Hepatitis C Virus: From Molecular Virology to Antiviral Therapy

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Publisher : Springer Science & Business Media
ISBN 13 : 3642273408
Total Pages : 353 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Hepatitis C Virus: From Molecular Virology to Antiviral Therapy by : Ralf Bartenschlager

Download or read book Hepatitis C Virus: From Molecular Virology to Antiviral Therapy written by Ralf Bartenschlager and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.

Eliminating the Public Health Problem of Hepatitis B and C in the United States

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Author :
Publisher : National Academies Press
ISBN 13 : 0309438020
Total Pages : 187 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Eliminating the Public Health Problem of Hepatitis B and C in the United States by : National Academies of Sciences, Engineering, and Medicine

Download or read book Eliminating the Public Health Problem of Hepatitis B and C in the United States written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-06-01 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world's hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 viral hepatitis, of which hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common types, surpassed HIV and AIDS to become the seventh leading cause of death worldwide. The world now has the tools to prevent hepatitis B and cure hepatitis C. Perfect vaccination could eradicate HBV, but it would take two generations at least. In the meantime, there is no cure for the millions of people already infected. Conversely, there is no vaccine for HCV, but new direct-acting antivirals can cure 95 percent of chronic infections, though these drugs are unlikely to reach all chronically-infected people anytime soon. This report, the first of two, examines the feasibility of hepatitis B and C elimination in the United States and identifies critical success factors. The phase two report will outline a strategy for meeting the elimination goals discussed in this report.

Hepatitis C Virus I

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Publisher : Springer
ISBN 13 : 9784431560968
Total Pages : 0 pages
Book Rating : 4.5/5 (69 download)

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Book Synopsis Hepatitis C Virus I by : Tatsuo Miyamura

Download or read book Hepatitis C Virus I written by Tatsuo Miyamura and published by Springer. This book was released on 2016-11-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is composed of chapters that review important fundamental aspects of HCV biology and disease pathogenesis including, for example, the discovery and identification of the HCV genome, early virus-cell interactions including identification of various cellular receptors, HCV gene expression studied using the HCV replicon system, identification and characterization of HCV structural- and non-structural HCV proteins, HCV replication in cultured cells, and host factors involved in viral replication. This volume also contains chapters dealing with immunity to HCV infection and pathogenesis. This is particularly important in understanding hepatitis C because HCV infection alone is not cell lytic. Mechanisms underlying the persistent nature of HCV infection are also discussed in these chapters. Many of the authors published articles that were listed among the “top 10 papers” published in the 24 years since HCV was discovered in 1989. Their citations are above 1,000 (Web of Science). The authors describe the background and significance of their contributions to the field in the context of findings from other research groups.

Saliva Protection and Transmissible Diseases

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Publisher : Academic Press
ISBN 13 : 0128136820
Total Pages : 122 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Saliva Protection and Transmissible Diseases by : Crispian Scully

Download or read book Saliva Protection and Transmissible Diseases written by Crispian Scully and published by Academic Press. This book was released on 2017-07-19 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Saliva Protection and Transmissible Diseases provides a review of saliva protection, raising debate on micro-organisms potentially transmissible in saliva, and also considering the evidence on diseases that may be transmitted by kissing. Saliva is a complex body fluid essential to health, especially mastication, swallowing and speech, and hyposalivation can lead to dysfunction and even infection. More serious pathogens, such as herpes viruses and papillomaviruses can be conveyed by kissing, as can potentially lethal micro-organisms present in some saliva, such as meningococci, fungal organisms and Ebola viruses. Stipulates the defensive roles of saliva, an important topic not previously reviewed in-depth in literature Provides awareness that saliva also transmits infectious agents that can produce serious or even lethal diseases Gives understanding that kissing may be an at-risk practice

Hepatitis and Liver Cancer

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Publisher : National Academies Press
ISBN 13 : 0309146283
Total Pages : 252 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Hepatitis and Liver Cancer by : Institute of Medicine

Download or read book Hepatitis and Liver Cancer written by Institute of Medicine and published by National Academies Press. This book was released on 2010-05-23 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: The global epidemic of hepatitis B and C is a serious public health problem. Hepatitis B and C are the major causes of chronic liver disease and liver cancer in the world. In the next 10 years, 150,000 people in the United States will die from liver disease or liver cancer associated with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infections. Today, between 800,000 and 1.4 million people in the United States have chronic hepatitis B and between 2.7 and 3.9 million have chronic hepatitis C. People most at risk for hepatitis B and C often are the least likely to have access to medical services. Reducing the rates of illness and death associated with these diseases will require greater awareness and knowledge among health care workers, improved identification of at-risk people, and improved access to medical care. Hepatitis B is a vaccine-preventable disease. Although federal public health officials recommend that all newborns, children, and at-risk adults receive the vaccine, about 46,000 new acute cases of the HBV infection emerge each year, including 1,000 in infants who acquire the infection during birth from their HBV-positive mothers. Unfortunately, there is no vaccine for hepatitis C, which is transmitted by direct exposure to infectious blood. Hepatitis and Liver Cancer identifies missed opportunities related to the prevention and control of HBV and HCV infections. The book presents ways to reduce the numbers of new HBV and HCV infections and the morbidity and mortality related to chronic viral hepatitis. It identifies priorities for research, policy, and action geared toward federal, state, and local public health officials, stakeholder, and advocacy groups and professional organizations.

Update on Hepatitis C

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 9535135635
Total Pages : 240 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Update on Hepatitis C by : Martina Smolic

Download or read book Update on Hepatitis C written by Martina Smolic and published by BoD – Books on Demand. This book was released on 2017-10-04 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few years, remarkable progress has been made in our understanding of HCV biology, pathogenesis of infection, and structure-function relationships. This has led to quantum advances in clinical efficacy and tolerability. Yet, in spite of this amazing progress, there remain obstacles to widespread successful treatment. These issues include biological failures even with direct-acting agents, lack of options for individual with organ failures, drug-drug interactions, access to medications either due to lack of availability or affordability, and psychiatric and social issues. These problems are likely to remain in the future. Therefore, this book has been created by distinguished faculties from around the world to address the progress in our understanding of HCV infection and to review new treatment options, limitations, and accessibility of new therapeutic options.

Chronic Hepatitis C Virus

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Publisher : Springer Science & Business Media
ISBN 13 : 9781461411925
Total Pages : 332 pages
Book Rating : 4.4/5 (119 download)

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Book Synopsis Chronic Hepatitis C Virus by : Mitchell L. Shiffman

Download or read book Chronic Hepatitis C Virus written by Mitchell L. Shiffman and published by Springer Science & Business Media. This book was released on 2011-11-17 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.

Essential Concepts in Molecular Pathology

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Publisher : Academic Press
ISBN 13 : 0128132582
Total Pages : 634 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Essential Concepts in Molecular Pathology by : William B. Coleman

Download or read book Essential Concepts in Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2019-11-23 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today’s advances in pathology and medicine. Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology

Hepatitis C in Renal Disease, Hemodialysis, and Transplantation

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Author :
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805598203
Total Pages : 143 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Hepatitis C in Renal Disease, Hemodialysis, and Transplantation by : J. M. Morales

Download or read book Hepatitis C in Renal Disease, Hemodialysis, and Transplantation written by J. M. Morales and published by Karger Medical and Scientific Publishers. This book was released on 2012-01-01 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely update on HCV infection and the kidney Hepatitis C virus (HCV) infection is a major health problem worldwide, with currently over 150 million HCV-infected people on the five continents. Although there have been important advances in the diagnosis, prevention and therapy, the infection remains an important health problem in most countries. HCV infection is considered a systemic disease: Not only does it affect the liver, it can induce autoimmune, dermatological and renal disease. Moreover, soon after the discovery of HCV as the major cause of non-A non-B hepatitis, HCV infection was recognized as an important cause and consequence of chronic kidney disease. The publication at hand is an update on the most important topics concerning HCV infection, renal disease and problems with dialysis in the general population as well as in renal transplant patients. Also included is a chapter on the emerging problem of renal complications associated with HCV virus in patients with HIV infection. Containing contributions from a panel of internationally acclaimed experts, this publication is a timely update on HCV infection and the kidney.

Viral Hepatitis: Chronic Hepatitis C

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Publisher : Springer
ISBN 13 : 9783030037567
Total Pages : 0 pages
Book Rating : 4.0/5 (375 download)

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Book Synopsis Viral Hepatitis: Chronic Hepatitis C by : Resat Ozaras

Download or read book Viral Hepatitis: Chronic Hepatitis C written by Resat Ozaras and published by Springer. This book was released on 2019-07-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents up-to-date, practically oriented information on major topics in chronic hepatitis C. The coverage encompasses epidemiology; diagnosis, including molecular methods; treatment and challenges; and the management of co-infections. Readers will find guidance on pretherapeutic evaluation with respect to disease severity and extrahepatic manifestations. Resistance to antiviral treatment and its management are discussed, and the nature of optimal follow-up is addressed in detail. Treatment of HCV/HIV co-infection is considered separately, and the approach in special patient populations is thoroughly examined. Chronic Hepatitis C will be of high value for general practitioners and specialists in gastroenterology, infectious diseases, and internal medicine. It will be international in scope in terms of both authorship and appeal.

Models of Viral Hepatitis

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805578091
Total Pages : 173 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Models of Viral Hepatitis by : Fritz von Weizsäcker

Download or read book Models of Viral Hepatitis written by Fritz von Weizsäcker and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral hepatitis B or C is the most common cause of chronic liver disease worldwide and accounts for about 80% of all hepatocellular carcinoma cases. Thus, combating viral hepatitis remains one of the most pressing public health issues today. Animal models and cell-based systems are essential tools for addressing the many still unresolved basic and clinical problems. Experimental models are needed to better understand the viral life cycles, pathogenetic aspects and natural defense mechanisms, while preclinical models are required for evaluating novel preemptive and therapeutic strategies. This.

A National Strategy for the Elimination of Hepatitis B and C

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Author :
Publisher : National Academies Press
ISBN 13 : 0309457327
Total Pages : 297 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis A National Strategy for the Elimination of Hepatitis B and C by : National Academies of Sciences, Engineering, and Medicine

Download or read book A National Strategy for the Elimination of Hepatitis B and C written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-06-30 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world's hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 viral hepatitis, of which hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common types, surpassed HIV and AIDS to become the seventh leading cause of death worldwide. The world now has the tools to prevent hepatitis B and cure hepatitis C. Perfect vaccination could eradicate HBV, but it would take two generations at least. In the meantime, there is no cure for the millions of people already infected. Conversely, there is no vaccine for HCV, but new direct-acting antivirals can cure 95 percent of chronic infections, though these drugs are unlikely to reach all chronically-infected people anytime soon. This report, the second of two, builds off the conclusions of the first report and outlines a strategy for hepatitis reduction over time and specific actions to achieve them.

Diagnostic Molecular Pathology

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Publisher : Academic Press
ISBN 13 : 0128229934
Total Pages : 846 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Diagnostic Molecular Pathology by : William B. Coleman

Download or read book Diagnostic Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2023-10-27 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease. Includes new material on mass spectrometry for infectious diseases, microbiome, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more Provides insights on the value of the molecular test in comparison to traditional methods, which include speed, precision, sensitivity and clinical impacts for the patient Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for the prognostication of disease

Advances in Treatment of Hepatitis C and B

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Publisher : BoD – Books on Demand
ISBN 13 : 9535129937
Total Pages : 408 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Advances in Treatment of Hepatitis C and B by : Naglaa Allam

Download or read book Advances in Treatment of Hepatitis C and B written by Naglaa Allam and published by BoD – Books on Demand. This book was released on 2017-03-08 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: As in many areas of medicine, treatment of viral hepatitis has seen an acceleration of change driven by new therapies and evolving technology. Thanks to the direct-acting antiviral agents (DAAs), the era of HCV eradication and cure has begun. As regards to hepatitis B therapy, potent antiviral drugs for suppression of viral replication are available, new research activities to enhance eradication are visible, and these may influence clinical practice in the coming years. This book covers the latest advances in hepatitis C and hepatitis B therapeutics as well as the emerging and investigational treatment strategies. "Advances in Treatment of Hepatitis C and Hepatitis B" book is an up-to-date source of information for physicians, residents, and advanced medical students seeking a broader understanding of treatment of viral hepatitis. The authors of the chapters come from many eminent centers around the world and are experts in their respective fields.

Viral Hepatitis

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Publisher :
ISBN 13 :
Total Pages : 612 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Viral Hepatitis by : Arie J. Zuckerman

Download or read book Viral Hepatitis written by Arie J. Zuckerman and published by . This book was released on 1993 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses all aspects of viral hepatitis, from structure and molecular virology, and natural history and experimental models, to epidemiology, diagnosis and prevention. A section on clinical aspects covers transfusion-associated hepatitis, occupational aspects and paediatric infection.

Guidelines on Hepatitis B and C Testing

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Author :
Publisher : World Health Organization
ISBN 13 : 9789241549981
Total Pages : 0 pages
Book Rating : 4.5/5 (499 download)

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Book Synopsis Guidelines on Hepatitis B and C Testing by : World Health Organization

Download or read book Guidelines on Hepatitis B and C Testing written by World Health Organization and published by World Health Organization. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Testing and diagnosis of hepatitis B (HBV) and C (HCV) infection is the gateway for access to both prevention and treatment services, and is a crucial component of an effective response to the hepatitis epidemic. Early identification of persons with chronic HBV or HCV infection enables them to receive the necessary care and treatment to prevent or delay progression of liver disease. Testing also provides an opportunity to link people to interventions to reduce transmission, through counselling on risk behaviors and provision of prevention commodities (such as sterile needles and syringes) and hepatitis B vaccination. These are the first WHO guidelines on testing for chronic HBV and HCV infection and complement published guidance by WHO on the prevention, care and treatment of chronic hepatitis C and hepatitis B infection. These guidelines outline the public health approach to strengthening and expanding current testing practices for HBV and HCV, and are intended for use across age groups and populations.

Health Information for International Travel 2005-2006

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (729 download)

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Book Synopsis Health Information for International Travel 2005-2006 by : Paul Arguin

Download or read book Health Information for International Travel 2005-2006 written by Paul Arguin and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: