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Synthetic Methods For Biologically Active Molecules
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Book Synopsis Modern Tools for the Synthesis of Complex Bioactive Molecules by : Janine Cossy
Download or read book Modern Tools for the Synthesis of Complex Bioactive Molecules written by Janine Cossy and published by John Wiley & Sons. This book was released on 2012-10-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: All the latest tools needed to plan and perform the synthesis of complex bioactive molecules Focusing on organic, organometallic, and bio-oriented processes, this book explores the impact and use of the latest synthetic tools for the synthesis of complex biologically active compounds. Readers will discover step by step how these synthetic tools have provided new, elegant solutions to many synthetic puzzles. Moreover, they will discover innovative methods that make it possible to control the exact connectivity of atoms within a molecule in order to set precise three-dimensional arrangements. Modern Tools for the Synthesis of Complex Bioactive Molecules features sixteen chapters, each one written by one or more leading experts in organic synthesis from around the world. It covers a broad range of topics that enable readers to take advantage of the latest methods for synthesizing complex molecules, including: Modern catalysis, emphasizing key transformations such as C-H functionalizations, cross-couplings, gold-catalyzed reactions, metathesis-based syntheses, and asymmetric organocatalysis Eco-compatible transformations, including rearrangements and domino reactions Tools for the synthesis of carbohydrates and alkaloids New techniques, including the use of fluorous tags and engineered biosynthesis The last two chapters explore target- and diversity-oriented organic synthesis as well as the use of DNA-based asymmetric catalysis, which are all promising tools for the successful synthesis of complex bioactive molecules. Modern Tools for the Synthesis of Complex Bioactive Molecules is ideal for students and researchers who need to plan and perform the synthesis of complex molecules as efficiently as possible. The book's expert advice will help these readers quickly resolve a broad range of problems that can arise in organic syntheses.
Book Synopsis Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules by : Yuichi Kobayashi
Download or read book Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules written by Yuichi Kobayashi and published by Springer. This book was released on 2020-08-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.
Book Synopsis Synthetic Methods for Biologically Active Molecules by : Elisabetta Brenna
Download or read book Synthetic Methods for Biologically Active Molecules written by Elisabetta Brenna and published by John Wiley & Sons. This book was released on 2013-08-29 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This useful reference focuses on the currently available toolbox of bio-catalysed reductions of C=O, C=C and formal C=N bonds to show which transformations can be reliably used in manufacturing processes and which still require improvements. Following an introductory chapter, chapters 2-4 present the synthetic strategies that are currently available for the reduction of C=C and C=O bonds and for reductive amination, by means of whole-cell catalysts and isolated enzymes. Chapters 5-7 go on to describe the improvements achieved thus far, illustrating the current versatility of enzymes in organic synthesis. Chapters 8-12 present the improvements brought about by the optimization of reaction conditions, and the use of particular synthetic sequences. The final chapter describes practical applications of bio-reductions for the synthesis of active pharmaceutical ingredients. With its excellent and comprehensive overview, this book will be of great interest to those working in academia and industry. From the contents: * Development of Sustainable Biocatalyzed Reduction Processes for Organic Chemists * Reductases: From Natural Diversity to Biocatalysis and Emerging Enzymatic Activities. * Synthetic Strategies Based on C=C Bioreductions * Synthetic Strategies Based on C=O Bioreductions * Development of Novel Enzymes for the Improved Reduction of C=C Double Bonds * Development of Novel Enzymes for the Improved Reduction of C=O Double Bonds * Synthetic Applications of Aminotransferases * Strategies for Cofactor Regeneration in Biocatalyzed Reductions * Effects of Solvent System and Substrate Loading in Bioreduction * Perspectives in the Use of In-Situ Product Removal (ISPR) Techniques in Bioreductions * Multi-Enzymatic Cascade Reactions Based on Reduction Processes * Relevant Practical Applications of Bioreduction Processes in the Synthesis of Active Pharmaceutical Ingredients
Book Synopsis Modern Tools for the Synthesis of Complex Bioactive Molecules by : Janine Cossy
Download or read book Modern Tools for the Synthesis of Complex Bioactive Molecules written by Janine Cossy and published by John Wiley & Sons. This book was released on 2012-09-04 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: All the latest tools needed to plan and perform the synthesisof complex bioactive molecules Focusing on organic, organometallic, and bio-oriented processes,this book explores the impact and use of the latest synthetic toolsfor the synthesis of complex biologically active compounds. Readerswill discover step by step how these synthetic tools have providednew, elegant solutions to many synthetic puzzles. Moreover, theywill discover innovative methods that make it possible to controlthe exact connectivity of atoms within a molecule in order to setprecise three-dimensional arrangements. Modern Tools for the Synthesis of Complex BioactiveMolecules features sixteen chapters, each one written by one ormore leading experts in organic synthesis from around the world. Itcovers a broad range of topics that enable readers to takeadvantage of the latest methods for synthesizing complex molecules,including: Modern catalysis, emphasizing key transformations such as C-Hfunctionalizations, cross-couplings, gold-catalyzed reactions,metathesis-based syntheses, and asymmetric organocatalysis Eco-compatible transformations, including rearrangements anddomino reactions Tools for the synthesis of carbohydrates and alkaloids New techniques, including the use of fluorous tags andengineered biosynthesis The last two chapters explore target- and diversity-orientedorganic synthesis as well as the use of DNA-based asymmetriccatalysis, which are all promising tools for the successfulsynthesis of complex bioactive molecules. Modern Tools for the Synthesis of Complex BioactiveMolecules is ideal for students and researchers who need toplan and perform the synthesis of complex molecules as efficientlyas possible. The book's expert advice will help these readersquickly resolve a broad range of problems that can arise in organicsyntheses.
Book Synopsis Biologically Active Molecules by : Urs P. Schlunegger
Download or read book Biologically Active Molecules written by Urs P. Schlunegger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past few years there has been a remarkable and rapid development of modern analytical methods, and the fields of nuclear magnetic resonance and mass spectrometry have been no exception. In addition to being able to do "more and faster", new innovative techniques have also arisen to contribute to a growing understanding of the relationship between chemical structure and biological activity. In order to explore a few of the more interesting points of those developments and applications, a seminar "From Biological Activity to Structure" was organized from September 5-7, 1988, at Interlaken. The four invited speakers, Richard M. Caprioli, Howard R. Morris, Wolfgang Steglich and Dudley H. Williams were kind enough to attend and discuss many facets of their research, especially methodological and technical developments and their applications to specific problems. Participants were introduced to continuous flow FAB (fast atom bombardment) and its use, for example, in the real time monitoring of biochemical reactions in vitro and in vivo; the structural elucidation of secondary metabolites from fungi; the analysis of molecule-receptor interactions; the determination of posttranslational modifications of peptides; and the location of S-S bridges in determining the tertiary structure of proteins.
Book Synopsis Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules by : Yuichi Kobayashi
Download or read book Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules written by Yuichi Kobayashi and published by Springer. This book was released on 2019-05-30 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.
Book Synopsis Biotechnological Production of Bioactive Compounds by : Madan L. Verma
Download or read book Biotechnological Production of Bioactive Compounds written by Madan L. Verma and published by Elsevier. This book was released on 2019-07-20 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotechnological Production of Bioactive Compounds provides insights on the most recent innovations, trends, concerns, solutions and practical challenges encountered in the fields of enzyme technology and nanobiotechnology for the production of bioactive materials with extra health benefits. As nanobiotechnology has improved the bioactive extraction process significantly, many bioactives, including bioflavonoids, omega-3 fatty acids, biopigments and low calorie sugar substitutes are a pivotal part of the food industry. The book highlights the production of extra health benefits “bioactives’’ from plants and microbes and explains how the extraction efficiency of bioactives molecules improves significantly with the recent advances in nanobiotechnology. Researchers in the fields of biochemical engineering, biotechnology, bioremediation, environmental sustainability and those in pharma industries will find the information in this book very helpful and illuminating. Outlines technological advances in bioactives extraction Covers bioflavonoids, biopigments, omega-3-fatty acids and low sugar substitutes Explains the mechanisms of Green cargo (biogenic nanoparticles) for the delivery of bioactive molecules
Book Synopsis Green Synthetic Approaches for Biologically Relevant Heterocycles by : Goutam Brahmachari
Download or read book Green Synthetic Approaches for Biologically Relevant Heterocycles written by Goutam Brahmachari and published by Elsevier. This book was released on 2021-02-26 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field of greener heterocycle synthesis Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches Presents information in an accessible style with an emphasis on sustainability
Book Synopsis Beyond the Molecular Frontier by : National Research Council
Download or read book Beyond the Molecular Frontier written by National Research Council and published by National Academies Press. This book was released on 2003-03-19 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.
Book Synopsis Exercises in Organic Synthesis Based on Synthetic Drugs by : Marcus Vinícius Nora de Souza
Download or read book Exercises in Organic Synthesis Based on Synthetic Drugs written by Marcus Vinícius Nora de Souza and published by Bentham Science Publishers. This book was released on 2020-12-23 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exercises in Organic Synthesis Based on Synthetic Drugs presents information on topics about the synthesis of biologically active compounds which are used against a range of diseases in both humans and animals. Topics are supplemented by notes and exercises for students to stimulate inquiry and learning in the academic environment. Readers will be equipped with basic knowledge of synthetic techniques used in organic chemistry and pharmaceutical research and development. Key Features: - Presents information about different techniques and strategies for the synthesis of organic compounds - Covers a broad range of biologically active compounds - Easy to read topical presentation - Exercises, with answers, designed for improving concepts in organic synthesis and medicinal chemistry - Wide range of bibliographic references for further reading and exercises presented, Exercises in Organic Synthesis Based on Synthetic Drugs is an essential textbook for students in beginner level courses in organic chemistry, organic synthesis and medicinal chemistry.
Book Synopsis Asymmetric Synthesis with Chemical and Biological Methods by : Dieter Enders
Download or read book Asymmetric Synthesis with Chemical and Biological Methods written by Dieter Enders and published by John Wiley & Sons. This book was released on 2007-06-27 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by two of the leading researchers in the field, this book provides a deep, interdisciplinary insight into stoichiometric and catalytic reactions in this continuously expanding area. A plethora of top German scientists with an international reputation covers various aspects, from classical organic chemistry to process development, and from the theoretical background to biological methods using enzymes. Throughout the focus is on the development of new synthetic methods in asymmetric synthesis, the synthesis of natural and bioactive compounds and the latest developments in both chemical and biological methods of catalysis, as well as the investigation of special technical and biotechnical aspects.
Book Synopsis Chemical and Biological Synthesis by : Nick J Westwood
Download or read book Chemical and Biological Synthesis written by Nick J Westwood and published by Royal Society of Chemistry. This book was released on 2018-08-16 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic chemistry plays a central role in many areas of chemical biology; utilising recent case studies, the goal of Chemical and Biological Synthesis is to highlight the full impact that the preparation of novel reagents can have in chemical biology. Covering the synthetic approaches that can be applied across the whole field of chemical biology, this book provides synthetic chemists with the broader context to which their work contributes and the biological questions that can be addressed through it. An ideal guide for postgraduate students and researchers in synthetic organic chemistry and chemical biology, Chemical and Biological Synthesis introduces synthetic techniques and methods to those who wish to incorporate synthesis for the first time in their biology-focused research programmes.
Book Synopsis Green Synthetic Approaches for Biologically Relevant Heterocycles by : Goutam Brahmachari
Download or read book Green Synthetic Approaches for Biologically Relevant Heterocycles written by Goutam Brahmachari and published by Elsevier. This book was released on 2014-11-08 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green Synthetic Approaches for Biologically Relevant Heterocycles reviews this significant group of organic compounds within the context of sustainable methods and processes. Each clearly structured chapter features in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles classified on the basis of ring-size and/or presence of heteratoms(s). Techniques covered include microwave heating, ultrasound, ionic liquids, solid phase, solvent-free, heterogeneous catalysis, and aqueous media, along with multi-component reaction strategies. This book also integrates advances in green chemistry research into industrial applications and process developments. Green Synthetic Approaches for Biologically Relevant Heterocycles is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in medicinal, organic, natural product, and agricultural chemistry. Includes global coverage of a wide variety of green synthetic techniques Features cutting-edge research in the field of bioactive heterocyclic compounds Focuses extensively on applications, with numerous examples of biologically relevant heterocycles
Book Synopsis Recent Advances in Application of Synthetic Biology for Production of Bioactive Compounds by : Luan Luong Chu
Download or read book Recent Advances in Application of Synthetic Biology for Production of Bioactive Compounds written by Luan Luong Chu and published by Frontiers Media SA. This book was released on 2022-02-09 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Small Molecule Drug Discovery by : Andrea Trabocchi
Download or read book Small Molecule Drug Discovery written by Andrea Trabocchi and published by Elsevier. This book was released on 2019-11-23 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology. Outlines modern concepts and synthetic strategies underlying the building of small molecules and their chemical libraries useful for drug discovery Provides modern biophysical methods to screening small molecule libraries, including high-throughput screening, small molecule microarrays, phenotypic screening and chemical genetics Presents the most advanced chemoinformatics tools to characterize the structural features of small molecule libraries in terms of chemical diversity and complexity, also including the application of virtual screening approaches Gives an overview of structural features and classification of natural product-derived small molecules, including carbohydrate derivatives, peptides and peptidomimetics, and alkaloid-inspired small molecules
Book Synopsis Non-Conventional Synthesis by : György Keglevich
Download or read book Non-Conventional Synthesis written by György Keglevich and published by Walter de Gruyter GmbH & Co KG. This book was released on 2023-11-06 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis DFT Based Studies on Bioactive Molecules by : Ambrish Kumar Srivastava
Download or read book DFT Based Studies on Bioactive Molecules written by Ambrish Kumar Srivastava and published by Bentham Science Publishers. This book was released on 2021-08-13 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a guide for researchers, academics and experimentalists who wish to explore density functional theory (DFT) on selected molecular systems. The salient features of the book include concise and complete coverage of DFT on biologically active molecules, a basic guide to DFT for beginners followed by its computational application using a powerful Gaussian program. Subsequently, discussions on synthetic compounds, amino acids, and natural products have been offered by the authors for the benefit of the reader. The book also features an exclusive chapter on the quantum theory of atoms in molecules and is supplemented by an appendix on the Gaussian output for methane. Key Features: · basic introduction of density functional theory · practical introduction to Gaussian program · interpretation of input and output files · explanation of calculated parameters · examples of several bioactive molecules (syenthetic and natural) · correlation between theory and experiments · exploration of the hydrogen bonds · appendix covering Gaussian outputs for methane · beginner friendly text · references at the end of each chapter DFT Based Studies on Bioactive Molecules is a suitable handbook for academics, students and researchers who are learning the basic biophysics and computational chemistry of bioactive molecules with reference to DFT models.
