The Pulmonary Neuroepithelial Body Microenvironment

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The Pulmonary Neuroepithelial Body Microenvironment

Author : Inge Brouns
Publisher : Springer Nature
ISBN 13 : 3030658171
Total Pages : 112 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis The Pulmonary Neuroepithelial Body Microenvironment by : Inge Brouns

Download or read book The Pulmonary Neuroepithelial Body Microenvironment written by Inge Brouns and published by Springer Nature. This book was released on 2021-05-05 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors

The Pulmonary Neuroepithelial Body Microenvironment

Author : Inge Brouns
Publisher :
ISBN 13 : 9783030658182
Total Pages : 0 pages
Book Rating : 4.6/5 (581 download)

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Book Synopsis The Pulmonary Neuroepithelial Body Microenvironment by : Inge Brouns

Download or read book The Pulmonary Neuroepithelial Body Microenvironment written by Inge Brouns and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors.

The Microenvironment of Pulmonary Neuroepithelial Bodies

Author : Line Verckist
Publisher :
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.:/5 (111 download)

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Book Synopsis The Microenvironment of Pulmonary Neuroepithelial Bodies by : Line Verckist

Download or read book The Microenvironment of Pulmonary Neuroepithelial Bodies written by Line Verckist and published by . This book was released on 2018 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Functional Exploration of the Neuroepithelial Body Microenvironment in an Ex Vivo Lung Model

Author : Ian de Proost
Publisher :
ISBN 13 :
Total Pages : 288 pages
Book Rating : 4.:/5 (91 download)

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Book Synopsis Functional Exploration of the Neuroepithelial Body Microenvironment in an Ex Vivo Lung Model by : Ian de Proost

Download or read book Functional Exploration of the Neuroepithelial Body Microenvironment in an Ex Vivo Lung Model written by Ian de Proost and published by . This book was released on 2008 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Neuroepithelial Body Microenvironment

Author : Robrecht Lembrechts
Publisher :
ISBN 13 :
Total Pages : 231 pages
Book Rating : 4.:/5 (91 download)

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Book Synopsis The Neuroepithelial Body Microenvironment by : Robrecht Lembrechts

Download or read book The Neuroepithelial Body Microenvironment written by Robrecht Lembrechts and published by . This book was released on 2012 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease

Author : Venkataramana K Sidhaye
Publisher : Academic Press
ISBN 13 : 0128038810
Total Pages : 277 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease by : Venkataramana K Sidhaye

Download or read book Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease written by Venkataramana K Sidhaye and published by Academic Press. This book was released on 2017-03-09 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences

Arterial Chemoreception

Author : Colin A. Nurse
Publisher : Springer Science & Business Media
ISBN 13 : 9400745834
Total Pages : 399 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Arterial Chemoreception by : Colin A. Nurse

Download or read book Arterial Chemoreception written by Colin A. Nurse and published by Springer Science & Business Media. This book was released on 2012-10-19 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arterial chemoreceptors are unique structures which continuously monitor changes in arterial blood oxygen, carbon dioxide, glucose, and acid. Alterations in these gases are almost instantaneously sensed by arterial chemoreceptors and relayed into a physiological response which restores blood homeostasis. Arterial Chemoreception contains updated material regarding the physiology of the primary arterial chemoreceptor; the carotid body. Moreover, this book also explores tantalizing evidence regarding the contribution of the aortic bodies, chromaffin cells, lung neuroepithelial bodies, and brainstem areas involved in monitoring changes in blood gases. Furthermore this collection includes data showing the critical importance of these chemoreceptors in the pathophysiology of human disease and possible therapeutic treatments. This book is a required text for any researcher in the field of arterial chemoreception for years to come. It is also a critical text for physicians searching for bench-to-bedside treatments for heart failure, sleep apnea, and pulmonary hypertension.

The Lung

Author : Kent Pinkerton
Publisher : Elsevier
ISBN 13 : 0128002883
Total Pages : 533 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Lung by : Kent Pinkerton

Download or read book The Lung written by Kent Pinkerton and published by Elsevier. This book was released on 2014-10-23 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of The Lung: Development, Aging and the Environment provides an understanding of the multi-faceted nature of lung development, aging, and how the environment influences these processes. As an essential resource to respiratory, pulmonary, and thoracic scientists and physicians it provides an interface between the “normal and “disease cluster of chapters, allowing for a natural complement to each other. The interface between different lung diseases affecting the pediatric lung also adds a useful source for comparing how different lung diseases share key pathophysiological features. This same complementarity comes across in the logical line up of chapters dealing with the “normal pediatric lung. New research, including cell-based strategies for infant lung function, epigenetics, and prenatal alcohol exposure on lung development and function are some of the important additions to this edition of this reference work. Describes the normal processes of lung development, growth and aging Considers the effects of the environmental contaminants in the air, water, soil, and diet on lung development, growth and health Describes genetic factors involved in susceptibility to lung disease Covers respiratory health risk in children

Stem Cells in the Lung

Author : Ivan Bertoncello
Publisher : Springer
ISBN 13 : 3319210823
Total Pages : 366 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Stem Cells in the Lung by : Ivan Bertoncello

Download or read book Stem Cells in the Lung written by Ivan Bertoncello and published by Springer. This book was released on 2015-10-31 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive overview of the current understanding of the organization of endogenous lung stem and progenitor cell compartments during fetal lung development, postnatal lung growth and in adulthood. Progressing stage by stage, the chapters on fetal lung development emphasize the integrated role of epithelial, stromal, vascular and neural cell elements in building a functional lung, while the subsequent chapters on adult lung regeneration describe the nature and properties of adult lung stem/progenitor cells distributed along the proximal-distal axis of the airway tree. The chapters on regulation of lung regeneration and repair discuss how regenerative cells interact with their niche microenvironment and how regulation of lung regeneration and repair in the steady state and following injury recapitulates ontogeny. And, lastly, the chapters on cellular therapies for lung disease and bioengineering the lung focus on promising emerging therapies and approaches in lung regenerative medicine. The scope of this volume of the Stem Cell Biology and Regenerative Medicine series focuses on exploring the topic of building and rebuilding the lung from a cellular rather than a molecular perspective. Thus, the section on cellular therapies does not include extensive coverage of each of the numerous lung diseases, including cancer, which could be amenable to stem cell-based therapies, although the final chapter does include some discussion on the future prospects and challenges. All of the contributors are working on the cutting edge of the lung stem cell field, making this book essential reading for those with an interest in the field of lung stem cell biology and the potential role of cellular therapies and tissue bioengineering approaches in lung regenerative medicine, including biomedical scientists, graduate students, post-graduate researchers and respiratory clinicians.

Lung Diseases

Author : Elvis Irusen
Publisher : BoD – Books on Demand
ISBN 13 : 9535101803
Total Pages : 706 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Lung Diseases by : Elvis Irusen

Download or read book Lung Diseases written by Elvis Irusen and published by BoD – Books on Demand. This book was released on 2012-03-02 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt: The developments in molecular medicine are transforming respiratory medicine. Leading clinicians and scientists in the world have brought their knowledge and experience in their contributions to this book. Clinicians and researchers will learn about the most recent advances in a variety of lung diseases that will better enable them to understand respiratory disorders. This treatise presents state of the art essays on airways disease, neoplastic diseases, and pediatric respiratory conditions. Additionally, aspects of immune regulation, respiratory infections, acute lung injury/ARDS, pulmonary edema, functional evaluation in respiratory disorders, and a variety of other conditions are also discussed. The book will be invaluable to clinicians who keep up with the current concepts, improve their diagnostic skills, and understand potential new therapeutic applications in lung diseases, while scientists can contemplate a plethora of new research avenues for exploration.

Spencer's Pathology of the Lung

Author : Philip Hasleton
Publisher : Cambridge University Press
ISBN 13 : 1139618970
Total Pages : 4616 pages
Book Rating : 4.1/5 (396 download)

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Book Synopsis Spencer's Pathology of the Lung by : Philip Hasleton

Download or read book Spencer's Pathology of the Lung written by Philip Hasleton and published by Cambridge University Press. This book was released on 2013-01-17 with total page 4616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully rewritten and updated for the cutting-edge sixth edition, Spencer's Pathology of the Lung follows in its predecessors' footsteps as the gold-standard textbook of pulmonary diseases. All recognized diseases of the lungs are discussed and illustrated with extensive, high-quality color images. Each chapter includes practical, clear and concise diagnostic features, including immunohistochemistry, molecular tests and differential diagnoses, while rare entities are discussed and illustrated in detail. This thoroughly reworked edition includes new classification schemes and the latest understanding of the pathophysiology and molecular aspects of a wide range of diseases. Non-neoplastic diseases are presented according to epidemiology, genetics, clinical manifestations, radiographic findings, pathology, cytology, laboratory findings, pathogenesis, differential diagnosis, prognosis and natural history. Neoplasms are discussed according to cell or origin with sections devoted to genetics, molecular findings and clinicopathologic correlations. Downloadable versions of all images are available on a CD-ROM packaged with the print book. Written and edited by leading experts in the field, this is an essential resource for practising and trainee pathologists.

Issues in Allied Fields of Medicine: 2013 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1490108467
Total Pages : 508 pages
Book Rating : 4.4/5 (91 download)

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Book Synopsis Issues in Allied Fields of Medicine: 2013 Edition by :

Download or read book Issues in Allied Fields of Medicine: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-05-01 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Allied Fields of Medicine / 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Allied Health. The editors have built Issues in Allied Fields of Medicine: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Allied Health in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Allied Fields of Medicine: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Lung Stem Cells in Development, Health and Disease

Author : Nikolic, Marko Z.
Publisher : European Respiratory Society
ISBN 13 : 1849841349
Total Pages : 395 pages
Book Rating : 4.8/5 (498 download)

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Book Synopsis Lung Stem Cells in Development, Health and Disease by : Nikolic, Marko Z.

Download or read book Lung Stem Cells in Development, Health and Disease written by Nikolic, Marko Z. and published by European Respiratory Society. This book was released on 2021-04-01 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science

Handbook of Fluorescent Dyes and Probes

Author : R. W. Sabnis
Publisher : John Wiley & Sons
ISBN 13 : 1119007097
Total Pages : 467 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Handbook of Fluorescent Dyes and Probes by : R. W. Sabnis

Download or read book Handbook of Fluorescent Dyes and Probes written by R. W. Sabnis and published by John Wiley & Sons. This book was released on 2015-05-05 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: A COMPLETE, UP-TO-DATE RESOURCE OF INFORMATION ON MORE THAN 150 FLUORESCENT DYES AND PROBES Handbook of Fluorescent Dyes and Probes is the most comprehensive volume available on the subject, covering all the available dyes and probes known to date in the literature for uses in various fields. Top dye expert Dr. Ram Sabnis organizes the compounds alphabetically by the most commonly used chemical name. He presents an easy-to-use reference complete with novel ideas for breakthrough research in medical, biological, chemical, color, material, physical and related allied fields. The ease of use of the handbook is further enhanced by various appendixes provided at the end of the book to conveniently and easily locate the dye as per the reader's need. This is the first book to give the CAS registry numbers, chemical structure, Chemical Abstract (CA) index name, all other chemical names, Merck Index number, chemical/dye class, molecular formula, molecular weight, physical form, solubility, melting point, boiling point, pKa, absorption maxima, emission maxima, molar extinction coefficient, and quantum yield of fluorescent dyes and probes, as well as to provide access to synthetic procedures (lab scale and industrial scale) of dyes and probes in a single source. This user-friendly handbook also features references on safety, toxicity and adverse effects of dyes and probes on humans, animals and the environment, including: acute/chronic toxicity aquatic toxicity carcinogenicity cytotoxicity ecotoxicity genotoxocity hematotoxicity hepatotoxicity immunotoxicity marine toxicity microbial toxicity mutagenicity nephrotoxicity neurotoxicity nucleic acid damage oral toxicity phototoxicity phytotoxicity reproductive toxicity skin toxicity Containing imaging/labeling applications, biological/medical applications and industrial applications, Handbook of Fluorescent Dyes and Probes is a convenient, vital resource for industrial and academic researchers, and a valuable desktop reference for medical professionals, lab supervisors, scientists, chemists, biologists, engineers, physicists, intellectual property professionals, students, and professors. Includes all fluorescent dyes & probes known to date and provides a complete, up-to-date library of information in one reference/handbook Includes more than 300 fluorescent dyes & probes organized alphabetically by the commonly used Chemical Name Provides access to synthesis procedures (lab scale and industrial scale) of fluorescent dyes & probes First book to provide references on safety, toxicity and adverse effects of fluorescent dyes and probes on humans, animals, and the environment User-friendly and convenient resource guide for chemical, biological, medical, and intellectual property professionals in a broad range of disciplines

Squamous Cell Carcinoma

Author : Xiaoming Li
Publisher : BoD – Books on Demand
ISBN 13 : 9535100246
Total Pages : 318 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Squamous Cell Carcinoma by : Xiaoming Li

Download or read book Squamous Cell Carcinoma written by Xiaoming Li and published by BoD – Books on Demand. This book was released on 2012-02-03 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book points to some new areas for investigation on squamous cell carcinoma (SCC). Firstly, the features and management of some specific SCC is discussed to give the readers the general principles in dealing with these uncommon and sophisticated conditions. Some new concepts in adjuvant therapy including neoadjuvant therapy and gold nanoparticle-based photo dynamic therapy are introduced. Secondly, a detailed discussion of molecular aspects of tumor invasion and progression in SCC is provided with the emphasis on the roles of some important factors. The role of tumor microenvironment in head and neck SCC is specifically discussed. Thirdly, the roles of cancer stem cells (CSC) in cancer therapy of SCC are described. Molecular mechanisms involving therapeutic resistance and new therapeutic strategies targeting CSC are discussed in detail. Finally, other aspects concerning SCC are included, which involve the assessment, genetic manipulation and its possible clinical implications for the treatment of SCC.

Respiratory Neurobiology

Author :
Publisher : Elsevier
ISBN 13 : 0323915353
Total Pages : 462 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Respiratory Neurobiology by :

Download or read book Respiratory Neurobiology written by and published by Elsevier. This book was released on 2022-08-12 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Respiratory Neurobiology: Physiology and Clinical Disorders, Part One, Volume 188 is one of two volumes on the neurology of breathing. This volume focuses on the neurophysiology of breathing, while the second volume focuses on pathologies attributable to abnormalities of the neural control of breathing, breathing problems that may occur in neurological diseases, and the neurological complications of respiratory diseases. Explores the assessment and treatment of neural disorders of breathing Identifies neural complications of respiratory diseases Includes SIDS, stroke, Parkinson's, dementia, epilepsy, muscular dystrophy, and more

The Pulmonary Epithelium in Health and Disease

Author : David Proud
Publisher : John Wiley & Sons
ISBN 13 : 9780470727003
Total Pages : 460 pages
Book Rating : 4.7/5 (27 download)

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Book Synopsis The Pulmonary Epithelium in Health and Disease by : David Proud

Download or read book The Pulmonary Epithelium in Health and Disease written by David Proud and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is essential reading for everyone who would like to update their knowledge of the pulmonary epithelium. It offers a comparison between laboratory animal models and human lungs, highlighting the differences and the similarities between the two, which will be particularly useful to researchers." –Doody's, April 2009 The past two decades have seen extraordinary advances in our understanding of the role of the pulmonary epithelium in airway health and disease. Our understanding of epithelial biology has expanded exponentially in the past decade. This book provides a unique comprehensive description of the structure of the epithelium, its damage by various agents and the mechanism of epithelial repair. In addition, it's detailed coverage includes not only the multiple ways in which the epithelium contributes to host defence, but also the nature and functional consequences of the interactions of inhaled pathogens, including viruses, bacteria, allergens and pollutants. the role of the epithelium in regulating airway inflammation and structure is also discussed, as is the role of the epithelium as a target for inhaled medications and as a route for novel drug delivery. Containing chapters on multiple aspects of epithelial function in health and disease, each one is written by a leader in the field. This is essential reading for pulmonary researchers and physicians requiring detailed advanced understanding of the epithelium as well as those working in allergy, biomedical and pharmaceutical research.