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The Early Phases
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Author :Paul Peeters, Jaap van Asperen, Martin Jacobs, Hans Vonk, and others Publisher :Nesma ISBN 13 :9076258201 Total Pages :68 pages Book Rating :4.0/5 (762 download)
Book Synopsis The application of Function Point Analysis (FPA) in the early phases of the application life cycle A Practical Manual: Theory and case study by : Paul Peeters, Jaap van Asperen, Martin Jacobs, Hans Vonk, and others
Download or read book The application of Function Point Analysis (FPA) in the early phases of the application life cycle A Practical Manual: Theory and case study written by Paul Peeters, Jaap van Asperen, Martin Jacobs, Hans Vonk, and others and published by Nesma. This book was released on with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis An Introduction to Statistics in Early Phase Trials by : Steven Julious
Download or read book An Introduction to Statistics in Early Phase Trials written by Steven Julious and published by John Wiley & Sons. This book was released on 2010-01-19 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: All new medicines and devices undergo early phase trials to assess, interpret and better understand their efficacy, tolerability and safety. An Introduction to Statistics in Early Phase Trials describes the practical design and analysis of these important early phase clinical trials and provides the crucial statistical basis for their interpretation. It clearly and concisely provides an overview of the most common types of trials undertaken in early phase clinical research and explains the different methodologies used. The impact of statistical technologies on clinical development and the statistical and methodological basis for making clinical and investment decisions are also explained. Conveys key ideas in a concise manner understandable by non-statisticians Explains how to optimise designs in a constrained or fixed resource setting Discusses decision making criteria at the end of Phase II trials Highlights practical day-to-day issues and reporting of early phase trials An Introduction to Statistics in Early Phase Trials is an essential guide for all researchers working in early phase clinical trial development, from clinical pharmacologists and pharmacokineticists through to clinical investigators and medical statisticians. It is also a valuable reference for teachers and students of pharmaceutical medicine learning about the design and analysis of clinical trials.
Book Synopsis So Much More Than the ABCs by : MOLLY F.. SCHICKEDANZ COLLINS (JUDITH A.)
Download or read book So Much More Than the ABCs written by MOLLY F.. SCHICKEDANZ COLLINS (JUDITH A.) and published by . This book was released on 2024-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The foundation for success in learning to read and write begins in infancy. As early childhood professionals, we have both the opportunity and the privilege to shape the progress young children make in acquiring the literacy skills, oral language skills, and background knowledge vital to their later success in learning to read and write. By engaging infants, toddlers, and preschoolers in experiences that foster oral language and content knowledge, literacy skills, and cognitive ability, we build a foundation for children's later academic success. Promoting children's desire to read and write is as important as helping children develop the necessary understandings and skills essential for learning how to read and write. Without motivation, children will read and write relatively little and only what and when they must. This book addresses four main points: What children need to learn in these early years The strategies that teachers can use to help children acquire these foundations The features of emergent literacy and language understandings and skills How to design the physical environment in early childhood classrooms to support language and literacy learning This revision updates information, cites new research, and includes new figures. The newest edition of this bestselling book will help early childhood professionals and families support young children in acquiring the understandings, knowledge, and skills needed for later success in learning to read and write.
Book Synopsis The Supporting Role of Logistics during the Early Stage of Retail Internationalisation by : Linnea Haag
Download or read book The Supporting Role of Logistics during the Early Stage of Retail Internationalisation written by Linnea Haag and published by Linköping University Electronic Press. This book was released on 2019-03-08 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: Retail internationalisation refers to the establishment of retailers into foreign sales markets and is an important success factor for many retail chains. Logistics has been acknowledged as an important prerequisite and key component of retail internationalisation, enabling physical distribution to new foreign markets as well as ensuring customer satisfaction in terms of on-time delivery and product availability. Despite the recognition of logistics, logistics managers struggle to adapt their logistics organisation and operations in order to efficiently and effectively support retail internationalisation due to the complexity of operating in multiple markets. Previous research seldom mentions how logistics supports retail internationalisation, especially when retail chains are at the beginning of their retail-internationalisation journey. By exploring the supporting role of logistics during the early stage of retail internationalisation, retailers can better understand how logistics organisation and operations can be organised in order to successfully expand into foreign sales markets. Therefore, the purpose of this licentiate thesis is to: Explore the supporting role of logistics during the early stage of retail internationalisation. This licentiate thesis is based on an abductive, multiple-case-study approach that combines empirical data with literature in an iterative process in order to explore the supporting role of logistics during the early stage of retail internationalisation. The selected case companies were three large-sized Swedish retail chains that have recently established themselves into nearby foreign sales markets. The findings of this licentiate thesis suggest that logistics plays both a reactive and a proactive supporting role during the early stage of retail internationalisation. The reactive supporting role refers to logistics that adapts to predetermined conditions set by the retail company’s top management team. As a reactive supporter, the logistics organisation is typically involved at an operational level and scales up its logistics operations in order to supply multiple markets. Beyond its reactive role, logistics can also play a proactive supporting role. This refers to its involvement at a strategic level within the retail company where it can influence the conditions of retail internationalisation. When logistics is involved more proactively, its operations can become better aligned with the other company operations involved in retail internationalisation. Furthermore, proactive logistics support enables more efficient and effective logistics that can better cope with increased complexity as well as more effectively keeping track of logistics costs. In addition to these findings, the importance of top management has been identified as a key aspect of proactive logistics support. More specifically, logistics competence within the top management team enables logistics to be prioritised at a strategic level and to be better integrated during retail internationalisation, including during individual establishments into new markets. The findings also suggest that the importance of logistics increases over time during retail internationalisation. The more markets the retailer enters, the more important efficient logistics becomes in order to deal with both complexity and logistics costs. By involving proactive logistics from the start of retail internationalisation, retail chains can more efficiently and effectively establish into and operate within foreign sales markets, which in turn supports a sustainable retail internationalisation. One of the main academic contributions of this licentiate thesis has been to study logistics in the specific context of retail internationalisation, which has previously not been researched in any great detail. In addition, logistics has often been studied as a static aspect, but in this thesis it is studied from a dynamic perspective in order to understand how its supporting role changes over time during the early stage of retail internationalisation. Another important contribution is that the role of logistics has been studied from both a strategic and an operational level, as previous research has mostly focused on the strategic level of logistics related to retail internationalisation. In terms of practical contributions, this licentiate thesis clarifies the logistics characteristics and supply-chain capabilities that support the early stage of retail internationalisation. This licentiate thesis can also help practitioners to better prepare their logistics organisation and logistics operations for a future retail internationalisation, as well as helping them to avoid making logistical mistakes during the early stage of retail internationalisation.
Book Synopsis Early Phase Drug Evaluation in Man by : John O'Grady
Download or read book Early Phase Drug Evaluation in Man written by John O'Grady and published by CRC Press. This book was released on 2020-02-03 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early Phase Drug Evaluation in Man is a comprehensive, practical guide that covers pre-clinical information relevant to early human studies, including pharmaceutical, metabolic, toxicological, and regulatory aspects, as well as the general considerations relevant to all early human studies. Each major therapeutic area is considered by class of activity of drug. The chapters describe what measurements of drug activity are available in healthy human subjects and in patients, how to make the measurements, their value and their limitations. The contributors have been drawn internationally from the pharmaceutical industry and academia. Early Phase Drug Evaluation in Man will provide an important reference guide for industry and academic professionals involved in the development of new drugs.
Book Synopsis Pre-Milestone A and Early-Phase Systems Engineering by : National Research Council
Download or read book Pre-Milestone A and Early-Phase Systems Engineering written by National Research Council and published by National Academies Press. This book was released on 2008-03-11 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of U.S. military forces to field new weapons systems quickly and to contain their cost growth has declined significantly over the past few decades. There are many causes including increased complexity, funding instability, bureaucracy, and more diverse user demands, but a view that is gaining more acceptance is that better systems engineering (SE) could help shorten development time. To investigate this assertion in more detail, the US Air Force asked the NRC to examine the role that SE can play during the acquisition life cycle to address root causes of program failure especially during pre-milestone A and early program phases. This book presents an assessment of the relationship between SE and program outcome; an examination of the SE workforce; and an analysis of SE functions and guidelines. The latter includes a definition of the minimum set of SE processes that need to be accounted for during project development.
Book Synopsis What to do when the doctor says it's early-stage Alzheimer's by :
Download or read book What to do when the doctor says it's early-stage Alzheimer's written by and published by Fair Winds. This book was released on 2005 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Novel Designs of Early Phase Trials for Cancer Therapeutics by : Shivaani Kummar
Download or read book Novel Designs of Early Phase Trials for Cancer Therapeutics written by Shivaani Kummar and published by Academic Press. This book was released on 2018-05-22 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Designs of Early Phase Trials for Cancer Therapeutics provides a comprehensive review by leaders in the field of the process of drug development, the integration of molecular profiling, the changes in early phase trial designs, and endpoints to optimally develop a new generation of cancer therapeutics. The book discusses topics such as statistical perspectives on cohort expansions, the role and application of molecular profiling and how to integrate biomarkers in early phase trials. Additionally, it discusses how to incorporate patient reported outcomes in phase one trials. This book is a valuable resource for medical oncologists, basic and translational biomedical scientists, and trainees in oncology and pharmacology who are interested in learning how to improve their research by using early phase trials. Brings a comprehensive review and recommendations for new clinical trial designs for modern cancer therapeutics Provides the reader with a better understanding on how to design and implement early phase oncology trials Presents a better and updated understanding of the process of developing new treatments for cancer, the exciting scientific advances and how they are informing drug development
Book Synopsis Living Your Best with Early-Stage Alzheimer's by : Lisa Snyder
Download or read book Living Your Best with Early-Stage Alzheimer's written by Lisa Snyder and published by Sunrise River Press. This book was released on 2011-09-08 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Speaks directly to the person diagnosed with early-stage Alzheimer's and offers them the information they need to move ahead.
Book Synopsis Indicating Value in Early-Stage Technology Venture Valuation by : Christoph Philipp Wessendorf
Download or read book Indicating Value in Early-Stage Technology Venture Valuation written by Christoph Philipp Wessendorf and published by Springer Nature. This book was released on 2021-08-24 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundraising for venture capital investments have continued to increase in recent years. One crucial step in the investment process is the valuation of the target company. Investors are faced with the great challenge of valuing a young venture without a corporate or financial history, a firm customer relationship or even a business model, while still taking into account the tremendous growth potential. Especially the valuation of technology companies is a difficult and often subjective process. Motivated by these considerations, this dissertation details a design science research project, which aims to develop an artifact that improves the indication of value in early-stage technology venture valuation while enabling operationalizable and fair valuation. This approach ensures a more meaningful valuation and better applicability to early-stage technology ventures compared to traditional methods while supporting the deliberate reduction of information asymmetries between entrepreneurs and investors. Firm-specific characteristics and practical applicability are taken into account.
Book Synopsis Dose-Finding Designs for Early-Phase Cancer Clinical Trials by : Takashi Daimon
Download or read book Dose-Finding Designs for Early-Phase Cancer Clinical Trials written by Takashi Daimon and published by Springer. This book was released on 2019-05-21 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This book also covers more complex and updated dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding designs, and so on.
Book Synopsis Early Phase Cancer Immunotherapy by : Sandip Pravin Patel
Download or read book Early Phase Cancer Immunotherapy written by Sandip Pravin Patel and published by Springer. This book was released on 2017-11-03 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, a state-of-the-art review of early phase clinical trials for cancer immunotherapy, discusses biomarker selection, combinatorial strategies and their safety or toxicity, determination of Phase 2 dosing, endpoints in the setting of radiographic pseudoprogression, histology selection, and novel immunotherapeutics as they relate to early phase cancer immunotherapy.
Book Synopsis Pandemic Influenza Preparedness and Response by : World Health Organization
Download or read book Pandemic Influenza Preparedness and Response written by World Health Organization and published by World Health Organization. This book was released on 2009 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guidance is an update of WHO global influenza preparedness plan: the role of WHO and recommendations for national measures before and during pandemics, published March 2005 (WHO/CDS/CSR/GIP/2005.5).
Book Synopsis Early-Stage Interventions by : Randy Sprick
Download or read book Early-Stage Interventions written by Randy Sprick and published by . This book was released on 2020-02 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Early Stage Investments in New Technology Based Firms by : Holger Ludewig
Download or read book Early Stage Investments in New Technology Based Firms written by Holger Ludewig and published by diplom.de. This book was released on 1999-01-04 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inhaltsangabe:Abstract: In recent years the issue of early stage investment in new technology based firms has drawn considerable attention. Its relevance emerges from the rise of high technology industries in the global economy. As competition in established, mature industries all over the world is ever increasing, the importance of keeping up and increasing the speed of innovation to ensure competitiveness of companies and national wealth is widely recognized. Innovation may concern products or processes. It refers to the development of new proprietary knowledge, i. e. technology, which is embodied in marketable products or services. In as far as the added private knowledge increases the utility of a product to the customers, it adds value. Unless the new features of a product are matched by competitors, a company may earn innovation rents. Thus proprietary knowledge attained through innovation is an important source of strategic advantage. In a competitive, dynamic market, however innovation rents are not sustainable. Competitors will attempt to match and exceed the innovation advantage. This may be achieved by imitation or by adding other or more innovative features. Whereas following the product life cycle model initial growth may be steep and rents may be high for the first mover, imitators competing on price and other rivals competing on innovations, may inflate the monopolistic power of the proprietary knowledge. Striving to maintain and increase market shares and profitability, companies thus have a strong incentive to keep innovating. For new technology-based firms the importance of proprietary knowledge is particularly pronounced. These start-ups operate in a hostile competitive environment, characterized by high uncertainty, offering the potential for rapid growth and high profits on the upside, but also the substantial threat of incurring deep losses on the downside. Whereas large companies generally possess a diversified product portfolio and a host of strategic assets, small companies will need to compete on a single new product or service and the determination of its management team. Politicians, worried by high unemployment and budget deficits, lately fell in love with the high-technology start-ups for their ability to create jobs and ensure future tax revenues. New technology-based firms are drivers of structural change in the economy in that they are among the first to enter new high growth potential industries. For [...]
Book Synopsis Early-Stage Breast Cancer: New Developments and Controversies, An Issue of Surgical Oncology Clinics - E- Book by : Eleftherios P. Mamounas
Download or read book Early-Stage Breast Cancer: New Developments and Controversies, An Issue of Surgical Oncology Clinics - E- Book written by Eleftherios P. Mamounas and published by Elsevier Health Sciences. This book was released on 2010-07-30 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of the Surgical Oncology Clinics will focus on new advances in Breast Cancer Surgery, and will include articles on Chemoprevention, Breast MRI, Genomics, Sentinel Node Biopsy, Extra-axillary Sentinel Nodes, Skin-Sparing and Nipple Sparing Mastectomy, Oncoplastic Techniques, Neoadjuvant Hormonal Therapy, Neoadjuvant Chemotherapy, Adjuvant Hormonal Therapy, Adjuvant Chemotherapy, and Biologic Targeted Therapies.
Book Synopsis Early Stage and Discovery Deals: Strategy, Structure and Payment Terms 2nd Edition by :
Download or read book Early Stage and Discovery Deals: Strategy, Structure and Payment Terms 2nd Edition written by and published by Pharmalicensing. This book was released on with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt:
