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Test No 443 Extended One Generation Reproductive Toxicity Study
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Book Synopsis Test No. 443: Extended One-Generation Reproductive Toxicity Study by : OECD
Download or read book Test No. 443: Extended One-Generation Reproductive Toxicity Study written by OECD and published by OECD Publishing. This book was released on 2011-07-28 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 415: One-Generation Reproduction Toxicity Study by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 415: One-Generation Reproduction Toxicity Study written by OECD and published by OECD Publishing. This book was released on 1983-05-26 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline for reproduction testing is designed to provide general information concerning the effects of a test substance (Solid, liquid, gas or vapour) on male and female reproductive performance. The test substance is administered orally ...
Book Synopsis How ECHA Identifies the Design for the Extended One-generation Reproductive Toxicity Study (EOGRTS) Under Dossier Evaluation by :
Download or read book How ECHA Identifies the Design for the Extended One-generation Reproductive Toxicity Study (EOGRTS) Under Dossier Evaluation written by and published by . This book was released on 2016 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extended one-generation reproductive toxicity study (EOGRTS) is a modular test method where breeding and assessment of a second filial (F2) generation and testing for developmental neurotoxicity (DNT) and developmental immunotoxicity (DIT) are distinct and independent modules. The appropriate study design needs to be defined, justified and documented. Specification is required for the: - length of the premating exposure duration and dose level selection, - need to extend Cohort 1B to include the mating of F1 animals to produce a F2 generation, - need to include the DNT cohorts, and - need to include the DIT cohort. The information sources the Agency considers crucial for defining the EOGRTS design are discussed in this document in addition to aspects of triggering the study itself and its various designs.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 443: Extended One-Generation Reproductive Toxicity Study by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 443: Extended One-Generation Reproductive Toxicity Study written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 416: Two-Generation Reproduction Toxicity by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 416: Two-Generation Reproduction Toxicity written by OECD and published by OECD Publishing. This book was released on 2001-01-22 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline for two-generation reproduction testing is designed to provide general information concerning the effects of a test substance on the integrity and performance of the male and female reproductive systems, and on the growth and ...
Book Synopsis Evaluating Results from 55 Extended One-generation Reproductive Toxicity Studies Under REACH by :
Download or read book Evaluating Results from 55 Extended One-generation Reproductive Toxicity Studies Under REACH written by and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this project was to evaluate the performance of the extended one-generation reproductive toxicity study (EOGRTS) in terms of design, conduct, analysis, and reporting, and how the results support hazard assessment in the EU regulatory context. To achieve this, the study summaries of REACH registration dossiers and the corresponding full study reports of 55 EOGRTS were evaluated. The main findings highlighted issues related to identifying effect levels and reproductive toxicants/endocrine disruptors, using the F2 generation, selecting adequate dose levels, methodological aspects, reporting issues, and proficiency for conducting investigations. While the EOGRTS was found to be generally effective in identifying substances of concern and the F2 generation was deemed useful, some methodological issues were identified. The selection of inadequate dose levels was regularly observed, and the developmental immunotoxicity (DIT) and developmental neurotoxicity (DNT) cohorts were particularly challenging in terms of test laboratory proficiency. This report also includes two sections on recommendations to support test laboratories and sponsors to improve the design, conduct, analysis, and reporting of future EOGRTS.
Book Synopsis Reproductive and Developmental Toxicology by : Ramesh C Gupta
Download or read book Reproductive and Developmental Toxicology written by Ramesh C Gupta and published by Academic Press. This book was released on 2011-04-04 with total page 1243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reproductive toxicology is a complex subject dealing with three components—parent, placenta, and fetus—and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife. Provides a complete, integrated source of information on the key risk stages during reproduction and development Includes coverage of emerging science such as stem cell application, toxicoproteomics, metabolomics, phthalates, infertility, teratogenicity, endocrine disruption, surveillance and regulatory considerations, and risk assessment Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 414: Prenatal Developmental Toxicity Study by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 414: Prenatal Developmental Toxicity Study written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to ...
Book Synopsis Test No. 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test by : OECD
Download or read book Test No. 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test written by OECD and published by OECD Publishing. This book was released on 1996-03-22 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks; females should be dosed throughout the study (approximately 54 days). Normally, matings “one male to one ...
Book Synopsis Poisonous Plants and Phytochemicals in Drug Discovery by : Andrew G. Mtewa
Download or read book Poisonous Plants and Phytochemicals in Drug Discovery written by Andrew G. Mtewa and published by John Wiley & Sons. This book was released on 2020-12-22 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career
Book Synopsis Triggering and Waiving Criteria for the Extended One-generation Reproduction Toxicity Study by : ECETOC. AISBL.
Download or read book Triggering and Waiving Criteria for the Extended One-generation Reproduction Toxicity Study written by ECETOC. AISBL. and published by . This book was released on 2008 with total page 51 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Toxicological Profile for Lead written by and published by . This book was released on 2007 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :United States. Public Health Service. Office of the Surgeon General Publisher : ISBN 13 : Total Pages :728 pages Book Rating :4.:/5 (318 download)
Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Book Synopsis Toxicological Profile for Styrene by :
Download or read book Toxicological Profile for Styrene written by and published by . This book was released on 1992 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 426: Developmental Neurotoxicity Study by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 426: Developmental Neurotoxicity Study written by OECD and published by OECD Publishing. This book was released on 2007-10-15 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ...
Book Synopsis Methods for Measuring the Toxicity and Bioaccumulation of Sediment-associated Contaminants with Freshwater Invertebrates by :
Download or read book Methods for Measuring the Toxicity and Bioaccumulation of Sediment-associated Contaminants with Freshwater Invertebrates written by and published by . This book was released on 2000 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Toxicological Profile for Nitrophenols by :
Download or read book Toxicological Profile for Nitrophenols written by and published by . This book was released on 1992 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
