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The Hsp60 Chaperonin
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Book Synopsis The Hsp60 Chaperonin by : Peter Bross
Download or read book The Hsp60 Chaperonin written by Peter Bross and published by Springer. This book was released on 2015-12-08 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this unique overview of the Hsp60 chaperonin, Peter Bross addresses molecular biologists, medical research scientists and individuals interested in molecular or general biology. First, Bross discusses the basics of the Hsp60 chaperonin in terms of its structure and the molecular mechanisms determining its function. Second, the author highlights the multiple roles of Hsp60 for cellular systems and regulatory pathways, especially in connection with neurodegenerative diseases caused by Hsp60 deficiency. Finally, the author highlights controversial observations suggesting additional, non-standard functions of Hsp60 in and outside mitochondria as well as possible gaps in our understanding of the chaperonin. This volume serves as a snapshot suitable for experienced researcher working in fields related to molecular chaperones yet still accessible to researchers entering the field.
Book Synopsis HSP60 Family of Chaperonins by : Kevin Patrick O'Reilly
Download or read book HSP60 Family of Chaperonins written by Kevin Patrick O'Reilly and published by . This book was released on 1997 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chaperonin Protocols by : Christine Schneider
Download or read book Chaperonin Protocols written by Christine Schneider and published by Humana Press. This book was released on 2000-01-19 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Christine Schneider has assembled a unique collection of readily reproducible protocols for the study of chaperonins, intracellular proteins critical to many biological processes. Written by experienced investigators who have successfully honed their methods to a fineness, the protocols focus on the purification of chaperonins from different species along with their corresponding cofactors, and on chaperonin activity assays for in vivo as well as in vitro work. Many activity assays are given for GroEL, which can also be applied to mitochondrial Hsp60. There are also assays for the eukaryotic chaperonin TRiC and handy methods-for example, one for preparing labeled probes-that can be used for various purposes and prove helpful in numerous different procedures. Informative and highly practical, Chaperonin Protocols offers both novice and experienced investigators fast access to today's best and most productive chaperonin methods, all explained in step-by-step detail to ensure robust and reproducible results.
Book Synopsis The Molecular Basis of Hyperthermophily by : National Aeronautics and Space Adm Nasa
Download or read book The Molecular Basis of Hyperthermophily written by National Aeronautics and Space Adm Nasa and published by . This book was released on 2018-09-27 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this study, we aim to understand how S. shibatae copes with high temperatures. In particular, we investigated the role of the 60 kDa heat shock protein (HSP60 or chaperonin) with the hypothesis that chaperonin stabilizes the cell membrane under stressful conditions. To prove the hypothesis, this year two questions were addressed: (1) Is the chaperonin localized in the cytoplasm or on the cell membrane? (2) Does the chaperonin show affinity to lipid in vivo? In addition to those, we intensively studied newly discovered chaperonin-related protein, gamma, to understand how it influenced the function of the other components of chaperonin and how their combined activities contributed to hyperthermophily. Kagawa, Hiromi Ames Research Center ...
Book Synopsis Heat Shock Protein 60 in Human Diseases and Disorders by : Alexzander A. A. Asea
Download or read book Heat Shock Protein 60 in Human Diseases and Disorders written by Alexzander A. A. Asea and published by Springer. This book was released on 2020-11-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Book Synopsis The Chaperonopathies by : Alberto J.L. Macario
Download or read book The Chaperonopathies written by Alberto J.L. Macario and published by Springer Science & Business Media. This book was released on 2013-04-10 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments.
Book Synopsis The Chaperonins by : Robert L. Ellis
Download or read book The Chaperonins written by Robert L. Ellis and published by Elsevier. This book was released on 1996-04-01 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this volume presents the latest research findings on the chaperonins, the best studied family of a class of proteins known as molecular chaperones. These findings are changing our view of some fundamental cellular processes involving proteins, especially how proteins fold into their functional conformations. Origins of the new view of protein folding Prokaryotic chaperonins Eukaryotic chaperonins Evolution of the chaperonins Refolding of denatured proteins Organelle biosynthesis Biomedical aspects
Book Synopsis The mitochondrial chaperonin complex Hsp60 by :
Download or read book The mitochondrial chaperonin complex Hsp60 written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Multitasking Molecular Chaperone HSP60 by : Francesco Cappello
Download or read book The Multitasking Molecular Chaperone HSP60 written by Francesco Cappello and published by Elsevier. This book was released on 2024-11-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Multitasking Molecular Chaperone HSP60: Structure, Function, and Impact on Health and Disease provides a complete overview of HSP60. It analyzes the molecular structure, localization and functions of HSP60 in normal and pathological cells and tissues in humans. The book then moves on to discuss the role of abnormal HSP60 in disease, considering it across a wide range of skin disorders, heart and blood vessel diseases, respiratory diseases and digestive disorders among others. Genetic chaperonopathies are also covered, and the book moves on to discussion of Hsp60-based therapeutic strategies that can be implemented in the treatment of some diseases. This book is an invaluable reference for researchers and students in molecular biology, biochemistry, biophysics, biomedicine, pharmacology and related life sciences. Discusses therapeutic strategies for diagnosis, patient monitoring, and treatment of disorders in which HSP60 plays a role Considers the fundamental biophysics, genetics, and comparative phylogeny of HSP60 Explores the mechanisms involving HSP60 abnormalities that lead to disease, including carcinogenesis, inflammation, autoimmunity, and neurodegenerative disorders
Book Synopsis The Mitochondrial Chaperonin Complex Hsp60/Hsp10 by : Anne Sigaard Bie
Download or read book The Mitochondrial Chaperonin Complex Hsp60/Hsp10 written by Anne Sigaard Bie and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chaperone, Mediated Protein Folding in Mitochondria by : Neela Heyrovska
Download or read book Chaperone, Mediated Protein Folding in Mitochondria written by Neela Heyrovska and published by . This book was released on 1997 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Identification of a Chaperonin Protein (hsp60) Associated with Alanine Resistance and Increased A System Transport Activity and the Solubilization and Reconstitution of A System Amino Acid Transport in Chinese Hamster Ovary Cells by : Michael Kennis Jones
Download or read book Identification of a Chaperonin Protein (hsp60) Associated with Alanine Resistance and Increased A System Transport Activity and the Solubilization and Reconstitution of A System Amino Acid Transport in Chinese Hamster Ovary Cells written by Michael Kennis Jones and published by . This book was released on 1992 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Mitochondrial Chaperonin Complex Hsp60 by : Anne Sigaard Bie
Download or read book The Mitochondrial Chaperonin Complex Hsp60 written by Anne Sigaard Bie and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Prokaryotic Chaperonins by : C. M. Santosh Kumar
Download or read book Prokaryotic Chaperonins written by C. M. Santosh Kumar and published by Springer. This book was released on 2017-08-30 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on a topical and timely aspect of prokaryotic biology - the biology of prokaryotic multiple chaperonins. Chaperonins are a class of molecular chaperones, the proteins that assist folding of other proteins in the cell. The book begins with an introductory chapter on the structural and functional aspects of chaperonins, followed by an outline on different mechanisms of their regulation. Subsequently, the book provides a comprehensive overview on how the multiple-chaperonins have embraced biological requirements in different classes of microbes, discussing their functional diversity, evolutionary paths and the latest advances in the field. It brings together leading experts from across the globe in offering a detailed account of the structural, biochemical, functional and phylogenetic characteristics of microbial chaperonins for students, researchers and teachers working in the area of microbiology/ biophysics/ parasitology – more specifically, in protein folding pathways.
Author :David S. (David Stuart) Allan Publisher :National Library of Canada = Bibliothèque nationale du Canada ISBN 13 :9780612754331 Total Pages :346 pages Book Rating :4.7/5 (543 download)
Book Synopsis Secretion of Hsp60 Chaperonin (GroEL) Homologs by Legionella Pneumophila [microform] by : David S. (David Stuart) Allan
Download or read book Secretion of Hsp60 Chaperonin (GroEL) Homologs by Legionella Pneumophila [microform] written by David S. (David Stuart) Allan and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 2002 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Investigating Chalcones and Their Ability to Inhibit the Human HSP60/10 Chaperonin System and Colorectal Cancer Cells by : Siddhi Arun Chitre
Download or read book Investigating Chalcones and Their Ability to Inhibit the Human HSP60/10 Chaperonin System and Colorectal Cancer Cells written by Siddhi Arun Chitre and published by . This book was released on 2019 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Folding in the Cell written by and published by Elsevier. This book was released on 2002-02-20 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Advances in Protein Chemistry provides a broad, yet deep look at the cellular components that assist protein folding in the cell. This area of research is relatively new--10 years ago these components were barely recognized, so this book is a particularly timely compilation of current information. Topics covered include a review of the structure and mechanism of the major chaperone components, prion formation in yeast, and the use of microarrays in studying stress response. Outlines preceding each chapter allow the reader to quickly access the subjects of greatest interest. The information presented in this book should appeal to biochemists, cell biologists, and structural biologists.
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