Cancer Gene Therapy

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Gene Therapy of Cancer

Author : Stanton L. Gerson
Publisher : Elsevier
ISBN 13 : 9780080491363
Total Pages : 534 pages
Book Rating : 4.4/5 (913 download)

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Book Synopsis Gene Therapy of Cancer by : Stanton L. Gerson

Download or read book Gene Therapy of Cancer written by Stanton L. Gerson and published by Elsevier. This book was released on 2002-04-04 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. Key Features * Provides in-depth description of targeted systems and treatment strategies * Explains the underlying cancer biology necessary for understanding a given therapeutic approach * Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses * Presents translational focus with emphasis on requirements for clinical implementation * Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference

Gene Therapy for Cancer

Author : Kelly K. Hunt
Publisher : Springer Science & Business Media
ISBN 13 : 159745222X
Total Pages : 469 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Gene Therapy for Cancer by : Kelly K. Hunt

Download or read book Gene Therapy for Cancer written by Kelly K. Hunt and published by Springer Science & Business Media. This book was released on 2007-10-26 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Cancer Gene Therapy

Author : David T. Curiel
Publisher : Springer Science & Business Media
ISBN 13 : 1592597858
Total Pages : 490 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Cancer Gene Therapy by : David T. Curiel

Download or read book Cancer Gene Therapy written by David T. Curiel and published by Springer Science & Business Media. This book was released on 2007-11-03 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.

Gene-Based Therapies for Cancer

Author : Jack A. Roth
Publisher : Springer Science & Business Media
ISBN 13 : 144196102X
Total Pages : 282 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Gene-Based Therapies for Cancer by : Jack A. Roth

Download or read book Gene-Based Therapies for Cancer written by Jack A. Roth and published by Springer Science & Business Media. This book was released on 2010-07-28 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their experience in developing gene therapies for a variety of cancers. Translational gene therapy approaches are emphasized. Chapters include discussions of specific gene delivery technologies as well as their application to various cancers with extensive discussions of ongoing clinical trials. This information should be useful to both students, fellows, and experienced scientists with an interest in this rapidly developing area.

Gene Therapy of Cancer

Author : Wolfgang Walther
Publisher : Springer Science & Business Media
ISBN 13 : 1592590861
Total Pages : 633 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Gene Therapy of Cancer by : Wolfgang Walther

Download or read book Gene Therapy of Cancer written by Wolfgang Walther and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of the molecular structure of genes and the unveiling of the molecular basis of numerous human diseases, scientists have been fas- nated with the possibility of treating certain diseases by transducing foreign DNA into the affected cells. Initially, it was proposed that the foreign DNA could either replace defective nonfunctional genes, or code for therapeutic proteins. This concept has evolved into the rapidly growing field of gene therapy. Even though surgery, radiotherapy, and chemotherapy are widely ava- able and routinely used for cancer treatment, these therapies fail to cure approximately 50 percent of cancer patients. Therefore, since it is a disease characterized by aberrant gene expression, cancer has been a target of gene therapy research since the inception of this treatment modality. Numerous cancer gene therapy strategies are currently being investigated, including gene replacement therapy, the regulation of gene expression to modulate immu- logical responses to tumors, the direct killing of tumor cells, and direct int- ference with tumor growth. In this context, gene transfer systems, tumor-specific expression vectors, and novel therapeutic genes have been extensively st- ied. All these strategies aim for the selective destruction of human malignant disease while circumventing the destruction of nonmalignant cells and tissues thereby minimizing toxicity to the patient.

Gene Therapy of Cancer

Author : Edmund C. Lattime
Publisher : Academic Press
ISBN 13 : 0123946328
Total Pages : 554 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Gene Therapy of Cancer by : Edmund C. Lattime

Download or read book Gene Therapy of Cancer written by Edmund C. Lattime and published by Academic Press. This book was released on 2013-08-28 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive. Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies. In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response. Explains the underlying cancer biology necessary for understanding proposed therapeutic approaches Presents in-depth description of targeting systems and treatment strategies Covers the breadth of gene therapy approaches including immunotherapeutic, drug resistance,oncolytic viruses, as well as regulatory perspectives from both the NCI and FDA

Current Strategies in Cancer Gene Therapy

Author : Wolfgang Walther
Publisher : Springer
ISBN 13 : 3319429345
Total Pages : 124 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Current Strategies in Cancer Gene Therapy by : Wolfgang Walther

Download or read book Current Strategies in Cancer Gene Therapy written by Wolfgang Walther and published by Springer. This book was released on 2017-01-17 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well as in gene suppression and miRNA therapies. Many of the described strategies focus on the generation of more efficient and specific means of attack at known and novel cellular targets associated with tumor development and progression. The book also details parallel improvements in vector design, vector delivery, and therapeutic efficacy. It offers readers a stimulating, broad overview of advances in the field, linking experimental strategies to their clinical applications.

Gene Therapy of Solid Cancers

Author : Wolfgang Walther
Publisher : Humana
ISBN 13 : 9781493955923
Total Pages : 0 pages
Book Rating : 4.9/5 (559 download)

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Book Synopsis Gene Therapy of Solid Cancers by : Wolfgang Walther

Download or read book Gene Therapy of Solid Cancers written by Wolfgang Walther and published by Humana. This book was released on 2016-10-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides insight into recent developments on experimental and clinical strategies for cancer gene therapy. Gene Therapy of Solid Cancers: Methods and Protocols guides readers through protocols on gene therapeutic strategies in combination with helpful technical notes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Concise and easy-to-use, Gene Therapy of Solid Cancers: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Gene Therapy and Cancer Research Focus

Author : Rebecca N. Campbell
Publisher : Nova Publishers
ISBN 13 : 9781600219702
Total Pages : 354 pages
Book Rating : 4.2/5 (197 download)

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Book Synopsis Gene Therapy and Cancer Research Focus by : Rebecca N. Campbell

Download or read book Gene Therapy and Cancer Research Focus written by Rebecca N. Campbell and published by Nova Publishers. This book was released on 2008 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. The volume presents significant new research results in this promising field.

Cancer Gene Therapy

Author : Nagy Habib
Publisher : Springer Science & Business Media
ISBN 13 : 0306468174
Total Pages : 496 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Cancer Gene Therapy by : Nagy Habib

Download or read book Cancer Gene Therapy written by Nagy Habib and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the coming of the new millennium we are witnessing a revolution in our understanding of cancer genetics. These are very exciting times. Today we have at our disposal the technology to diagnose abnormalities in our cancer genes and the means to correct the deficit and very soon we will have the complete sequence of the human genome. With the use of gene chip technology the way doctors will be able to assess patients will change completely. Today we can diagnose abnormalities in ten thousand genes and within a short period of time we will be able to screen through our genome and discover potential abnormalities in our proto-oncogenes, tumour suppressor genes, differentiating genes, apoptotic genes and pro-inflammatory genes. In this book various authors have highlighted specific genes that could be expressed, overexpressed, neutralised or h- nessed to achieve cancer control. The problem of transferring the therapeutic gene into the cancer cell has been partly addressed with major developments in the field of naked plasmid DNA, adenovirus, retrovirus and adeno-associated viruses. However, further improvements are yet to be made to achieve significant gene transfer. Gene expression, in particular specificity of gene transfer, is obviously an important issue and one which is highlighted in this book by the use of specific promoter.

Gene Therapy and Cancer Research Progress

Author : Jessica L. Lewis
Publisher : Nova Publishers
ISBN 13 : 9781600218118
Total Pages : 240 pages
Book Rating : 4.2/5 (181 download)

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Book Synopsis Gene Therapy and Cancer Research Progress by : Jessica L. Lewis

Download or read book Gene Therapy and Cancer Research Progress written by Jessica L. Lewis and published by Nova Publishers. This book was released on 2008 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. This new book presents the latest research in the field from around the world.

Gene and Cellular Immunotherapy for Cancer

Author : Armin Ghobadi
Publisher : Springer Nature
ISBN 13 : 303087849X
Total Pages : 371 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Gene and Cellular Immunotherapy for Cancer by : Armin Ghobadi

Download or read book Gene and Cellular Immunotherapy for Cancer written by Armin Ghobadi and published by Springer Nature. This book was released on 2022-01-01 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field.

Cancer Gene Therapy by Viral and Non-viral Vectors

Author : Malcolm Brenner
Publisher : John Wiley & Sons
ISBN 13 : 1118501659
Total Pages : 176 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Cancer Gene Therapy by Viral and Non-viral Vectors by : Malcolm Brenner

Download or read book Cancer Gene Therapy by Viral and Non-viral Vectors written by Malcolm Brenner and published by John Wiley & Sons. This book was released on 2014-02-25 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides expert, state-of-the-art insight into the currentprogress of viral and non-viral gene therapy Translational medicine has opened the gateway to the era ofpersonalized or precision medicine. No longer a one-size-fits-allapproach, the treatment of cancer is now based on an understandingof underlying biologic mechanisms and is increasingly beingtailored to the molecular specificity of a tumor. This book provides a comprehensive overview of the pertinentmolecular discoveries in the cancer field and explains how theseare being used for gene-based cancer therapies. Designed as avolume in the Translational Oncology book series, Cancer GeneTherapy by Viral and Non-viral Vectors deals with the practiceof gene-therapy, with reference to vectors for gene expression andgene transfer, as well as viral therapy. It covers the history andcurrent and future applications of gene transfer in cancer, andprovides expert insight on the progress of viral and non-viral genetherapy with regard to delivery system, vector design, potentialtherapeutic genes, and principles and regulations for cancer genetherapy. Presented in three parts, Cancer Gene Therapy by Viral andNon-viral Vectors covers: Delivery Systems • Translational Cancer Research: Gene Therapy by Viraland Non-viral Vectors • Retroviruses for Cancer Therapy • DNA Plasmids for Non-viral Gene Therapy ofCancer • Cancer Therapy with RNAi delivered by Non-viralMembrane/Core Nanoparticles Targeted Expression • Cancer Gene Therapy by Tissue-specific andCancer-targeting Promptors • MicroRNAs as Drugs and Drug Targets in Cancer Principles of Clinical Trials in Gene Therapy • Regulatory issues for Manufacturers of Viral Vectorsand Vector-transduced Cells for Phase I/II Trials • US Regulations Governing Clinical Trials in GeneTherapy • Remaining Obstacles to the Success of Cancer GeneTherapy Focusing on speeding the process in clinical cancer care bybringing therapies as quickly as possible from bench to bedside,Cancer Gene Therapy by Viral and Non-viral Vectors is anabsolutely vital book for physicians, clinicians, researchers, andstudents involved in this area of medicine.

A Glance at Advances in the Techniques and Methodologies of Cancer Gene Therapy.

Author : Dr.Hakim Saboowala
Publisher : Dr.Hakim Saboowala
ISBN 13 :
Total Pages : 57 pages
Book Rating : 4./5 ( download)

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Book Synopsis A Glance at Advances in the Techniques and Methodologies of Cancer Gene Therapy. by : Dr.Hakim Saboowala

Download or read book A Glance at Advances in the Techniques and Methodologies of Cancer Gene Therapy. written by Dr.Hakim Saboowala and published by Dr.Hakim Saboowala. This book was released on 2020-05-06 with total page 57 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Glance at Advances in the Techniques and Methodologies of Cancer Gene Therapy. Cancer is the second leading cause of mortality worldwide after cardiovascular diseases, predominantly due to the lack of early symptoms and early diagnosis, and high relapse rate after radical surgery and conventional therapies. Therefore, novel approaches such as gene therapy have raised hope to significantly improve the survival rate of patients with cancers. Thus it would be worth at this stage providing an up-to-date information concerning gene therapy including: · Improved vectors, · Suicide genes, · Cancer suppressor genes, · Anti-tumor angiogenesis, · Gene silencing, · Oncolytic virotherapy, and · Gene-editing technology. Whilst specific issues still exist before gene therapy can completely cure cancers, an effort has been made in this Booklet to highlight the potential of gene therapy in cancer treatment and expect to see continuous breakthroughs in techniques therapy. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)

Cancer Gene Therapy: New Insights for the Healthcare Professional: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464902089
Total Pages : 117 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Cancer Gene Therapy: New Insights for the Healthcare Professional: 2011 Edition by :

Download or read book Cancer Gene Therapy: New Insights for the Healthcare Professional: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Gene Therapy: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Cancer Gene Therapy in a concise format. The editors have built Cancer Gene Therapy: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer Gene Therapy in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer Gene Therapy: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

New Gene Therapy and Cancer Research

Author : Wilma B. Gustafsson
Publisher : Nova Publishers
ISBN 13 : 9781600219696
Total Pages : 332 pages
Book Rating : 4.2/5 (196 download)

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Book Synopsis New Gene Therapy and Cancer Research by : Wilma B. Gustafsson

Download or read book New Gene Therapy and Cancer Research written by Wilma B. Gustafsson and published by Nova Publishers. This book was released on 2008 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. This book offers research from around the globe dedicated to this subject.

Handbook of Research on Advancements in Cancer Therapeutics

Author : Kumar, Sumit
Publisher : IGI Global
ISBN 13 : 1799865312
Total Pages : 913 pages
Book Rating : 4.7/5 (998 download)

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Book Synopsis Handbook of Research on Advancements in Cancer Therapeutics by : Kumar, Sumit

Download or read book Handbook of Research on Advancements in Cancer Therapeutics written by Kumar, Sumit and published by IGI Global. This book was released on 2020-11-27 with total page 913 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complexity of cancer demands an integrated approach from both a cancer biology standpoint and a pharmaceutical basis to understand the different anticancer modalities. Current research has been focused on conventional and newer anticancer modalities, recent discoveries in cancer research, and also the advancements in cancer treatment. There is a current need for more research on the advances in cancer therapeutics that bridge the gap between basic research (pharmaceutical drug development processes, regulatory issues, and translational experimentation) and clinical application. Recent promising discoveries such as immunotherapies, promising therapies undergoing clinical trials, synthetic lethality, carbon beam radiation, and other exciting targeted therapies are being studied to improve and advance the studies of modern cancer treatment. The Handbook of Research on Advancements in Cancer Therapeutics serves as a comprehensive guide in modern cancer treatment by combining and merging the knowledge from both cancer biology and the pharmacology of anticancer modalities. The chapters come from multi-disciplinary backgrounds, including scientists and clinicians from both academia and various industries, to discuss nascent personalized therapies and big data-driven cancer treatment. While highlighting topic areas that include cancer prevention, cancer therapeutics, and cancer treatments through the lenses of technology, medicine/drugs, and alternate therapies, this book is ideally intended for oncologists, radiation oncologists, surgical oncologists, and cancer biologists, along with practitioners, stakeholders, researchers, academicians, and students who are interested in understanding the most fundamental aspects of cancer and the available therapeutic opportunities.