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Author : W. Doerfler
Publisher : Springer Science & Business Media
ISBN 13 : 3642464947
Total Pages : 269 pages
Book Rating : 4.6/5 (424 download)
Download or read book The Molecular Biology of Adenoviruses 2 written by W. Doerfler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Walter Doerfler
Publisher : Springer Science & Business Media
ISBN 13 : 3642794998
Total Pages : 291 pages
Book Rating : 4.6/5 (427 download)
Download or read book The Molecular Repertoire of Adenoviruses II written by Walter Doerfler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological and epidemiological investigations in mammalian molecular biology. In this, the second of three volumes, the attention is turned to such topics as DNA replication, recombination and integration, and post-transcriptional control. The chapters have been written by an international group of leading experts in their respective fields of interest.
Author : Walter Doerfler
Publisher : Springer Science & Business Media
ISBN 13 : 9783540131380
Total Pages : 110 pages
Book Rating : 4.1/5 (313 download)
Download or read book The Molecular Biology of Adenoviruses 3 written by Walter Doerfler and published by Springer Science & Business Media. This book was released on 1984 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David T. Curiel
Publisher : Academic Press
ISBN 13 : 0128005106
Total Pages : 870 pages
Book Rating : 4.1/5 (28 download)
Download or read book Adenoviral Vectors for Gene Therapy written by David T. Curiel and published by Academic Press. This book was released on 2016-03-10 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials
Author : Harold S. Ginsberg
Publisher : Springer Science & Business Media
ISBN 13 : 1468479350
Total Pages : 620 pages
Book Rating : 4.4/5 (684 download)
Download or read book The Adenoviruses written by Harold S. Ginsberg and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of adenoviruses naturally induced a new interest in viruses of the human upper respiratory tract since previously unknown viruses infecting this portion of the human body had not been identified in 20 years, and their unique characteristics stimulated investigations into the biochemical events essential for replication of animal viruses. Indeed, the field of molecular virology has evolved during the period since their dis covery, and adenoviruses have played a major role in this development. The exciting discoveries made with adenoviruses have had such a pro found effect on knowledge in basic virology, molecular biology, viral ge netics, human and animal infections, and cell transformation that this seemed a propitious time to have some of the major contributors review this field. This volume pays tribute to the late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial discoveries of adenoviruses have tremendously enriched virology. Harold S. Ginsberg vii Contents Chapter 1 An Overview 1 Harold S. Ginsberg Chapter 2 The Architecture of Adenoviruses M. V. Nermut I. Introduction ................................... . 5 II. Chemical and Physical Properties ................... . 6 III. Virus Capsid: Composition and Organization .......... . 7 A. Hexon ..................................... . 10 B. Penton .................................... . 12 C. Other Virus Polypeptides Associated with the Capsid 13 D. Organization of the Capsid ..................... . 14 IV. Virus Core .................................... . 15 A. Evidence for the Core Shell ..................... . 17 B. Organization of the DNA-Protein Complex (Nucleoc- sid) ....................................... . 18 C. Tentative Model of the Adenovirus Nucleocapsid ... . 22 V. Model of the Adenovirion ......................... . 29 32 References .......................................... .
Author : W. Doerfler
Publisher : Springer Science & Business Media
ISBN 13 : 3642694608
Total Pages : 240 pages
Book Rating : 4.6/5 (426 download)
Download or read book The Molecular Biology of Adenoviruses I written by W. Doerfler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The de velopment of a plaque assay for poliomyelitis virus in 1953 led us to the threshold of quantitative virology, and in the same year the double-helical structure of DNA was discovered and became a cornerstone of mo lecular biology. The potential of adenoviruses as research tools in the molecular and cellular biology of eukaryotic cells was recognized as early as the late 1950s and early 1960s by several investigators. Structural and biochemical stu dies dominated the early years. In 1962, some of the adenoviruses were the first human viruses shown to be oncogenic in experimental animals. Thus adenovirology offered the investigator the entire gamut of host cell interactions, productive and abortive, as well as trans formed and tumor cell systems. The possibilities that adenoviruses afforded for the study of the molecular biology and genetics of eukaryotic cells were fully rea lized in the late 1960s and the 1970s.
Author : William S. M. Wold
Publisher : Springer Science & Business Media
ISBN 13 : 1597452777
Total Pages : 738 pages
Book Rating : 4.5/5 (974 download)
Download or read book Adenovirus Methods and Protocols written by William S. M. Wold and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenovirus Methods and Protocols, Second Edition, now in two volumes, is an essential resource for adenovirus (Ad) researchers beginning in the field, and an inspirational starting point for researchers looking to branch into new areas of Ad study. In addition to updating and expanding important chapters from the first edition, the authors have added new chapters that address innovative, exciting areas of emphasis in Ad research, including Ad vector construction and use, real-time PCR, use of new animal models, and methods for quantification of Ad virus or virus expression/interactions. The protocols presented are written by trendsetting researchers.
Author : S Jane Flint
Publisher : World Scientific
ISBN 13 : 9813109815
Total Pages : 416 pages
Book Rating : 4.8/5 (131 download)
Download or read book Human Adenoviruses: From Villains To Vectors written by S Jane Flint and published by World Scientific. This book was released on 2016-12-21 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human adenoviruses play a central role in human diseases and as vectors for vaccines and gene delivery. This monograph describes the underlying principles of adenovirus molecular and structural biology, pathogenesis, antiviral measures and vector development. Much of the history of this virus and the many contributions made by its study are embedded in these discussions. Topics and questions that require further investigation are also considered.Although current virology textbooks cover topics related to adenoviruses, this book provides a comprehensive description of the virus and its interactions with the host. Students and researchers with a particular interest in adenoviruses, gene therapists, and virologists interested in viral pathogenesis will benefit from this book, which presents a unique integration of the basics with applied research in the field.
Author : William S. M. Wold
Publisher : Springer Science & Business Media
ISBN 13 : 1597451665
Total Pages : 246 pages
Book Rating : 4.5/5 (974 download)
Download or read book Adenovirus Methods and Protocols written by William S. M. Wold and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenovirus Methods and Protocols, Second Edition, now in two volumes, is an essential resource for adenovirus (Ad) researchers beginning in the field, and an inspirational starting point for researchers looking to branch into new areas of Ad study. In addition to updating and expanding the first edition, the authors have added new chapters that address innovative areas of emphasis in Ad research, including Ad vector construction and use, real-time PCR, use of new animal models, and methods for quantification of Ad virus or virus expression/interactions. Each of the protocols presented in these volumes is written by trendsetting researchers.
Author : Walter Doerfler
Publisher : Springer Science & Business Media
ISBN 13 : 3642795862
Total Pages : 322 pages
Book Rating : 4.6/5 (427 download)
Download or read book The Molecular Repertoire of Adenoviruses III written by Walter Doerfler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological and epidemiological investigation in mammalian molecular biology. In the first of the three volumes, we present an overview of adenovirus research. In the second volume, we turn our attention to such topics as DNA replication, recombination and integration and post-trans- criptional control. This, the third volume then looks at transformation and E1A, adenovirus genetics, pathogenesis and gene therapy.
Author : L. Philipson
Publisher :
ISBN 13 : 9783709183922
Total Pages : 128 pages
Book Rating : 4.1/5 (839 download)
Download or read book Molecular Biology of Adenoviruses written by L. Philipson and published by . This book was released on 2014-01-15 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Walter Doerfler
Publisher : Springer Science & Business Media
ISBN 13 : 9780898387582
Total Pages : 486 pages
Book Rating : 4.3/5 (875 download)
Download or read book Adenovirus DNA written by Walter Doerfler and published by Springer Science & Business Media. This book was released on 1986 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although adenoviruses have been established for quite some time as one of the most pliable tools to study the molecular biology of mammalian cells, rapid progress continues to be made with this virus system. The adenoviral genome introduced into the nucleus of cells as a Trojan Horse, as it were, is now facili tating investigators to uncover details of cellular mechanisms. In this volume twelve chapters have been collected that summarize important current research on different mechanisms in adenovirus infected and -transformed cells. It has become increasingly apparent that some of these mechanisms do not only pertain to highly specialized strategies of the viral genome and its expres sion or replication, but may simultaneously shed light on events indigenous to the cell. "Adenovirus DNA: The Viral Genome and its Expression" high lights the first publication of the entire annotated sequence of 35. 937 nucleotide pairs of adenovirus type 2 DNA by the Cold Spring Harbor and Uppsala groups (chapter 1). Goran Akusjarvi, Ulf Pettersson (Uppsala University) and Rich Roberts (Cold Spring Harbor) present a survey on the structure and function of the adenovirus-2 genome (chapter 2). A considerable amount of in formation has been collected on the biochemical mechanisms in vol ved in adenov irus DNA repl ication in human cells. Al though highly specialized in the way of initiating DNA replication, adenov irus DNA repl ication represents probably one of the best studied systems in work on eukaryotic DNA replication.
Author : Walter Doerfler
Publisher : Springer
ISBN 13 :
Total Pages : 128 pages
Book Rating : 4.F/5 ( download)
Download or read book The Molecular Biology of Adenoviruses written by Walter Doerfler and published by Springer. This book was released on 1984 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Walter Doerfler
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (741 download)
Download or read book The Molecular Biology of Adenoviruses written by Walter Doerfler and published by . This book was released on 1983 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David T. Curiel
Publisher : Springer Science & Business Media
ISBN 13 : 1592597858
Total Pages : 491 pages
Book Rating : 4.5/5 (925 download)
Download or read book Cancer Gene Therapy written by David T. Curiel and published by Springer Science & Business Media. This book was released on 2007-11-03 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.
Author : Walter Doerfler
Publisher : Springer Science & Business Media
ISBN 13 : 3662055996
Total Pages : 369 pages
Book Rating : 4.6/5 (62 download)
Download or read book Adenoviruses: Model and Vectors in Virus-Host Interactions written by Walter Doerfler and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: After three volumes on adenoviruses in 1995 the past years have seen rapid progress in the field of adenovirus research. Moreover, adenoviruses have attracted considerable interest as vectors in gene transfer regimens. After the first volume on virion and structure, viral replication and host-cell interaction this second volume deals with the immune system, oncogenesis and gene therapy.
Author : Lennart Philipson
Publisher : Springer Science & Business Media
ISBN 13 : 9783211812846
Total Pages : 115 pages
Book Rating : 4.8/5 (128 download)
Download or read book Molecular Biology of Adenoviruses written by Lennart Philipson and published by Springer Science & Business Media. This book was released on 1975 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt:
