates and Cumulative Risk Assessment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309128412
Total Pages : 208 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Phthalates and Cumulative Risk Assessment by : National Research Council

Download or read book Phthalates and Cumulative Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2009-01-19 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: People are exposed to a variety of chemicals throughout their daily lives. To protect public health, regulators use risk assessments to examine the effects of chemical exposures. This book provides guidance for assessing the risk of phthalates, chemicals found in many consumer products that have been shown to affect the development of the male reproductive system of laboratory animals. Because people are exposed to multiple phthalates and other chemicals that affect male reproductive development, a cumulative risk assessment should be conducted that evaluates the combined effects of exposure to all these chemicals. The book suggests an approach for cumulative risk assessment that can serve as a model for evaluating the health risks of other types of chemicals.

The Role of Evidence in Risk Characterization

Author : Peter M. Wiedemann
Publisher : John Wiley & Sons
ISBN 13 : 3527622365
Total Pages : 239 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis The Role of Evidence in Risk Characterization by : Peter M. Wiedemann

Download or read book The Role of Evidence in Risk Characterization written by Peter M. Wiedemann and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the few books to focus on the critical problem of the correct characterization of conflicting data for an adequate risk evaluation, this title comprehensively covers the different approaches in various research areas in the US and in Europe, while also considering the ethical implications of risk evaluation. In addition, special attention is paid to the sensitive topic of potential health risks through electromagnetic fields. Written by leading experts in the field, this is an indispensable resource for policy makers and professionals in health risk assessment.

U.S. EnvironmentaL Protection Agency

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (138 download)

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Book Synopsis U.S. EnvironmentaL Protection Agency by :

Download or read book U.S. EnvironmentaL Protection Agency written by and published by . This book was released on 1988 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Owner's Role in Project Risk Management

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309095182
Total Pages : 102 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis The Owner's Role in Project Risk Management by : National Research Council

Download or read book The Owner's Role in Project Risk Management written by National Research Council and published by National Academies Press. This book was released on 2005-03-25 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Effective risk management is essential for the success of large projects built and operated by the Department of Energy (DOE), particularly for the one-of-a-kind projects that characterize much of its mission. To enhance DOE's risk management efforts, the department asked the NRC to prepare a summary of the most effective practices used by leading owner organizations. The study's primary objective was to provide DOE project managers with a basic understanding of both the project owner's risk management role and effective oversight of those risk management activities delegated to contractors.

Acceptable Evidence

Author : Deborah G. Mayo
Publisher : Oxford University Press
ISBN 13 : 0195358325
Total Pages : 305 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis Acceptable Evidence by : Deborah G. Mayo

Download or read book Acceptable Evidence written by Deborah G. Mayo and published by Oxford University Press. This book was released on 1994-02-17 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discussions of science and values in risk management have largely focused on how values enter into arguments about risks, that is, issues of acceptable risk. Instead this volume concentrates on how values enter into collecting, interpreting, communicating, and evaluating the evidence of risks, that is, issues of the acceptability of evidence of risk. By focusing on acceptable evidence, this volume avoids two barriers to progress. One barrier assumes that evidence of risk is largely a matter of objective scientific data and therefore uncontroversial. The other assumes that evidence of risk, being "just" a matter of values, is not amenable to reasoned critique. Denying both extremes, this volume argues for a more constructive conclusion: understanding the interrelations of scientific and value issues enables a critical scrutiny of risk assessments and better public deliberation about social choices. The contributors, distinguished philosophers, policy analysts, and natural and social scientists, analyze environmental and medical controversies, and assumptions underlying views about risk assessment and the scientific and statistical models used in risk management.

Forensic Case Formulation

Author : Peter Sturmey
Publisher : John Wiley & Sons
ISBN 13 : 9780470683958
Total Pages : 0 pages
Book Rating : 4.6/5 (839 download)

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Book Synopsis Forensic Case Formulation by : Peter Sturmey

Download or read book Forensic Case Formulation written by Peter Sturmey and published by John Wiley & Sons. This book was released on 2011-09-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forensic Case Formulation is the first text that describes the principles and application of case formulation specifically to forensic clinical practice. Addresses risk assessment and its implications for case formulation and treatment Covers a range of serious forensic problems such as violence, sexual offending, personality disorder, and substance misuse Offers guidance in training clinicians on ways to create useful formulations

Nutritional Risk Assessment

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309108713
Total Pages : 146 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Nutritional Risk Assessment by : Institute of Medicine

Download or read book Nutritional Risk Assessment written by Institute of Medicine and published by National Academies Press. This book was released on 2007-12-08 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than two decades, the practice of risk assessment has been applied to human public health issues, and policy makers have used the results of risk assessments in their decision-making process. Approaches for risk assessment have been developed for nonnutrients such as drugs, food additives, and pesticides, but approaches for risk assessment have received less attention in the nutrition area. Some aspects of the risk assessment approach used for nonnutrients are applicable to the assessment of risks related to nutrition. The overall approach, however, must be adapted and modified to take into account the unique aspects of nutrients, including the fact that both high and low nutrient intakes are associated with risk. Experience with the application of a risk assessment process to the setting of upper levels of intake for essential nutrients, for example, has uncovered a number of challenges. Adapting and developing risk assessment strategies for application in nutrition science could lead to improved approaches to the development of dietary and nutritional recommendations and thus is a topic of considerable interest. One nonscientific but overall challenge to nutritional risk assessment relates to increasing and improving communication among experts from key disciplines in ways that could inform the nutritional risk assessment process. Among these key disciplines are nutrition, toxicology, dietary exposure assessment, economics, risk analysis, and epidemiology. How can the perspectives and methods of these diverse fields be brought together to develop more effective approaches for quantitative nutritional risk assessment? How can they be applied to a spectrum of topics related to food and nutrition-micronutrients, macronutrients, dietary supplements, whole foods, food groups, and dietary patterns? How can they help overcome the data challenges that confront nutritional risk assessors? As a step toward improving the communication and sharing methods and information across disciplines, members of the Interagency Risk Assessment Consortium, the U.S. Health and Human Services Office of the Assistant Secretary for Planning and Evaluation, the Institute of Medicine's Food Forum, and the International Life Sciences Institute planned the Nutritional Risk Assessment Workshop. The workshop was held on February 28 and March 1, 2007, in Washington, D.C. This workshop, which was envisioned as one in a series, focused on opening a dialogue to explore the unique questions and challenges faced by nutritionists and the potential use of risk assessment methodologies to answer them. Nutritional Risk Assessment : Perspectives, Methods, and Data Challenges, Workshop Summary summarizes the happenings of this workshop.

Assessing Nanoparticle Risks to Human Health

Author : Gurumurthy Ramachandran
Publisher : William Andrew
ISBN 13 : 0323354084
Total Pages : 286 pages
Book Rating : 4.3/5 (233 download)

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Book Synopsis Assessing Nanoparticle Risks to Human Health by : Gurumurthy Ramachandran

Download or read book Assessing Nanoparticle Risks to Human Health written by Gurumurthy Ramachandran and published by William Andrew. This book was released on 2016-07-21 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assessing Nanoparticle Risks to Human Health provides a systematic overview of nanoparticle risks and considers the limitations of this paradigm in a context where extreme uncertainties prevail. As well as exploring conventional risk assessment methodology, the contributing authors investigate several alternate approaches. The adequacy of current frameworks for risk management and regulatory oversights, including corporate approaches in the US and EU, are explored, and suggestions are made as to how these frameworks can be modified to make them more efficient and effective. Presenting a coherent framework for analysis of the available information, this book presents the latest scientific understanding of the toxicity and health effects of nanoparticles, the technical issues relating to exposure assessment and management, and the ways in which the current risk paradigm can be used/modified to deal with the challenges of nanoparticle risks. All chapters of this new edition have been thoroughly updated to reflect the many changes in the field since the first edition. Additions and updates in the second edition of the book include: New exposure assessment strategies for nanomaterials including life cycle exposure assessment approaches and detailed information on nanoparticle exposure control and protection in the workplace. A state-of-the-art scientific update on the hazard and risk assessment of nanomaterials: discussion of key additional publications on the toxicology and biokinetics of nanomaterials; available data and methods to characterize the health hazard and risk of exposure to nanomaterials in the workplace; additional examples of the use of such data and methods to develop occupational safety and health guidance; and discussion of progress to date, ongoing efforts, and remaining challenges in nanomaterials hazard and risk characterization. New studies on the use of expert judgment in nanotechnology. Quantitative data from Lawrence Berkeley National Laboratory’s 4-phase study. A description and evaluation of new CB tools and new ISO technical specifications. A comprehensive update of the legal frameworks in the US and the EU. With the second edition of Assessing Nanoparticle Risks to Human Health Prof. Ramachandran provides researchers and practitioners producing or using nanoparticles, or those involved in nanomaterials risk assessments, technology, health science, policy, safety, environment and regulatory aspects an invaluable reference to adopt the right technologies and strategies and to comply to legal frameworks and regulations. For policy makers and advisory firms it provides the knowledge needed to advise on compliance with or development of new regulations on nanomaterials. Makes essential reading for risk assessment professionals, companies working with nanoparticles, nanotechnology research groups and regulators Explores the use of risk assessment methodologies in an occupational health setting, and their limitations Provides a framework for evidence-based decision making in a context with many uncertainties