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Systemic Lupus Erythematosus Pathogenesis And Management
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Book Synopsis Systemic Lupus Erythematosus - Pathogenesis and Management by : Sophia Lionaki
Download or read book Systemic Lupus Erythematosus - Pathogenesis and Management written by Sophia Lionaki and published by Intechopen. This book was released on 2023-08-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Edited Volume "Systemic Lupus Erythematosus - Pathogenesis" and Management" is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of lupus erythematosus. The book comprises single chapters authored by various researchers and edited by an expert active in the lupus research area. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on lupus, and open new possible research paths for further novel developments.
Book Synopsis Systemic Lupus Erythematosus: Pathogenesis and Treatment by : Jasper Meyer
Download or read book Systemic Lupus Erythematosus: Pathogenesis and Treatment written by Jasper Meyer and published by American Medical Publishers. This book was released on 2021-11-16 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic lupus erythematosus (SLE) is a medical condition whereby the body's natural defense system targets the healthy tissues of the body. SLE is caused by a defect of the immune system that may arise due to a genetic susceptibility coupled with an environmental trigger. Vitamin D deficiency is another factor associated with lupus. Genetic studies show that SLE is an oligogenic trait with multiple genes contributing to it. The immune response once triggered produces antibodies against itself, and specifically the proteins in the cell nucleus. Since SLE involves a number of different organ systems and exhibit a multitude of symptoms, its treatment is ideally based on its severity. The treatment of SLE is aimed at preventing flares, reducing the severity of flares and their duration when they occur. Treatment can comprise of anti-malarial drugs, immunosuppressive drugs, analgesics and intravenous immunoglobulins. This book contains some path-breaking studies in systemic lupus erythematosus. Also included in this book is a detailed explanation of the pathogenesis and treatment of systemic lupus erythematosus. The topics covered herein offer the readers new insights in this condition.
Book Synopsis Cohort Studies in Health Sciences by : René Mauricio Barría
Download or read book Cohort Studies in Health Sciences written by René Mauricio Barría and published by . This book was released on 2018-09 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pathogenesis of Systemic Lupus Erythematosus by : Alberta Hoi
Download or read book Pathogenesis of Systemic Lupus Erythematosus written by Alberta Hoi and published by Springer Nature. This book was released on 2021-11-15 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.
Download or read book Lupus written by Sophia Lionaki and published by BoD – Books on Demand. This book was released on 2020-03-25 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic lupus erythematosus, the prototype of an autoimmune disorder, may affect several organs and may run a chronic course between relapse and remission. This book covers important aspects of the disease, including epidemiology, pathophysiology, and neuropsychiatric manifestations, including basic science and clinical features and management. In affected patients, the fundamental problem of fertility is reassessed including the risk of the disease, the possibility of fetal loss, the safety of drugs during pregnancy, and the current diagnostic and suggested therapeutic strategies of reproductive medicine. Finally, the issue of pathogenesis is revisited with a thorough description of animal models in relation to physiology and potential novel therapies.
Book Synopsis Neuropsychiatric Systemic Lupus Erythematosus by : Shunsei Hirohata
Download or read book Neuropsychiatric Systemic Lupus Erythematosus written by Shunsei Hirohata and published by Springer. This book was released on 2018-12-28 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropsychiatric manifestation in systemic lupus erythematosus (NPSLE) is one of the most recalcitrant complications of the disease. According to the 1999 ACR nomenclature and case definitions, diffuse psychiatric/neuropsychological syndromes in NPSLE (anxiety disorder, acute confusional state, cognitive dysfunction, mood disorder, psychosis) (diffuse NPSLE) present psychiatric manifestations unlike neurologic syndromes (focal NPSLE) originating from focal CNS lesions, such as cerebrovascular disease, demyelinating syndrome, headache, aseptic meningitis, chorea, seizures and myelopathy. A number of studies have reported that diffuse NPSLE is usually associated with the presence of autoantibodies against neuronal cells in serum as well as in cerebrospinal fluid (CSF). Moreover, IL-6 has been shown to be elevated in CSF of patients with diffuse NPSLE. Recently, it has been demonstrated that the severity of blood-brain barrier damages plays a crucial role in the development of acute confusional state, the severest form of diffuse NPSLE through the accelerated entry of larger amounts of autoantibodies to NMDA receptor subunit NR2 into the CNS. Since the importance of autoantibodies in the NPSLE has been now evident, such an aggressive treatment, especially B cell depleting therapy, would make sense in that it would reduce the levels of pathogenic autoantibodies, leading to a better prognosis of NPSLE. As far as we know, no single book specifically dedicated to NPSLE alone has been published as yet. As mentioned above, NPSLE constitutes a vastly expanding field of research with increasing numbers of papers published annually. Therefore, we believe that an effort to collect and critically review these publications is invaluable. Such an effort will provide an important contribution to basic researchers as well as clinicians working in the field of neurology, rheumatology, psychiatry and internal medicine fields.
Author :Ns. Arif Rohman Mansur, S.Kep., M.Kep. Publisher :PENERBIT KBM INDONESIA ISBN 13 :6234999018 Total Pages :154 pages Book Rating :4.2/5 (349 download)
Book Synopsis SYSTEMIC LUPUS ERYTHEMATOSUS: A Comprehensive Guide by : Ns. Arif Rohman Mansur, S.Kep., M.Kep.
Download or read book SYSTEMIC LUPUS ERYTHEMATOSUS: A Comprehensive Guide written by Ns. Arif Rohman Mansur, S.Kep., M.Kep. and published by PENERBIT KBM INDONESIA. This book was released on 2024-08-14 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic Lupus Erythematosus: A Comprehensive Guide, authored by Ns. Arif Rohman Mansur S.Kep., M.Kep., provides an in-depth exploration of Systemic Lupus Erythematosus (SLE), a multifaceted autoimmune disorder affecting multiple organ systems. The book starts with a clear definition of SLE, detailing its characteristics and its impact on various bodily systems. It includes a historical overview, tracing the recognition of the disease and scientific advancements that have informed current understanding and treatment. The guide comprehensively covers the genetic, environmental, hormonal, and immunological factors that predispose individuals to Lupus, offering insight into the disease’s triggers and exacerbating factors. It provides a detailed examination of symptoms categorized by affected organ systems, such as skin, joints, kidneys, and the nervous system, to give readers a thorough understanding of its manifestations. Diagnostic criteria are meticulously outlined, with descriptions of the latest advancements in serological tests and imaging studies aiding in early detection and accurate diagnosis. Treatment strategies are extensively covered, discussing conventional medications like NSAIDs and corticosteroids, alongside newer biologic agents and lifestyle adjustments crucial for symptom management and improving patient outcomes. The book also addresses potential complications associated with Lupus and factors influencing its prognosis, emphasizing the importance of regular medical monitoring and personalized treatment plans. Through this detailed guide, Ns. Mansur educates healthcare professionals and patients about SLE and empowers them with the knowledge to improve outcomes and enhance the quality of life for those affected by this challenging disease.
Book Synopsis Systemic Lupus Erythematosus by : Robert G. Lahita
Download or read book Systemic Lupus Erythematosus written by Robert G. Lahita and published by Academic Press. This book was released on 2010-10-29 with total page 1155 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic lupus erythematosus (S.L.E.), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment is the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, anti-malarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, similar to those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well regarded reference which combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries. Highly illustrated and in full color throughout Basic science section expanded to allow the reader to focus on the newest techniques in molecular medicine and its effects on disease expression and treatment Clinical aspects and new drugs will be covered in great detail providing a useful reference to both experienced clinicians and physicians with an interest in lupus in their clinical practice
Book Synopsis Systemic Lupus Erythematosus - Predisposition Factors, Pathogenesis, Diagnosis, Treatment and Disease Models by : Kutty Selva Nandakumar
Download or read book Systemic Lupus Erythematosus - Predisposition Factors, Pathogenesis, Diagnosis, Treatment and Disease Models written by Kutty Selva Nandakumar and published by Frontiers Media SA. This book was released on 2023-01-30 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Systemic Lupus Erythematosus by : George C. Tsokos
Download or read book Systemic Lupus Erythematosus written by George C. Tsokos and published by Elsevier Health Sciences. This book was released on 2007-01-01 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find 'one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment. Provides the very latest understanding of the pathogenesis of SLE. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more. Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage. Contains expert discussion of processes that are responsible for tissue injury - a hallmark of this text. Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAP's, and therapies on the horizon. Discusses the latest treatment options on disease modifying or disease controlling agents.
Book Synopsis Systemic Lupus Erythematosus E-Book by : George Tsokos
Download or read book Systemic Lupus Erythematosus E-Book written by George Tsokos and published by Elsevier Health Sciences. This book was released on 2007-02-23 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find ‘one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment. Provides the very latest understanding of the pathogenesis of SLE. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more. Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage. Contains expert discussion of processes that are responsible for tissue injury - a hallmark of this text. Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAP's, and therapies on the horizon. Discusses the latest treatment options on disease modifying or disease controlling agents.
Download or read book Systemic Lupus Erythematosus written by and published by . This book was released on 2017 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Lahita's Systemic Lupus Erythematosus by : Robert G. Lahita
Download or read book Lahita's Systemic Lupus Erythematosus written by Robert G. Lahita and published by Academic Press. This book was released on 2021-07-23 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness.To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries. Completely updated, revised, and expanded with the most comprehensive and accessible reference on SLE for clinicians and scientists Full-color presentation throughout the book Provides the latest information available on diagnosis and treatment Incorporates an international panel of authors who are experts in their fields, with an emphasis on young, cutting-edge scientists and physicians
Book Synopsis Lupus Erythematosus by : Peter H. Schur
Download or read book Lupus Erythematosus written by Peter H. Schur and published by Springer Science & Business Media. This book was released on 2012-07-06 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Often considered the prototypic autoimmune disease, Lupus is characterized by protean manifestations and affects a wide range of organ systems. Despite widespread availability of anti nuclear antibody testing and other technological diagnostic advances, the diagnosis of lupus can be elusive, difficult, and inexact. Treatment of the disease can also be challenging. Advances in immunology and biotechnology have led to a burgeoning world of new therapies in development that offer patients the real possibility of new therapies and physicians and scientists novel insights into the pathogenesis of this complicated immunological disease. Lupus Erythematosus: Clinical Evaluation and Treatment summarizes the clinical aspects of lupus facing the general clinician in the 21st century. In this invaluable, practical book, the reader will find introductory chapters regarding general diagnostic and treatment principles, followed by chapters addressing the lupus-specific organ manifestations. Special topics regarding pregnancy and comorbidities are also presented. Written by highly experienced physicians with special expertise in lupus, Lupus Erythematosus: Clinical Evaluation and Treatment is an indispensable reference for the common and not so common problems affecting patients with lupus.
Book Synopsis Systemic Lupus Erythematosus by : George Tsokos
Download or read book Systemic Lupus Erythematosus written by George Tsokos and published by Academic Press. This book was released on 2016-02-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic Lupus Erythematosus combines basic science with clinical science to provide a translational treatment of the disease and is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.
Book Synopsis Systemic Lupus Erythematosus by : George Tsokos
Download or read book Systemic Lupus Erythematosus written by George Tsokos and published by Academic Press. This book was released on 2020-04-07 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: This completely updated and expanded 2nd edition of Systemic Lupus Erythematosus, A Manual includes topics not covered previously with contributors who are at the forefront of each specific topic and with a global appeal. Each chapter is short and is presented critically with selected references, which should be valuable to a wider audience. This book combines basic with clinical science to help internists and specialists in the diagnosis and management of patients with SLE. It is a quick referral for people in the pharmaceutical industry in their efforts to bring much-needed drugs. It provides all the needed information to basic researchers old and new alike, who wish to enter the field of lupus and systemic autoimmunity in general. Focused state-of-the-art chapters prepared by top-notch experts in the field Latest understanding of cellular, molecular, biochemical aspects of disease pathogenesis Advanced aspects of genetic, microbiome, environmental, hormonal, and immunological contribution to the expression of the disease Current understanding of clinical features of the disease Recent efforts to develop new treatments
Book Synopsis Dubois' Lupus Erythematosus and Related Syndromes - E-Book by : Daniel Wallace
Download or read book Dubois' Lupus Erythematosus and Related Syndromes - E-Book written by Daniel Wallace and published by Elsevier Health Sciences. This book was released on 2018-08-16 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 50 years, Dubois’ Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It’s an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes. Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients. Offers an increased focus on the clinical management of related disorders such as Sjogren’s syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS). Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment. Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout.
