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Author : Keshwar Baboolal
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (595 download)
Download or read book The Renin Angiotensin System in Experimental Renal Disease written by Keshwar Baboolal and published by . This book was released on 1996 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gunter Wolf
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805572751
Total Pages : 278 pages
Book Rating : 4.8/5 (55 download)
Download or read book The Renin-angiotensin System and Progression of Renal Diseases written by Gunter Wolf and published by Karger Medical and Scientific Publishers. This book was released on 2001-01-01 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The renin-angiotensin system (RAS) has long been seen as a systemic endocrine system in which angiotensin II (ANG II) is solely involved in blood pressure regulation and the mediation of aldosterone release. However, it is now known that specific organ systems exhibit their own local RAS, functioning for the most part independently from their systemic counterpart. A deluge of data from the last decade has shown that ANG II displays many more functions than just regulating blood pressure: ANG II is a growth factor, exhibits profibrogenic actions, and even serves as a proinflammatory cytokine. It is now clear that this peptide plays a pivotal role in the progression of chronic kidney disease towards endstage renal failure. Clinical studies have provided compelling evidence that interference with ANG II slows this deterioration of renal function.This publication presents the first comprehensive summary of this important topic: Basic concepts as well as clinical aspects of the RAS are reviewed by international experts who made many of the key discoveries that constitute our contemporary understanding of ANG II as a central factor in the progression of renal disease. This publication should be read by physicians treating patients with chronic renal diseases (internists, nephrologists and urologists). Moreover, basic scientists such as renal physiologists, renal pathologists and biochemists who want a comprehensive overview of the subject will profit from reading this book.
Author : Hiromichi Suzuki (M.D.)
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805577516
Total Pages : 181 pages
Book Rating : 4.8/5 (55 download)
Download or read book Kidney and Blood Pressure Regulation written by Hiromichi Suzuki (M.D.) and published by Karger Medical and Scientific Publishers. This book was released on 2004 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic kidney disease is one of the world's major public health problems, and the prevalence of kidney failure is rising steadily. Among the risk factors for a faster progression of renal disease are hypertension and proteinuria, many studies clearly demonstrating that hypertension is both a cause and consequence of chronic kidney disease. Namely, renal blood pressure regulation seems to be involved in five major pathophysiological mechanisms (all closely related to the renin-angiotensin system): Pressure-natriuresis, renal sympathetic nervous system, renal blood flow, intraglomerular pressure and tubuloglomerular feedback. This book reviews experimental data which form the basis of our current understanding of the association between hypertension and kidney diseases: The pathogenesis of increased blood pressure, the mechanisms by which systemic hypertension promotes progressive kidney failure, and the impact of antihypertensive agents on experimental renal mechanisms involved in hypertension. Furthermore, the role of angiotensin II receptor blockers in both the control of systemic blood pressure and the reduction of proteinuria is examined in an attempt to define optimal therapeutic strategies to prevent the otherwise inexorable deterioration of renal function in patients with chronic kidney disease.
Author : Dulce Elena Casarini
Publisher : Bentham Science Publishers
ISBN 13 : 1681083132
Total Pages : 387 pages
Book Rating : 4.6/5 (81 download)
Download or read book New Aspects of the Renin Angiotensin System in Cardiovascular and Renal Diseases written by Dulce Elena Casarini and published by Bentham Science Publishers. This book was released on 2016-11-03 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: The renin-angiotensin system (RAS) is a hormonal system that is responsible for regulating plasma sodium ion concentration and arterial blood pressure in the body. The system involves several peptides such as angiotensin I and II as well as angiotensin converting enzyme (ACE) to enable the constriction of arterial blood vessels in the lung. Angiotensin II also stimulates the production of the hormone aldosterone in the kidneys which brings sodium ions into the bloodstream in exchange for potassium ions. Malfunctions of the RAS can lead to hypertension, heart failure, diabetes and renal complications. Thus the biochemical components of this system serve as important targets for therapeutic drugs. This monograph is a compilation of updated reviews on the RAS. The monograph covers describes the components of the system to explaining its physiological and clinical features in the cardiovascular system and the kidneys. This is followed by sections explaining the biochemistry of the RAS system in cardiovascular and renal disease and the pharmacology of relevant therapeutic drugs. Additional information on the effect of exercise states and methods to quantify angiotensins for molecular diagnosis is also presented in the concluding sections. Information in the monograph will be of interest to physiologists and endocrinologists involved in medical studies or clinical practice. Readers will be able to understand the RAS with a holistic frame of reference.
Author : National kidney disease foundation
Publisher :
ISBN 13 :
Total Pages : 268 pages
Book Rating : 4.:/5 (439 download)
Download or read book Angiotensin system and experimental renal diseases written by National kidney disease foundation and published by . This book was released on 1963 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Samy I. McFarlane
Publisher : BoD – Books on Demand
ISBN 13 : 1839682868
Total Pages : 170 pages
Book Rating : 4.8/5 (396 download)
Download or read book Renin-Angiotensin Aldosterone System written by Samy I. McFarlane and published by BoD – Books on Demand. This book was released on 2021-11-24 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Renin-Angiotensin Aldosterone System (RAAS) plays an important role not only in salt and water homeostasis but also in the cardiovascular system, the kidney, and the brain. While several volumes address different aspects of the RAAS function, this book provides cutting-edge information on the pathogenesis of various disorders related to RAAS overactivation. It also presents unique aspects of RAAS functioning that have not been sufficiently described in the literature. Topics covered include assessment of hypoaldosteronism in infancy, RASS and cognitive decline, and the role of RAAS in the pathogenesis of COVID-19. Written by experts in the field in an easy-to-follow and illustrated format, this volume will benefit students and practitioners, as well as clinical and basic science investigators alike.
Author : May Sherman
Publisher :
ISBN 13 :
Total Pages : 152 pages
Book Rating : 4.F/5 ( download)
Download or read book Renin-angiotensin Mechanisms written by May Sherman and published by . This book was released on 1970 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Xiao C. Li
Publisher : Biota Publishing
ISBN 13 : 1615046755
Total Pages : 72 pages
Book Rating : 4.6/5 (15 download)
Download or read book The Renin-Angiotensin System and the Kidney written by Xiao C. Li and published by Biota Publishing. This book was released on 2015-03-01 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: The renin-angiotensin system (RAS) is one of the most important endocrine (tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) humoral systems in the regulation of blood pressure, cardiovascular, and kidney function in health and disease. The RAS has remarkably evolved from the initial discovery of the rate-limiting enzyme renin to a complex biochemical and physiological cascade involving more than a dozen members. Currently, there are up to five axes or pathways identified in the RAS; each has its substrate, enzyme, effector peptide, receptor, and downstream signaling pathways. These include the renin/ACE/ANG II/AT1 receptor, the APA/ANG III/AT2 receptor, the ACE2/ANG (1-7)/Mas receptor, the prorenin/prorenin receptor (PRR), and the ANG IV/AT4 receptor (IRAP) pathways. Accordingly, the roles of the RAS have expanded well beyond the classic endocrine paradigm as a powerful vasoconstrictor, a potent aldosterone stimulator, or a sodium-retaining hormonal system. The goals of this article are to review and discuss the current insights into and new perspectives on the expression, localization, and novel actions of the RAS with a focus in the kidney. Special emphasis will be placed on recently discovered new members of the RAS derived from studies using innovative mutant rats or mice that either overexpress (knockin) or are deficient (knockout) of a particular substrate, enzyme, ANG peptide, or receptor. This new knowledge will help improve our understanding how each of these pathways act directly or indirectly to regulate blood pressure, cardiovascular and kidney function in physiology, and can be targeted to treat hypertension, cardiovascular and renal diseases.
Author : Aleksandar Kibel
Publisher : BoD – Books on Demand
ISBN 13 : 1789854210
Total Pages : 179 pages
Book Rating : 4.7/5 (898 download)
Download or read book Selected Chapters from the Renin-Angiotensin System written by Aleksandar Kibel and published by BoD – Books on Demand. This book was released on 2020-08-19 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selected Chapters from the Renin-Angiotensin System aims to provide a comprehensive overview of the most important physiological and pathophysiological roles of the renin-angiotensin system (RAS). The complex and convoluted RAS has been investigated for many years and, through rigorous scientific research, many important and previously unknown components and functions of the RAS have come to light. These discoveries have been crucial in the understanding of this system and provide a basis for effective modulation of the system as part of therapeutic strategies for a number of widespread disorders. New studies are continuing to elucidate the RAS and the mechanisms associated with its functions. This book discusses relevant scientific knowledge about the RAS and intends to introduce the reader to cutting-edge research with an accentuation on the mechanisms at the functional/physiological and molecular/cellular levels.
Author : Thomas Unger
Publisher : Academic Press
ISBN 13 : 0128014857
Total Pages : 312 pages
Book Rating : 4.1/5 (28 download)
Download or read book The Protective Arm of the Renin Angiotensin System (RAS) written by Thomas Unger and published by Academic Press. This book was released on 2015-04-18 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.
Author :
Publisher :
ISBN 13 :
Total Pages : 172 pages
Book Rating : 4.:/5 (228 download)
Download or read book Kidney and Blood Pressure Regulation written by and published by . This book was released on 2004 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Paul P. Leyssac
Publisher :
ISBN 13 :
Total Pages : 64 pages
Book Rating : 4.U/5 (183 download)
Download or read book The Renin Angiotensin System and Kidney Function written by Paul P. Leyssac and published by . This book was released on 1976 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Anna Tolekova
Publisher : BoD – Books on Demand
ISBN 13 : 9535133519
Total Pages : 270 pages
Book Rating : 4.5/5 (351 download)
Download or read book Renin-Angiotensin System written by Anna Tolekova and published by BoD – Books on Demand. This book was released on 2017-07-12 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring the contractile activity of smooth muscle segments isolated from various organs of healthy animals and animals with experimentally induced diabetes, she obtained original data about angiotensin II-induced force and time parameters. For the first time, she established the effect of ghrelin on angiotensin II-provoked contraction of the urinary bladder. Original data on the role of both types of angiotensin receptors for the contractile activity of the various segments of the gastrointestinal tract and bladder were obtained. By applying specific software for force and time parameter analysis, the contribution of different types of angiotensin receptors on muscle contractility has been shown. The new methodology was used to analyze the data obtained during the registration of smooth muscle relaxation activity, which allows the determination of not only the magnitude of the mechanical response but also the parameters related to the time and speed of the contractions. Plasma renin activity models have been developed using mathematical approaches to predict the effect of different drug doses on the behavior of the system.
Author : National Kidney Disease Foundation
Publisher :
ISBN 13 :
Total Pages : 268 pages
Book Rating : 4.:/5 (867 download)
Download or read book Angiotensin Systems and Experimental Renal Diseases written by National Kidney Disease Foundation and published by . This book was released on 1963 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book ANGIOTENSIN SYSTEMS AND EXPERIMENTAL RENAL DISEASES- 14TH ANNUAL CONFERENCE ON THE KIDNEY- PROCEEDINGS- NATIONAL KIDNEY DISEASE FOUNDATION THE KIDNEY. written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jack Metcoff
Publisher :
ISBN 13 :
Total Pages : 268 pages
Book Rating : 4.:/5 (6 download)
Download or read book Angiotensin Systems and Experimental Renal Diseases written by Jack Metcoff and published by . This book was released on 1963 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Eberhard Ritz
Publisher :
ISBN 13 :
Total Pages : 220 pages
Book Rating : 4.3/5 (91 download)
Download or read book Issues in Glomerulonephritis and Renin System written by Eberhard Ritz and published by . This book was released on 1984 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
