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The Inflammatory Process
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Book Synopsis Inflammation and the Microcirculation by : D. Neil Granger
Download or read book Inflammation and the Microcirculation written by D. Neil Granger and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Book Synopsis The Inflammatory Process by : Benjamin W. Zweifach
Download or read book The Inflammatory Process written by Benjamin W. Zweifach and published by Academic Press. This book was released on 2014-05-12 with total page 950 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Inflammatory Process focuses on the approaches, methodologies, and technologies involved in the study of the inflammatory process, including capillary structure, tissue injury, and inflammatory response. The selection first offers information on the experimental approach to inflammation, ultrastructural and biochemical consequences of cell injury, and ultrastructural basis of capillary permeability. Discussions focus on permeability of capillaries, cytoplasm, nucleus, gross pathology of inflammation, light microscope and the study of inflammation, and the physiologic approach to problems of inflammation. The text then elaborates on the microvascular aspects of tissue injury and the sticking and emigration of white blood cells in inflammation. The book examines neutrophil and eosinophil leucocytes, "life history" and functions of lymphocytes, and metabolism and physiology of mononuclear phagocytes. Topics include inflammatory response, biochemistry and metabolism, special relationships to bacteria and viruses, and origins and early development of lymphocytes. The text also ponders on the role of lysosomes in tissue injury, hemostatic mechanisms in tissue injury, and anti-inflammatory agents. The selection is a vital source of data for researchers interested in the inflammatory process.
Book Synopsis Fundamentals of Inflammation by : Charles N. Serhan
Download or read book Fundamentals of Inflammation written by Charles N. Serhan and published by Cambridge University Press. This book was released on 2010-04-26 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.
Book Synopsis The Resolution of Inflammation by : Adriano Rossi
Download or read book The Resolution of Inflammation written by Adriano Rossi and published by Springer Science & Business Media. This book was released on 2008-03-17 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.
Book Synopsis Janeway's Immunobiology by : Kenneth Murphy
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Book Synopsis Inflammation, 4 Volume Set by : Jean-Marc Cavaillon
Download or read book Inflammation, 4 Volume Set written by Jean-Marc Cavaillon and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 1818 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieses Fachbuch erläutert die molekularen Grundlagen von Entzündungen, spannt den Bogen zu Infektionskrankheiten und den Zusammenhang zwischen Entzündungen und chronischen Erkrankungen, behandelt abschließend den Heilungsprozess und zeigt Therapiemöglichkeiten.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cooperation of Liver Cells in Health and Disease by : Z. Kmiec
Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.
Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Book Synopsis The Inflammatory Process by : Benjamin W. Zweifach
Download or read book The Inflammatory Process written by Benjamin W. Zweifach and published by Academic Press. This book was released on 2014-05-15 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Inflammatory Process, Second Edition is an account of the inflammatory process and covers topics ranging from microvascular aspects of tissue injury and capillary permeability to rheologic factors in inflammation. The effects of inflammation on the lymphatic system are also explored, along with the sticking and emigration of white blood cells in inflammation. Comprised of 11 chapters, this volume begins with an overview of vascular events in the inflammatory process, paying particular attention to the microvascular aspects of tissue injury and structural and physiological considerations in capillary permeability. The rheology of inflammation and the effects of inflammation on the lymphatic system are also examined. Subsequent chapters focus on the natural role of amines, polypeptides, and proteases in the inflammatory process; mediation of increased vascular permeability in inflammation; and hemostatic mechanisms in tissue injury. The book concludes with an analysis of thrombosis as an initiator of inflammation and as a complication of inflammation, and how it can be prevented. This monograph will be of interest to practitioners in fields ranging from biochemistry to pathology, bacteriology, physiology, and immunology.
Book Synopsis Concepts in Viral Pathogenesis by : A. L. Notkins
Download or read book Concepts in Viral Pathogenesis written by A. L. Notkins and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current proliferation of scientific information makes it difficult for even the most diligent reader to keep up with the latest developments in his/her own field, let alone other areas of interest. Review articles are one solution, but they too have become so voluminous and detailed that they often defeat the purpose for which they were intended. We have attempted to ease this problem by using a different format. In this volume on Concepts in Viral Pathogenesis, we have assembled a series of mini-reviews/editorials, 1,000 to 2,000 words in length. Each is a pithy distil lation of the state-of-the-art with emphasis on current thinking and unifying concepts rather than a compendium of the literature. The 53 articles, all written by active workers in their respective fields, are organized systemati cally so that the book will provide busy investigators, teachers and students of up-to-date information in a very brief and easily read a conceptual core able form. In addition, the authors have attempted to identify unresolved problems and point to future directions.
Book Synopsis Inflammation and Cancer by : Bharat B. Aggarwal
Download or read book Inflammation and Cancer written by Bharat B. Aggarwal and published by Springer. This book was released on 2014-05-12 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Book Synopsis Pathology: The Big Picture by : William Kemp
Download or read book Pathology: The Big Picture written by William Kemp and published by McGraw Hill Professional. This book was released on 2007-08-22 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get the BIG PICTURE of Pathology - and focus on what you really need to know to score high on the course and board exam If you want a streamlined and definitive look at Pathology - one with just the right balance of information to give you the edge at exam time - turn to Pathology: The Big Picture. You'll find a succinct, user-friendly presentation especially designed to make even the most complex concept understandable in the shortest amount of study time possible. This perfect pictorial and textual overview of Pathology delivers: A “Big Picture” emphasis on what you must know verses “what's nice to know” Expert authorship by award-winning, active instructors Coverage of the full range of pathology topics - everything from cellular adaptations and injury to genetic disorders to inflammation to diseases of immunity Magnificent 4-color illustrations Numerous summary tables and figures for quick reference and rapid retention of even the most difficult topic Highlighted key concepts that underscore integral aspects of histology (key concepts are also listed in a table at the end of each chapter) USMLE-type questions, answers, and explanations to help you anticipate what you'll encounter on the exams And much more!
Book Synopsis Hot Topics in Burn Injuries by : Selda Pelin Kartal
Download or read book Hot Topics in Burn Injuries written by Selda Pelin Kartal and published by BoD – Books on Demand. This book was released on 2018-05-23 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to give readers a broad review of burn injuries, which may affect people from birth to death and can lead to high morbidity and mortality. The book consists of four sections and seven chapters. The first section consists of the introductory review chapter, which overviews the burn injuries. The second section includes chapter "Burn Etiology and Pathogenesis," which focuses on burn injuries and clinical findings. The third section consists of chapter "Controlling Inflammation in Burn Injury" and is devoted to the role of inflammatory response, which is fundamental to the healing process, while a prolonged inflammation may lead to scarring and fibrosis. The fourth section consists of four chapters as follows: "Therapeutic Effects of Conservative Treatments on Burn Scars," "Herbal Therapy for Burns and Burn Scars," "Platelet-Rich Plasma in Burn Treatment," and "Surgical Treatment of Burn Scars." The book is easy to read and includes hot topics on burn injury to enhance the reader's understanding and knowledge.
Book Synopsis Immunomodulatory Biomaterials by : Stephen F. Badylak
Download or read book Immunomodulatory Biomaterials written by Stephen F. Badylak and published by Woodhead Publishing. This book was released on 2021-07-30 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area
Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash
Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Book Synopsis Parkinson's Disease and Related Disorders by : Peter Riederer
Download or read book Parkinson's Disease and Related Disorders written by Peter Riederer and published by Springer Science & Business Media. This book was released on 2006-11-23 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives a comprehensive overview on current clinical and basic research issues related to Parkinson’s disease and its related disorders. The book is the result of the 16th International Congress of Parkinson’s Disease and Related disorders congress 2005. Its contents are suitable for neurologists, psychiatrists, neurosurgeons, basic researchers, geneticians and patients as well as their relatives.
