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Hepatitis C Virus From Molecular Virology To Antiviral Therapy
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Book Synopsis Hepatitis C Virus: From Molecular Virology to Antiviral Therapy by : Ralf Bartenschlager
Download or read book Hepatitis C Virus: From Molecular Virology to Antiviral Therapy written by Ralf Bartenschlager and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.
Book Synopsis HCV: The Journey from Discovery to a Cure by : Michael J. Sofia
Download or read book HCV: The Journey from Discovery to a Cure written by Michael J. Sofia and published by Springer Nature. This book was released on 2019-11-23 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis C is a liver disease caused by the hepatitis C virus (HCV) and infects approximately 75 million individuals worldwide. It is also one of the major causes of liver cancer and liver transplants. The elucidation of the HCV genome, and the development of a whole cell system to study the virus spurred the search for novel direct acting antiviral drugs to cure this disease. This global effort culminated in the development of direct acting antiviral drugs that led to cure rates approaching 100% in all patient populations after only 8-12 weeks of therapy. These efforts resulted in one of the greatest achievements in public health and provides the potential for eliminating HCV as a major disease worldwide. This volume is aimed at a broad audience of academic and industrial scientists interested in the discovery and development of drugs to treat viral diseases and those interested in reading about one of the most unique accomplishments in biomedical research. The volume will provide a one of a kind reference work that highlights the many efforts, from the discovery of the HCV virus, to the invention of breakthrough medicines and their use in the real world to cure patients. It is the companion book to the volume "HCV: The Journey from Discovery to a Cure - Volume II".
Book Synopsis Hepatitis Prevention and Treatment by : Joseph M. Colacino
Download or read book Hepatitis Prevention and Treatment written by Joseph M. Colacino and published by Birkhäuser. This book was released on 2012-12-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic viral hepatitis has emerged as one of the most common causes of disease and death worldwide. Because of their unique modes of replication and intimate association with the host immune system, hepatitis B virus (HBV) and hepatitis C virus (HCV) pose challenging problems to scientists in basic and applied research as well as to clinicians engaged in disease management. Although approved antiviral therapy is available for chronic HBV, the emergence of viral resistance provides a rationale for the development of novel chemotherapeutic agents. The lack of a robust cell culture system for HCV replication and a readily accessible small-animal model of HCV infection have hampered the development of antiviral agents for HCV. Neverthe-less, new antiviral agents targeting HCV are now in preclinical and clinical development. This monograph, providing an up-to-date overview of the field of Hepatitis Prevention and Treatment, includes contributions from internationally recognized experts in the field of viral hepatitis, and covers the current state of knowledge and practice regarding the molecular biology, immunology, biochemistry, pharmacology and clinical aspects of chronic HBV and HCV infection. The volume includes salient topics such as: the history and epidemiology of HBV and HCV; recent insights into the molecular mechanisms of viral replication; the host immune response to infection and a discussion of the use (HBV) or potential development (HCV) of vaccines; the current standard of care for chronically-infected patients; and emerging therapies and issues associated with current antiviral treatments. The latest information to researchers and clinicians actively engaged in viral hepatitis research is provided, but also sufficient background and discussion of the literature to benefit the newcomer to the field.
Download or read book Hepatitis C written by Seng-Lai Tan and published by Caister Academic Press Limited. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hepatitis C virus (HCV) is a significant public health problem of international importance. HCV is capable of establishing chronic infections resulting in progressive liver damage and other problems. Current drug therapies are ineffective, highlighting the need for better antiviral drugs. Recent research in HCV genetics and molecular biology have led to significant advances in our understanding of the life cycle of this important pathogen and may ultimately lead to better antiviral strategies. The editors of this book have recruited experts from around the world to produce a timely and well-compiled review of current HCV research, with an emphasis on antiviral drug development. The chapters provide in-depth reviews of the most critical areas of research. Topics include: the HCV life cycle * HCV assays * HCV resources * HCV databases * HCV infection systems * models of hepatitis C infections * overview of the drug pipeline * clinical trial design * clinical virology and drug development * NS3 protease inhibitors * NS3-NS4A complex inhibitors * NS3 helicase inhibitors * NS4B targets and inhibitors * NS5A inhibitors * nucleoside inhibitors * NS5B polymerase inhibitors * glycoprotein-dependent entry * host cell targets and inhibitors * innate immunity for HCV antiviral therapy.
Download or read book Molecular Virology written by Moses Adoga and published by BoD – Books on Demand. This book was released on 2012-03-21 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers various aspects of Molecular Virology. The first chapter discusses HIV-1 reservoirs and latency and how these twin phenomena have remained a challenge to eradication. Aspects regarding the molecular evolution of hepatitis viruses including their genetic diversities with implications for vaccine development are treated in the second chapter. Metabolic disorders that are a consequence of hepatitis C virus infection are discussed in the succeeding chapter. The following two chapters discuss influenza C virus and the applications of viral vectors in therapeutic research. Avian influenza is handled in the sixth chapter and the therapeutic potential of belladonna-200 against japanese encephalitis virus infection is discussed in the succeeding chapter. The last two chapters discuss baculoviruses and their interaction with polydnaviruses. Researchers, lecturers and students will find this book an indispensable companion.
Download or read book Hepatitis C written by Imran Shahid and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The propagation of hepatitis C from acute to chronic infection and afterward to end-stage liver diseases (hepatic fibrosis, cirrhosis, and hepatocellular carcinoma) involves a highly orchestrated series of molecular and cellular events, including a plethora of genes and cell signaling cascades. The treatment paradigms was revolutionized after the development and approval of all oral interferon-free direct-acting antivirals achieving higher sustained virologic response rates in treated individuals. This book pragmatically overviews the intricate interplay between viral and host factors during hepatitis C virus infection progression, as well as other hepatitis C-associated clinical implications. Hepatitis C - From Infection to Cure also provides up-to-date information about hepatitis C cures for clinicians, physicians, and healthcare providers with an ample understanding of the current treatment horizon, as well as other investigational and emerging treatment strategies. The authors with their valuable scientific contributions belong to many eminent institutes around the world and are much experienced in hepatitis C virology, pathology, and therapeutics.
Book Synopsis Hepatitis B Virus Infection by : Hong Tang
Download or read book Hepatitis B Virus Infection written by Hong Tang and published by Springer Nature. This book was released on 2019-11-18 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a state-of-the-art review of the key aspects of HBV. It covers our current understanding of the HBV genome and lifecycle, liver-enriched factors in the regulation of HBV transcription and translation, HBV protein structures and biological functions, and the immunology and pathogenesis of HBV. It also provides an update on cell and animal models, as well as molecular approaches. The respective chapters also cover the clinical management of hepatitis B and discuss future research directions, in particular, the identification of molecular targets for pharmacological intervention. Given its scope, the book offers a valuable resource for students, researchers, clinicians, and health practitioners in the fields of virology, infectious disease, public health etc. Dr Hong Tang is a Professor and Director of the Center of Infectious Diseases, West China Hospital of Sichuan University.
Book Synopsis Hepatitis C Virus I by : Tatsuo Miyamura
Download or read book Hepatitis C Virus I written by Tatsuo Miyamura and published by Springer. This book was released on 2018-06-29 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is composed of chapters that review important fundamental aspects of HCV biology and disease pathogenesis including, for example, the discovery and identification of the HCV genome, early virus-cell interactions including identification of various cellular receptors, HCV gene expression studied using the HCV replicon system, identification and characterization of HCV structural- and non-structural HCV proteins, HCV replication in cultured cells, and host factors involved in viral replication. This volume also contains chapters dealing with immunity to HCV infection and pathogenesis. This is particularly important in understanding hepatitis C because HCV infection alone is not cell lytic. Mechanisms underlying the persistent nature of HCV infection are also discussed in these chapters. Many of the authors published articles that were listed among the “top 10 papers” published in the 24 years since HCV was discovered in 1989. Their citations are above 1,000 (Web of Science). The authors describe the background and significance of their contributions to the field in the context of findings from other research groups.
Book Synopsis Fields Virology: Emerging Viruses by : Peter M. Howley
Download or read book Fields Virology: Emerging Viruses written by Peter M. Howley and published by Lippincott Williams & Wilkins. This book was released on 2020-02-11 with total page 2597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: Emerging Viruses, 7th Edition covers recent changes in emerging viruses, providing new or extensively revised chapters that reflect these advances in this dynamic field.
Book Synopsis Hepatitis C Virus Disease by : Emilio Jirillo
Download or read book Hepatitis C Virus Disease written by Emilio Jirillo and published by Springer Science & Business Media. This book was released on 2007-11-20 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite numerous hepatitis C virus infection studies, its pathogenesis and medical treatment have not been fully explained. This comprehensive volume, written by experts in the field, covers the most recent advances in the study of HCV, moving from basic research to clinical applications. The first chapters of this volume analyze the full spectrum of immune responses to HCV. The volume also includes contributions that explain the state of the art in IFN-alpha treatment of HCV patients.
Book Synopsis Hepatitis C Virus Treatment by : Kazuaki Chayama
Download or read book Hepatitis C Virus Treatment written by Kazuaki Chayama and published by Springer. This book was released on 2016-11-01 with total page 75 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to Direct Acting Antiviral (DAAs) agents, newly developed drugs to treat chronic hepatitis C virus infection, which have an excellent anti-viral effect on virus replication. These drugs have been developed to enhance the effect of interferon and ribavirin, as the resistant strains against each drug have been described both in vitro and in vivo and the existences of naturally occurring variants have been reported. However, since the combination of different classes of DAAs is sufficient to completely eradicate the virus without the need for interferon or ribavirin, the current treatment regimen does not include interferon. Ribavirin is used in combination with sofosbuvir, a potent polymerase inhibitor, to enhance its antiviral effects. Hepatitis C Virus Treatment offers readers a comprehensive guide to hepatitis C; describing the resistance profiles against these drugs and shedding light on the difficulties involved in DAA therapy and the direction of future treatments, it will equip doctors to understand the essentials of treating the disease. It also describes in detail new and innovative DAA treatments, the effects of the agents, and the characteristics of resistance, providing cutting-edge information not only for hepatologists, but also for researchers, clinical residents, and medical students.
Book Synopsis The Hepatitis C Viruses by : C.H. Hagedorn
Download or read book The Hepatitis C Viruses written by C.H. Hagedorn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic hepatitis C is a major worldwide health problem affecting more than 170 million people. Chronic infections lead to cirrhosis and liver failure or hepatocellular cancer in many instances. This volume includes comprehensive reviews that cover much of the vast literature that has appeared since the identification of the hepatitis C virus RNA genome. It will be an invaluable collection for anyone wanting an up-to-date picture of HCV transmission, molecular virology, immune response, cellular/molecular pathogenesis, and possible avenues for developing effective new therapeutics and vaccines.
Book Synopsis Hepatitis C Virus: New Insights for the Healthcare Professional: 2011 Edition by :
Download or read book Hepatitis C Virus: New Insights for the Healthcare Professional: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis C Virus: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Hepatitis C Virus. The editors have built Hepatitis C Virus: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hepatitis C Virus in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Hepatitis C Virus: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Viral Hepatitis by : Howard C. Thomas
Download or read book Viral Hepatitis written by Howard C. Thomas and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 915 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been an explosion of both the incidence and medicalknowledge of viral hepatitis over the last two decades. Not only isthe incidence of infection and disease increasing, but newhepatitis viruses have been discovered, as well as the launch ofnew pharmaceutical products. Previously published by Churchill Livingstone, ViralHepatitis by Zuckerman & Thomas was the first comprehensivebook on hepatitis and is recognized as the standardreference text in this field. The new third edition, now published by Blackwell Publishing,addresses the recent advances in diagnosis and treatment withentirely revised and current topics. It covers the entire spectrumof viral hepatitis and has something of interest for everyspecialist. Viral Hepatitis presents the latest thinking from theleading international researchers and clinicians working in thisfield and the Editors are joined by a North American co-Editor forthis edition - Professor Stanley Lemon of the University of Texas,Galveston, TX, USA. This book offers an ideal reference for all healthcareprofessionals involved in the research and patient care of thisdisease.
Book Synopsis Hepatitis C: Epidemiology, Prevention and Elimination by : Angelos Hatzakis
Download or read book Hepatitis C: Epidemiology, Prevention and Elimination written by Angelos Hatzakis and published by Springer Nature. This book was released on 2021-04-30 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on epidemiology, genetic diversity and global distribution of Hepatitis C, as well as laboratory diagnosis. Furthermore, the book explores the natural history of the virus and discusses international elimination strategies. The two volume work on Hepatitis C introduces to the topic by reviewing virology, diagnosis, epidemiology, prevention and elimination of HCV. The book provides a valuable source at full length for researchers and clinicians working on Hepatitis C.
Book Synopsis Chronic Viral Hepatitis by : Kirti Shetty
Download or read book Chronic Viral Hepatitis written by Kirti Shetty and published by Springer Science & Business Media. This book was released on 2001-09-07 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading scientists, clinicians, and clinical investigators comprehensively review the epidemiology, molecular virology, diagnosis, treatment, and prevention of chronic hepatitis caused by the B and C viruses. The discussion of patient management includes contributions on developing novel therapeutics, supporting patients during therapy, alternative treatments, the use of drugs in chronic viral hepatitis, liver transplantation, and pregnancy in chronic viral hepatitis. Attention is also given to the treatment of patients with concomitant autoimmune disorders, the management of HIV co-infection, and the management of HBV/HCV co-infection.
Download or read book Hepatitis C written by and published by Elsevier. This book was released on 2000-10-09 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: The anticipated encore volume of the Biomedical Research Reports Series, Hepatitis C is the first book that offers comprehensive and up-to-date coverage of this "silent epidemic." The subject matter ranges from basic science to clinical medicine, with contributions from more than 30 international experts in the field. This important new book details the hepatitis C virus and the disease that it causes, including its prevalence, means of spread, symptoms, complications, natural history, prevention, and therapy. The editors, T. Jake Liang, M.D., and Jay H. Hoofnagle, M.D., are both hepatologists and clinical and laboratory researchers who are well known leaders in the hepatitis field. Their team of authors provide the latest information on key issues such as the role of hepatitis C in liver cancer and evolving therapy for hepatitis C, including special subgroups of patients such as children, patients with renal failure, patients undergoing liver transplantation, and patients with HIV coinfection. The book also addresses future directions in antiviral therapy of hepatitis C and the real challenges of developing a vaccine. Hepatitis C is the integrated reference book for all researchers, clinicians, and students dealing with this troubling virus. Key Features * Provides comprehensive coverage of hepatitis C, ranging from basic science to clinical application * Includes contributions from more than 30 international experts in the field * Supplies current recommendations on management of hepatitis C * Designed in an easy-to-use format with consistent organization * Includes extensive illustrations
