Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
The Blood Brain Barrier Amino Acids And Peptides
Download The Blood Brain Barrier Amino Acids And Peptides full books in PDF, epub, and Kindle. Read online The Blood Brain Barrier Amino Acids And Peptides ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis The Blood-Brain Barrier, Amino Acids and Peptides by : M. Segal
Download or read book The Blood-Brain Barrier, Amino Acids and Peptides written by M. Segal and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Definition of the barrier The interstitial fluid (rSF) of the brain is separated from the blood by the blood-brain barrier (BBB). This barrier must not be thought of as a single entity or as an absolute restriction to all molecules, but as a multiple structure located at several sites within the brain. The first of these interfaces is located at the endothelium of the brain capillaries. Secondly there is a potential site for interchange on the outer linings of the brain between the dura and the arachnoid membranes. Thirdly, there are the choroid plexuses and the cerebrospinal fluid (CSF) which is in contact with the very permeable internal ependymal lining of the brain (Figure 1. 1). Finally there are areas of the brain which lack a blood-brain barrier. These areas constitute the circumventricu lar organs and have leaky capillaries with a barrier at the ependyma which limits the spread of molecules from those regions (Figure 1. 2). Each of these BBB sites has its own characteristic permeability and transport functions. We will now consider the properties of each of these barrier sites between the blood and the brain. THE CEREBRAL CAPILLARY ENDOTHELIUM Morphology This interface has both the largest surface area and the shortest path length between the blood and the brain rSF. The cerebral capillaries, which at first sight seem little different from the rest of the systemic circulation, are in fact unique to the brain.
Book Synopsis Peptide and Amino Acid Transport Mechanisms in the Central Nervous System by : Ljubiša Rakić
Download or read book Peptide and Amino Acid Transport Mechanisms in the Central Nervous System written by Ljubiša Rakić and published by Stockton Press. This book was released on 1988 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addresses the regulation, within the brain extracellular fluid, of peptide and amino acid levels, particularly neurotransmitters and neuromodulators. Particular attention is devoted to the way in which peptides may either penetrate the blood-brain barrier or alter its permeability to other solutes. Focuses on central nervous system disease, especially in designing drugs and agents which will penetrate the blood-brain barrier and expert central nervous actions. Annotation copyrighted by Book News, Inc., Portland, OR
Book Synopsis An Introduction to the Blood-brain Barrier by : Davson
Download or read book An Introduction to the Blood-brain Barrier written by Davson and published by CRC Press. This book was released on 1993 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to exploring the complexities of the blood-brain barrier. The book begins by reviewing the historical experiments that led to the concept of a barrier protecting the brain from variations in the blood. Transport kinetics and carrier-mediated processes are described, and the mechanism by which molecules can cross the barrier is discussed. Ways in which the barrier can be disrupted and opened are covered as well. Subsequent chapters in the book describe the transport of glucose and amino acids into the central nervous systems, cover recent findings by which peptides and proteins are able to gain entry or are excluded from the brain, and analyze models that can be used for investigating how the blood-brain barrier can be disordered in neurological disease processes.
Book Synopsis Peptide Transport and Delivery into the Central Nervous System by : Laszlo Prokai
Download or read book Peptide Transport and Delivery into the Central Nervous System written by Laszlo Prokai and published by Birkhäuser. This book was released on 2012-12-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypo- or hypersecretion, alteration in storage, release, catabolism, and post-translational processing of neuropeptides are associated with the etiology of many diseases affecting the central nervous system (CNS). Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics developed as their agonists or antagonists could be useful in the treatment of these CNS maladies. However, peptides face a formidable obstacle in reaching the intended site of action due to the existence of the blood-brain barrier (BBB), a vital element in the regulation of the internal environment of the brain and the spinal cord. After reviews on the role and neuropharmaceutical potential of peptides, properties of the BBB in the context of peptide transport in the CNS and potential transport mechanisms to cross the BBB, this volume discusses the development, present state-of-the-art and future trends of various strategies to overcome this major obstacle to peptide pharmacotherapy involving the CNS. Chapters are devoted to cover invasive approaches that circumvent the BBB by direct administration into the brain or the spinal cord and by transiently opening the tight junctions of or permeabilizing the endothelial cells separating the systemic circulation from the interstitial fluid of the CNS. Subsequently, physiologically based strategies that utilize biological carriers to gain access to the CNS are discussed in detail, followed by methods encompassing prodrug and chemical delivery/targeting strategies, which aim at altering the properties of the peptide to enhance BBB transport, and drug delivery strategies based on peptide vectors. Finally, a comparative evaluation on the present status and perspectives of the techniques is presented.
Author :Michael W.B. Bradbury Publisher :Springer Science & Business Media ISBN 13 :3642768946 Total Pages :562 pages Book Rating :4.6/5 (427 download)
Book Synopsis Physiology and Pharmacology of the Blood-Brain Barrier by : Michael W.B. Bradbury
Download or read book Physiology and Pharmacology of the Blood-Brain Barrier written by Michael W.B. Bradbury and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: The blood-brain barrier is still not completely understood and therefore the subject of fascinating study. How are endogenous substances transported through the blood-brain barrier? What are the known therapeutic and toxic agents? How are they transported across cerebral microvessels? The discussion of these and other questions with far-reaching consequences for all neuroscientists can be found in this volume. This authoritative and up-to-date review of the blood-brain barrier gives a proper understanding of the topic. The experimental principles, the results of very recent research, as well as the implications that experimental research has for clinical treatment are thoroughly covered. Information is given on: - new findings based on classical physiological and pharmacological techniques, - results obtained from brain capillaries in vitro and in culture, - results obtained from the new scanning techniques (PET and MRI), - the immunology of the blood-brain barrier, - trace metal transport, - the pathological breakdown of the barrier and - the modification of drugs to increase their entry into the brain. Here is a source of information that is invaluable to specialists concerned with basic research in the neurosciences, with the design of neuropharmacological agents, with the radiological diagnosis of cerebral pathology or with the treatment of cerebral lesions!
Book Synopsis The Role of Protein and Amino Acids in Sustaining and Enhancing Performance by : Institute of Medicine
Download or read book The Role of Protein and Amino Acids in Sustaining and Enhancing Performance written by Institute of Medicine and published by National Academies Press. This book was released on 1999-09-15 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contains the committee's summary of the workshop, responses to the Army's questions, conclusions, and recommendations. The remainder of the book contains papers contributed by speakers at the workshop on such topics as, the effects of aging and hormones on regulation of muscle mass and function, alterations in protein metabolism due to the stress of injury or infection, the role of individual amino acids, the components of proteins, as neurotransmitters, hormones, and modulators of various physiological processes, and the efficacy and safety considerations associated with dietary supplements aimed at enhancing performance.
Book Synopsis Introduction to the Blood-Brain Barrier by : William M. Pardridge
Download or read book Introduction to the Blood-Brain Barrier written by William M. Pardridge and published by Cambridge University Press. This book was released on 1998-08-28 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: The blood-brain barrier serves to protect the brain from toxic substances whilst simultaneously allowing access to essential nutrients and chemical signals. At the interface between brain and body, knowledge of the blood-brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. Nevertheless, it seems that ignorance of both the biology of this important membrane and the methodology suitable for its investigation still remains an impediment to progress in many fields, including, for example, the development of new and efficacious neuropharmaceuticals, cerebrovascular disease, Alzheimer's disease, cerebral AIDS and brain tumours. This introduction for both researchers and clinicians across the medical sciences is intended to aid both those beginning work directly in this area and those wishing simply to be better informed when interpreting information where the blood-brain barrier may be involved. Advances in both methodology and biology are detailed in 50 chapters from international authorities.
Author :Pierre-Olivier Couraud Publisher :Springer Science & Business Media ISBN 13 :1475794894 Total Pages :366 pages Book Rating :4.4/5 (757 download)
Book Synopsis Biology and Physiology of the Blood-Brain Barrier by : Pierre-Olivier Couraud
Download or read book Biology and Physiology of the Blood-Brain Barrier written by Pierre-Olivier Couraud and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than !50 participants. including investigators in basic neuroscience, physicians. and stu dents, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain.
Book Synopsis Peptide Drug Delivery to the Brain by : William M. Pardridge
Download or read book Peptide Drug Delivery to the Brain written by William M. Pardridge and published by Raven Press (ID). This book was released on 1991 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses new and established strategies for delivering peptides and antibodies through the blood-brain barrier. It reviews concepts on blood-brain barrier transport biology, assesses the utility and limitations of traditional brain drug delivery methods and describes new drug delivery techniques.
Download or read book Brain Barrier Systems written by and published by Elsevier. This book was released on 2014-05-14 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Barrier Systems
Book Synopsis The Blood-brain Barrier by : William M. Pardridge
Download or read book The Blood-brain Barrier written by William M. Pardridge and published by Lippincott Williams & Wilkins. This book was released on 1993 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: The characterization of the blood-brain barrier (BBB) is undergoing a paradigm shift as the century-old concept of a passive, impermeable barrier that segregates blood and brain interstitial fluid is giving way to the idea that the BBB is a dynamic conduit for the transport between blood and brain of those nutrients, peptides, proteins, or immune cells that have access to certain transport systems localized within the BBB membranes. This volume contains 20 contributed chapters organized in four parts: cell-cell interactions, subcellular organelle function, signal transduction mechanisms, and gene expression. There is also a foreword by the late W.H. Oldendorf (1925-1992) on the teleology of the blood-brain barrier and the survival advantage conferred upon the organism by its presence in the vertebrate brain. Annotation copyright by Book News, Inc., Portland, OR
Book Synopsis Fluid Environment of the Brain by : Helen Cserr
Download or read book Fluid Environment of the Brain written by Helen Cserr and published by Elsevier. This book was released on 2012-12-02 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluid Environment of the Brain presents the proceedings of a symposium held in Bar Harbor, Maine in September 1974 under the joint sponsorship of the Mount Desert Island Biological Laboratory and the National Cancer Institute. Contributors discuss the fluid matrix of the brain and the functional relationships among neurons, neuroglia, and their extracellular fluids in normal and pathological states. They focus on the cerebral interstitial fluid and the membranes—or barrier mechanisms—which contribute to the regulation of the physical and chemical characteristics of these fluids. This book is organized into four sections encompassing 17 chapters and begins with an overview of anatomical relationships, with special reference to the morphology of the walls around fluid compartments in the nervous tissue. The reader is then introduced to the physiology of the blood-brain barrier and the choroid plexus, as well as the exchange between the cerebrospinal fluid (CSF) and brain. Methods for determining the permeability of the blood-brain barrier are described. The book also explores amino acid transport mechanisms in the choroid plexus, distribution of hormones by CSF, and the physiological aspects of lactate and peptides in the CSF. Special consideration is given to the attempts to use CSF as a means of studying the chemistry, metabolism, and possible endocrine functions of the brain. This book is of interest to pharmacologists and clinicians, as well as physiologists and neurochemists.
Book Synopsis New Concepts of a Blood—Brain Barrier by : D.J. Begley
Download or read book New Concepts of a Blood—Brain Barrier written by D.J. Begley and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific contribution of Mike Bradbury to the study of the blood-brain barrier is considerable and wide-ranging, starting with his M.D. thesis in 1962 and still continuing today. The varied spectrum of topics relating to the blood-brain barrier presented in this volume and the many geographical locations from which both speakers and participants gathered to attend the symposium are a fitting testament both to Mike's wide-spread influence in the field and to the esteem in which he is held. When we first had the idea of afestschrift to mark Mike's retirement as Professor of Physiology at King's College London and the beginning of a new vie libre as scientist and yachtsman the plan was initially for a gathering of all of the many colleagues, collaborators and students who had worked with him over the years. However what we had not taken into account was the closeness of the international community of workers in the field, the widespread influence that Mike had wielded and the speed with which word would spread. We should have anticipated all three. The final outcome was an excellent symposium with the majority of the world's key workers either contributing or attending. We hope that this volume presents an adequate record of the meeting.
Book Synopsis The Blood Brain Barrier (BBB) by : Gert Fricker
Download or read book The Blood Brain Barrier (BBB) written by Gert Fricker and published by Springer. This book was released on 2014-10-24 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Book Synopsis Bioavailability of Drugs to the Brain and the Blood-brain Barrier by : Jerry Frankenheim
Download or read book Bioavailability of Drugs to the Brain and the Blood-brain Barrier written by Jerry Frankenheim and published by U.S. Government Printing Office. This book was released on 1992 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Metabolism of Brain Peptides by : Gerard O'Cuinn
Download or read book Metabolism of Brain Peptides written by Gerard O'Cuinn and published by CRC Press. This book was released on 2020-02-03 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolism of Brain Peptides discusses neuropeptide metabolism in light of recent research. It describes the processing mechanisms in the production of biologically active peptides. It details distribution of the variety of neuropeptides in the brain and comprehensively reviews the effects of these neuropeptides on behavioral and physiological functions. The book also examines termination mechanisms for the biological activities of neuropeptides in light of recent knowledge of their distribution, their receptors and their possible inactivation enzymes in various functional regions of the brain and at the blood-brain barrier.
Book Synopsis Amino Acid Availability and Brain Function in Health and Disease by : Gerald Huether
Download or read book Amino Acid Availability and Brain Function in Health and Disease written by Gerald Huether and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: The picture on the following page is being reproduced here, at the request of the partici pants in the Advanced Research Workshop "Amino Acid Availability and Brain Function in Health and Disease". I displayed this limewood carving, entitled "Neurochemistry", during my closing remarks to this extraordinarily stimulating and productive workshop so ably organized by my collaborator Dr. Gerald Huether. We scientists need two sturdy legs to carry us through all the twists and turns of our academic careers. We should also have, as it were, a reserve leg handy, to help us stay upright when this career ends. My "third leg" is wood carving. The idea for "Neurochemis try" came to me in the plane carrying me to the congress of the International Neuro chemical Society in Jerusalem. We need the hands for our meticulous experimental work, and at least one ear to listen to the messages our neurons send us. A few years ago it would have been premature to hold a workshop on this subject. Now, however, the time was just right to allow an overview of the status of current re search, and to point out the promising new openings it has created. There is no doubt that the book to be published as a result of this workshop will be, for the next years at least, the standard text on the subject. Hearty thanks to all speakers for their brilliant con tributions and to all participants for the lively, uninhibited and stimulating discussion.
