The Martins Of Cromartin

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Chromatin

Author : Randall H. Morse
Publisher : Academic Press
ISBN 13 : 0128148101
Total Pages : 586 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Chromatin by : Randall H. Morse

Download or read book Chromatin written by Randall H. Morse and published by Academic Press. This book was released on 2024-06-15 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin: Structure, Function, and History covers the basics of chromatin biology, beginning with the discoveries that culminated in the recognition of the nucleosome as the basic subunit of chromatin. Chromatin folding, nucleosome positioning, and histone variants are discussed, as well as research on chromatin modifications and remodeling, which exploded in the early to mid-1990s and led to widespread interest in epigenetics. Considerable attention is given to methods and experiments that led to key insights and recent developments such as the use of genome-wide approaches and innovations in imaging approaches are also emphasized. By providing historical background together with detailed discussion of contemporary studies, the book aims to instill in the reader an appreciation not only of our current knowledge of chromatin structure and function, but also of the remarkable path that has taken chromatin to the forefront of modern research. Provides a current, expansive, and well-documented resource on chromatin and epigenetics Addresses the role of chromatin in transcription regulation and chromatin abnormalities in disease Reviews the historical background of specific areas of chromatin research, enabling readers to understand how the field was born and to appreciate the discoveries and technical advances that have propelled it forward

Fundamentals of Chromatin

Author : Jerry L. Workman
Publisher : Springer Science & Business Media
ISBN 13 : 1461486246
Total Pages : 594 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Fundamentals of Chromatin by : Jerry L. Workman

Download or read book Fundamentals of Chromatin written by Jerry L. Workman and published by Springer Science & Business Media. This book was released on 2013-12-04 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it.

Chromatin Signaling and Diseases

Author : Olivier Binda
Publisher : Academic Press
ISBN 13 : 012802609X
Total Pages : 468 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Chromatin Signaling and Diseases by : Olivier Binda

Download or read book Chromatin Signaling and Diseases written by Olivier Binda and published by Academic Press. This book was released on 2016-08-06 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling. Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored. Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with aging Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathology Explores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signaling Helps researchers learn about the quickly expanding field of chromatin signaling

DNA Repair Enzymes: Cell, Molecular, and Chemical Biology

Author :
Publisher : Academic Press
ISBN 13 : 0128118474
Total Pages : 480 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis DNA Repair Enzymes: Cell, Molecular, and Chemical Biology by :

Download or read book DNA Repair Enzymes: Cell, Molecular, and Chemical Biology written by and published by Academic Press. This book was released on 2017-06-20 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Repair Enzymes, Part A, Volume 591 is the latest volume in the Methods in Enzymology series and the first part of a thematic that focuses on DNA repair enzymes. Topics in this new release include chapters on the Optimization of Native and Formaldehyde iPOND Techniques for Use in Suspension Cells, the Proteomic Analyses of the Eukaryotic Replication Machinery, DNA Fiber Analysis: Mind the Gap!, Comet-FISH for Ultrasensitive Strand-Specific Detection of DNA Damage in Single Cells, Examining DNA Double-Strand Break Repair in a Cell Cycle-Dependent Manner, Base Excision Repair Variants in Cancer, and Fluorescence-Based Reporters for Detection of Mutagenesis in E. coli. Includes contributions from leading authorities working in enzymology Focuses on DNA repair enzymes Informs and updates on all the latest developments in the field of enzymology

Centromeres and Kinetochores

Author : Ben E. Black
Publisher : Springer
ISBN 13 : 3319585924
Total Pages : 552 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Centromeres and Kinetochores by : Ben E. Black

Download or read book Centromeres and Kinetochores written by Ben E. Black and published by Springer. This book was released on 2017-08-23 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms controlling the transmission of genetic material between cell divisions and from parent to offspring. The chapters cover five major areas related to the current study of centromeres and kinetochores: 1) their genetic and epigenetic features, 2) key breakthroughs at the molecular, proteomic, imaging and biochemical level, 3) the constitutive centromere proteins, 4) the role of centromere proteins in the physical process of chromosome segregation and its careful orchestration through elaborate regulation, and 5) intersections with reproductive biology, human health and disease, as well as chromosome evolution. The book offers an informative and provocative guide for newcomers as well as those already acquainted with the field.

Targeting DNA Repair and the DNA Damage Response: Beyond the Standard PI3 Kinase-like Kinases

Author : John J. Turchi
Publisher : Frontiers Media SA
ISBN 13 : 2832504647
Total Pages : 216 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Targeting DNA Repair and the DNA Damage Response: Beyond the Standard PI3 Kinase-like Kinases by : John J. Turchi

Download or read book Targeting DNA Repair and the DNA Damage Response: Beyond the Standard PI3 Kinase-like Kinases written by John J. Turchi and published by Frontiers Media SA. This book was released on 2022-11-09 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Clinician's Guide to Sperm DNA and Chromatin Damage

Author : Armand Zini
Publisher : Springer
ISBN 13 : 3319718150
Total Pages : 598 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis A Clinician's Guide to Sperm DNA and Chromatin Damage by : Armand Zini

Download or read book A Clinician's Guide to Sperm DNA and Chromatin Damage written by Armand Zini and published by Springer. This book was released on 2018-03-05 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, up-to-date text, which brings together the key practical elements of the rapidly evolving field of sperm DNA and chromatin abnormalities, is divided thematically into five main sections. Part I discusses human sperm chromatin structure and nuclear architecture, while part II presents laboratory evaluation of sperm DNA damage, including SCSA, SCD, TUNEL and Comet assays, and cytochemical tests. Biological and clinical factors in the etiology of sperm DNA damage are discussed in part III, including oxidative stress, abortive apoptosis, cancer, and environmental and lifestyle factors. Part IV presents clinical studies on the utility of sperm DNA damage tests, both with natural and ART-assisted pregnancies, and debates the clinical utility of such tests. Finally, part V discusses current treatment options, such as antioxidant therapy, varicocelectomy, advanced sperm processing techniques and the use of testicular sperm. We are now beginning to better understand the unique organization of the sperm chromatin, as well as the nature and etiology of sperm DNA damage. Written and edited by worldwide experts in andrology, A Clinician's Guide to Sperm DNA and Chromatin Damage is an excellent resource for reproductive medicine and REI specialists, urologists, reproductive biologists and any professional working with the infertile male.

The Evolving Chromatin and Transcriptional Landscapes – Emerging Methods, Tools and Techniques

Author : Jean-Philippe Lambert
Publisher : Frontiers Media SA
ISBN 13 : 2889719219
Total Pages : 157 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis The Evolving Chromatin and Transcriptional Landscapes – Emerging Methods, Tools and Techniques by : Jean-Philippe Lambert

Download or read book The Evolving Chromatin and Transcriptional Landscapes – Emerging Methods, Tools and Techniques written by Jean-Philippe Lambert and published by Frontiers Media SA. This book was released on 2022-01-03 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Sperm Chromatin

Author : Armand Zini
Publisher : Springer Science & Business Media
ISBN 13 : 1441968571
Total Pages : 515 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Sperm Chromatin by : Armand Zini

Download or read book Sperm Chromatin written by Armand Zini and published by Springer Science & Business Media. This book was released on 2011-08-04 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.

Repetitive DNA Sequences

Author : Andrew G. Clark
Publisher : MDPI
ISBN 13 : 3039283669
Total Pages : 206 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Repetitive DNA Sequences by : Andrew G. Clark

Download or read book Repetitive DNA Sequences written by Andrew G. Clark and published by MDPI. This book was released on 2020-03-05 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Repetitive DNA is ubiquitous in eukaryotic genomes, and, in many species, comprises the bulk of the genome. Repeats include transposable elements that can self-mobilize and disperse around the genome, and tandemly-repeated satellite DNAs that increase in copy number due to replication slippage and unequal crossing over. Despite their abundance, repetitive DNA is often ignored in genomic studies due to technical challenges in their identification, assembly, and quantification. New technologies and methods are now providing the unprecedented power to analyze repetitive DNAs across diverse taxa. Repetitive DNA is of particular interest because it can represent distinct modes of genome evolution. Some repetitive DNA forms essential genome structures, such as telomeres and centromeres, which are required for proper chromosome maintenance and segregation, whereas others form piRNA clusters that regulate transposable elements; thus, these elements are expected to evolve under purifying selection. In contrast, other repeats evolve selfishly and produce genetic conflicts with their host species that drive adaptive evolution of host defense systems. However, the majority of repeats likely accumulate in eukaryotes in the absence of selection due to mechanisms of transposition and unequal crossing over. Even these neutral repeats may indirectly influence genome evolution as they reach high abundance. In this Special Issue, the contributing authors explore these questions from a range of perspectives.

New Research on DNA Repair

Author : Breehn R. Landseer
Publisher : Nova Publishers
ISBN 13 : 9781600213854
Total Pages : 412 pages
Book Rating : 4.2/5 (138 download)

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Book Synopsis New Research on DNA Repair by : Breehn R. Landseer

Download or read book New Research on DNA Repair written by Breehn R. Landseer and published by Nova Publishers. This book was released on 2007 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a major defence against environmental damage to cells DNA repair is present in all organisms including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. DNA repair is involved in processes that minimise cell killing, mutations, replication errors, persistence of DNA damage and genomic instability. Abnormalities in these processes have been implicated in cancer and ageing. This book presents leading-edge research from around the world in this frontal field.

DNA Repair

Author :
Publisher : Academic Press
ISBN 13 : 0128155604
Total Pages : 383 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis DNA Repair by :

Download or read book DNA Repair written by and published by Academic Press. This book was released on 2019-02-22 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Repair, Volume 115, the latest release in the Advances in Protein Chemistry and Structural Biology series, provides an overview of current developments in mechanisms underlying DNA repair, their involvement in maintaining chromatin repair, the balance between chromosome breaks repair pathways, tumorigenesis, immune signaling and infection-induced inflammation. Specific chapters cover the Structure and function of the multi-subunit TFIIH with insights into nucleotide excision repair, Chromatin repair: how DNA packaging controls double-strand break repair, Controlling the balance between chromosome breaks repair pathways, The targeting of DNA repair pathways in the era of precision oncology, and much more. Describes advances in our understanding on DNA repair mechanisms and the involvement of their dysregulation in promoting diseases Presents data that is targeted to a very wide audience of specialists, researchers and students Contains timely chapters written by well-renowned authorities in their field Provides targeted information that is well supported by a number of high-quality illustrations, figures and tables

The Nuclear Envelope

Author : David Evans
Publisher : Garland Science
ISBN 13 : 0203643399
Total Pages : 320 pages
Book Rating : 4.2/5 (36 download)

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Book Synopsis The Nuclear Envelope by : David Evans

Download or read book The Nuclear Envelope written by David Evans and published by Garland Science. This book was released on 2004-09-01 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nuclear Envelope brings together the major current topics in nuclear envelope structure, transport, transcriptional regulation and cell signaling. The volume is divided into four sections: 1. Proteins of the nuclear envelope, including nuclear envelope proteomics, structure and function. 2. Nuclear pores and transport at the nuclear envelope, including pore complex structure, assembly and function and import and export pathways. 3. Nuclear envelope dynamics, including dynamics of lamina assembly and disassembly. 4. Nuclear signaling and transcription regulation, including signaling to the nucleus and spectrin repeat proteins and their implications or communication between the nucleus and cytoplasm.

Fanaroff and Martin's Neonatal-Perinatal Medicine E-Book

Author : Richard J. Martin
Publisher : Elsevier Health Sciences
ISBN 13 : 0323081118
Total Pages : 2022 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Fanaroff and Martin's Neonatal-Perinatal Medicine E-Book by : Richard J. Martin

Download or read book Fanaroff and Martin's Neonatal-Perinatal Medicine E-Book written by Richard J. Martin and published by Elsevier Health Sciences. This book was released on 2010-10-04 with total page 2022 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fanaroff and Martin’s Neonatal-Perinatal Medicine covers everything you need to improve the quality of life and long-term outcomes of your patients. Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh, along with a multi-disciplinary team of contributors guide you through the sweeping developments in diagnosis and treatment of the mother fetus, and neonate. The completely updated 9th edition keeps you current on the late preterm infant, the fetal origins of adult disease, neonatal anemia, genetic disorders, and more. Get comprehensive guidance on treating patients through a dual focus on neonatology and perinatology. See nuances and details in over 800 illustrations that depict disorders in the clinical setting and explain complex information. Find the information you need easily with indexing in both volumes that provides quick access to specific guidance. Spot genetic problems early and advise parents of concerns thanks to completely new section on this topic. Tackle the health problems associated with preterm births through a new chapter on The Late Preterm Infant. Understand the fetal origins of adult disease through a new chapter that focuses on conditions that originate in the womb. Stay current on the developments and research surrounding neonatal anemia from the entirely new chapter on Blood and Hematopoietic System highlights. Obtain more global perspectives and best practices from an increased number of international contributions in this edition.

Chromatin Accessibility

Author : Georgi K. Marinov
Publisher : Springer Nature
ISBN 13 : 1071628992
Total Pages : 337 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Chromatin Accessibility by : Georgi K. Marinov

Download or read book Chromatin Accessibility written by Georgi K. Marinov and published by Springer Nature. This book was released on 2023-02-20 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume provides a comprehensive resource covering the existing and state-of-the-art tools in the field of profiling chromatin accessibility and its dynamics. Beginning with a section on bulk-cell methods for profiling chromatin accessibility and nucleosome positioning that rely on enzymatic cleavage of accessible DNA and produce information about relative accessibility, the book continues with methods that use single-molecule and enzymatic approaches to solving the problem of mapping absolute occupancy/accessibility, emerging tools for mapping DNA accessibility and nucleosome positioning in single cells, imaging-based methods for visualizing accessible chromatin in its nuclear context, as well as computational methods for the processing and analysis of chromatin accessibility datasets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Chromatin Accessibility: Methods and Protocols serves as an extensive and useful reference for researchers studying different facets of chromatin accessibility in a wide variety of biological contexts. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Molecular Biology

Author : Nancy L. Craig
Publisher : Oxford University Press, USA
ISBN 13 : 0198788657
Total Pages : 1018 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis Molecular Biology by : Nancy L. Craig

Download or read book Molecular Biology written by Nancy L. Craig and published by Oxford University Press, USA. This book was released on 2021-01-20 with total page 1018 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fresh, distinctive approach to the teaching of molecular biology. With its focus on key principles, its emphasis on the commonalities that exist between the three kingdoms of life, and its integrated coverage of experimental methods and approaches, Molecular Biology is the perfect companion to any molecular biology course.

Advances in DNA Damage and Repair

Author : Miral Dizdaroglu
Publisher : Springer Science & Business Media
ISBN 13 : 1461548659
Total Pages : 502 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Advances in DNA Damage and Repair by : Miral Dizdaroglu

Download or read book Advances in DNA Damage and Repair written by Miral Dizdaroglu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This volume covers the most recent developments in this research field and contains contributions from scientists working in various fields.