The Isoquinoline Alkaloids Chemistry And Pharmacology

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The Isoquinoline Alkaloids Chemistry and Pharmacology

Author : Maurice Shamma
Publisher : Elsevier
ISBN 13 : 0323144500
Total Pages : 615 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis The Isoquinoline Alkaloids Chemistry and Pharmacology by : Maurice Shamma

Download or read book The Isoquinoline Alkaloids Chemistry and Pharmacology written by Maurice Shamma and published by Elsevier. This book was released on 2012-12-02 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Isoquinoline Alkaloids: Chemistry and Pharmacology presents an overview of the chemistry, biogenesis, spectroscopy, and pharmacology of the isoquinoline alkaloids. This book examines the significant and interesting aspects of alkaloids. Organized into 32 chapters, this book starts with a discussion of the biogenesis of the isoquinolines and the various pharmacological effects of simple tetrahydroisoquinolines that have stimulant and convulsive properties. This text then explores the infrared absorptions, with emphasis on wavelength and frequency. Other chapters include topics on synthesis, degradation, reactions, absolute configuration, as well as on ultraviolet and nuclear magnetic resonance spectroscopy. This book further explores the various methods available for the preparation of simple tetrahydroisoquinolines, including the Bischler–Napieralski, Pictet–Spengler, and phenolic cyclization, as well as the Friedel–Crafts acylation. The last chapter deals with ancistrocladine, which is the first isoquinoline alkaloid found to possess a methyl group. Biochemists and biophysicists will find this book useful.

The Chemistry and Biology of Isoquinoline Alkaloids

Author : J.D. Phillipson
Publisher : Springer Science & Business Media
ISBN 13 : 3642701280
Total Pages : 315 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis The Chemistry and Biology of Isoquinoline Alkaloids by : J.D. Phillipson

Download or read book The Chemistry and Biology of Isoquinoline Alkaloids written by J.D. Phillipson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Isoquinolines form one of the largest groups of plant alkaloids and they in clude a number of valuable clinical agents such as codeine, morphine, eme tine and tubocurarine. Research into different aspects of isoquinolines con tinues in profusion, attracting the talents of botanists, chemists, bioche mists, analysts, pharmacists and pharmacologists. Many of these aspects are of an interdisciplinary nature, and in April 1984, The Phytochemical Society of Europe arranged a 3-day symposium on The Chemistry and Bi ology of Isoquinoline Alkaloids in order to provide a forum for scientists of differing disciplines who are united by a common interest in this one class of natural product. Each chapter in this volume is based on a lecture given at this symposium. Attempts have been made to make the aims and objectives, experimental findings and conclusions reached, intelligible to scientists of differing backgrounds. The introductory chapter, which is mainly based on a historical discus sion, stresses that plants containing isoquinolines have proved to be both a boon and a curse to mankind. The Opium Poppy, Papaver somniferum, produces the medicinally used alkaloids morphine, codeine, noscapine and papaverine whilst it also continues to provide drugs of abuse, particularly morphine and its readily prepared O,O-diacetyl derivative, heroin. Numer ous other alkaloids have been isolated from other members of the Papaver acea, and a knowledge of their presence and distribution within the various species has proved a useful adjunct to systematic botanical studies.

The Isoquinoline Alkaloids

Author : K. W. Bentley
Publisher : Elsevier
ISBN 13 : 1483152235
Total Pages : 273 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis The Isoquinoline Alkaloids by : K. W. Bentley

Download or read book The Isoquinoline Alkaloids written by K. W. Bentley and published by Elsevier. This book was released on 2014-04-24 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Isoquinoline Alkaloids: A Course in Organic Chemistry is a description of the chemical structures of alkaloids. The book discusses the processes for degradation of isoquinoline alkaloids to recognizable compounds such as oxidation and exhaustive methylation. The associated processes in removing the nitrogen atom are also explained. The commonly used Hofmann process and the interpretation of its result are evaluated in the degradation of alkaloids. The cactus ""pellote"" used by Mexican Indians to induce hallucinatory experiences is examined. The active ingredient is identified as mescaline; its composition is analyzed to contain one primary amino and three methoxyl groups. The different syntheses made to duplicate mescaline are described. The structures of morphine, codeine, and thebain, which are all alkaloids of opium, are also analyzed. Another example of a principal alkaloid found in a plant is emetine found in the root of the ipecac. The pharmacological bases of emetine are isolated and noted as emetamine, cephaeline, psychotrine, and O-methylpsychotrine. The text also traces many other structural relationships within the subgroups of the isoquinoline alkaloids. Chemists, students and professors in organic chemistry, and laboratory technicians whose work is related to pharmacology will find this book informative.

The Alkaloids: Chemistry and Pharmacology

Author :
Publisher : Academic Press
ISBN 13 : 9780080865607
Total Pages : 336 pages
Book Rating : 4.8/5 (656 download)

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Book Synopsis The Alkaloids: Chemistry and Pharmacology by :

Download or read book The Alkaloids: Chemistry and Pharmacology written by and published by Academic Press. This book was released on 1990-01-12 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Alkaloids: Chemistry and Pharmacology

Handbook of Natural Products Data: Isoquinoline alkaloids

Author : Atta-ur- Rahman
Publisher : Elsevier Science & Technology
ISBN 13 :
Total Pages : 796 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Handbook of Natural Products Data: Isoquinoline alkaloids by : Atta-ur- Rahman

Download or read book Handbook of Natural Products Data: Isoquinoline alkaloids written by Atta-ur- Rahman and published by Elsevier Science & Technology. This book was released on 1990 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt: Isoquinoline alkaloids represent one of the two largest groups of alkaloids, the other being indole alkaloids. The present volume, which is the third of this series, describes the spectral data of about 700 isoquinoline alkaloids and covers the literature up to 1992. The spectral data of the remaining classes of isoquinoline alkaloids will be published in another volume within a year.The compounds are arranged according to their structural types in various subclasses. Within each subclass they are arranged in order of increasing molecular weight. Compounds in the same subclass and having the same molecular weight are arranged in order of increasing carbon number.The UV, IR, 1 H-NMR and 13 C-NMR spectral data are given in descending orders of magnitude. All &egr values in the UV spectra have been converted to log &egr. The chemical shifts in the 1 H-NMR spectral data are presented in ppm and the chemical shifts in the older data published in &tgr values have been converted to &dgr values to ensure uniformity of format. The protons and carbons to which the data refers have been italicised. If any of the data given is that of a salt (e.g. hydrochloride) then this is indicated in brackets before the data. If the compounds are known by more than one name, the older names are given in brackets after the newer one. Spectral data of simple derivatives of compounds are also reported, but only if the data for acetyl, benzoyl, methyl and ethyl derivatives are given. The numbering systems used are given both at the beginning of each sub-class as well as at the end of the book. Compound, molecular formula, molecular weight, plant sources and compound-type indices are also included which should enhance the utility of the book.

Isoquinoline Alkaloids Research 1972–1977

Author : Maurice Shamma
Publisher : Springer
ISBN 13 : 9781461588214
Total Pages : 426 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Isoquinoline Alkaloids Research 1972–1977 by : Maurice Shamma

Download or read book Isoquinoline Alkaloids Research 1972–1977 written by Maurice Shamma and published by Springer. This book was released on 2012-12-12 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Substantial advances in the realm of isoquinoline alkaloids have occurred since The Isoquinoline Alkaloids, Chemistry and Pharmacology, was published in 1972. The present volume represents an effort to describe important developments since that time. The organization of the present book is essentially the same as in The Isoquinoline Alkaloids. Each chapter begins with a discussion of structural elucidation and synthesis, a description of typical reactions then follows, and the chapter ends with coverage of biogenesis, pharmacology, and spectroscopy. New chapters have had to be added to describe the completely new alkaloidal types discovered since 1972. These include baluchistanamine (an isoquinolone benzylisoquinoline dimer), the aporphine-pavine dimers, the 4,5-dioxoapor phines, the secoberbines, the 3-arylisoquinolines, eupolauridine, and very recently imerubrine. Another new chapter discusses the chemistry of the aristolo chic acids and aristolactams, a group of substituted phenanthrenes, obviously of isoquinoline derivation in spite of the fact that they do not incorporate a basic nitrogen function. The aristolochic acids and aristolactams were not in cluded in The Isoquinoline Alkaloids even though they were known at the time that book was written. On the other hand, one group of alkaloids which was included in The Isoquinoline Alkaloids and nevertheless was deemed not to belong properly in the present work is the naphthalenoisoquinolines, which include ancistro cladine and its relatives. These bases do not originate biogenetically· from tyrosine, and beside incorporating tetrahydroisoquinoline moieties show no clear structural relationship to the more orthodox isoquinoline alkaloids.

The Alkaloids

Author : Arnold Brossi
Publisher :
ISBN 13 : 9780124695337
Total Pages : 360 pages
Book Rating : 4.6/5 (953 download)

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Book Synopsis The Alkaloids by : Arnold Brossi

Download or read book The Alkaloids written by Arnold Brossi and published by . This book was released on 1988-07-01 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemistry and Pharmacology

Author :
Publisher : Academic Press
ISBN 13 : 9780080865706
Total Pages : 364 pages
Book Rating : 4.8/5 (657 download)

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Book Synopsis Chemistry and Pharmacology by :

Download or read book Chemistry and Pharmacology written by and published by Academic Press. This book was released on 1995-08-31 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Internationally acclaimed for more than forty years, this serial, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structureelucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Pharmacology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile. Indispensible reference work written by leading experts in the field Provides up-to-date, timely reviews on compounds and classes of great interest Covers synthesis, biosynthesis, biology, as well as isolation and structure elucidation An essential research tool for anyone working with alkaloids from a chemical or biological perspective

Isoquinoline Alkaloids Research 1972–1977

Author : Maurice Shamma
Publisher : Springer Science & Business Media
ISBN 13 : 1461588197
Total Pages : 426 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Isoquinoline Alkaloids Research 1972–1977 by : Maurice Shamma

Download or read book Isoquinoline Alkaloids Research 1972–1977 written by Maurice Shamma and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Alkaloids

Author : Hans-Joachim Knolker
Publisher : Elsevier
ISBN 13 : 0443188343
Total Pages : 202 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis The Alkaloids by : Hans-Joachim Knolker

Download or read book The Alkaloids written by Hans-Joachim Knolker and published by Elsevier. This book was released on 2023-01-31 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Alkaloids, Volume 89, the newest release in a series that has covered the topic for more than 60 years, discusses key aspects of alkaloid chemistry, biology and pharmacology. Sections in this release include chapters on Recent Progress in the Chemistry of Naphthylisoquinoline Alkaloids, The Biological Activities of Quinolizidine Alkaloids, and C NMR Spectral Data and Pharmacological Activities of Aporphine Alkaloids. Provides the latest information on the study of alkaloids Covers alkaloid chemistry, biology, pharmacology and medical applications Contains more than 80 published volumes in this interesting field of study

Alkaloids: Chemical and Biological Perspectives

Author : S. William Pelletier
Publisher : Springer Science & Business Media
ISBN 13 : 1461229081
Total Pages : 378 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Alkaloids: Chemical and Biological Perspectives by : S. William Pelletier

Download or read book Alkaloids: Chemical and Biological Perspectives written by S. William Pelletier and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 8 of this series presents four timely reviews on alkaloids: Chapter 1 is a magnificent and monumental review of curare, "a group of dart and/or arrow poisons varying in composition and featuring muscle relaxation as their basic pharmacological action." The fascinating history of curare is recounted, beginning with early encounters by the Spanish Conquistadores through its use as arrow poisons by the forest tribes in hunting and warfare, its chemistry, ethnography, botany and pharmacology. A terminal section of this chapter treats the development of modern muscle relaxants. This chapter thus traces how curare-initially only a crude plant extract-has given rise to the widely used and very important neuromuscular blocking agents of today. The precise role of plant secondary metabolites and their interactions with insect herbivores have been focal points for research by chemists, botanists and entomologists for many years. Alkaloids and their glycosides are frequently involved as feeding deterrents. Chapter 2 treats the relationships between the chemistry of alkaloids in host plants and the effects that these compounds may have on insect herbivores. Interestingly, an alkaloid produced by a plant may manifest different effects on different insects.

The Alkaloids

Author : Richard Helmuth Fred Manske
Publisher :
ISBN 13 :
Total Pages : 446 pages
Book Rating : 4.3/5 (555 download)

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Book Synopsis The Alkaloids by : Richard Helmuth Fred Manske

Download or read book The Alkaloids written by Richard Helmuth Fred Manske and published by . This book was released on 1950 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Alkaloids: Chemical and Biological Perspectives

Author : S.W. Pelletier
Publisher : Elsevier
ISBN 13 : 9780080527000
Total Pages : 392 pages
Book Rating : 4.5/5 (27 download)

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Book Synopsis Alkaloids: Chemical and Biological Perspectives by : S.W. Pelletier

Download or read book Alkaloids: Chemical and Biological Perspectives written by S.W. Pelletier and published by Elsevier. This book was released on 1996-12-12 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 11 of this series presents five timely reviews on current research on alkaloids. Chapter 1 by Paul L. Schiff, Jr. is a monumental survey of research that has been carried out over the past decade on the Thalictrum alkaloids. Forty-six new alkaloids are described from fifteen species of the genus Thalictrum, as well as 116 alkaloids of known structure from thirty-six species and subspecies of the genus. The chapter includes discussions of isolation and structure elucidation, analysis, biosynthesis, cell culture, and pharmacology. Also featured are inclusive compilations of botanical sources, alkaloids by alkaloid types, and calculated molecular weights of the Thalictrum alkaloids. Chapter 2 by Giovanni Appendino provides a fascinating treatment of Taxine, a collective name referring to a mixture of diterpenoid alkaloids from the yew tree (genus: Taxus). Taxine is responsible for the toxic properties of the yew tree that has been documented in historical and fictional literature, from Julius Caesar to Shakespeare, and from Agatha Christie to T.S. Eliot. The chapter treats the history, isolation techniques, structure elucidation, chemistry, and pharmacology of Taxine. Chapter 3 by Mary D. Menachery surveys the alkaloids of South American Menispermaceae (moonseed family). Many different structural types are included in this family. The alkaloid-bearing plants are woody-vines, shrubs, or small trees. Several of these species possess potent curare activity. The chemistry as well as pharmacology of these alkaloids is summarized. Chapter 4 by Russell J. Molyneux, Robert J. Nash, and Naoki Asano treats the chemistry and biological activity of the calystegines and related nortropane alkaloids. These polyhydroxylated bicyclic alkaloids represent another class of compounds that inhibit glycosidases, producing profound effects in biological systems by disrupting the essential cellular function of glycoprotein processing. Chapter 5, a related chapter by Robert J. Nash, Naoki Asano, and Alison A. Watson, reviews polyhydroxylated alkaloids that inhibit glycosidases. Topics covered include distribution, ecological significance and toxicity, isolation, synthesis, and biosynthesis.

The Alkaloids

Author : Richard Helmuth Fred Manske
Publisher :
ISBN 13 : 9780124695177
Total Pages : 611 pages
Book Rating : 4.6/5 (951 download)

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Book Synopsis The Alkaloids by : Richard Helmuth Fred Manske

Download or read book The Alkaloids written by Richard Helmuth Fred Manske and published by . This book was released on 1979 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Alkaloids

Author :
Publisher : Elsevier
ISBN 13 : 0443295557
Total Pages : 446 pages
Book Rating : 4.4/5 (432 download)

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Book Synopsis The Alkaloids by :

Download or read book The Alkaloids written by and published by Elsevier. This book was released on 2024-06-14 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Alkaloids: Chemistry and Biology, Volume 91, the newest release in a series that has covered the topic for more than 60 years, discusses key aspects of alkaloid chemistry, biology and pharmacology. Sections in this release include chapters on Recent Progress in the Chemistry of Naphthylisoquinoline Alkaloids. Provides the latest information on the study of alkaloids Covers alkaloid chemistry, biology, pharmacology, and medical applications Contains more than 80 published volumes in this interesting field of study

The Alkaloids: Chemistry and Pharmacology

Author :
Publisher : Academic Press
ISBN 13 : 9780080865638
Total Pages : 363 pages
Book Rating : 4.8/5 (656 download)

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Book Synopsis The Alkaloids: Chemistry and Pharmacology by :

Download or read book The Alkaloids: Chemistry and Pharmacology written by and published by Academic Press. This book was released on 1991-01-10 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Alkaloids: Chemistry and Pharmacology

Ranunculales Medicinal Plants

Author : Da-Cheng Hao
Publisher : Academic Press
ISBN 13 : 0128142332
Total Pages : 404 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Ranunculales Medicinal Plants by : Da-Cheng Hao

Download or read book Ranunculales Medicinal Plants written by Da-Cheng Hao and published by Academic Press. This book was released on 2018-04-23 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ranunculales Medicinal Plants: Biodiversity, Chemodiversity and Pharmacotherapy comprehensively covers this order of flowering plants, detailing the phytochemistry, chemotaxonomy, molecular biology, and phylogeny of selected medicinal plants families and genera and their relevance to drug efficacy. The book carries out an exhaustive survey of the literature in order to characterize global trends in the application of flexible technologies. The interrelationship between Chinese species, and between Chinese and non-Chinese species, is inferred through molecular phylogeny and based on nuclear and chloroplast DNA sequencing. The book discusses the conflict between chemotaxonomy and molecular phylogeny in the context of drug discovery and development. Users will find invaluable and holistic coverage on the study of Ranunculales that will make this the go-to pharmaceutical resource. Describes current perceptions of biodiversity and chemodiversity of Ranunculales Explains how the conceptual framework of plant pharmacophylogeny benefits the sustainable exploitation of Ranunculales Details how Ranunculales medicinal plants work from the chemical level upward Covers how the polypharmacology of Ranunculales compounds might inspire new chemical entity design and development for improved treatment outcomes