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The Isolated Hepatocyte
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Book Synopsis The Isolated hepatocyte by : E.J. Rauckman
Download or read book The Isolated hepatocyte written by E.J. Rauckman and published by Elsevier. This book was released on 2012-12-02 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Isolated Hepatocyte: Use in Toxicology and Xenobiotic Biotransformations covers the link between research on the isolated hepatocyte and the disciplines of cell culture, toxicology, metabolism, and molecular biology. This book is composed of 11 chapters and begins with an overview of the regulation of liver growth, sulfation, glucuronidation of xenobiotics in specific liver sites. The next chapters deal with toxicology studies in cultured hepatocytes from various species and the in vitro control of hepatocyte proliferation. These topics are followed by discussions of choices and methods of cytotoxicity measures; hepatoxicity of metals; the metabolism and toxicity of xenobiotics in a primary culture; and the mechanism of carcinogen-induced pleiotropic drug resistance in hepatocytes. The concluding chapters describe the in vivo and in vitro measurement of chemically-induced DNA repair in hepatocytes, as well as the genotoxicity studies with human hepatocytes. This book is intended primarily to toxicologists and researchers.
Book Synopsis Isolated Hepatocytes: Preparation, Properties and Applications by : M.N. Berry
Download or read book Isolated Hepatocytes: Preparation, Properties and Applications written by M.N. Berry and published by Elsevier. This book was released on 1991-09-30 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book sets out clearly and effectively the preparation and working methods of laboratory techniques involving isolated hepatocytes and will make life easier for every laboratory worker concerned with these techniques.
Book Synopsis The Isolated Hepatocyte by : Marion E. Sauers
Download or read book The Isolated Hepatocyte written by Marion E. Sauers and published by . This book was released on 1981 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Hepatocyte Review by : M. N. Berry
Download or read book The Hepatocyte Review written by M. N. Berry and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is thirty years since the technique of high-yield preparation of isolated hepatocytes, by collagenase perfusion of the liver, was published. The original method described by Berry and Friend has undergone many minor modifications by other workers, and the two-step procedure introduced by Seglen in 1976 has become the most frequent way to prepare hepatocyte suspensions. An important development introduced by Bissell in 1973 was the use of the cells as the first step in monolayer culture. The availability of the isolated hepatocyte preparation as cells in suspension or culture has undoubtedly facilitated research on the liver. This was emphasised in our book, published (with Dr. Greg Barritt) in 1990, which described in detail methods of preparation and the properties of the isolated hepatocytes. It also discussed the usefulness of the preparation for the study of intermediary and xenobiotic metabolism, calcium ion transport, and the growth and differentiation of hepatocytes in culture. The book also touched briefly on a range of specialised techniques, including peri fusion, subcellular fractionation, transplantation, cryopreservation and measurement of intracellular pH. Although standard procedures for the manipulation of hepatocytes have not changed a great deal in ten years, they have undoubtedly been refined. This applies particularly to hepatocyte culture techniques, cryopreservation, and even to preparation of hepatocyte suspensions, where it is now feasible to use purified enzymes. There is also much more emphasis on the use and study of human hepatocytes, particularly in the field of pharmacology and therapeutics.
Book Synopsis Isolated and Cultured Hepatocytes by : André Guillouzo
Download or read book Isolated and Cultured Hepatocytes written by André Guillouzo and published by . This book was released on 1986 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Isolation, Characterization, and Use of Hepatocytes by : Robert Allison Harris
Download or read book Isolation, Characterization, and Use of Hepatocytes written by Robert Allison Harris and published by North-Holland. This book was released on 1983 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hepatotoxicology by : Robert G. Meeks
Download or read book Hepatotoxicology written by Robert G. Meeks and published by CRC Press. This book was released on 1991-07-24 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is destined to serve as a classic reference source to which researchers can turn for a historical perspective and basic information on the physiology, biochemistry, and pathology of the liver. Major areas covered in the book include histological organization, classification of chemical-induced injury, stages of cellular injury, and xenobiotic metabolism. Chapters discussing the use of biochemical methods to determine liver damage, the effects of various chemical agents of the liver, and hepatocarcinogenesis are also presented. Toxicologists, physiologists, physicians, biochemists, industrial hygienists, and others interested in the effects of chemical agents on the structure and function will find this book to be an indispensable source of information.
Book Synopsis Isolated and Cultured Hepatocytes by : Christiane Guguen-Guillouzo
Download or read book Isolated and Cultured Hepatocytes written by Christiane Guguen-Guillouzo and published by . This book was released on 1986 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug-Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Download or read book Tumor Organoids written by Shay Soker and published by Humana Press. This book was released on 2017-10-20 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.
Book Synopsis An Isolated Hepatocyte Model of Carbon Tetrachloride Hepatotoxicity by : Scot Davis Pencil
Download or read book An Isolated Hepatocyte Model of Carbon Tetrachloride Hepatotoxicity written by Scot Davis Pencil and published by . This book was released on 1984 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hepatocyte Transplantation by : S. Gupta
Download or read book Hepatocyte Transplantation written by S. Gupta and published by Springer Science & Business Media. This book was released on 2002-09-30 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there has been an increasing need for transplantation, but the number of donor livers available has increased only slightly, despite intensive public relations activities. New concepts in the field of transplantation, for instance the transplantation of living donor organs or the splitting of organs, are urgently required, to safeguard the treatment of patients with severe liver disease. The development and clinical application of cell therapy for patients with liver disease could soon present a significant enhancement of the therapeutic options. The aim of such cell therapy is to repair or improve the biological function of the chronically and acutely damaged liver. Even though systematic trials are not available, individual case reports and small series already show promising clinical results. Present concepts of cell therapy for liver diseases based on the use of primary hepatocytes have recently been considerably extended through new data on the biology of stem cells. The adult haematopoetic stem cell as a pool for hepatocyte grafts - what would be the perspectives for the clinical application? This book is the proceedings of the Falk Symposium No. 126 on `Hepatocyte Transplantation' (Progress in Gastroenterology and Hepatology Part III) held in Hannover, Germany, October 2-3, 2001, and is a forum for basic research, but also for questions concerning clinical applications in the field of hepatocyte transplantation.
Book Synopsis Isolated Hepatocytes by : Michael N. Berry
Download or read book Isolated Hepatocytes written by Michael N. Berry and published by . This book was released on with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Comparison of Freshly Isolated Human Hepatocytes with Human Hepatocytes-like Cells by : Jing Yuan
Download or read book Comparison of Freshly Isolated Human Hepatocytes with Human Hepatocytes-like Cells written by Jing Yuan and published by . This book was released on 2003 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hepatocyte and Kupffer Cell Interactions by : Timothy R. Billiar
Download or read book Hepatocyte and Kupffer Cell Interactions written by Timothy R. Billiar and published by CRC Press. This book was released on 1992-09-11 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatocyte and Kupffer Cell Interactions presents a comprehensive discussion of historical and recent information regarding this diverse field of research. The role of Kupffer cells and hepatoctyes in normal physiology, nonseptic pathological states, and in sepsis is examined. Microanatomy and methods of experimental study are covered as well. In each of the book's chapters, the role of the Kupffer cell and hepatocyte interaction is placed in context with information on particular liver functions or disease states. Hepatocyte and Kupffer Cell Interactions is an essential reference for leukocyte specialists, gastroenterologists, immunologists, and other researchers working in this fascinating field.
Book Synopsis Isolation and Characterization of Ruminant Hepatocytes by : Mary Ellen Camille Looney
Download or read book Isolation and Characterization of Ruminant Hepatocytes written by Mary Ellen Camille Looney and published by . This book was released on 1981 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Isolated Hepatocytes by : Michael N. Berry
Download or read book Isolated Hepatocytes written by Michael N. Berry and published by . This book was released on 2000 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt:
