Technological And Medical Implications Of Metabolic Control Analysis

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Technological and Medical Implications of Metabolic Control Analysis

Author : Athel Cornish-Bowden
Publisher : Springer Science & Business Media
ISBN 13 : 9401140723
Total Pages : 366 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Technological and Medical Implications of Metabolic Control Analysis by : Athel Cornish-Bowden

Download or read book Technological and Medical Implications of Metabolic Control Analysis written by Athel Cornish-Bowden and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two decades have passed since the mechanisms of protein synthesis became well enough understood to permit the genetic modification oforganisms. An impressive amount of new knowledge has emerged from the new technology, but much ofthe promise of20years ago has notyet been fulfilled. In biotechnology, efforts to increase the yields of commercially valuable metabolites have been less successful than ex pected, and when they have succeeded it has often been as much from selective breeding as from new methods. The cell is more complicated than what is presented in the classical teaching of biochemistry, it contains more structure than was dreamed of 20 years ago, and the behaviour ofany systemofenzymes is more elaborate than can be explained in terms ofa single supposedly rate-limiting enzyme. Even if classical enzymology and meta bolism may have seemed rather unfashionable during the rise ofmolecular biology, they remain central to any modification ofthe metabolic behaviour oforganisms. As such modification is essential in much ofbiotechnology and drug development, bio technologists can only ignore these topics at their peril.

Metabolic Engineering

Author : Sang Yup Lee
Publisher : John Wiley & Sons
ISBN 13 : 352782345X
Total Pages : 1075 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Metabolic Engineering by : Sang Yup Lee

Download or read book Metabolic Engineering written by Sang Yup Lee and published by John Wiley & Sons. This book was released on 2021-06-02 with total page 1075 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation. Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya. The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about: Metabolic engineering concepts and a historical perspective on their development The different modes of analysis, including flux balance analysis and quantitative flux analysis An illuminating and complete discussion of the thermodynamics of metabolic pathways The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.

Sensing, Signaling and Cell Adaptation

Author : J.M. Storey
Publisher : Elsevier
ISBN 13 : 0080541070
Total Pages : 357 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Sensing, Signaling and Cell Adaptation by : J.M. Storey

Download or read book Sensing, Signaling and Cell Adaptation written by J.M. Storey and published by Elsevier. This book was released on 2002-09-16 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume of Cell and Molecular Responses to Stress articles provide up-to-date information on key areas of signal sensing (sensing of pain, heat, cold, light, infrared radiation), molecules involved in the intracellular transmission of these signals, metabolic responses to stress including changes in gene expression and production of specialized proteins that aid cell responses to factors including interrupted blood supply (ischemia), oxygen limitation (hypoxia/anoxia), freezing and dehydration, amino acid limitation, radiation and processing drugs. There are chapters which also provide insights into new technologies (such as cDNA arrays), analysis of metabolic control theory (a key method for analysing stress effects on cells), and examine how enzymes evolve in the face of stress.

Metabolome Analyses:

Author : Seetharaman Vaidyanathan
Publisher : Springer Science & Business Media
ISBN 13 : 0387252401
Total Pages : 396 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Metabolome Analyses: by : Seetharaman Vaidyanathan

Download or read book Metabolome Analyses: written by Seetharaman Vaidyanathan and published by Springer Science & Business Media. This book was released on 2006-03-20 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolome analysis is now recognized as a crucial component of functional genomic and systems biology investigations. Innovative approaches to the study of metabolic regulation in microbial, plant and animal systems are increasingly facilitating the emergence of systems approaches in biology. This book highlights analytical and bioinformatics strategies now available for investigating metabolic networks in microbial, plant and animal systems. The contributing authors are world leaders in this field and they present an unambiguous case for pursuing metabolome analysis as a means to attain a systems level understanding of complex biological systems.

The Scientist's Guide to Cardiac Metabolism

Author : Michael Schwarzer
Publisher : Academic Press
ISBN 13 : 0128026146
Total Pages : 241 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Scientist's Guide to Cardiac Metabolism by : Michael Schwarzer

Download or read book The Scientist's Guide to Cardiac Metabolism written by Michael Schwarzer and published by Academic Press. This book was released on 2015-11-04 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease. Provides a quick and comprehensive introduction into cardiac metabolism Contains an integrated view on cardiac metabolism and its interrelation in metabolism with other organs Presents insights into substrate metabolism in relation to intracellular organization and structure as well as whole organ function Includes historical perspectives that reference important investigators that have contributed to the development of the field

Metabolomics

Author : Ute Roessner
Publisher : BoD – Books on Demand
ISBN 13 : 9535100467
Total Pages : 378 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Metabolomics by : Ute Roessner

Download or read book Metabolomics written by Ute Roessner and published by BoD – Books on Demand. This book was released on 2012-02-10 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolomics is a rapidly emerging field in life sciences, which aims to identify and quantify metabolites in a biological system. Analytical chemistry is combined with sophisticated informatics and statistics tools to determine and understand metabolic changes upon genetic or environmental perturbations. Together with other 'omics analyses, such as genomics and proteomics, metabolomics plays an important role in functional genomics and systems biology studies in any biological science. This book will provide the reader with summaries of the state-of-the-art of technologies and methodologies, especially in the data analysis and interpretation approaches, as well as give insights into exciting applications of metabolomics in human health studies, safety assessments, and plant and microbial research.

Metabolic Engineering in the Post Genomic Era

Author : Boris N. Kholodenko
Publisher : Garland Science
ISBN 13 : 9780954523220
Total Pages : 472 pages
Book Rating : 4.5/5 (232 download)

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Book Synopsis Metabolic Engineering in the Post Genomic Era by : Boris N. Kholodenko

Download or read book Metabolic Engineering in the Post Genomic Era written by Boris N. Kholodenko and published by Garland Science. This book was released on 2004 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Horizon Scientific Press titles focus on high-level microbiology and molecular biology topics. Written by internationally renowned and highly respected leaders in the field, titles in this series comprise of review manuals, practical manuals, and reference texts for research scientists, bioscience professionals and graduate students. Engineering living cells continues to pose immense challenges to the researcher. In fact many bioengineers have only just started to appreciate the full extent of the hierarchical control used by living systems: upon attempts to increase the activity of a "rate-limiting" step, the multiple feedbacks at the metabolic, signaling and genetic levels result in the rate limiting step shifting to elsewhere in that pathway or even to elsewhere in the whole organism. The advent of full-force genomics should enable preventing this response, however, it has been difficult for researchers to know where to turn for guidance. This book aims to help the reader understand and deal with the plasticity of living cell factories and to turn the plasticity into the desired rather than the adverse direction. The book brings together all the recent, most important breakthroughs in this exciting field: Internationally renowned key scientists have reviewed each topic in detail. In the Introduction, the editors give an overview of new approaches and spell out what the engineer and the industry may now really begin to aim for; they even adapt the definition of metabolic engineering to befit the post-genomics era. Other topics included are: the experimental approaches necessary to understand cellular regulation at all of its hierarchical levels, including proteomics [Chapter 2], metabolomics [Chapter 3] and fluxomics [Chapter 4]; new tools that help metabolic engineering [Chapters 5-7]; modeling of living cells, e.g. finding metabolic pathways [Chapter 8] and comparing the actual and predicted use of these in living organisms such as E. coli and Corynebacteria [Chapters 9, 10]; the optimization of cell factories as production organisms (e.g., use of whole cell models, silicon cells, and coordinate manipulation of multiple genes [Chapters 12-15]). A chapter on future perspectives directs further developments of the field in the near future. Metabolic Engineering in the Post Genomic Erais an essential reading for everyone with an interest in engineering living cells including: Metabolic egnineers, bioengineers, biotechnologists, molecular biologists, and pharmaceutical and biotechnology companies.

Antimicrobial Resistance

Author : R Lawrence
Publisher : ALPHA SCIENCE INTERNATIONAL LIMITED
ISBN 13 : 8184874715
Total Pages : 422 pages
Book Rating : 4.1/5 (848 download)

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Book Synopsis Antimicrobial Resistance by : R Lawrence

Download or read book Antimicrobial Resistance written by R Lawrence and published by ALPHA SCIENCE INTERNATIONAL LIMITED. This book was released on 2013-05-13 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the pursuit of tackling the menace of antimicrobial resistance, egressed this groovy compilation contributed by eminent scientists, medical fraternity, agriculturists, environmentalists, microbiologists, pharmacologists, computational biologists, stakeholders, policy makers and industrialists in this field. As the drivers of antimicrobial resistance are multifarious, the volume illustrates the prevalence of resistance among microbes of human and animal origin, various perspectives in the resistance flux with modern agricultural practices, distribution of resistance genes in the environment, challenges in pharmacodynamic studies, pro-drug delivery systems, computational simulation approaches in drug development against resistant microbial pathogens and regulatory aspects of antimicrobial resistance. The book gives a better understanding to analyse the present scenario of antimicrobial resistance, interpret the trends and identify the strategies to prevent or control the menace. It will be a source of inspiration to the leading drug developers and can also serve as a vehicle for elucidation of national policy guidelines.

Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods

Author : Debasis Bagchi
Publisher : John Wiley & Sons
ISBN 13 : 0813821320
Total Pages : 370 pages
Book Rating : 4.8/5 (138 download)

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Book Synopsis Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods by : Debasis Bagchi

Download or read book Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods written by Debasis Bagchi and published by John Wiley & Sons. This book was released on 2010-02-04 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nutraceutical and functional food field is rapidly growing in diverse sectors, including academic, commercial and government. This has brought a corresponding shift in research focus and in public awareness. Understanding the relevance of the scientific principles in determining the safety and effectiveness of functional foods and nutraceuticals is increasingly important. It is becoming increasingly evident that genomic research technologies will be used in the coming years and there is a need to provide resources that will facilitate this growth. This book incorporates the most recent advances in the three major sectors of the field within one volume. Genomics, proteomics, and metobolomics represent three major scientific research areas that contribute to nutraceutical and functional food research for studies of effectiveness and safety.

Systems Biology

Author : Fred Boogerd
Publisher : Elsevier
ISBN 13 : 9780080475271
Total Pages : 360 pages
Book Rating : 4.4/5 (752 download)

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Book Synopsis Systems Biology by : Fred Boogerd

Download or read book Systems Biology written by Fred Boogerd and published by Elsevier. This book was released on 2007-03-20 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecedented in its combination of biology with a great many other sciences, from physics to ecology, from mathematics to medicine, and from philosophy to chemistry. Studying the philosophical foundations of systems biology may resolve a longer standing issue, i.e., the extent to which Biology is entitled to its own scientific foundations rather than being dominated by existing philosophies. * Answers the question of what distinguishes the living from the non-living * An in-depth look to a vigorous and expanding discipline, from molecule to system * Explores the region between individual components and the system

Nuclear Magnetic Resonance

Author : G A Webb
Publisher : Royal Society of Chemistry
ISBN 13 : 1847553877
Total Pages : 550 pages
Book Rating : 4.8/5 (475 download)

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Book Synopsis Nuclear Magnetic Resonance by : G A Webb

Download or read book Nuclear Magnetic Resonance written by G A Webb and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a spectroscopic method, Nuclear Magnetic Resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Acids" and "NMR of Carbohydrates, Lipids and Membranes". For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an in valuable source of current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.

Fundamental Bioengineering

Author : John Villadsen
Publisher : John Wiley & Sons
ISBN 13 : 3527336745
Total Pages : 576 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Fundamental Bioengineering by : John Villadsen

Download or read book Fundamental Bioengineering written by John Villadsen and published by John Wiley & Sons. This book was released on 2016-02-23 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thorough introduction to the basics of bioengineering, with a focus on applications in the emerging "white" biotechnology industry. As such, this latest volume in the "Advanced Biotechnology" series covers the principles for the design and analysis of industrial bioprocesses as well as the design of bioremediation systems, and several biomedical applications. No fewer than seven chapters introduce stoichiometry, kinetics, thermodynamics and the design of ideal and real bioreactors, illustrated by more than 50 practical examples. Further chapters deal with the tools that enable an understanding of the behavior of cell cultures and enzymatically catalyzed reactions, while others discuss the analysis of cultures at the level of the cell, as well as structural frameworks for the successful scale-up of bioreactions. In addition, a short survey of downstream processing options and the control of bioreactions is given. With contributions from leading experts in industry and academia, this is a comprehensive source of information peer-reviewed by experts in the field.

Functional Metabolism

Author : Kenneth B. Storey
Publisher : John Wiley & Sons
ISBN 13 : 0471675571
Total Pages : 640 pages
Book Rating : 4.4/5 (716 download)

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Book Synopsis Functional Metabolism by : Kenneth B. Storey

Download or read book Functional Metabolism written by Kenneth B. Storey and published by John Wiley & Sons. This book was released on 2005-02-25 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Metabolism of Cells is the first comprehensive survey of metabolism, offering an in-depth examination of metabolism and regulation of carbohydrates, lipids, and amino acids. It provides a basic background on metabolic regulation and adaptation as well as the chemical logic of metabolism, and covers the interrelationship of metabolism to life processes of the whole organism. The book lays out a structured approach to the metabolic basis of disease, including discussion of the normal pathways of metabolism, altered pathways leading to disease, and use of molecular genetics in diagnosis and treatment of disease. It also takes a unique comparative approach in which human metabolism is a reference for metabolism in microorganisms and plant design, and presents novel coverage of development and aging, and human health and animal adaptation. The final chapter reviews the past and future promise of new genetic approaches to treatment and bioinformatics. This, the most exhaustive treatment of metabolism currently available, is a useful text for advanced undergraduates and graduates in biochemistry, cell/molecular biology, and biomedicine, as well as biochemistry instructors and investigators in related fields.

Metabolic Engineering

Author : Jens Nielsen
Publisher : Springer
ISBN 13 : 3540453008
Total Pages : 193 pages
Book Rating : 4.5/5 (44 download)

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Book Synopsis Metabolic Engineering by : Jens Nielsen

Download or read book Metabolic Engineering written by Jens Nielsen and published by Springer. This book was released on 2003-07-03 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic engineering is a rapidly evolving field that is being applied for the optimization of many different industrial processes. In this issue of Advances in Biochemical Engineering/Biotechnology, developments in different areas of metabolic engineering are reviewed. The contributions discuss the application of metabolic engineering in the improvement of yield and productivity - illustrated by amino acid production and the production of novel compounds - in the production of polyketides and extension of the substrate range - and in the engineering of S. cerevisiae for xylose metabolism, and the improvement of a complex biotransformation process.

Bioanalysis and Biosensors for Bioprocess Monitoring

Author : Bernhard Sonnleitner
Publisher : Springer
ISBN 13 : 3540487735
Total Pages : 257 pages
Book Rating : 4.5/5 (44 download)

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Book Synopsis Bioanalysis and Biosensors for Bioprocess Monitoring by : Bernhard Sonnleitner

Download or read book Bioanalysis and Biosensors for Bioprocess Monitoring written by Bernhard Sonnleitner and published by Springer. This book was released on 2003-06-30 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts

Polysaccharides

Author : Inamuddin
Publisher : John Wiley & Sons
ISBN 13 : 111971138X
Total Pages : 786 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Polysaccharides by : Inamuddin

Download or read book Polysaccharides written by Inamuddin and published by John Wiley & Sons. This book was released on 2021-06-29 with total page 786 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the whole spectrum of polysaccharides from basic concepts to commercial market applications. Chapters cover various types of sources, classification, properties, characterization, processing, rheology and fabrication of polysaccharide-based materials and their composites and gels. The applications of polysaccharides include in cosmetics, food science, drug delivery, biomedicine, biofuel production, marine, packaging, chromatography and environmental remediation. It also reviews the fabrication of inorganic and carbon nanomaterials from polysaccharides. The book incorporates industrial applications and will fill the gap between the exploration works in the laboratory and viable applications in related ventures.

Advances in Microbial Physiology

Author :
Publisher : Elsevier
ISBN 13 : 008046050X
Total Pages : 312 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Advances in Microbial Physiology by :

Download or read book Advances in Microbial Physiology written by and published by Elsevier. This book was released on 2005-10-21 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Microbial Physiology is one of the most successful and prestigious series from Academic Press, an imprint of Elsevier. It publishes topical and important reviews, interpreting physiology to include all material that contributes to our understanding of how microorganisms and their component parts work.First published in 1967, it is now in its 50th volume. The Editors have always striven to interpret microbial physiology in the broadest context and have never restricted the contents to “traditional views of whole cell physiology. Now edited by Professor Robert Poole, University of Sheffield, Advances in Microbial Physiology continues to be an influential and very well reviewed series. In 2004, the Institute for Scientific Information released figures showing that the series had an Impact Factor of 8.947, with a half-life of 6.3 years, placing it 5th in the highly competitive category of Microbiology.