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Author : Qutaiba Amir Tawfic
Publisher :
ISBN 13 :
Total Pages : 6 pages
Book Rating : 4.:/5 (936 download)
Download or read book The Dilemma of Opioid-Induced Hyperalgesia and Tolerance in Chronic Opioid Therapy written by Qutaiba Amir Tawfic and published by . This book was released on 2013 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jianren Mao
Publisher : CRC Press
ISBN 13 : 1420089005
Total Pages : 204 pages
Book Rating : 4.4/5 (2 download)
Download or read book Opioid-Induced Hyperalgesia written by Jianren Mao and published by CRC Press. This book was released on 2016-04-19 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first clinically focused text dedicated to the newly emerging area of pain medicine known as opioid-induced hyperalgesia (OIH), Opioid-Induced Hyperalgesia provides pain specialists, anesthesiologists, and neurologists with the most current, cutting-edge research and therapeutic options for treating OIH patients. It supplies best practice guide
Author : Theresa Alexandra Mattioli
Publisher :
ISBN 13 :
Total Pages : 316 pages
Book Rating : 4.:/5 (845 download)
Download or read book Opioids and Glia written by Theresa Alexandra Mattioli and published by . This book was released on 2013 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultra-low doses (ULD) of the opioid receptor antagonists, naloxone and naltrexone, augment the analgesic actions of morphine, block the induction of tolerance, and reverse established tolerance by an unknown mechanism. Preclinical studies demonstrate that chronic morphine administration induces spinal gliosis and that inhibition of gliosis prevents the development of analgesic tolerance to opioids. Thus, this thesis investigated the inhibition of spinal gliosis as a mechanism by which ULD antagonists attenuate analgesic tolerance and opioid-induced hyperalgesia. Immune cell activation is implicated in the etiology of morphine tolerance and intrathecal catheterization, a technique commonly used to study the spinal effects of drugs, causes profound gliosis. Thus, the first study investigated the effects of catheter-induced gliosis on acute and chronic morphine analgesic tolerance. Catheterization-induced gliosis did not alter antinociceptive responses to acute intrathecal morphine; however, tolerance to chronic morphine was exacerbated in catheterized rats compared to sham and surgery-naïve controls. The potentiation of analgesic tolerance to chronic morphine by spinal gliosis provided evidence that glia modulate opioid analgesia; therefore, inhibition of opioid-induced activation of glia was explored as a potential mechanism by which ULD antagonists prevent tolerance. The second series of experiments reported morphine-induced activation of spinal microglia and astrocytes was blocked by co-administering ULD naltrexone with morphine. These findings prompted us to elucidate the specific molecular target through which ULD antagonists attenuate opioid analgesia. Activation of glial Toll-like receptor 4 (TLR4) induces gliosis and may contribute to analgesic tolerance and/or morphine-induced hyperalgesia (MIH). Antagonism of TLR4 by the opioid receptor-inactive (+) stereoisomer of naloxone was identified as a potential mechanism by which ULD antagonists modulate opioid analgesia. Tolerance and MIH developed in mice expressing non-functional TLR4 and in wildtype controls. Analgesic tolerance was stereoselectively blocked by ULD ( - )naloxone, whereas MIH was blocked by both naloxone enantiomers. Collectively, these studies demonstrate analgesic tolerance and MIH occur through distinct mechanisms. ULD naloxone attenuates analgesic tolerance likely via an opioid receptor-mediated mechanism that is TLR4-independent. ULD antagonists do not attenuate tolerance via inhibition of spinal gliosis as hypothesized. In contrast, ULD antagonists prevent MIH by inhibiting opioid-induced gliosis in an opioid receptor- and TLR4-independent manner. Immune cell activation is implicated in the etiology of morphine tolerance and intrathecal catheterization, a technique commonly used to study the spinal effects of drugs, causes profound gliosis. Thus, the first study investigated the effects of catheter-induced gliosis on acute and chronic morphine analgesic tolerance. Catheterization-induced gliosis did not alter antinociceptive responses to acute intrathecal morphine; however, tolerance to chronic morphine was exacerbated in catheterized rats compared to sham and surgery-naïve controls. The potentiation of analgesic tolerance to chronic morphine by spinal gliosis provided evidence that glia modulate opioid analgesia; therefore, inhibition of opioid-induced activation of glia was explored as a potential mechanism by which ULD antagonists prevent tolerance. The second series of experiments reported morphine-induced activation of spinal microglia and astrocytes was blocked by co-administering ULD naltrexone with morphine. These findings prompted us to elucidate the specific molecular target through which ULD antagonists attenuate opioid analgesia. Activation of glial Toll-like receptor 4 (TLR4) induces gliosis and may contribute to analgesic tolerance and/or morphine-induced hyperalgesia (MIH). Antagonism of TLR4 by the opioid receptor-inactive (+) stereoisomer of naloxone was identified as a potential mechanism by which ULD antagonists modulate opioid analgesia. Tolerance and MIH developed in mice expressing non-functional TLR4 and in wildtype controls. Analgesic tolerance was stereoselectively blocked by ULD ( - )naloxone, whereas MIH was blocked by both naloxone enantiomers. Collectively, these studies demonstrate analgesic tolerance and MIH occur through distinct mechanisms. ULD naloxone attenuates analgesic tolerance likely via an opioid receptor-mediated mechanism that is TLR4-independent. ULD antagonists do not attenuate tolerance via inhibition of spinal gliosis as hypothesized. In contrast, ULD antagonists prevent MIH by inhibiting opioid-induced gliosis in an opioid receptor- and TLR4-independent manner.
Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309459575
Total Pages : 483 pages
Book Rating : 4.3/5 (94 download)
Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Author : Raymond S. Sinatra
Publisher : Cambridge University Press
ISBN 13 : 1139491989
Total Pages : 551 pages
Book Rating : 4.1/5 (394 download)
Download or read book The Essence of Analgesia and Analgesics written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2010-10-14 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
Author : Raymond S. Sinatra
Publisher : Cambridge University Press
ISBN 13 : 0521874912
Total Pages : 729 pages
Book Rating : 4.5/5 (218 download)
Download or read book Acute Pain Management written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2009-04-27 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
Author : Jianren Mao
Publisher : Nova Publishers
ISBN 13 : 9781600212055
Total Pages : 370 pages
Book Rating : 4.2/5 (12 download)
Download or read book Translational Pain Research: Comparing preclinical studies and clinical pain management. Lost in translation? written by Jianren Mao and published by Nova Publishers. This book was released on 2006 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic science and clinical pain research is particularly challenging for several reasons. First, pain is a subjective experience in response to nociception that follows actual or potential tissue damage. Since the ability to respond to this warning signal is essential for our survival, the nociceptive system that produces and transmits nociceptive signals is remarkably redundant and involves diffuse regions of the central nervous system. Second, unlike other sensory modalities, pain is a multi-dimensional experience including at least cognitive, affective, and sensory-discriminative components. Third, pain experiences can be influenced by psychological, socioeconomic, cultural, and genetic predispositions, making it exceedingly complicated to study pain and pain modulation. The topics covered in this volume are carefully selected and directly related to the daily practice of pain medicine. These topics include 1) central mechanisms of pain and pain modulation (Dickenson, Donovan-Rodriguez, Mattews) and clinical use of ion channel blockers (Chen); 2) spinal glutamatergic mechanisms (Guo, Dubner, Ren) and issues related to glutamate receptor antagonists in pain management (Mao); 3) basic science of opioid analgesics (Gintzler, Chakrabarti) and clinical opioid use (Smith, McCleane); 4) inflammatory cytokines (Samad) and clinical use of anti-inflammatory drugs (Fink, Brenner); 5) role of the sympathetic nervous system in pain mechanisms and its relation to clinical pain management (Sharma, Raja); 6) preclinical studies on tricyclic antidepressants (Gerner, Wang) and clinical use of antidepressants in pain management (Greenberg); 7) developing pain pathways and analgesic mechanisms during the developmental stage (Fitzgerald) and challenges of pediatric pain management (Lebel); 8) basic science mechanisms of serotonin agonists and their use in the clinical management of migraine headache (Biondi); 9) clinical research on gender differences in clinical pain and their implications for clinical pain management (Holdcroft); 10) current modalities of clinical cancer pain management (Popescu, Hord); and 11) preclinical and clinical information on alternative medicine (Chen).
Author : Tariq Malik
Publisher : Springer Nature
ISBN 13 : 3030466752
Total Pages : 389 pages
Book Rating : 4.0/5 (34 download)
Download or read book Practical Chronic Pain Management written by Tariq Malik and published by Springer Nature. This book was released on 2020-06-19 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on both the management of the pain as well as the pain patient and is formatted as a practical, evidence-based guide to managing chronic pain conditions. It meets the market need for a reference that aides physicians in understanding and improving chronic pain in their patients. Organized across 46 chapters, the book begins with an introduction on chronic pain evaluation, and specifically stresses the importance of complete patient evaluation including social and psychological evaluation. Subsequent chapters then start with an evaluation, medical and interventional options available, how and when to move from one option to another and the level of evidence offered for each intervention. These unique chapter elements provide the reader with a case-based approach to managing their patients. Additionally, a brief discussion of epidemiology and pathophysiology of the disease process is included and the technical aspects of interventional techniques are reviewed. Edited by a leader in the field with international contributing authors across pain medicine, Practical Chronic Pain Management this book is written primarily for anesthesiologists, pain specialists, rheumatologists, and primary care physicians.
Author : Jeffrey L. Benovic
Publisher : Wiley-Liss
ISBN 13 : 9780471252771
Total Pages : 0 pages
Book Rating : 4.2/5 (527 download)
Download or read book Regulation of G Protein Coupled Receptor Function and Expression written by Jeffrey L. Benovic and published by Wiley-Liss. This book was released on 1999-11-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in molecular and cell biology enabling the cloning, expression, and mutagenesis of signal transduction proteins has prompted an explosion of knowledge in the field of receptor regulation, facilitating the discovery of new classes of regulatory proteins, and providing a basis and means for manipulating receptor function through multiple intracellular targets. This volume covers methods used to examine how the function(s) of receptors are regulated. Understanding how to regulate the function and expression of these receptors is critical in determining how to modify receptors and to translocating receptors away from the cell surface and its recycling. Individual chapters focus on specific techniques used to characterize receptors (epitope tagging, measurement and analysis of receptor phosphorylation, analysis of the kinetics of receptor desensitization, and assessment of receptor/G protein coupling); the role of regulatory proteins (receptor kinases and phosphatases, arrestins) in modulating receptor function; and the methods used to measure receptor trafficking (ligand binding, immunofluoresence) and expression (transcriptional and translational regulation). * Covers a broad range of important concepts and methodologies which are current in the study of G protein-coupled receptors (GPCRs) * G-protein coupled receptors make up over 40% of the current pharmacological targets * Provides detailed protocols for executing various strategies and offers informed judgments as to what approaches are and aren't useful * Volume Editor, Jeffrey Benovic, is a dominant world leader in the study of receptor regulation of GPCR kinases and is highly respected in the field
Author : Magdalena Anitescu
Publisher : Oxford University Press
ISBN 13 : 0190271787
Total Pages : 401 pages
Book Rating : 4.1/5 (92 download)
Download or read book Pain Management written by Magdalena Anitescu and published by Oxford University Press. This book was released on 2018 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain Management: A Problem-Based Learning Approach combines comprehensive didactics on pain management topics with board like questions grouped in real-time pain practice exams. It is uniquely designed to maximize the retaining of learned information by the long-life learner in the ABA certification/recertification process. It is also ideally used as a reference compendium offering theoretical and practical advice to the busy pain practitioner.
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 030921484X
Total Pages : 383 pages
Book Rating : 4.3/5 (92 download)
Download or read book Relieving Pain in America written by Institute of Medicine and published by National Academies Press. This book was released on 2011-10-26 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic pain costs the nation up to $635 billion each year in medical treatment and lost productivity. The 2010 Patient Protection and Affordable Care Act required the Department of Health and Human Services (HHS) to enlist the Institute of Medicine (IOM) in examining pain as a public health problem. In this report, the IOM offers a blueprint for action in transforming prevention, care, education, and research, with the goal of providing relief for people with pain in America. To reach the vast multitude of people with various types of pain, the nation must adopt a population-level prevention and management strategy. The IOM recommends that HHS develop a comprehensive plan with specific goals, actions, and timeframes. Better data are needed to help shape efforts, especially on the groups of people currently underdiagnosed and undertreated, and the IOM encourages federal and state agencies and private organizations to accelerate the collection of data on pain incidence, prevalence, and treatments. Because pain varies from patient to patient, healthcare providers should increasingly aim at tailoring pain care to each person's experience, and self-management of pain should be promoted. In addition, because there are major gaps in knowledge about pain across health care and society alike, the IOM recommends that federal agencies and other stakeholders redesign education programs to bridge these gaps. Pain is a major driver for visits to physicians, a major reason for taking medications, a major cause of disability, and a key factor in quality of life and productivity. Given the burden of pain in human lives, dollars, and social consequences, relieving pain should be a national priority.
Author : Kanishka Rajput
Publisher : Springer Nature
ISBN 13 : 3030552624
Total Pages : 429 pages
Book Rating : 4.0/5 (35 download)
Download or read book Pain Control in Ambulatory Surgery Centers written by Kanishka Rajput and published by Springer Nature. This book was released on 2021-03-08 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of the challenges, risk stratification, approaches and techniques needed to improve pain control in ambulatory surgery centers (ASCs). It addresses not only the management of acute perioperative pain but also describes modalities that could potentially reduce the risk of evolution of acute pain into chronic pain, in addition to weaning protocols and follow ups with primary surgical specialties and pain physicians as needed. Organized into five sections, the book begins with the foundations of managing ASCs, with specific attention paid to the current opioid epidemic and U.S. policies relating to prescribing opioids to patients. Section two and three then explore facets of multimodal analgesia and non-operating room locations, including the use of ultrasounds, sedation in specific procedures, regional anesthesia, ketamine infusions, and the management of perioperative nausea and intractable pain in outpatient surgery. Section four examines the unique challenges physicians face with certain patient demographics, such as the pediatric population, those suffering from sleep apnea, and those with a history of substance abuse. The book closes with information on discharge considerations, ambulatory surgery protocols, recovery room protocols, and mandatory pain management services. An invaluable reference for all health personnel and allied specialties, Pain Control in Ambulatory Surgery Centers (ASCs) meets the unmet need for a resource that covers optimum pain control in patients undergoing outpatient surgery as well as the urgent ASCs challenges that are presented on an immense scale with national and international impact.
Author : Alan David Kaye
Publisher : Cambridge University Press
ISBN 13 : 1107682894
Total Pages : 547 pages
Book Rating : 4.1/5 (76 download)
Download or read book Case Studies in Pain Management written by Alan David Kaye and published by Cambridge University Press. This book was released on 2014-10-16 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by internationally recognized pain experts, this book offers 73 clinically relevant cases, accompanied by discussion in a question-and-answer format.
Author : Lorraine M Sdrales
Publisher : Elsevier Health Sciences
ISBN 13 : 032351183X
Total Pages : 544 pages
Book Rating : 4.3/5 (235 download)
Download or read book Miller's Anesthesia Review E-Book written by Lorraine M Sdrales and published by Elsevier Health Sciences. This book was released on 2017-08-31 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encompassing all anesthesia topics from basic to advanced, Miller’s Anesthesia Review, 3rd Edition, by Drs. Lorraine M. Sdrales and Ronald D. Miller, is an ideal study guide to assess your knowledge and deepen your understanding. This easy-to-use resource is conveniently cross-referenced to the newest edition of Miller & Pardo: Basics of Anesthesia. Hundreds of questions cover everything from physiologic and pharmacologic principles through anesthetic machine systems, anesthetic delivery in a variety of settings, and anesthesia administration for a full range of disease states. Corresponds to Miller & Pardo’s Basics of Anesthesia to help you make the most of your study time and learn more efficiently. Provides immediate feedback with detailed answers to each question at the end of every chapter, cross-referenced to specific pages in Basics of Anesthesia. Includes new chapters on Neurotoxicity of Anesthesia, Palliative Care, Sleep Medicine, and Perioperative Surgical Home. Brings you fully up to date with revised questions throughout, progressing logically from basic to advanced topics. Covers hot topics such as Implantable Cardiac Pulse Generators, Anesthesia for Robotic Surgery, Perioperative Blindness, Human Performance and Patient Safety, and Civil, Chemical, and Biological Warfare.
Author : Richard K. Ries
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1469883791
Total Pages : 4573 pages
Book Rating : 4.4/5 (698 download)
Download or read book The ASAM Principles of Addiction Medicine written by Richard K. Ries and published by Lippincott Williams & Wilkins. This book was released on 2014-05-14 with total page 4573 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the midst of an addiction epidemic, this newly updated edition of The American Society of Addiction Medicine Principles of Addiction Medicine, 5th edition is the sought-after text every addiction researcher and care provider needs. This comprehensive reference text dedicates itself to both the science and treatment of addiction. You’ll receive a thorough grounding in both the scientific principles behind the causes of addiction and the practical aspects of clinical care. Chapters are written by recognized experts, covering areas such as the basic science of addiction medicine; diagnosis, assessment and early intervention; pharmacologic and behavioral interventions; mutual help and twelve-step; and co-occurring addiction, medical and psychiatric disorders—backed by the latest research data and successful treatment methods. Features: Numerous figures, tables and diagrams elucidate the text Chapters include case examples List of data research reports provided at end of each chapter NEW material on Prescription Drug Abuse, Club Drugs, Nursing Roles in Addressing Addiction, Conceptual and Treatment Issues in Behavioral Addictions, Rehabilitation Approaches to Pain Management, Comorbid Pain and Addiction, Pharmacotherapy for Adolescents with Substance Use Disorders, Preventing and Treating Substance Use Disorders in Military Personnel, and more.
Author : Magdalena Anitescu
Publisher : Oxford University Press
ISBN 13 : 0190271809
Total Pages : 401 pages
Book Rating : 4.1/5 (92 download)
Download or read book Pain Management written by Magdalena Anitescu and published by Oxford University Press. This book was released on 2018-05-01 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain Management: A Problem-Based Learning Approach provides a comprehensive review of the dynamic and ever-changing field of pain medicine. Its problem-based format incorporates a vast pool of practical, ABA board-exam-style multiple-choice questions for self-assessment. Each its 46 case-based chapters is accompanied by 20 questions and answers, accessible online in a full practice exam. The cases presented are also unique, as each chapter starts with a case description, usually a compilation of several actual cases; it then branches out through case-based questions, to increasingly complex situations. This structure is designed to create an authentic experience that mirrors that of an oral board examination. The discussion sections that follow offer a comprehensive approach to the chapter's subject matter, thus creating a modern, complete, and up-to-date medical review of that topic. This book is equally a solid reference compendium of pain management topics and a comprehensive review to assist the general practitioner both in day-to-day practice and during preparation for certification exams. Its problem-based format makes it an ideal resource for the lifelong learner and the modern realities of education.
Author : Peter S. Staats
Publisher : Springer
ISBN 13 : 3319309641
Total Pages : 325 pages
Book Rating : 4.3/5 (193 download)
Download or read book Controlled Substance Management in Chronic Pain written by Peter S. Staats and published by Springer. This book was released on 2016-05-28 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive guide covers prescribing controlled substances for patients with acute or chronic pain and provides a balanced discussion on appropriate treatment, addiction, safety and complications. Chapters feature evidence-based strategies and clinical modalities that address diagnostic challenges, treatment guidance, alternatives to opioid management and the significant legal risks within the current regulatory environment. Authored by leaders in pain medicine, physicians and appropriate health care professionals will find Controlled Substance Management in Chronic Pain to be an indispensable resource.
