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A Clinicians Guide To Sperm Dna And Chromatin Damage
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Book Synopsis A Clinician's Guide to Sperm DNA and Chromatin Damage by : Armand Zini
Download or read book A Clinician's Guide to Sperm DNA and Chromatin Damage written by Armand Zini and published by Springer. This book was released on 2018-03-05 with total page 605 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, up-to-date text, which brings together the key practical elements of the rapidly evolving field of sperm DNA and chromatin abnormalities, is divided thematically into five main sections. Part I discusses human sperm chromatin structure and nuclear architecture, while part II presents laboratory evaluation of sperm DNA damage, including SCSA, SCD, TUNEL and Comet assays, and cytochemical tests. Biological and clinical factors in the etiology of sperm DNA damage are discussed in part III, including oxidative stress, abortive apoptosis, cancer, and environmental and lifestyle factors. Part IV presents clinical studies on the utility of sperm DNA damage tests, both with natural and ART-assisted pregnancies, and debates the clinical utility of such tests. Finally, part V discusses current treatment options, such as antioxidant therapy, varicocelectomy, advanced sperm processing techniques and the use of testicular sperm. We are now beginning to better understand the unique organization of the sperm chromatin, as well as the nature and etiology of sperm DNA damage. Written and edited by worldwide experts in andrology, A Clinician's Guide to Sperm DNA and Chromatin Damage is an excellent resource for reproductive medicine and REI specialists, urologists, reproductive biologists and any professional working with the infertile male.
Book Synopsis Sperm Chromatin for the Clinician by : Armand Zini
Download or read book Sperm Chromatin for the Clinician written by Armand Zini and published by Springer. This book was released on 2013-07-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise, truncated version of Zini and Agarwal's Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction offers select, clinical chapters for a handy, more affordable, state-of-the-art resource. Sperm Chromatin for the Clinician addresses such vital issues as: -Male subfertility and sperm chromatin damage -Aging and sperm DNA damage -Cancer and implications for sperm quality -Environmental factors -Cryopreservation and sperm DNA integrity -Postnatal effects of sperm chromatin damage Practical for clinicians and researchers alike, Sperm Chromatin for the Clinician contains all of the need-to-know information about this cutting-edge topic in reproductive medicine.
Download or read book Sperm Chromatin written by Armand Zini and published by Springer Science & Business Media. This book was released on 2011-08-04 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.
Download or read book Sperm Chromatin written by Armand Zini and published by Springer. This book was released on 2016-08-23 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.
Book Synopsis Sperm Chromatin for the Researcher by : Armand Zini
Download or read book Sperm Chromatin for the Researcher written by Armand Zini and published by . This book was released on 2013-09-30 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Manual of Sperm Function Testing in Human Assisted Reproduction by : Ashok Agarwal
Download or read book Manual of Sperm Function Testing in Human Assisted Reproduction written by Ashok Agarwal and published by Cambridge University Press. This book was released on 2021-04-15 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on modern sperm function testing, this guide is essential in selecting sperm that will produce viable and healthy embryos.
Book Synopsis Genetics of Male Infertility by : Mohamed Arafa
Download or read book Genetics of Male Infertility written by Mohamed Arafa and published by Springer Nature. This book was released on 2020-03-14 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique, case-based guide provides a thoughtful and comprehensive overview of the genetic basis of male infertility for the practicing clinician. In addition to discussing the molecular foundations of sperm production and the consequences of genetic abnormalities on various stages of sperm development, it examines the clinical aspects of acknowledged genetic disorders and their implications on male fertility. In so doing, it offers the necessary tools required by the clinician for the diagnosis and treatment of infertile men with genetic abnormalities. Moreover, it provides essential algorithms that may aid in counseling patients in the clinic. The text is arranged in four thematic sections for easy reference. The genetic foundation of male reproduction is presented in part 1, including regulation of sperm production, the structure of sperm chromatin, and spermatogenesis. The impact of genetic abnormalities on male infertility is the subject of part 2, covering sperm defects, mitochondrial function and DNA fragmentation. The clinical case material in part 3 illustrates real-world examples of genetic etiologies and the current diagnostic and therapeutic strategies for conditions such as vas asplasia, cryptorchidism, immotile cilia syndrome, sperm aneuploidy and other challenging scenarios. Casting forward, the fourth and final section presents an overview of future possibilities for management of genetic causes of male infertility, including gene editing. Fully exploring the clinical context of these genetic conditions in a practical manner that appeals to the practicing clinician, Genetics of Male Infertility is an exciting and essential text for reproductive medicine specialists, andrologists, urologists, researchers and all other clinicians treating infertile patients.
Book Synopsis Manual of Sperm Function Testing in Human Assisted Reproduction by : Ashok Agarwal
Download or read book Manual of Sperm Function Testing in Human Assisted Reproduction written by Ashok Agarwal and published by Cambridge University Press. This book was released on 2021-04-15 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selecting good-quality sperm for use in in-vitro fertilization is a key step in assisted reproduction. For many years purely morphological attributes have been used to assess suitability, but increasingly biochemical and molecular biological techniques are now identifying sperm with the best chances of producing viable and healthy embryos. Focusing on modern sperm function testing, this manual provides technical details of commonly used tests and gives an overview of the laboratory techniques used to evaluate sperm samples. Covering a variety of testing methods in detail, from manual and computer-assisted semen analysis to zona pellucida binding assays, and tests assessing sperm DNA damage such as the TUNEL assay. Describing the underlying science, practical advice for performing the tests is given, including tips for optimizing outcomes and trouble-shooting. This is an essential guide for reproductive medicine specialists, clinical andrologists, urologists and gynecologists working with sub-fertile men.
Book Synopsis Male Infertility by : Sijo J. Parekattil
Download or read book Male Infertility written by Sijo J. Parekattil and published by Springer Nature. This book was released on 2020-01-24 with total page 895 pages. Available in PDF, EPUB and Kindle. Book excerpt: A groundbreaking contribution to the literature now in its revised and expanded second edition, this textbook offers a comprehensive review of diagnostic and treatment techniques for male infertility. This state-of-the-art, evidence-based textbook incorporates new multidisciplinary and complementary medicine approaches to create a first-of-its-kind guide to treatment strategies for male infertility and beyond. While this new edition is primarily designed as a reference for students and residents in reproductive medicine and andrology, it will be equally useful as well for professionals in urology, reproductive endocrinology, embryology, and research fields who are interested in the role that antioxidants play in male infertility. World-renowned experts in these areas have been selected to participate in this work. Careful selection of the highest quality content will span the whole range of topics in the area of male infertility, providing a complete review of well-established and current diagnostic and treatment techniques for male infertility. The incorporation of 20 new chapters will enhance the book’s appeal by including the most recent advances brought to the male infertility arena. Additionally, this edition incorporates new features, including bulleted key points, review criteria and select video clips demonstrating some of the most fascinating male infertility treatment modalities. A dedicated new section on current guidelines on male infertility will enlighten readers on how to most optimally manage male infertility clinical scenarios. Covering all aspects of diagnosis and management, ART, lifestyle factors and associated conditions for male infertility, Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants will be a readily accessible, high quality reference for medical students and residents, and will be of significant value to professionals working in the various fields treating this condition as well.
Book Synopsis Male Infertility in Reproductive Medicine by : Botros Rizk
Download or read book Male Infertility in Reproductive Medicine written by Botros Rizk and published by CRC Press. This book was released on 2019-10-16 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: This useful illustrated text summarizes for an audience of clinicians in Reproductive Medicine the practical essentials of what they need to know about diagnosis and management of the infertile male patient, whether they need to instruct or liaise with a colleague or undertake the procedures themselves.
Book Synopsis The Complete Guide to Male Fertility Preservation by : Ahmad Majzoub
Download or read book The Complete Guide to Male Fertility Preservation written by Ahmad Majzoub and published by Springer. This book was released on 2017-10-27 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, multidisciplinary guide provides an up-to-date presentation of fertility preservation techniques with male cancer patients and other challenging conditions. Divided into four thematic sections, part one provides an overview of the pathophysiologic processes interrelating cancer and its treatment with infertility and discusses different methods of sperm preservation and fertility outcomes in cancer patients. Part two then explores male fertility preservation in various non-cancerous conditions, such as immunosuppressed, hypogonadal and transgender patients. The fundamental principles of cryobiology and sperm optimization are covered in part three, which also offers essential building blocks for scientists to develop a sperm banking service and implement high standards of practice. The final section describes the current practices of male fertility preservation along with its psychological impact on patients, and extends beyond to future innovative methods—tissue preservation, xenografting and artificial gametes—being researched and implemented in this field. Fertility preservation among cancer patients and survivors is an evolving practice, which involves focused research and timely collaboration of professionals from related fields. The Complete Guide to Male Fertility Preservation is unique and original in its design and will appeal to a larger audience of andrologists, reproductive endocrinologists, urologists, embryologists, and all other clinicians practicing reproductive medicine and oncology.
Book Synopsis A Practical Guide to Basic Laboratory Andrology by : David Mortimer
Download or read book A Practical Guide to Basic Laboratory Andrology written by David Mortimer and published by Cambridge University Press. This book was released on 2022-03-10 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preceded by A practical guide to basic labratory andrology / Lars Bjèorndahl... [et al.]. 2010.
Book Synopsis Studies on Men's Health and Fertility by : Ashok Agarwal
Download or read book Studies on Men's Health and Fertility written by Ashok Agarwal and published by Springer Science & Business Media. This book was released on 2012-03-17 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies on Men’s Health and Fertility provides a comprehensive series of up-to-the-minute reviews addressing the role of oxidative stress in the aetiology of reproductive pathologies in the male. This volume represents by far the most detailed, authoritative review of the field that has been produced to date. The text encompasses the basic science of reactive oxygen species (ROS) production by mammalian spermatozoa, the way in which these highly reactive molecules are processed by the germ line and the physiological significance of this redox activity in the generation of a functional gamete. The factors responsible for perturbing the delicate balance between physiological redox signaling on the one hand and oxidative stress on the other are also extensively reviewed and some of the first clues concerning the underlying mechanisms (age, heat, infection, cryostorage, aberrant lipid metabolism), clearly identified. From a clinical perspective there are chapters setting out the methods we should be using to diagnose oxidative stress in the male germ line, a clinical perspective on the aetiology of this condition and detailed considerations of the most suitable means of ameliorating such stress from a therapeutic point of view. Studies on Men’s Health and Fertility is intended to provide clinicians and scientists with a snap shot of the current status of this exciting, rapidly moving field. The book will be of value to clinicians interested in strategies for the management of oxidative stress in their infertility patients and scientists wishing to understand the molecular mechanisms underpinning the generation of ROS by these cells and its pathophysiological significance. It was not so long ago that the ability of spermatozoa to generate ROS was a hotly disputed topic. With the publication of this book such doubts can finally be laid to rest. There is now no doubt that these cells actively generate ROS, that oxidative stress is a major contributor to defects in male reproductive health and that the successful clinical management of this condition depends on developing a deeper understanding of the underlying molecular mechanisms. In this quest, Studies on Men’s Health and Fertility will be seen as a clear and important milestone.
Book Synopsis Genetic Damage in Human Spermatozoa by : Elisabetta Baldi
Download or read book Genetic Damage in Human Spermatozoa written by Elisabetta Baldi and published by Springer. This book was released on 2019-07-12 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are several types of damage that can be found in the male gamete. This book covers the genetic damage in spermatozoa that can originate during spermatogenesis, or during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.
Book Synopsis Textbook of Assisted Reproductive Techniques by : David K. Gardner
Download or read book Textbook of Assisted Reproductive Techniques written by David K. Gardner and published by CRC Press. This book was released on 2023-12-13 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established as the definitive reference for the IVF clinic, the sixth edition has been extensively revised, with the addition of several important new contributions on laboratory topics, including KPIs for the IVF laboratory, Quality control in the cloud, Artificial Intelligence, AI in gamete and embryo selection, Demystifying vitrification, Microfluidics, Gene editing, Disaster management, and Early human embryo development revealed by static imaging. As previously, methods, protocols, and techniques of choice are presented by IVF pioneers and eminent international experts.
Book Synopsis Male Reproductive Anatomy by : Wei Wu
Download or read book Male Reproductive Anatomy written by Wei Wu and published by BoD – Books on Demand. This book was released on 2022-01-19 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: The male reproductive system, which is made up of the testes, scrotum, epididymis, vas deferens, seminal vesicles, prostate gland, bulbourethral gland, ejaculatory duct, urethra, and penis, functions mainly in the production, nourishment, and temporary storage of spermatozoa. Epigenetic modifications are essential to regulate normal gonadal development and spermatogenesis. The sperm epigenome is highly susceptible influence by a wide spectrum of environmental stimuli. This book focuses on the male reproductive system, discussing topics ranging from aspects of anatomy and risk factors for male infertility to clinical techniques and management of male reproductive health.
Book Synopsis Disentangling Mechanisms of Genomic Regulation of Cell Functions at the Gene Level by : Hans Binder
Download or read book Disentangling Mechanisms of Genomic Regulation of Cell Functions at the Gene Level written by Hans Binder and published by MDPI. This book was released on 2021-04-22 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this Special Issue, we have several papers related to fuel-cell-based cogeneration systems; the management and control of fuel cell systems; the analysis, simulation, and operation of different types of fuel cells; modelling and online experimental validation; and the environment assessment of cathode materials in lithium-ion battery energy generation systems. A paper which gives a comprehensive review with technical guidelines for the design and operation of fuel cells, especially in a cogeneration system setup, which can be an important source of references for the optimal design and operation of various types of fuel cells in cogeneration systems, can also be found in this Special Issue.
