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The Landscape Of Comprehensive Therapy Based On Systemic Therapy For Unresectable Hepatocellular Carcinoma Uhcc In China
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Book Synopsis The Landscape of Comprehensive Therapy Based on Systemic Therapy for Unresectable Hepatocellular Carcinoma (uHCC) in China by : Jia Fan
Download or read book The Landscape of Comprehensive Therapy Based on Systemic Therapy for Unresectable Hepatocellular Carcinoma (uHCC) in China written by Jia Fan and published by Frontiers Media SA. This book was released on 2022-11-14 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Combining localised and systemic therapy options for advanced hepatocellular carcinoma by : Ji Hoon Shin
Download or read book Combining localised and systemic therapy options for advanced hepatocellular carcinoma written by Ji Hoon Shin and published by Frontiers Media SA. This book was released on with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Systemic Therapy in Hepatocellular Carcinoma by : chanchai Charonpongsuntorn
Download or read book Systemic Therapy in Hepatocellular Carcinoma written by chanchai Charonpongsuntorn and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic therapy of advanced stage hepatocellular carcinoma (HCC) was limited to the sorafenib in the past decade since 2007. Novel agents including multiple targeting agents, immune checkpoint inhibitors and anti-angiogenesis reported efficacy in treatment. This is the first time, the combination of atezolizumab and bevacizumab as first-line treatment is superior to sorafenib. Standard guideline in advanced HCC was changing. New novel drugs increase in available including multiple targeting agents and immune checkpoint blockade such as Lenvatinib, regorafenib, cabozantinib, ramucirumab and immunotherapy as first line or second line therapy will benefit in term of survival benefit and quality of life in advanced stage or unresectable hepatocellular carcinoma.
Book Synopsis Immunotherapy of Hepatocellular Carcinoma by : Tim F. Greten
Download or read book Immunotherapy of Hepatocellular Carcinoma written by Tim F. Greten and published by Springer. This book was released on 2018-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.
Book Synopsis Past, Present, and Future Perspectives on the Systemic Therapy for Advanced Hepatocellular Carcinoma (HCC) - A Comprehensive Review by : Ahmed Abu-Zaid
Download or read book Past, Present, and Future Perspectives on the Systemic Therapy for Advanced Hepatocellular Carcinoma (HCC) - A Comprehensive Review written by Ahmed Abu-Zaid and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatocellular carcinoma (HCC) is the fifth most frequent cancer, the third leading cause of cancer-related mortality, and the first leading cause of death in patients with cirrhosis. Management of primary locally advanced, inoperable, recurrent or metastatic HCC is very challenging and continues to be a topic of controversy. Herein, we shed light on the past, present, and future perspectives on the systemic therapy (hormonal therapy, cytotoxic chemotherapy, and novel molecularly targeted therapy) for management of patients with advanced HCC.
Book Synopsis Effectiveness of Chinese Medicines in Treating Chronic Liver Diseases by : FAN. CHEUNG
Download or read book Effectiveness of Chinese Medicines in Treating Chronic Liver Diseases written by FAN. CHEUNG and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Effectiveness of Chinese Medicines in Treating Chronic Liver Diseases" by Fan, Cheung, 張凡, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Chronic liver diseases mainly indicate liver fibrosis (LF) and cirrhosis. Advanced liver fibrosis may result in fatal complications including liver cirrhosis and hepatocellular carcinoma (HCC). LF is suggested to be reversible but lack of conclusive evidence on effective and safe therapy currently. Transarterial chemoembolization (TACE) is the primary option with severe adverse effects for unresectable HCC patients because most HCC are detected at a very advanced stage. Meanwhile, Chinese medicine (CM) has been considered as an alternative therapy for LF and HCC because of its low cost and high safety. This thesis aims to (1) conduct comprehensive meta-analysis and systematic reviews of randomized controlled clinical trials (RCTs) to critically evaluate the efficacy and safety of CMs in treating LF and unresectable HCC; (2) explore its potential as an evidence-based alternative or adjuvant therapy for LF or HCC. The studies were conducted according to the Cochrane guidelines for systematic review and PRISMA statement. Comprehensive databases were used including MEDLINE, AMED, EMBASE, The Cochrane Library, CINAHL Plus, PubMed, CNKI, TCMOnline, Chinese Biomedical Literature Database, WanFang Database, and Chinese Medical Current Contents. The bibliographies of identified studies were also screened. RCTs examining the effects of CMs in treating LF patients or CMs combined with TACE in treating unresectable HCC patients were included. Inverse-variance random effects model was used to calculate the mean difference (MD) with 95% confidence intervals (CIs) in the LF systematic review when both risk ratios (RRs) and MD were used in the HCC review. Heterogeneity and publication bias were estimated. The methodological quality of included RCTs were assessed using the Cochrane 'risk of bias' assessment. Twenty-three RCTs (number of patients=2123) were eligible for LF review and 67 RCTs (number of patients=5211) for HCC review. For LF review, 15 RCTs were classified as high quality. Significant reduction in LF biomarkers including HA, LN, PC-III and IV-C was found in CHM alone and CHM plus Western medicine group when compared with Western medicine alone. For HCC review, 26 RCTs were ranked as high quality. Significant improvement in tumor response, survival, immunity and quality of life, and decrease of TACE toxicity were found in the CMs plus TACE compared with TACE alone. No clinically significant CMassociated adverse events were observed for both LF and HCC trials. The results of both LF and HCC reviews have shown that CMs may exert antifibrotic and anti-HCC properties. The findings indicate that CMs can be considered as a potential alternative therapy for LF or HCC. Due to the low methodological quality and significant heterogeneity, RCTs with large sample size, long-term follow-up, and standard research protocols compliance with CONSORT guidelines are needed for further investigation. Subjects: Liver - Diseases - Treatment Medicine, Chinese
Download or read book Liver Cancers written by Tim Cross and published by Springer. This book was released on 2018-12-12 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in detail the primary liver cancers of hepatocellular carcinoma and cholangiocarcinoma examining the pathogenesis of disease along with diagnosis and current management options together with exploration of future treatment strategies and areas of controversy. Furthermore, the book highlights management of the common secondary malignancies and touches on benign liver tumours and how to best manage these. Written in a clear and didactic style, this volume includes summaries of the key learning points and questions so that the reader can gauge their knowledge and understanding. This book is aimed to broaden the knowledge base of primary care physicians, general physicians along with specialists in hepatology, oncology and hepato-biliary surgery
Book Synopsis Multi-Drug Resistance in Cancer by : Jun Zhou
Download or read book Multi-Drug Resistance in Cancer written by Jun Zhou and published by Humana Press. This book was released on 2012-08-09 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemotherapy is one of the major treatment options for cancer patients; however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance p- tein to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The book also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression. In addition, this book contains techniques for the detection and imaging of drug transporters, methods for the investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. The book intends to provide a state-of-the-art collection of reviews and methods for both basic and clinician investigators who are interested in cancer multidrug resistance mechanisms and reversal strategies. Tianjin, China Jun Zhou v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1 Multidrug Resistance in Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Bruce C. Baguley 2 Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets . . . . . . . . . . . . . . . . . . . . . . . . . .
Book Synopsis Hepatobiliary Diseases by : Jesus Prieto
Download or read book Hepatobiliary Diseases written by Jesus Prieto and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1132 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last few years have witnessed major developments in molecular biology which have had a significant impact on biomedical knowledge. As a result new concepts in cell biology have emerged, new etiologic agents have been discovered, and new drugs have become available. Furthermore, the world of mediators, cytokines, and humoral factors has enlarged considerably in a relatively short period and this has modified our views of diverse physio pathologic processes as well as opened up new therapeutic prospects. In addition, recent technologic advances have revolutionized our diagnostic methodology and have greatly enhanced the power of our therapeutic resources. All these factors have contributed to a substantial remodeling of both liver science and clinical hepatology, and these changes have generated the motivation for the production of the present book, which attempts to give an account of well-known clinical facts in the light of current thinking. It is the fruit of the coordinated work of experts from different countries in three continents. In a sense, it is a manifestation of the fact that inter national cooperation is becoming increasingly important not only in the expansion of science but also in its exposition. We hope that Hepatobiliary Diseases will be useful to both students and clinicians and that internists, gastroenterologists, and general practitioners will find in its contents a satifactory coverage of their field of interest.
Book Synopsis Hepatobiliary Cancers: Translational Advances and Molecular Medicine by :
Download or read book Hepatobiliary Cancers: Translational Advances and Molecular Medicine written by and published by Elsevier. This book was released on 2022-08-15 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75 % of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15 % 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis; advances in molecular genomics for personalizing tumor classification and targeted therapies; innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies. Up-to date review of hepatobiliary cancers molecular genetics, novel predictive molecular biomarkers, and distinct mechanisms of inter-and intratumor heterogeneity Novel insights into the role of tumor microenvironment as a promoter of hepatobiliary cancer progression and therapeutic resistance, as well as an emerging therapeutic target Current and emerging approaches and strategies for advancing personalized molecular therapeutic targeting and immunotherapy of hepatobiliary cancers
Book Synopsis Immunological Surveillance by : Macfarlane Burnet
Download or read book Immunological Surveillance written by Macfarlane Burnet and published by Elsevier. This book was released on 2014-05-17 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological Surveillance
Book Synopsis Drug-Coated Balloons by : Bernardo Cortese
Download or read book Drug-Coated Balloons written by Bernardo Cortese and published by Springer. This book was released on 2019-06-19 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, up-to-date summary of drug-coated balloon (DCB) technology and the role of DCBs in the treatment of coronary and peripheral arterial disease. In addition to clear explanation of how DCBs works, readers will find an enlightening analysis of the mistakes and successes of the past decade and the emergence of the latest delivery systems, which combine a more deliverable device with much improved drug delivery to the vessel wall. The full range of current applications of DCBs are reviewed in detail, drawing on the latest scientific evidence. Due attention is paid to newer devices, with provision of technical insights and documentation of the available clinical data. Ongoing research projects, remaining technical challenges, likely future directions, and reimbursement issues are also carefully considered. This book will be a useful tool for any interventional cardiologist, interventional radiologist, or vascular surgeon who wishes to acquire a deep knowledge of this technology and its application in both coronary and peripheral interventions.
Book Synopsis Malignant Liver Tumours: Basic Concepts and Clinical Management by : F. Berr
Download or read book Malignant Liver Tumours: Basic Concepts and Clinical Management written by F. Berr and published by Springer Science & Business Media. This book was released on 2002-11-30 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), both increasing in incidence, have become a major topic of basic and clinical research as well as clinical practice in hepatology. Experts in the field update the current concepts on the carcinogenesis of HCC and CC such as genetic alterations in the pathways of cell cylce and apoptosis regulation, the hypothesis of dedifferentiation of hepatocytes to the malignant phenotype vs that of activation of hepatic progenitor cells incapable of maturation (maturation arrest hypothesis). In spite of an increasing number of genetic alterations described in human HCC as well as cell regulatory pathways tested in experimental HCC models, the key hits causing progression of the cell cycle in imbalance with apoptosis, tissue invasive growth and metastatic potential of cell clones still remain elusive. Very powerful genomic and proteomic techniques are promising insights into the carcinogenesis of liver malignancies that will allow more efficient therapeutic strategies. The current concepts on risk profiling, surveillance of risk groups and therapeutic strategies are evidence-based for HCC and less detailed for CC. Surveillance of risk groups improves detection of liver tumours in curable stages. Best strategies for curative treatment of HCC use neoadjuvant antitumour therapies before liver transplantation and a role is emerging for living donor-related liver transplantation. New palliative therapies for HCC are in the experimental stage with biological response modifiers, including angiogenesis inhibitors, and entering phase II clinical trials with the alpha-fetoprotein derived vaccines.
Book Synopsis Malignant Liver Tumors by : Pierre-Alain Clavien
Download or read book Malignant Liver Tumors written by Pierre-Alain Clavien and published by John Wiley & Sons. This book was released on 2011-09-23 with total page 1039 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive and critical review of current and established treatment modalities for malignant liver tumors is designed to help you sort through the proliferation of competitive approaches and choose the best treatment options for your patient. Dr. Clavien and his contributors consider all the options – radiological, surgical, pharmaceutical, and emerging/novel therapies – and help you find the best single or combined therapy. Building on the success of the previous edition, this extremely thorough revision: features a new section on Guidelines for Liver Tumors, where you will find specific strategies for treating common liver malignancies; the guidelines were prepared by the Associate Editors and take into account national and international society guidelines reflects actual practice by taking a multidisciplinary approach, with contributions from international experts who have extensive experience with this patient population achieves comprehensive and balanced coverage by having each chapter reviewed by the Editor, Deputy Editor, two Associate Editors, and at least one external reviewer includes 16 new chapters that cover liver anatomy, histologic changes in the liver, epidemiology and natural history of HCC, CCC and colorectal liver metastases, strategies of liver resection, and economic aspects as well as novel therapies facilitates the kind of daily interaction among hepatologists, hepatic surgeons, medical oncologists, radiotherapists, and interventional radiologists that is essential when treating patients with complex liver malignancies In 44 chapters organized into six major sections, the book covers the full range of liver tumors. The perfect blend of evidence and experience, Malignant Liver Tumors: Current and Emerging Therapies, 3rd Edition, illuminates the path to better patient care.
Book Synopsis Robotic Radiosurgery by : Richard Francis Mould
Download or read book Robotic Radiosurgery written by Richard Francis Mould and published by Cyberknife Society. This book was released on 2005 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers a wide range of topics on robotic radiosurgery. General topics on robotic radiosurgery include: 9 chapters on history, physics, radiobiology and technology and 24 chapters on CNS, non-CNS and future applications in robotic radiosurgery. Includes 157 figures and 93 tables,
Author :Dmitry I. Gabrilovich Publisher :Springer Science & Business Media ISBN 13 :1489980563 Total Pages :471 pages Book Rating :4.4/5 (899 download)
Book Synopsis Tumor-Induced Immune Suppression by : Dmitry I. Gabrilovich
Download or read book Tumor-Induced Immune Suppression written by Dmitry I. Gabrilovich and published by Springer Science & Business Media. This book was released on 2014-02-10 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs. The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy to provide breakthroughs in cancer treatment. It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance, but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune suppression to make any progress in the field and this monograph provides these important insights.
Book Synopsis Development of Antibody-Based Therapeutics by : Mohammad A. Tabrizi
Download or read book Development of Antibody-Based Therapeutics written by Mohammad A. Tabrizi and published by Springer. This book was released on 2018-09-11 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as immune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2012) where recent innovations warrant elaboration. This, the second edition of Development of Antibody-Based Therapeutics: Translational Considerations, represents a comprehensive evaluation of progress in the field, which sits alongside the first edition to inform, in detail, professional and academic researchers, as well as graduate students.
